급성 담낭염에 대한 내과적 치료의 역할

강성원,조한래,한설해,박현주,정인성,홍선미,김성걸,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

In 58 patients who were admitted to department of internal medicine, ChungNam national university hospital from January 1989 to March, 1993. We evaluated for medical treatments and the following results were obtained. 1) The ratio of male and female was 1 : 1 and mean age of the patients was 57.4 years. 2) At arrival on hospital, the most common clinical symptom was pain in right upper quadrant and epigastrium(93.1%), the remainders were fever and chill(79.3%), nausea(51.7%) and vomiting(36.2 %) in order of frequency. 3) The most common physical findings was tenderness on the right upper quadrant and epaigastrium(98%), the remainders were jaundice(50%) and palpable gall bladder(13.8%) in order of freguency. 4) In laboratory examination, elevated levels of ESR(82.8%), leukocytosis(67.2%), elevated levels of AST(62.0%), ALT(50.0%), serum total bilirubin(51.7%) and alkaline phosphatase (43.1%) were noted. 5) The mean period of NPO was 3.9 days and the mean hospital period was 13.5 days. 6) The rates of combined complications in patients with acute cholecystitis were 17.2%; these are gall bladder empyema(5.2%), hydrops(5.2%), perforation(3.4%), sepsis(3.4%) and intestinal obstruction (1.7%). 7) In 96.6 percent of 58 cases, the symptoms of acute cholecystitis were improved by conservative management. 8) The mean follow-up period was 25.5 months and the recurrence rate was 10% during this period.

조기위암에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Purpose: For evaluation of the role of tumohgenesis of p53 over expression and bcl-2 inhibition in early gastric cancer, the immunohistochemical tissue status of 31 primary early gastric cancer patients was investigated, and also the association between p53 , bcl-2 expression status and clinicopathologic parameters was analyzed for evaluation of prognostic relevance. Materials and Methods: DO7, a monoclonal antiserum to p53 protein and clone 124, monoclonal antibody to bcl-2 protein were used for the immunohistochemical analysis in 31 primary early gastric cancer tissue. The expressions were scored and divided into negative, positive, low expression, and over expression. Results: The clinocopathologic parameters; tumor depth of invasion, histologic type and differentiation were not related with the expression status of p53 and bcl-2. In 31 cases, the p53 over expression was 14 cases(45.2%), and the bcl-2 positive expression was 15 cases(48.4%), and 9 cases(29.0%) were the status of p53 over expression and bc1-2 positive expression. Conclusions: These results suggest that altered cell cycle and apoptosis control by p53 and bcl-2 may be an event in carcinogenesis of early gastric cancer but there are many other mediators that may fascilitate tumorigenesis.

조기위함에서 침윤, 유형 및 분화도에 따른 p53, bcl-2의 발현

권오선,조현득,오미혜,김의한,양승하 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

일 대학 병원 마취 · 회복실 간호사의 간호활동 분석

강윤경,김경미,김연이,박혜옥,서광희,송숙녀,이현숙,조의영 대한간호행정학회 2006 간호행정학회지 Vol.12 No.1

Purpose: This study was aimed to specify roles of nurses from the anesthesia and recovery room by analyzing nursing activities as well as anesthesia nursing during surgery. Method: The objects were 12 RNs working in the recovery room of a university hospital located in Incheon. Self-report was performed by measuring stop-watch for five days from May 17th to May 21st in 2004. Research method was designed to record the time and frequency of the nursing activity from anesthesia and recovery room based on nurses' statement and other references for five days. The data were analyzed with descriptive statistics, ANOVA, and t-test via SPSS Win 10.0 program. Result: Nursing activities in anesthesia recovery room were classified into two different characteristics such as direct and indirect nursing activity. The activities consisted of 11 direct nursing areas and 39 nursing activities in anesthesia preparation room. The indirect nursing was classified into 8 nursing areas and 32 nursing activities. The direct nursing was classified into 12 nursing areas and 55 nursing activity. Also, the indirect nursing was classified into 7 nursing areas and 21 nursing activities in recovery room. In terms of prevalence of nursing activities in the anesthesia preparation room, observation and cooperation of anesthesia was the most prevalent activity, drug and eqipment management the second prevalent, and drug administration the third. On the other hand, in the recovery room, the most prevalent activity was vital sign checking and observation, the second most prevalent activity informative activity, and the third body temperature control. Nursing activity time was recorded according to the nursing characteristics. In the anesthesia preparation room, the direct nursing spent for 8092.20 minutes was larger than the indirect nursing spent for 7198.50 minutes. Also, in the recovery room, the direct nursing spent for 2361.16 minutes was larger than the indirect nursing spent for 1134.13 minutes. 4. Nursing activity time was compared to duty shifts. In the anesthesia preparation room, the direct nursing was more prevalent on day shift and the indirect nursing was prevalent on evening shift. However, in the recovery room, both direct and indirect nursing activities were prevalent on day shift. Conclusion: The role of anesthesia and recovery room nurses was analysed according to the time, frequency, and its characteristics.

대전 대덕구 출토 복식 유물에 부착된 세균의 종류 및 섬유소분해효소 활성

이상준,차미선,조현혹,백영미,권영숙 한국의류산업학회 2005 한국의류산업학회지 Vol.7 No.1

This study was aimed to isolation and identification of attached bacteria on the clothes excavated from Deajeon area dating on the 16th century. From the observation with colony shape, 17 bacterial strains were isolated, and then 7 bacterial strains were identified with morphological and biochemical characteristics. Streptococcus sp., Alcah eves faecalis, Gemella sp., Acinetobacter sp., Pseudomones vesicularis, Aeromonas sails. salmonicida, Moraxella spp. In observation of the bacterial strains by the sort of textile, more bacterial strains were found in silk, cotton, and cotton bats than in ramie and hemp. It is suggest that hemp has antibacterial characteristics due to the presence of lignin. In the comparison washed samples with unwashed ones, there were more kinds of bacterial strains in washed samples. In the cellulase activity tests, all isolated bacteria had low level cellulase activity.

