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온풍 조건에서 수분 탈락 정도에 따른 피부 분류 및 개선 방안에 대한 연구
권오선 ( Oh Sun Kwon ),강현종 ( Hyun Jong Kang ),한승민 ( Seung Min Han ),윤지선 ( Ji S Eon Yoon ),조웅희 ( Woong Hee Cho ),오주영 ( Joo Young Oh ),임준만 ( Jun Man Lim ),송영숙 ( Young Sook Song ),박선규 ( Sun Gyoo Park ) 대한화장품학회 2020 대한화장품학회지 Vol.46 No.2
피부를 탄력있고 부드럽게 하는 역할은 각질층에 존재하는 수분량에 의해 좌우된다. 피부 수분량은 냉온풍, 건조환경 등 다양한 환경 변화에 의해 영향을 받음이 알려져 있으나, 개인 피부 차이에 따른 피부수분량 변화와 회복 정도에 대해서는 많은 연구가 이루어 지지 않은 실정이다. 본 연구에서는 온풍 조건하에서 피시험자들의 피부 수분 탈락 및 회복 정도를 비교 평가하여 새로운 피부 타입을 제시하고, 온풍 조건에서 저하되는 피부 수분량을 개선 시켜주는 효능 물질을 개발하고자 하였다. 온풍 환경 조성을 위해, 건강한 피험자(남: 10 명, 여: 39 명, 25 세 - 63 세)의 전완부에 온풍(30 cm, 40 ℃, 6 m/s)을 30 min 간 피부에 노출시켜, 피부 수분량의 변화를 평가하였다. 26명(남: 4 명, 여: 22 명, 평균 연령: 42.7 ± 9.4)이 온풍 노출전에 비하여 온풍 노출 후 수분량이 유의하게 감소하며, 노출 후 30 min이 지나도 회복이 되지 않았다. 온풍노출 후 수분량이 떨어지는 피험자(여: 10 명)를 대상으로 보수력이 높은 크림을 3 주간 전완부에 적용한 이후 동일 온풍 조건하에서 피부 수분량을 측정한 결과, 노출 30 min 후 피부 수분량이 온풍 노출 전 수준으로 회복됨을 확인하였다. 본 연구를 통하여 피부는 건조 조건에서 쉽게 수분을 잃어버리는 피부(탈수형 피부)가 존재하는 것을 확인하였다. 이는 앞으로 화장품 개발을 보습 기능뿐만 아니라, 이러한 환경변화에 따른 피부수분이 쉽게 빠져나가는 피부(탈수형 피부)의 특성에 맞는 제품의 효능 개발이 필요함을 보여준다. Elasticity and softness of the skin depend on the level of moisture present in the stratum corneum, which is known to be affected by various environmental changes, such as cold and hot winds and dry environments. However, not many studies have been conducted on changes in skin moisture and the degree of recovery due to individual skin differences. In the present study, we aimed to investigate the effect of warm air heating on skin hydration levels and develop moisturizing formulas to improve lowered skin hydration levels. In order to deliver warm air heating condition, heating dryer (40 ℃, 6 m/s, 30 cm apart from forearm) was applied into inner forearm of healthy subjects (male: 10, female: 39, age: 25 - 63) Among 49 subjects, 26 subjects showed significantly lowered skin hydration levels until 30 min after warm air heating exposure (lowered group). In addition, moisturizing cream with high water holding capacity was applied to forearm of 10 subjects in lowered group for 3 weeks and skin hydration levels after warm air heating were significantly improved at the levels of before application of warm air heating. From this study, we found out that there is a skin type that skin hydration levels are significantly decreased under warm air heating condition (dehydrated skin) and this dehydrated skin can be improved by moisturizing formulas with high water holding capacity.
