A toxicogenomics study of two chemicals in coffee roasting process

Kyung‑Taek Rim,Soo‑Jin Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Roasted coffee beans are broadly consumed in nearly all classes of the population. 2,3-Butanedione is a food flavor that causes obstructive bronchiolitis in microwave popcorn manufacturing workers. It can be naturally produced when coffee is roasted. Objective To determine effects of 2,3-butanedione (diacetyl) and 2,3-pentanedione on workers’ health during the coffee roasting process, we performed a toxicogenomics study for differentially expressed genes in lung cells after exposure to the two chemicals. Results Gene selection was performed by clustering, gene ontology/pathway, and data mining using microarray data. Target microRNAs and genes were selected based on the expression of microRNAs and correlation analysis of genes and microRNAs. As a result of expression analysis of target gene miRNAs affected by the two chemicals, it was evaluated that Fosl1, Rb1, Aspn, Dusp1, Rnf19b, Jun, and Hbegf were over-regulated by targeting down-regulated miRNAs mutated by two chemicals. Using OMIM database and KEGG pathway, we found that Terc and Bmpr2 were two changed genes by matching with the KEGG disease pathway database. Conclusion Dosage, duration, exposure, and extrapolations are necessary to reflect effects of diacetyl and 2,3-pentanedione on workers in the coffee roasting process. This study focuses on early biochemical changes, mechanisms, and early biomarker discovery when normal lung cells are exposed to these two chemicals.

ISD 모델에 기초한 농업인 안전교육 프로그램 개발

김진모,이택선,이경숙,김경란,길대환,김효철,이찬 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.3

이 연구의 목적은 ISD 모델에 기초하여 농업인 안전교육 프로그램을 개발하는데 있으며,이를 위해 분석-설계-개발-실행-평가의 다섯 단계로 구성된 개발모형을 설정하였다. 구체적인 프로그램 내용을 개발하기 위해 환경분석,학습자분석,과제분석을 실시하였고,그 결과를 반영하여 ‘안전의식 함양’,‘근골격계질환’,‘농약중독예방’,‘농기계 안전 사용’의 4개 모듈과 10개의 레슨을 설계하였다. 요구분석 및 설계 결과를 바탕으로 농업인 안전교육 프로그램의 교재/보조 자료/매체를 개발하였다. 교재의 경우,학습자용과 강사용을 구분하여 개발하였다. 개발된 프로그램 및 운영체제에 대한 검토 및 보완을 위한 전문가 협의회를 개최하여 프로그램 시연회를 실시한 후 교육프로그램을 수정,보완하였다. 그 후,농작업안전시범마을의 농업인을 대상으로 농업인 안전교육 프로그램을 시험 운영하였고,그 결과를 반영하여 농업인 안전교육 프로그램을 완성하였다. 또한 이상의 프로그램 개발 과정을 통해 나타난 논점을 토대로 향후 교육 프로그램 개발을 위한 시사점을 제공하였다. The purpose of this study was to develop a agricultural safety and health training program based on ISD Model. We set up 5step(Analysis, Design, Development, Implementation, Evaluation) model for developing the program. After analyzing environment, learner and task, four modules(① Safety and Health Mindset, ② Musculoskeletal System Disorders, ③ Agrichemical Poisoning Prevention, and ③ Using Farm Machines Safely) and 10 lessons were designed. We developed teaching materials and supplement materials for the Agricultural Safety and Health Training Program based on need analysis and program design. Teaching materials consisted of the learner's and instructor's. The developed program was examined by expert groups and the weak points were revised through professional workshop. Finally, we tested the Agricultural Safety and Health Training Program at agricultural safety and health model village and fixed the program by reflecting the test results.

ATM망의 가상경로상에서 Threshold를 이용한 효율적인 대역관리

김상철,고승일,고성택,김경식,김경연 濟州大學校 情報通信硏究所 1999 情報通信硏究所論文集 Vol.2 No.-

Effective bandwidth allocation is desirable to control the ATM traffic. It should provide high fairness and utilization for different kinds of services in call admission. Complete bandwidth sharing is efficient for utilization of bandwidth but not efficient for fairness of call admission. Complete bandwidth partitioning is efficient for fairness but not efficient for utilization. We propose a new CST(Complete Sharing with Threshold) algorithm using threshold in a VP to improve fairness and utilization. Using CST algorithm. the system performance is improved by 1.4% compared with the RSC(Reserved Sharing with Common pool) algorithm.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

제주도 지하수 질산염 농도의 시·공간적 변화 특성: 장기(1993-2015) 모니터링 자료의 평가

김호림(Ho-Rim Kim),오준섭(Junseop Oh),도현권(Hyun-Kwon Do),이경진(Kyung-Jin Lee),현익현(Ik-Hyun Hyun),오상실(Sang-Sil Oh),감상규(Sang-Kyu Kam),윤성택(Seong-Taek Yun) 대한자원환경지질학회 2018 자원환경지질 Vol.51 No.1

