Sustained-release praziquantel tablet : pharmacokinetics and the treatment of clonorchiasis in beagle dogs

Hong, Sung-Tae,Lee, Sang Hyup,Lee, Seung-Jin,Kho, Weon-Gyu,Lee, Mejeong,Li, Shunyu,Chung, Byung-Suk,Seo, Min,Choi, Min-Ho 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12

Praziquantel is rapidly absorbed and secreted; and thus fractional doses are recommended for the treatment of cestode and trematode infections. In the present study, we developed a new praziquantel tablet formula allowing sustained-release (SRP). In vitro dissolution of SRP tablets showed that praziquantel at 300 ㎎/tablet combined with hydroxypropyl methylcellulose dissolved completely at a constant rate over 10 h, whereas the conventional praziquantel tablet (PZQ) was only 40% dissolved. Pharmacokinetic studies in dogs confirmed that SRP was absorbed more slowly than PZQ. The mean value of the area under the concentration/time curve from 0 h to the final observation time, the maximum concentration in serum, and the time of maximum concentration in serum for SRP were 3.471.500 ng/min for 0.25 ㎖, 10,300 ng for 0.25 ㎖, and 192 min. while the values for PZQ were 688,600 ng/min for 0.25㎖, 2,500 ng for 0.25㎖, and 135 min. The cure rate in dogs with a heavy infection (500 metacercariae) treated with a single dose of SRP (150 ㎎/tablet) at 50 ㎎/㎏ was 80%, while in dogs treated with a single dose of SRP (300 ㎎/tablet) at 30 mg/kg it was 60%, and the cure rate with PZQ was 20%. In each case. the egg reduction rate was similar (over 90%). No abnormal liver functions or hepatic or renal pathologies were observed in dogs administered with SRP at 30 ㎎/㎏. The SRP tablet showed sustained release and slow absorption; and it had an improved anthelmintic efficacy against Clonorchis sinensis in experimental dogs. compared with conventional praziquantel.

The relationship between aerobic capacity and the recruitment of activated sweat gland density with passive heating

( Tae Wook Kim ),( Jong Hyuck Kim ),( Nam Eun Bae ),( Hyung Seok Seo ),( Young Soo Baik ),( Jeong Beom Lee ),( Hun Mo Yang ),( Young Ki Min ) 한국운동영양학회 2012 Journal of exercise nutrition & biochemistry Vol.16 No.4

This study investigated whether the recruitment of activated sweat gland density during passive heating [immersion of the lower body into hot water, 41℃ for 30 min (PH), room temperature 23 ± 0.5℃ with 60 ± 3% relative humidity] is different in endurance-trained (Trainee), compared with that of untrained subjects (Control), as indicated by VO2max. Eight trainees and seven control female subjects (38.31 ± 4.91 ml·kg-1·min-1 and 31.8 ± 0.92 ml·kg-1·min-1, respectively, p < 0.01) were similar on all other physical characteristics. To compare the changes between the trainees and controls, serum cortisol and prolactin (PRL), tympanic temperature (TYMP), local activated sweat gland density (L-ASGD) and the mean whole body sweat loss volume (M-WBSLV) changes were measured after PH. The cortisol was significantly higher (p < 0.05) and the PRL tended to be higher in the Trainee than in the Control. The TYMP increased more in the Trainee than in the Control (p < 0.001). The L-ASGD showed a higher tendency in the Trainee than in the Control, there was a significant difference in the mean activated sweat gland density (p < 0.01) and the L-ASGD was significantly correlated with the VO2max (p < 0.001). The M-WBSLV was significantly higher in the Trainee (p < 0.001) and significantly correlated with the VO2max (p < 0.001). The results suggest that in humans, a high aerobic capacity is associated with a greater recruitment of activated sweat glands, whole body loss of volume and TYMP. Therefore, the decline in the heat loss responses, due to decrease in maximal oxygen consumption, may be masked by repeated endurance exercise training.