비소세포 폐암종에서 Epidiermal growth factor receptor(EGFR)의 발현 양상

임석호,이지혜,조현득,오미혜,김의한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

배경: 비소세포 폐암종에서 epidermal growth factor receptor (EGFR)의 발현이 예후에 미치는 영향에 대해서는 아직 일치된 결론에 이르지 못하고 있으며, 비소세포 폐암종의 조직 병리학적 소견으로는 종양의 진행 및 예후에 대해 예측이 불가능하다. 이에 저자들은 종양의 EGFR 발현과 임상 및 병리학적 특징과의 관계를 관찰하였다. 재료 및 방법: 1990년부터 2004년까지 순천향 대학교 천안병원에서 수술로 절제된 95명 환자의 포르말린에 고정한 파라핀 포매 조직을 이용하여 EGFR 항체를 이용한 면역조직화착 검사를 시행하였으며 이의 결과를 환자의 임상양상과 병리학적 소견과 비교 분석하였다. 결과: EGFR 발현과 환자의 생존기간을 비롯한 성별, TNM 임상병기, TU댕기, N-병기와는 관련이 없었으나 조직학적 유형중 편평상피암종은 47예중 43예가 양성 반응을 보여 통계학적으로 의미 있는 상관관계를 보였다(p=0.005). 그 외에 성별, 조직학적 유형, TNM 임상병기, T-병기, N-병기중 어떠한 변수도 생존기간과의 연관성을 보이지 않았다. 결론: 비소세포 폐암종에서 EGFR의 발현은 환자의 생존기간 및 임상병리학적 소견과 유의한 상관관계를 보이지 않으므로 예후인자로서의 이용은 현재로선 불가능하여 좀 더 많은 증례를 통한 연구가 필요할 것으로 사료된다. Background: The prognostic role of epidermal growth factor receptor (EGFR) remains controversial in patients with non-small cell lung cancer (NSCLC). Histopathologic findings cannot adequately predict disease progression, so we investigated the reladonship between EGFR and clinicopathologic feature. Methods: Using immunohistochemical techniques, we retrospecdvely analyzed formalin-fixed, paraffin-embedded samples from 95 padents with resected pathological NSCLCs. Then, we correlated these data with padents' clinical outcome and pathologic finding. Results: No reladonship was found between EGFR overexpression and patient survival when the entire cohort was considered. Multivariate factors including gender, histologic type, TNM stage, T stage and N stage were not correlated to poor outcome. Also, no factors revealed correlation with EGFR overexpression except histologic type. Squamous cell carcinoma showed positive reaction in 43 out of 47 patients(p=0.005). Condusion: This result indicated that EGFR overexpression in NSCLC showed no reladonship with patients' survival. Therefore, EGFR overexpression could not be used as a poor prognostic marker.

The impacts of land cover generated by earth system model on climate simulation over East Asia

Mee-Hyun Cho,Kyung-On Boo,Gill Martin,Johan Lee,Gyu-Ho Lim 한국기상학회 2014 한국기상학회 학술대회 논문집 Vol.2014 No.10

Regional climate response to land surface changes after harvest in the North China Plain under present and possible future climate conditions

Cho, Mee-Hyun,Boo, Kyung-On,Lee, Johan,Cho, Chunho,Lim, Gyu-Ho American Geophysical Union 2014 Journal of geophysical research. Atmospheres Vol.119 No.8

In this study, we investigated the impacts of land use alterations from harvesting practices on the regional surface climate over the North China Plain. The surface climate responses after harvest in June in regions where double-cropping is practiced were evaluated using observations and model simulations with the global climate model HadGEM2-Atmosphere. Responses were modeled under both present and possible future climate conditions. In the model, double-cropping was represented using the monthly varying fraction of vegetation. This contributed to an improvement in the model simulation over East Asia. Modeling results showed that the land surface was warmer and drier after harvest, and these simulation results were consistent with observations. The bare soil surface after harvest in June had biophysical impacts on the surface climate that were mediated by decreasing evapotranspiration and latent heat flux effects, which increased surface air temperatures and decreased surface humidity. An increase in shortwave radiation also contributed to the rise in temperatures. Under two Representative Concentration Pathways (RCP) scenarios for possible future climate conditions, land conversion induced additional warming in addition to greenhouse gases induced global warming. The RCP 8.5 and RCP 2.6 scenarios demonstrated a warming of 1.0 degrees C and 1.4 degrees C due to harvesting practices in June, respectively. The response magnitude was affected by the climate conditions in each RCP. Our results suggest that potential impacts of harvest on the local climate need to be considered in future projections of CO2-induced warming on a regional scale. Key Points <list id='jgrd51004-list-0001' list-type='bulleted'> <list-item id='jgrd51004-li-0001'>Harvest impacts on surface climate over the North China Plainare investigated <list-item id='jgrd51004-li-0002'>Harvesting could make the land surface warmer and drier <list-item id='jgrd51004-li-0003'>Sensitivity to climate from future projections of agricultural-induced land cover change 20 were evaluated

Vegetation-cloud feedbacks to future vegetation changes in the Arctic regions

Cho, Mee-Hyun,Yang, Ah-Ryeon,Baek, Eun-Hyuk,Kang, Sarah M.,Jeong, Su-Jong,Kim, Jin Young,Kim, Baek-Min Springer-Verlag 2018 Climate dynamics Vol.50 No.9