Endoscopic molecular imaging in inflammatory bowel disease

( Nam Seok Ham ),( Seung-jae Myung ) 대한장연구학회 2021 Intestinal Research Vol.19 No.1

Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providing characterization for patient stratification and assessing the response to molecular targeted therapy. In inflammatory bowel disease, endoscopic molecular imaging can be used to assess disease severity and predict therapeutic response and prognosis. Endoscopic molecular imaging is also able to visualize dysplasia in the presence of background inflammation. Several preclinical and clinical trials have evaluated endoscopic molecular imaging; however, this area is just beginning to evolve, and many issues have not been solved yet. In the future, it is expected that endoscopic molecular imaging will be of increasing interest among clinicians as a new technology for the identification and evaluation of colorectal neoplasm and colitis-associated cancer. (Intest Res 2021;19:33-44)

Practical experience of comparing rivaroxaban with enoxaparin for thromboprophylaxis (초)

( Nam Seok Ham ),( Kyoung Ha Kim ),( Yang Ki Kim ),( Hyung Suk Choi ),( You Sung Suh ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

대장내시경 시술 중 발생한 천공의 진단 및 치료

함남석 ( Nam Seok Ham ),배정호 ( Jung Ho Bae ),양동훈 ( Dong-hoon Yang ) 대한소화기학회 2019 대한소화기학회지 Vol.73 No.6

Colonoscopy is one of the most useful procedures for making the diagnosis and treating various colorectal diseases, but this procedure rarely causes serious complications such as perforation. The incidence of colon perforation during colonoscopy is low. However, as the demand for screening and surveillance colonoscopy has gradually increased and colonoscopic polypectomy has become a commoner procedure in daily clinical practice, endoscopists should pay attention to prevent and manage colonoscopy-related perforation. The purpose of this review is to briefly summarize the guidelines from the World Journal of Emergency Surgery for the management of colonoscopy-related perforation. (Korean J Gastroenterol 2019;73:327-331)

3,000 m 상당고도의 저압,저산소 환경에서 4주간의 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향

함주호 ( Joo Ho Ham ),남상석 ( Sang Seok Nam ),박훈영 ( Hun Yuong Park ),선우섭 ( Oo Sub Sun ) 한국운동생리학회(구 한국운동과학회) 2011 운동과학 Vol.20 No.4