1993년부터 2015년까지 관측된 제주도 지하수 장기모니터링 관측정(N = 4,835)에서 수집된 지하수 수질자료(N = 21,568)를 기반으로 질산성질소의 시공간적 변동 특성을 평가하였다. 제주도 지하수의 질산성질소 농도의 중앙값은 2.5 mg/L로서 다른 국가나 대륙의 조사 결과에 비해 다소 높거나 유사한 것으로 나타났다. 또한 지하수 용도, 행정구역 및 고도 별로 유의한 차이를 보였다. 특히, 산간 지역에 비해 저지대 해안가에 위치한 농업 및 주거지역에서 농도가 높음을 확인하였다. Mann-Kendall 및 Sen’s slope 분석을 활용한 질산성질소 농도의 추세 분석 결과, 하류 저지 대에 비해 중산간지역에서의 질산성질소 농도 증가 경향이 뚜렷하였다. 제주도 내 토지 피복의 시계열 변화 특성과 결부 지어 보면, 중산간지역의 오염 증가 추세는 농업지역의 확장 등 인위적 활동 증가에 기인한 결과로 판단된다. 반면,기지정된 지하수자원특별관리구역에서는 전반적으로 질산성질소 농도의 감소 경향이 나타났는데, 이는 지하수 관리 측면에서 수질관리를 위한 적극적인 정책이 유효함을 시사한다. 본 연구에서는 제주도 지하수의 질산성질소 오염관리를 위한 적정 방안을 제안한다. The spatio-temporal variations of nitrate concentrations in groundwater of Jeju Island were evaluated by an analysis of time series groundwater quality data (N = 21,568) that were collected from regional groundwater monitoring (number of wells = 4,835) for up to 20 years between 1993 and 2015. The median concentration of NO 3 -N is 2.5 mg/L, which is slightly higher than those reported from regional surveys in other countries. Nitrate concentrations of groundwater in wells tend to significantly vary according to different water usage (of the well), administrative districts, and topographic elevations: nitrate level is higher in low-lying agricultural and residential areas than those in high mountainous areas. The Mann-Kendall trend test and Sen’s slope analysis show that nitrate concentration in mid-mountainous areas tends to increase, possibly due to the expansion of agricultural areas toward highland. On the other hand, nitrate concentrations in the Specially Designated Groundwater Quality Protection Zones show the temporally decreasing trend, which implies the efficiency of groundwater management actions in Jeju. Proper measures for sustainable groundwater quality management are suggested in this study.

問題行動 修正을 위한 心理療法의 適用問題 考察

金慶澤 대구교육대학교 1972 論文集 Vol.8 No.-

Many pupils in the process of growth show various problem behaviors worth noticing. I think these problem behaviors can be corrected by changing desire or thought of the individual who has the emotional problems. and this study on psychotherapy deals with psychological methods applied to the relationship between counselor and client (counselee) to make more wholesome personality and with the way to apply the above method to the school education. Though there are a large number of viewpoints and assertions in psychotherapy, I laid, stress, in this study, on the problems of reception, interpretation, purification (as a kind of catharsis), guarantee security and insight. Because the problem behaviors of growing pupils, in most cases, are mainly caused by a distortion of human relationship at home or school in any stage of collective social life, these problem behaviors can be corrected gradually if the counselor in school and the parents at home are to discover the problem behaviors of a pupil in time and take the trouble to reform the pupil's life environment deliberately. The principal subject matters of this study are as follows: 1) The allopathic and the fundamental treatment as an approach to treatment technique. 2) Various viewpoints and assertions of psychotherapy. 3) The problems of fundamental concept in psychotherapy. 4) The aspect of treatment on the side of individual and on that of environment is psychotherapy. 5) The problem of methodical assortment in psychotherapy. 6) The problem of situations and that of applying the counseling in psychotherapy. 7) The situations of psychotherapy and the problem of the part played by psychological treatment.