인체혈장 중 에탐부톨의 HPLC 분석법의 검증 및 단일용량 투여에 의한 약물동태 연구
곽혜선,박경호,최준식,송진아,성민경,장정옥,이화정 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
An HPLC method was employed for the determination of ethambutol in human plasma. After addition of internal standard (IS, octylamine, 2 μg/mL) and alkalinization of the plasma with 5 M sodium hydroxide, the drug and IS were extracted into the mixture of chloroform and diethyl ether (40:60, v/v). Following a 15-min vortex-mixing and a 10-min centrifugation, the organic phase was spiked with 100 pL of phenylethylisocyanate (2000 μg/mL) for chemical derivatization, mixed for 5 min and evaporated to dryness under a stream of nitrogen. The residue was reconstituted with 100 μL of mobile phase and 20 pL was injected into Cl8 column with a mobile phase consisting of methanol:water (70:30, v/v). The samples were detected utilizing an ultraviolet detector at 200 nm. The method was specific and validated with a limit of 0.15 μg/mL. Infra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of this method was demonstrated by analysis of human plasma after oral administration of a single 1200-mg dose to 20 healthy subjects. From the plasma ethambutol concentration vs. time curves, the mean AUC was 9.61 ± 1.64 μg hr/mL. and Cmax of 2.68 μg/mL reached 2.73 hr after administration. The mean biological half-life of ethambutol was 3.46 ± 1.21 hr. Based on the results, this simple and validated assay could readily be used in any pharmacokinetic studies using humans.
Lee Sun Min,Choi Muncheong,전병오,Sun Kyunghwa,Kim Ki Sub,Kang Seung Wan,Song Hong-Sun,Moon So Young 대한치매학회 2022 Dementia and Neurocognitive Disorders Vol.21 No.3
Background and Purpose: The effects of high-intensity interval training (HIIT) interventions on functional brain changes in older adults remain unclear. This preliminary study aimed to explore the effect of physical exercise intervention (PEI), including HIIT, on cognitive function, physical performance, and electroencephalogram patterns in Korean elderly people. Methods: We enrolled six non-dementia participants aged >65 years from a community health center. PEI was conducted at the community health center for 4 weeks, three times/week, and 50 min/day. PEI, including HIIT, involved aerobic exercise, resistance training (muscle strength), flexibility, and balance. Wilcoxon signed rank test was used for data analysis. Results: After the PEI, there was improvement in the 30-second sit-to-stand test result (16.2±7.0 times vs. 24.8±5.5 times, p=0.027), 2-minute stationary march result (98.3±27.2 times vs. 143.7±36.9 times, p=0.027), T-wall response time (104.2±55.8 seconds vs.71.0±19.4 seconds, p=0.028), memory score (89.6±21.6 vs. 111.0±19.1, p=0.028), executive function score (33.3±5.3 vs. 37.0±5.1, p=0.046), and total Literacy Independent Cognitive Assessment score (214.6±30.6 vs. 241.6±22.8, p=0.028). Electroencephalography demonstrated that the beta power in the frontal region was increased, while the theta power in the temporal region was decreased (all p<0.05). Conclusions: Our HIIT PEI program effectively improved cognitive function, physical fitness, and electroencephalographic markers in elderly individuals; thus, it could be beneficial for improving functional brain activity in this population.
뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교
송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10
Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.
일 농촌지역 노인의 연령에 따른 신체조성, 체력 및 낙상경험 비교
송민선,김수근,김남초 노인간호학회 2009 노인간호학회지 Vol.11 No.2
Purpose: The purpose of this study was to identify the status of body composition, physical fitness and experience of falls according to age of elders in a rural community. Method: From June 2008 to May 2009, 306 elders participated in this study. Measurements were made for body composition using In body 3.0 and for physical fitness using arm curl, sit to stand, 2 minute walk, back stretch, chair sit and reach, one leg stand with eyes open, and 244 ㎝ up and go. Chi-square test, t-test, ANOVA and Scheffe‘s test were used with the SAS program for data analysis. Results: The results showed that the following were significantly different according to age: muscle mass(p<.001), arm curl(p<.001), sit to stand (p<.001), back stretch(p<.001), one leg stand with eyes open(p<.001), 244 ㎝ up and go(p<.001). Also, there was a significant difference in muscle mass(p=.003) according to experience of falls. Conclusion: The results indicate that elderly people need an exercise program which is appropriate for different body composition and physical fitness aspects according to age and experience of falls.