K-POP 커버댄스 운동이 청소년 폭력 관련 심리 변인 및 혈중 호르몬 농도에 미치는 영향

서태범(Tae-Beom Seo),김영숙(Young-Sook Kim),김유미(Yu-mi Kim),강민정(Min-Jeong Kang),서경호(Kyeong-Ho Seo),박해찬(Hae-Chan Park) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.5

The purpose of this study was to examine the effect of K-POP cover dance on violence related psychological factors, blood hormones, and neurotransmitters in adolescents. Participants in this study were 30 males and females taken blood sample and surveyed. All participants were performed K-POP cover dance (50~75%MHR, 80 min/day, 3days/week) during 8 weeks. School stress, assumed stress, interpersonal stress, ego stress were composed the stress factors. Body and verbal aggression, propriety, anger were composed aggression factors. School stress, assumed stress, interpersonal stress, ego stress were decreased significantly on K-POP cover dance. Also, body and verbal aggression, propriety, doubt, anger were decreased significantly on K-POP cover dance. Cortisol, melatonin, beta-endorphin, serotonin, dopamin were composed violence related blood factors. Cortisol were decreased significantly, but melatonin and dopamin were no significantly on K-POP cover dance. It is concluded that K-POP cover dance caused positive effects on violence and stress, stress related blood hormones.

전립선암과 전립선비대증 환자에서 혈청 유리 및 총전립선특이항원 측정의 의의

서혁준,박형민,권태균,정성광,김법완,이재태 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Purpose: This study was peformed to investigate whether the free to total PSA ratio(F/T PSA ratio) offers a better discriminant for the detection of patient with prostatic cancer(CaP) and those with benign prostatic hyperplasia(BPH) than serum total PSA alone. Materials and Methods: From September 1996 to February 1999, free and total PSA levels were measured on frozen sera samples of 154 men with BPH and 46 with CaP using immunoradiometric assay. Results: In all subjects, the mean total PSA was significantly higher in CaP group(72.57±66.58ng/ml) than BPH group(3.12±4.10ng/ml). The mean PSAD was significantly higher in CaP group(1.64± 1.86) than BPH group(0.08±0.01). The mean F/T PSA ratio was significantly lower in CaP group(0.19± 0.07) than BPH group(0.30±0.13). Among 41 subjects whose total PSA were between 4-20ng/ml, the mean PSAD was significantly higher in CaP group(0.37±7.16) than BPH group(0.17± 0.07), but the mean F/T PSA ratio was not significantly different between CaP(0.19± 0.10) and BPH group(0.25±7.13). By comparing the sensitivity and specificity of total PSA alone, PSAD and F/T PSA ratio on receiver operating characterislic (ROC) Cutie in all subiects and subiects with total PSA between 4-20ng/ml, F/T PSA ratio had no superiority than total PSA alone and PSAD for discrimination between CaP and BPH. Conclusions: We suggest that the F/T PSA ratio is not superior to total PSA alone and FSAD in the detection of prostatic cancer, and further evaluation of the usefulness of F/T PSA ratio should be required.

공동주택 장기수선계획 시스템 개발을 위한 분석ㆍ설계단계에 관한 기초적 연구

서민구,정영한,박태근 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

Extension of building life cycle and reduction of maintenance and management relevant expenses are the top issues in the current construction market. The fields of maintenance and management are newly highlighted for the limited land and domestic economic crisis known as the 2nd IMF. We studied on the long-term maintenance plan of apartment buildings in order to analyze the defective management system of existing apartment building and secure the development-oriented management system in this study. Purposes of this study are to prevent the unwanted loss of manpower and capital resulted from the careless storage of repair and management records, extend the building life cycle and resolve the conflict caused by the uncomfortable relation with the occupants. This study is focused on presenting the potential to develop the process required for the basic analysis and development of system as the beginning stage in the process of developing the long-term maintenance plan.

약죽요법에 관한 연구

徐海卿,吳旼錫,宋泰元 대전대학교 한의학연구소 2002 혜화의학회지 Vol.10 No.2

Objectives: There are a lot of food used herb medicine among the people in order to cure disease. A medicinal gruel is the easiest and most universal among alimmentotherapy. The purpose of this thesis is to understand a medicinal gruel therapy. Methods: I researched the definition, history, ingredients, application and special feature. Result and conclusion : A medicinal gruel therapy is alimmentotherapy for diseases prevent and diseases treatment which get mixed with her medicine and rice, based on oriental medicine theory. A medicinal gruel therapy was put on record in <A historical book>. A medicinal gruel therapy can be used in chronic diseases, convalescent stage, assistant treatment for acute disease, disease prevention, aging prevention, diet food and substitute food for breakfast.

