Ⅲ급 부정교합의 정형적ㆍ교정적 치료

양규호,박미란,최남기 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.4

Ⅲ급 부정교합, 특히 전치부 반대 교합은 부모나 주위 사람에 의해 쉽게 인지되기 때문에 비교적 어린 시기에 내원하는 빈도가 높아지고 있다. 이에 따라 치과의사는 치료시기에 대한 결정, 적절한 case의 선택, 장기간에 걸친 치료, 치료후의 재발등에 대한 심리적 부담감을 안게 되며 보호자 또한 시간적, 경제적인 어려움을 겪게 된다. 그러나, 반대 교합 그 자체는 조기 개선시 상악골의 성장 저해를 막을 수 있으며, 하악 과성장을 억제함으로써 기능성인 경우에 골격성으로의 발전을 억제 할 수 있다. 그리고 상하악골의 골격 부조화가 매우 크거나 좋은 예후를 기대하기 힘든 골격 구조에 대해서도 정확한 평가가 병행되어야 한다. 골격성 Ⅲ급 부정교합으로 내원한 환아를 성장기 동안 치료함으로써 다음과 같은 결론을 얻었다. 1. 상악골의 정상적인 성장 저해 요소를 제거하고, 하악골의 과성장을 조절해줌으로써 전치부 반대교합을 해소하였다. 2. 상악골과 상악 전치는 전하방으로, 하악골과 하악 전치는 후하방으로 이동하였다. 3. 경조직, 연조직의 변화로 인해 안모의 개선을 나타내었다. The conventional treatment of skeletal class Ⅲ malocclusion has been focused on the application of orthopedic force primarily to the mandible. Thus moderate Class Ⅲ malocclusions can be corrected by the anterior displacement of the maxilla and maxillary dentition, possibly by restricting the growth of the mandible or by changing its direction. The patients having skeletal Class Ⅲ molocclusion were treated with removable appliance & fixed appliance for detailed tooth movement and the following results were observed : 1.The anterior crossbite was corrected. 2.The forward and downward growth of the maxillary complex was obtained. 3.The lingual tipping of the mandiblar incisors was performed and the mandible was rotated in the clockwise direction.