송혁,송민정,최형욱,김선우 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1
The prediction of aircraft noise is based on the database of airplane's noise characteristics such as take-off and landing style etc. In this study, to predict the airplane flight noise, airplane which is being used for passengers and cargos currently are surveyed. The airplanes were divided into types and the noise characteristics of take off, flight at constant speed and landing were analyzed to establish database for prediction of aircraft noise. And the result of this study should be connected with GIS(Geographic Information System) to measure the area which is affected by aircraft noise.
난치성 만성정신분열증 환자의 생활의 질에 미치는 정신사회치료 프로그램의 효과에 대한 예비연구
송동호,배민진,이종호,이홍식,김선경,서호석,김찬형,전지용 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4
Objects : Recent studies of psychosocial adjustment after hospitalization have found that the combination of maintenance antipsychotic drug treatment and psychosocial treatment including psychoeducational program are highly predictive of social rehabilitation and reduction of subsequent relapse. Two groups of patients with refractory chronic schizophrenia were preliminarily compared to determine the effect of a psychosocial treatment program on the quality of life in refractory chronic schizophrenics in an open comparative trial. Methods : One group(N=11) was assigned to approximately six months of the psychosocial treatment program(including psychoeducation program and activity program such as interpersonal relationship program, social skill training, self management program, outings, etc), in a group format, twice a week and a fixed maintenance dosage of clozapine ; while scale(QLS) was used to provide an objective measure of changes in patient's psychosocial functioning and a general assessment of psychopathology was made using the Brief Psychiatric Rating Scale(BPRS). Results : Both BPRS total positive score and the QLS total score, especially in the intrapsychic foundation factor of the scale showed a statistically significant improvement in the psychosocial treatment group. But there was no significant change in both BPRS and QLS scores over a 6-month period in the non-psychosocial treatment group. A significant negative correlation was found between the negative symptom and changes of QLS total, instrumental role and common object and activities scores respectively after receiving a 6-month of the psychosocial treatment program. Conclusion : These results suggest that a psychosocial treatment program including the integration of psychoeducation and a skill training oriented activity program serve as an outpatient treatment modality to improve the quality of the life in refractory chronic schizophrenia. To further clarify the effect of psychosocial treatment in chronic schizophrenia, a randomized trial should be done.
송민선 노인간호학회 2008 노인간호학회지 Vol.10 No.2
Purpose: The purpose of this study was to investigate the needs of nursing students participating in a gerontological nursing practicum. Method: From June 2007 to September 2008. 114 nursing students were surveyed using structured questionnaires Data were analyzed using descriptive statistics. Results: For nursing seivice the need to be able to do position change wound discharge sampling urine glucose test fluid monitoring bedsore care exercise therapy was high A practicum program for the students needs to include programs on health promotion physical treatment oriental medical care and health exercise Many students want to have practice directed by general nurses in gerontological nursing in the long-term care hospitals and in social welfare centers. Conclusion: These results indicate that in planning a gerontological nursing practicum the needs of the nursing students should be considered.