무기고화제를 이용한 중금속 오염 광미의 안정화 처리를 위한 기초연구

민경원,김태풍,이현철,서의영 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.A

Stabilization treatment is one of processes for wastes and their components to reduce their toxicity and migration rates to surroundings. Inorganic binders such as calcium hydroxide, blast furnace slag and red mud were tested for their potential applicability to in-situ stabilization of heavy metal contaminated tailings in the abandoned metal mines. Columns(150mm dia. x 450mm length) filled with mixtures of inorganic binders and tailing from the Geumjang mine with various mixing ratios of binders to tailings, 5%, 7% and 9% were applied artificial rainfall tests for 28 days. Effluents from columns filled with calcium hydroxide and tailing showed high pH's of ~12.5 and a increasing trend of concentration in Pb and Zn with a significant decrease in permeability in terms of elapsed days. Those with burning slag and tailing showed pH's of ~8.5 and significantly low concentrations in heavy metals with a stable permeability. In case of red mud, effluents showed significantly low concentrations in heavy metals but a decreased permeability with pH's of ~10.5. Conclusively, this basic study suggests burning furnace slag be a potential stabilizer for effective treatment of heavy metal contaminated mine tailings.

고장성 식염수를 이용한 실험적 근육통에서의 통증 양상

손민균,김태민,서정수,김봉옥,윤승호 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.3

응집에 의한 생물학적 처리수의 색도 및 난분해성 유기물 제거

서태경, 박상민, 박노백, 임지영, 전항배 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

This study was to evaluate the optimum conditions for chemical coagulation to remove color and non-biodegradable organic matters from the biologically treated water of piggery wastewater. Raw water was fractionated by characteristics of dissolved organic matter. The fractions of hydrophilic substance and molecular weight cut-off(MWCO) below 500 in raw water were 51% and 74%, respectively. SC(streaming current) was measured to find out the optimum pH values and dosages for aluminium sulfate[Al₂(SO₄)₃·14H₂O] and ferric chloride[FeCl₃·6H₂O] as a coagulant, which was compared with color and turbidity removal efficiencies followed by coagulation, flocculation and sedimentation. From several jar tests, optimum pH values and dosages of coagulants were well matched with the results of SCD analyses. The optimum dosages(pH values) of aluminium and ferric were 5.84 mM(pH 4.0) and 7.03 mM(pH 5.6), respectively. At optimum conditions of coagulation, color removal efficiencies for aluminium sulfate and ferric chloride were as high as 89.3 and 97.9%, respectively. Chemical coagulation showed good performance to remove color and non-biodegradable organic matters from biologically treated water.

가열로의 열적해석 및 설계인자에 관한 연구

서용석,강성규,박원희,민동호,김태국 중앙대학교 기술과학연구소 1998 기술과학연구소 논문집 Vol.28 No.-

본 연구에서는 3차원 정육면체 가열로 내의 전도-대류-복사 복합열전달 특서을 해석하였으며, 연소가스의 유입속도, 벽면의 반사율과 매체의 흡수계수 등과 같은 인자들의 변화에 따른 영향을 살펴보았다. 가열로의 벽면들은 단열되어 있고 가열로 내부로 일정한 온도의 연소가스가 유입될 때 시스템 내부의 온도는 유입 온도와 비슷하게 균일한 온도 분포를 갖는 것으로 예측할 수 있었다. 유입 속도가 증가하더라도 가열로 내부의 온도에는 거의 영향을 미치지 않았으며, 가열로는 유입되는 연소가스의 흡수계수가 증가할수록 가열로 내부의 온도는 보다 균일하게 된다. 또한, 가열로 내부 벽의 반사율이 커질수록 벽의 온도는 감소하고 또한 벽면에 작용하는 유효복사열유속은 증가함을 알 수 있었다. 이러한 해석 결과로부터 가열로 내부의 온도 분포는 매체의 흡수계수가 클수록 그리고, 벽면 반사율이 작을수록 일정하게 유지될 수 있다는 것을 알 수 있었다. 그리고 이러한 결과들을 종합하여 볼 때 가열로의 설계 시 일정한 열의 유입과 가열로를 단열시키는 것이 중요하며, 그리고 매체의 흡수 계수를 크게 하고, 그리고 벽면의 반사율을 작게 하는 것은 가열로 내부의 온도를 일정하게 유지할 수 있는 중요한 조건이 된다는 것을 알 수가 있었다.