수종 치과용 광중합형 복합레진의 화학적 분해

양규호,최남기,박미란,박은혜 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.3

이상적인 수복재료의 요건으로 치아의 저작기능과 심미성을 충분히 회복시킬 수 있는 물리적. 화학적 성질을 갖추는 동시에 생물학적인 적합성과 구강내 환경변화에 따른 내구성 등을 들 수 있다 그러나 복합레진을 이용하여 치아를 수복하였을 때 수복물은 구강내에서 시간이 흐름에 따라 타액내에서 서서히 분해되고 교합력이나 음식물에 의해 마모되어가는 운명을 거친다. 본 연구에서는 현재 수복재료로서 많이 사용되고 있는 Definite(Degussa-Hiils AG. Germany), Revolution(Kerr, U.S.A.) Unifil(GC, Japan) , Palfique(Tokuyama, Japan)의 4종의 복합레진을 알카리성 용액 (0. IN NaOH)에 보관하였을 때 각 제품의 분해저항성을 평가하고자 하였다. 각 제품당 3개의 시편을 제작하여 무게측정을 한 후 0.IN NaOH에 저장하여 60℃에서 보관하였다. 2주 후 제거하여 HCI로 중화, 세척 후 60℃에서 건조하였다 무게손실, 표면하분해층 깊이, 용출된 Si농도를 기준으로 각 레진의 분해저항성을 평가하여 다음과 같은 결과를 얻었다. 1. 무게손실량은 Unifil에서 3.21%로 가장 높았으나 각각 제품간에 있어서의 차이를 보이지는 않았다. 2. 분해층 깊이는 107.69∼47.407n의 범위였고, Unifil, Palfique. Revolution, Definite 순으로 감소하였으며 Palfique. Definite를 제외한 다른 제품간에는 유의한 차이를 보였다(p(0.05). 3. Si 용출량은 Palfique가 8940.Oppm으로 가장 많은 용출량을 보였으며 Revolution과 Definite를 제외한 각 제품간에는 유의한 차이를 보였다(p<0.05). 4. 각 제품의 무게손실과 분해층 깊이 사이에는 높은 상관관계를 보였다(r= 0.06, p<0.05) 5. 각 제품의 무게손실과 Si 용출량, 분해층 깊이와 Si 용출량 사이 에는 유의한 상관관계를 보이지 않았다. 6. 주사전자현미경 관찰시 NaOH용액에 보관한 후 레진 기질과 필러 사이의 결합의 파괴를 관찰할 수 있었다. The aim of this study was to evaluate the resistance to degradation of four commercial composite resins in an alkaline solution. The brands studied were Unifil(GC, Japan) , Palfique(Tokuyama, Japan) , Definite(Degussa-Huls AG, Germany) . Revolution(Kerr U.S.A.) . Preweighed discs of each brand were exposed 0. IN NaOH solution at 60℃. After 14 days they were removed, neutralized with HCI, washed with water and dried. Resistance to degra-dation was evaluated on the basis of following parameters : (a) mass loss(%) - determined from pre-and post-ex-posed specimen weights: (b) Si loss(ppm) - obtained from ICP-AE analysis of solution exposed to specimens and (c) degradation depth(㎛) - measured microscopically (SEM) from polished circular sections of exposed specimens. The results were follows. 1 The mass loss of Unifil was 3.21%, it was the highest of materials. But, there was no significant difference among the materials. 2. The degree of degradation layer depth was 107.69∼47.40㎛, the sequence of the degree pf degradation layer depth was in descending order by Unifil, Palfique, Revolution Definitre. There was significant difference among the materials except Palfique and Definite. 3. The Si loss of Paltique was 8940.Oppm, it was the highest. There was significant difference among the materials, except Revolution and Definite(p<0.05). 4. The correlation coefficient between mass loss and degradation depth was relatively high(r = 0.06. p<0.05). 5. There was no significant coefficient correlation between Si loss and mass loss, and/or the degree of degradation layer depth and Si loss. 6. When observed with SEM, destruction of bonding is observed between resin matrix and filler. Above results suggested that the hydrolytic degradation is considered as evaluation factor of composite resins.

구치부 레진 수복 재료의 가수분해

양규호,박미란,최남기,박은혜 大韓小兒齒科學會 2001 大韓小兒齒科學會誌 Vol.28 No.4

우수한 심미성 수복재료로서 복합레진은 그 사용 빈도가 증가하고 있다. 이런 증가 추세에도 불구하고 복합레진의 부적절한 마모저항성 때문에 구치부 수복에서의 사용이 제한되어왔다. 이와 관련된 인자로 수복물의 표면하 분해가 고려되고 있다. 본 연구에서는 복합레진의 마모에 미치는 환경적 분해의 효과를 알기 위해 알카리성 용액(0.1 N NaOH)에 현재 많이 사용되는 Definite(Degussa-Hu¨ls AG, Germany), Prodigy(Kerr, USA), Pyramid(Bisco, USA) 및 Synergy(Coltene, Swiss)등 4종의 복합레진을 보관하였을 때 각 제품의 분해과정을 평가하고자 하였다. 각 제품 당 3개의 시편을 제작한 후 0.1N NaOH 용액에 저장하여 60℃에서 보관하였다. 2주 후 제거하여 HCI로 중화, 세척 후 60℃에서 건조하였다. 무게 손실, 분해층 깊이, Si 농도 등을 기준으로 분해저항성을 평가하여 다음과 같은 결과를 얻었다. 1. 무게 손실은 Synergy에서 1.24±0.002%로 가장 높은 값을 보였으나 각 제품간 유의한 차이는 보이지 않았다. 2. 분해층 깊이는 Synergy에서 107.83±2.52㎛로 가장 높은 값을 보였고, Synergy를 제외한 다른 제품에서는 유의한 차이를 보이지 않았다. 3. Si 용출량에 있어서는 4가지 제품 모두 차이를 보이지 않았다. 4. 무게 손실과 분해층 깊이 사이에는 높은 상관 관계를 보였다(r=0.6127, p<0.05). 5. 무게 손실과 Si 용출량, 분해층 깊이와 Si 용출량 사이에 상관 관계는 없는 것으로 나타났다. 6. 주사전자현미경 관찰시 NaOH 용액에 보관한 후 레진 기질과 필러 사이의 결합 파괴를 관찰할 수 있었다. The use of resin composites has continued to increase over the last several years. In spite of their growing popularity, composites continue to exhibit a number of undesirable characteristics. One of the major deficiencies of composite restorative resins is their inadequate resistance to wear. Of the multitude of factors that have been associated with wear, subsurface degradation within the restoration is considered to be one. The aim of this study was to evaluate the resistance to degradation of four commercial composite resins in an alkaline solution. This solution with a high concentration of hydroxyl ions is a convenient medium for accelerated degradation of silane coupling and filler particles. The brands studies were Definite(Degussa-Hu¨ls AG, Germany), Prodigy(Kerr, USA), Pyramid(Bisco, USA) and Synergy(Coltene, Swiss). Preweighed discs of each brand were exposed to 0.1N NaOH solution at 60℃. After 14 days they were removed, neutralized with HCI, washed with water and dried. Resistance to degradation was evaluated on the basis of following parameters: (a) mass loss(%)-determined from pre-and post-exposed specimen weights; (b) Si loss(ppm)-obtained from ICP-AE analysis of solution exposed to specimens; and (c) degradation depth(㎛)-measured microscopically (SEM) from polished circular sections of exposed specimens. The results were follows: 1. Mass loss of Synergy was 1.24±0.002%. it was the highest, there was no significant difference among the materials. 2. The degree of degradation layer depth of Synergy was 107.83±2.52㎛, it was the highest, there was no significant difference among any other materials than Synergy. 3. There was no difference among the four materials in Si loss. 4. The correlation coefficient between mass loss and degradation depth was relatively high(r=0.06, p<0.05). 5. There was no coefficient correlation between Si loss and mass loss, the degree of degradation layer depth and Si loss. 6. When observed with SEM, destruction of bonding is observed between resin matrix and filler.