송윤신,권순복,안금선,김영남,김수화,차민주 경복대학 2003 京福論叢 Vol.7 No.-
경기 K대학 치위생과 재학생들의 대학 진학시 학과선택 요인을 알아보고, 학과 만족도를 분석하여 치위생과 학과 경쟁력을 높이고 학생지도의 기초자료를 제공하고자 한다. 치위생과 입학 결정시 영향을 준 요인으로는 전반적으로 본인이 가장 높게 나타났으나 학년별로는 2학년이 77.5%로 가장 높았으며, 치위생과 선택이유로는 취업보장, 주위권유, 적성·흥미 순으로 조사되었다. 치위생과 학과만족도에서 강의실환경에 대해서는 전체 조사대상자 중 9.4%가 만족하다고 응답했고, 실험·실습기자재는 36.0%가 만족한다고 응답하였으며, 학우관계에서는 74.0%, 학과지도방침 38.9%, 치과위생사 직업만족도는 79.4%가 만족하고 있었다. 특히 조사대상자 중 다른 학년보다 2학년 학생들에게서 직업만족도를 제외한 다른 항목의 만족도가 가장 높게 나타나고 있다. 직업만족도는 1학년이 85.4%로 가장 높게 조사되었다. 휴학·자퇴를 고려한 경험유무에 대한 질문에서는 있다고 응답한 학생이 47.8%이었으며, 그 이유로 1학년은 경제적이유를, 2, 3학년은 적성이라고 응답하였다. 입학결정요인과 만족도와의 관계에서는 본인이 입학을 결정했을 때 재학만족도, 직업만족도, 학과지도방침, 전임교수에 만족한다고 응답한 경우가 가장 많았으며 진로계획에서는 취업이 가장 높았다. 학우관계와 만족도와의 관계에서는 학우관계에 만족한다고 응답한 경우 재학만족도, 직업만족도, 학과지도방침에 대한 만족도가 높은 것으로 분석되었다. 구강보건교육이 치위생과 선택에 미친 영향력에 대한 조사에서는 학년별 유의성은 보이지 않았으나, 전체조사대상 중 89.5%가 영향력이 보통이상이라고 응답해 높은 비율을 차지하는 것으로 나타났다. The purpose of this study is to identify the factors affecting selection of a major and the department satisfaction for improving the competitiveness of the dental hygiene department and providing the data for students guidance. The most influential person and factor in selecting a major is the person oneself(77.5% of the second-year students responded to the question) and the percentage of employment. The reaction of satisfaction with the classroom and practice facility indicates 9.4% and 36.0% in favor. 74.0% of surveyees is satisfied with classmates. In satisfaction with a course of department and profession, 38.9% and 79.4% of respondents answer in the affirmative. The second-year students of the respondents shows higher rate than other grades in .satisfaction with items above, except the satisfaction with profession. It appears that the freshman answered the most in that question. From the survey related to the experience of thinking over temporary absence from school or voluntary resignation, 47.8% of surveyees responded they had experienced thinking about that. The freshman answered the reason is financial difficulty and the second- and third-year students selected an aptitude. In the correlation coefficient of determinants for selection of college with the department satisfaction, when the determinant is oneself, the satisfaction with being at college, profession, a course of department, and teaching staff is high. In the correlation coefficient of classmates with department satisfaction, the students responding in the affirmative on classmate satisfaction had a high degree of satisfaction with being at college, profession, and a course of department. The experience of oral health education is not statically significant by grades to select the major, but 89.5% of the students majoring dental hygiene at K-college responded over average.
노인의 일상생활활동 및 우울 정도가 자아통합감에 미치는 영향
송민선,김남초 노인간호학회 2007 노인간호학회지 Vol.9 No.2
Purpose: The purpose of this study was to identify the factors influencing ego-integrity and to investigate levels of ego-integrity, activities of daily living (ADL) , instrumental activities of daily living (IADL). depression and their relationships in the institutionalized and non-lnstitutlonalized elderly. Method: From July to August 2007. 50 institutionalized elders and 47 non-institutionalized elders were surveyed through structured questionnaires. Result: Ego-integrity of the institutionalized elders was significantly lower than the non-institutionalizad elders (p= .00l). ADL (p=.OOl), IADL (p=.OOl) and depression (p= .00l) of the institutionalized elders was higher than the non-institutionalized elders. ADL and IADL (p=.OOl), and ADL and depression (p=.023) had significant positive correlations in the institutionalized elders. Ego-integrity and depression (p = .008) had a significant negative correlation in the non-institutionalized elders. ADL and IADL (p=.OOl), and ADL and depression (p=.002) lad significant positive correlations in the non-institutionalized elders. In multiple linear regression analysis, institutionalization and : depression were significantly related to egointegrity. Conclusion: It is necessary to try to enhance ego-integrity, ADL and IADL in the institutionalized elderly. Also, it is more urgent to develop health programs and a health care service system for institutionalized elders than for non-institutionalized elders. but also to develop supports to help elders stay in the community.