함주호, 남상석, 박훈영, 선우 섭. 3,000 m 상당고도 저압·저산소 환경에서 4주간의 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향. 운동과학, 제20권 4호 461-474, 2011. 본 연구는 3,000 m 상당고도와 평지에서 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향을 cross-over study로 비교한 것이다. 연구의 대상자들은 체육전공 남자 대학생 14명으로, 트레드밀 달리기를 경사도 10%, 스피드 15~17 km/hr의 운동 강도로 4주간, 주 3회, 30초×10세트, 세트 간 휴식은 2분으로 하였으며, 3,000 m 상당고도(526 mmHg)와 평지(760 mmHg)에서, 각각 1차 트레이닝을 실시한 후 8주간의 휴식기를 거친 후 2차 트레이닝을 실시하였다. 그 결과 체중과 근육량은 3,000 m 상당고도 트레이닝 후에 유의하게 감소하였다. CPK는 두 조건 모두 트레이닝 후에 유의한 변화가 없었으나, LDH는 3,000 m 상당고도 트레이닝 후에 고강도 운동직후와 회복 5분에 유의하게 감소하였다. 혈중산소운반능력은 두 조건 모두 트레이닝 후에 유의한 변화가 없었다. EPOC는 평지 및 3,000 m 상당고도 트레이닝 후에 유의하게 증가하였다. 무산소성 파워는 3,000 m 상당고도 트레이닝 후에 유의하게 증가 하였다. 하지근 등속성 근력은 평지 트레이닝 후에 유의하게 증가 하였으나, 3,000 m 상당고도 트레이닝 후에는 유의하게 감소하였다. 100 m time trial은 3,000 m 상당고도 트레이닝 후에 유의하게 감소하였으나, 400 m time trial은 두 조건 모두 유의한 변화가 없었다. Ham, J. H., Nam, S. S., Park, H. Y., Sunoo, S. Effects of 4 weeks intermittent sprint training on anaerobic energy metabolites and performance in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m. Exercise Science. 20(4): 461-474, 2011. The study was designed to investigate the effects of intermittent sprint training in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m and sea level on anaerobic energy metabolism and performance. Fourteen college male students majoring sports volunteered to participate in this research. Running grade, speed, time, repetition time, and interval between running were 10 percent, 15-17 km/hr, 30 seconds, 10 times, 2 minutes respectively. Training period was 4 weeks. They took 8 weeks rest after first training (4 weeks) in 3,000 m simulated altitude and sea level. Also second training practiced 4 weeks in that order (a cross-over study). The results of this study were as follows. Weight and muscle mass were significantly decreased after 3,000 m simulated altitude training. CPK was not significantly changed after 3,000 m simulated altitude and sea level training. LDH was significantly decreased immediately after exercise and recovery 5 minutes after 3,000 m simulated altitude training. Oxygen transporting capacity of the blood was not significantly changed after 3,000m simulated altitude and sea level training. EPOC was significantly increased after 3,000 m simulated altitude and sea level training. Anaerobic power was significantly increased after 3,000 m simulated altitude training. Leg isokinetic muscular strength was significantly increased after sea level training. But it was significantly decreased after 3,000 m simulated altitude training. 100 m time trial was significantly decreased after 3,000 m simulated altitude training. But 400 m time trial was not significantly changed in two groups. We have demonstrated that weight, muscle mass and 100 m time trial was significantly changed by 4 weeks of intermittent sprint training in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m, whereas the other physiological parameters was not significantly changed in two groups.

Isolation of a New Phlorotannin, Fucodiphlorethol G, from a Brown Alga Ecklonia cava

Ham, Young-Min,Baik, Jong-Seok,Hyun, Jin-Won,Lee, Nam-Ho Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.9

(Salen)Mn-Catalyzed Oxygenation of Vinyl Arenes to the Corresponding Alcohols in the presence of Sodium Borohydride

Ham, Sung-bin,Lee, Nam Ho,Baik, Jong Seok 濟州大學校 基礎科學硏究所 1999 基礎科學硏究 Vol.12 No.1

Oxygen molecule plays a pivot role in the biological systems. In addition, it is probably the most desirable oxidant in organic synthesis in terms of economical and environmental viewpoints. Therefore, lots of efforts have long been focused to utilize molecular oxygen for the oxidation of organic compounds expecially using transition metals as an activator. Recent studies have been directed to the development of more mild and efficient oxygenation procedures, and indeed some excellent examples have been published very recently in the case of alcohol oxidation. Undoubtedly, development of novel and mild oxygenation methods is still in demand.

3차 의료기관에 입원한 노숙환자에서 감염질환의 유병율

함세운,남기석,노혜진,홍경득,황래석,방지환,신형식 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