임상실습 교육을 위한 임상실습지도자제도(preceptorship)의 모형개발

안양희,최상순,허혜경,임영미,신윤희,박소미,김대란,김기경,김기연 연세대학교 교육대학원 2002 연세교육과학 Vol.50 No.-

The purpose of this study was to construct a modified preceptorship model that could be used to improve the quality of clinical practice for student nurses in the Department of Nursing, Wonju College of Medicine, Yonsei University. Through a literature review, three workshops, and analysis of the preceptorship performance of new nurses, three findings were identified. First, based on the literature review and workshops, a modified preceptorship proposal for clinical practice for student nurses in the hospital setting was developed. It contained standard criteria outlining qualifications and rewards for preceptors, training for preceptors, and regulations concerning reciprocal relations among preceptors, head nurses, clinical instructors, and students. Second, results of the analysis of the preceptorship performance of new nurses in the hospital found implications for improvement of self-esteem and self-confidence and, for burden in overloading. Third, based on the literature review, the modified preceptorship proposal, and the results of the analysis of the preceptorship performance of new nurses, a modified preceptorship model was constructed. The modified preceptorship model for clinical practice for student nurses in both hospital and community settings contained standard criteria outlining qualifications and rewards for preceptors, training and education fur preceptors, and regulations concerning reciprocal relations. The standard criteria for qualification as a preceptor should be at least a BSN, at least two years experience, and leadership ability. Rewards for preceptors could be job conditions. For the training and education of preceptors, the difference between hospital and community settings was the content and duration of training. The common training content for preceptors were objectives, orientation to curriculum and preceptorship, clinical practice guidelines, communication channels between health teams and preceptors, nursing process, nursing interventions, and evaluation. In conclusion, the findings suggest a need fur further study on preceptorship when used to improve the quality of clinical practice for student nurses in the both hospital and community settings. The ultimate goal of the research on preceptorship was not only to help student nurses to enhance their ability in clinical practice, but also to maintain the quality of clinical practice in the professional nurses in any clinical setting.

흰쥐의 비장에서 분리한 림프구를 이용한 형광백혈구 안저촬영술

정미란,이숙희,황정용,양연식 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: The study on retinal blood flow has been continuously pursued and recently new methods such as targeted dye delivery, fluorescent vesicle system, laser Doppler velocimetry and acridine orange staining method has been presented. The authors developed a new method, fluorescein leukocyte angiography using a scanning laser ophthalmoscope which include external staining of leukocyte with fluorescein dye and reintroducing this fluorescent leukocyte into the blood flow. However, visualization of the leukocytes was limited since the leukocytes used were from the peripheral blood in a small animal. Methods: The authors removed leukocytes from the spleen and stained these leukocytes which were reintroduced into the blood flow to observe the retinal and choroidal blood circulation. In four pair of rats, one group was injected with the leukocytes of another rat's spleen and the other group were injected with the leukocytes of each own's individual spleen and all underwent angiography. Results: There were only few lymphocytes visualized in the group of rats which eceived allo-injection of leukocytes and in the other group the lymphocytes were numerous and also had a longer existence. Conclusions: In small animals like rats the visualization of the lymphocytes used from the spleen was better than the those from the peripheral blood and lymphocytes from one own's spleen was useful for longer periods of visualization.

콤포머의 NaOH 용액 내에서의 화학적 분해

박미란,양규호,최남기,이영준,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

이상적인 수복재료는 치아의 저작기능과 심미성을 회복할 수 있어야 하며 동시에 생체 적합성과 구강 내 환경변화에 대한 내구성을 가지고 있어야 한다. 그러나 수복물이 장기간 구강 내 환경에 노출되면 수복물 표면의 마모와 변색 및 수복물 자체의 파괴가 발생될 수 있다. 콤포머도 복합 레진처럼 낮은 마모 저항성을 주요한 단점으로 지적할 수 있다. 본 연구에서는 현재 유치 수복에 많이 사용되고 있는 Dyract (Dentsply, USA), Elan(Kerr, USA), F-2000(3M, USA)의 3종의 콤포머(polyacid modified resin composites)를 알칼리성 용액(0.1N NaOH)에 보관하였을 때 각 제품의 무게손실, 분해층 깊이 및 시편내에서 용출된 Si, Al과 Ba의 농도를 평가하여 제품간의 분해저항성을 평가하고 비교를 하고자 하였다. 각 제품 당 6개의 시편을 제작하여 무게 측정을 한 후, 0.1N NaOH용액, 3㎖에 저장하여 60℃에서 보관하였다. 2주후 제거하여 1.23% HCI로 2시간동안 중화하고 증류수로 세척한 60℃에서 건조하였다. 분해저항성은 무게손실, 분해층 깊이 및 시편내의 Si, Al과 Ba의 농도 변화를 근거로 평가하여 다음과 같은 결과를 얻었다. 1. 각 제품의 무게 손실량은 1.43%~2.14%까지 다양하였으며 제품 간에 유의한 차이는 없었다. 2. 각 제품의 표면하 분해층 깊이는 182.92㎛~227.70㎛였으며 제품 간에 유의한 차이는 없었다. 3. 각 제품으로부터 용출된 Si, Al양은 각 제품마다 유의한 차이가 있었으며(p<0.05), Si는 Dyract에서 Al은 F-2000에서 가장 많은 양이 방출되었다. 용출된 Ba양은 각 제품마다 유의한 차이가 없었다. 4. 무게 손실량과 표면하 분해층 깊이 사이의 상관 관계에서 비교적 높은 상관관계를 보였다(r=0.64, p<0.05). 5. 주사전자현미경 관찰시 0.1N NaOH용액에 보관한 후 콤포머기질과 필러사이의 결합의 파괴를 관찰할 수 있었으며, 기질이 소실되어 필러입자가 두드러진 양상을 보였다. 또한 필러입자의 표면은 분해에 의해 탈회된 모습을 보였다. 이상의 결과에서 현재 유치 수복에 사용되고 있는 3종의 콤포머는 분해저항성에 있어 유의한 차이를 보이지 않았다. The aim of this study was to evaluate the resistance to degradation of three commercial compomers in an alkaline solution. Dyract(Dentsply). Elan(Kerr) and F-2000(3M) polyacid modified resin composites(compomers) were used in this study. The resistance to degradation was evaluated on the basis of mass loss(%), degradation depth(μm) and Si, Al, Ba loss(ppm). The results were as follows : 1. The mass loss of each brand was 1.42%-2.14% and there was no statistically significant difference of mass loss among Dyract, F2000 and Elan. 2. The degradation layer depth of each brand was 182.92-227.7μm and there was no statistically significant difference of degradation layer depth among Dyract, F2000 and Elan. 3. There was statistically significant differences in Si-loss and Al-loss among three compomers (p〈0.05). Si loss was the highest value in Dyract and Al loss was the highest value in F2000. 4. There was statistically significant correlation between mass loss and degradation layer depth (r=0.60, p〈0.05). 5. In SEM finding, there was some destruction of compomer matrix-filler interface in post-exposure specimen to NaOH solution. As the matrix decreased, the filler particles distinguished and the periphery of the filler particles appeared whitish color due to degradation.