목적 : 3차 의료기관에서 입원치료를 받았던 노숙자를 대상으로 감염성 질환의 유병율을 알아보고자 하였다. 재료 및 방법 : 2002년 1월부터 2004년 8월 사이에 국립의료원에서 입원 치료를 받았던 269명의 노숙자 환자들을 대상으로 의무기록을 조사하였다. 결과 : 연구 기간동안 입원치료를 받은 총 269명의 노숙자 환자 중 남자가 249명(92.9%), 여자가 19명(7.1%)이었다. 감염질환의 유병율은 B형 간염이 228명 중 15명(6.6%), C형 간염 113명 중 8명(7.1%), 결핵은 269명중 19명(7.1%), VDRL 양성인 경우는 234명 중 25명(10.7%), 항사람면역결핍바이러스항체 양성은 130명중 2명(1.5%)이었다. B형 간염표면항원에 대한 항체 형성자는 118명(51.7%), 항체 미형성자는 95명(41.7%)이었다. 결핵으로 진단된 19명 중 객담도말 및 배양검사와 조직검사로 확인된 경우가 14명, 균음성이나 임상적으로 의심되는 경우가 5명이었다. 간질환 및 관련된 합병증으로 입원한 환자 28명 중 B형 및 C형 간염바이러스에 관련된 경우는 5명(17.9%)에불과하였고 결핵은 19명중 13명(68.4%)이 폐결핵 및 림프절종대의 증상으로 입원치료를 받았다. 복합 감염의 경우는 총 9명이었는데 후천면역결핍증후군 환자였던 2명중 1명이 결핵에 이환되어 있으면서 VDRL 양성소견을 보였고 다른 1명이 HIV와 결핵의 동시감염이었다. 결론 : 노숙자 입원환자에서 결핵, C형 간염 및 매독의 유병율이 일반 인구에 비해 높았다. 노숙자환자를 담당하는 의료인력를 보호하고 환자의 감염질환 유무를 파악하기 위해 적절한 선별검사가 필요하며 감염질환의 확산을 방지하기 위한 정부의 적극적인 대책이 필요하다. Background : Despite the expected high prevalence of several infectious diseases among the homeless, a majority of them have not received screening test and early treatment. Materials and Methods : The subjects of this study were 269 homeless patients who had been hospitalized in the National Medical Center (Korea) between January 2002 and August 2004. Their medical histories and records were reviewed to analyze the prevalence and clinical characteristics of hepatitis B and C, syphilis, tuberculosis and HIV infection among them. Results : The entire 269 homeless patients being hospitalized during the period of this study consist of 249 male patients and 19 female patients. For the prevalence of infectious diseases, HBV was seen in 15 of 228 patients (6.6%); HCV in 8 of 113 patients (7.1%); VDRL positive in 25 of 234 patients (10.7 %); HIV antibody positive in 2 of 130 (1.5%); and tuberculosis in 19 of 269 (7.1%). The number of patients who had the antibody to hepatitis B was 118 (51.7%). Of 28 patients hospitalized with the chief complaints of liver diseases and/or their complications, the number of cases infected with hepatitis B and C viruses was only 5 (17.9%). On the other hand, for patients with tuberculosis, 13 of 19 cases (68.4%) were hospitalized with the chief complaints associated with symptoms of pulmonary tuberculosis or enlarged lymph nodes. The number of patients with multiple infectious diseases was 9 in total. Conclusion : As expected, the prevalence of some infectious diseases were higher among the homeless inpatients, than non-homeless population. Proper screening tests in order to determine the presence of any infectious diseases among the patients and protect involved medical staff are necessary. Further, the government should take proactive measures to prevent the spread of infectious diseases in the aspect of public health.

TP53 gain-of-function mutation promotes inflammation in glioblastoma

Ham, Seok Won,Jeon, Hee-Young,Jin, Xiong,Kim, Eun-Jung,Kim, Jun-Kyum,Shin, Yong Jae,Lee, Yeri,Kim, Se Hoon,Lee, Seon Yong,Seo, Sunyoung,Park, Min Gi,Kim, Hye-Mi,Nam, Do-Hyun,Kim, Hyunggee Nature Publishing Group 2019 Cell death and differentiation Vol.26 No.3

[P2-12] Administration of Buffers Lower the Incidence of Discolored Chicken Meat

Hyun-Seok Chae,Young-Mo Yoo,Jun-Sang Ham,Seok-Geun Jeong,Aera Jang,Chong Nam Ahn 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10

디지털 변전시스템 Process level 에서의 SV 데이터 전송성능 시뮬레이션 분석

김석곤(Seok-kon Kim),안용호(Yong-ho An),이남호(Nam-ho Lee),한정열(Jung-yeol Han),이유진(You-jin Lee),양효식(Hyo-sik Yang),함동욱(Dong-uk Ham) 대한전기학회 2014 대한전기학회 학술대회 논문집 Vol.2014 No.7