콤포머의 NaOH용액내에서의 화학적 분해

박미란,양규호 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3

Ideal restorative materials should have not only physical and chemical properties covering the chewing function and esthetics but also biological adaptability and durability to oral environmental changes. However when the restoration was exposed to oral environment for a long time, surface degradation of restoration, discoloration and destruction of restoration itself could be occurred. One of the major deficiencies of compomers using in pediatric dentistry in recent years is insufficient resistance to wear. Of the multitude of factors that have been associated with wear, subsurface degradation within the restoration is considered to be one. The aim of this study was to evaluate the resistance to degradation of three commercial compomers in an alkaline solution. Dyract(Dentsply), Elan(Kerr) and F-2000(3M) polyacid-modified resin composites(compomers) were used in this study. Preweighed discs of each material were exposed to 0.1N NaOH solution at 60℃ for 2 weeks. The resistance to degradation was evaluated on the basis of mass loss(%), degradation depth(㎛) and Si, Al, Ba loss(ppm). The results were as follows: 1. The mass loss of each brand was 1.42%∼2.14% and there was no statistically significant difference of mass loss among Dyract, F2000 and Elan. 2. The degradation layer depth of each brand was 182.92㎛∼227.7㎛ and there was no statistically significant difference of degradation layer depth among Dyarct, F2000 and Elan. 3. There were statistically significant difference of Si-loss and Al-loss among three compomers (p<0.05). Si loss was the highest value in Dyract and Al loss was the highest value in F2000. 4. There was statistically significant correlation between mass loss and degradation layer depth(r=0.60, p<0.05). 5. In SEM finding, there was destruction of compomer matrix-filter interface in post-exposure specimen to NaOH solution. As the matrix decreased, the filler particles distinguished and the periphery of the filler particles were appeared whitish color due to degradation.

서울과 경기지역 성인여성의 타우린 섭취량과 배설량 및 혈장 타우린 농도

임미형,양혜란,정진일,김을상 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.1

The purpose of this study was to investigate dietary taurine intakes, plasma taurine levels and urinary taurine excretions of women in Seoul(Kangbuk-ku) and Kyunggi(Yeoju) area, Korea. Seventy married women aged 39.7±8.9 have volunteered for this study: 36 from Seoul area and 34 from Kyunggi area. Diet samples were collected from the participants and the samples included three meals (breakfast, lunch and supper), snacks, drinks and whatever the participants had eaten for 24 hours. The plasma was obtained by allowing a 5 ml fasting blood sample to be in a heparinized tube for 30 min and centrifuging it at 11,000 × g for 20 min. The collected diets were blended, centrifuged and deproteinized. Taurine levels in the diet and plasma were determined as the dabsyl derivative using HPLC with Rf-detector. The intake of taurine ranged from 6.8 to 837.8 ㎎/day and its mean value was 145.5±64.0 ㎎/day (mean±SD). The 90th, 50th and 10th percentile values of the taurine intake were 280.0, 94.3 and 26.8 ㎎/day, respectively. There was a significant difference between two groups: 202.0±204.9 for Seoul area and 85.5±7.2 ㎎/day for Kyunggi area(p<0.001). The taurine level in plasma ranged from 42.1 to 201.9 μmol/L and its mean value was 74.9±22.8 μmol/L. The 90th, 50th and 10th percentile values of the plasma taurine were 101.1, 70.7 and 54.6 μmol/L, respectively. There was no significant difference between Seoul area and Kyunggi area in plasma taurine level.

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.

Mito-Tempo Can Protect Against the Allergic Airway Inflammation through Reducing Mitochondrial ROS Generation

( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.