PD 제어기를 이용한 회전시스템의 동특성에 관한 연구

김택현,김종태,김재경 朝鮮大學校 機械技術硏究所 2005 機械技術硏究 Vol.8 No.1

기계 회전 시스템을 통하여 응답특성 및 제어효과에 대한 연구를 목적으로 하여 PD제어기를 사용하여 응답특성을 확인하였는데 제어기를 사용함은 얻고자하는 대상 플랜트의 출력 특성을 제어하는데 목적이 있다. 우선, 실험으로 들어가 시스템의 관성 (inertia), 스프링 강성(spring stiffness), 감쇠계수(damping coefficient) 등의 매개변수 값들을 측정하고, 하드웨어 게인 값을 정의한다. 다음으로 PD제어기의 설계를 하는데 우선 강체로 모델링된 시스템에서의 step 응답, ramp 응답, parabolic 응답과 sinusoidal 응답에서의 비례게인, 미분게인 값이 시스템에 미치는 영향을 통하여 제어특성과 효과를 알아보고, 2자유도(two degree of freedom) 기계 회전 시스템에 대하여 PD제어실험을 통하여 회전 시스템의 상승시간(rising time), 정착시간 (settling time) 등의 응답속도 개선, 그리고 오버슈트(overshoot), 언더슈트(undershoot) 등의 응답성능의 향상을 꾀한다. The mechanical rotation system is made up of belts, mass disks and gears. This precise piece of equipment is controlled electro-mechanically by the motor and operation program. The control strategy of the system can be changed by belts' stiffness and change of the mass and gear. This system can be modeled as a rigid body, and also finds broad application in such diverse fields as machine tools, the cruise control system in automobiles, and control in the attitude and gimbals of spacecraft. This system proves the necessity and effect of a closed loop control. The study of the mechanical rotation system excited by its base motion is not only able to predict the rotational performance, but obtain the fundamental data for vibration isolation. In this thesis, we studied the response abilities such as steady overshoot, undershoot and ect. and the response velocities such as rising time, settling time, and ect. in the mechanical rotation system. through PD control experiment..

欲求不滿에 對한 反應行動과 忍耐性 指導問題

金慶澤 대구교육대학교 1970 論文集 Vol.6 No.-

An individual has various needs, and the needs combined with special goal cause behavior toward accomplishment of the goal. Unless this motivated behavior achieves well in a constant harmony with social demands and satisfies certain needs, a well adjustment is not reached. But all children do not meet their needs sufficiently in everyday life. Their needs are often restrained by the interior or exterior obstacles, and they experience the frustration. Each individual shows different behavior patterns to the frustration. Often in a certain case, because of failure to slove it by means of the reasonable social methods, the odd reaction or behavior……maladjustment is observed. In most cases, however, these needs keep in harmony with the outside demands: sometimes they become satisfied in other changed forms, or sometimes a certain frustrated situation is overcome. Thus, children learn the way of adjustment, while realizing frustraion and solving it. To give proper guidance to children, therefore, it is necessary to analize the abnormal, maladjustmental behaviors which are caused from frustration, and to understand it correctly, and to attempt to solve it. The frustration which shows the possibility of development in quality is the driving force, and it functions constantly in growth of children. Tolerance can be cultivated in the process of development of this kind of frustration. But it is not an easy problem. The positive guidance is inevitable to provide children with opportunity to realize it in daily life. Because only the tolerance obtained in a long process of life of children make them possible to understand liberty, to aware responsibility, and to perform individual or social duties successfully. For this purpose, the writer draw upon on this subject in this paper with various valuable reference.

도착 및 공평할당비율을 이용한 GFR 서비스 트래픽 제어 기법

김남희,정경택,박기홍 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

The Guaranteed Frame Rate(GFR) service has been designed to accomodate non-real-time applications and it is not only guarantees a minimum throughput at the frame level, but also supports a fair share of available resources. In this paper, we propose a cell scheduling scheme which can improve the fairness and the goodput through the traffic control in GFR service. For the evaluation of the proposed scheme, we compare the proposed scheme with the existing scheme in the fairness and the goodput. Simulation results show that proposed scheme can improve the fairness and goodput comparing with the existing buffer management scheme.

인공 건조법에 의한 마른 명태의 품질 개선에 관한 연구 : 1. 열풍 건조중의 명태의 핵산 관련 물질 및 유리 아미노산의 변화 1. Changes of Nucleotides and Their Related Compounds and Free Amino Acid Composition of Alaska Pollack during Hot-air Dehydration

金敬三,梁升澤,金用根,韓鳳浩,李應昊 釜山水産大學校 1972 釜山水産大學 硏究報告 Vol.12 No.1

북양산 냉동명태를 원료로서 열풍건조법으로 마른명태를 가공하였을 때, 건조중의 핵산관련물질 및 유리아미노산의 변화를 실험하였다. 원료육중에는 inosine 함량이 가장 많아 건물증량 기준으로 13.5μmole/g였고, 다음으로 함량이 높은 IMP였는데 5.1μmole/g로서 비교적 낮은 값이었다. 열풍건조중 IMP는 급격히 감소하여 잔존량은 14%에 불과하였으며, inosine은 건조중 50%감소하였다. 한편 hypoxanthine는 약 5배 증가하여 건물중량 기준으로 16.9μmole/g 였다. 건조후 3개월간 저장중에는 건조직후와 비교할 때 핵산관련물질의 변화는 거의 없었다. 그리고 원료 명태 육중의 유리아미노산 조성은 taurine이 가장 많아 전 유리아미노산의 40%를 차지하고 alanine, glycine, glutamic acid가 그 다음이고 비교적 함량이 낮은 것은 lysine, serine, histidine이며, 함량이 극히 낮은 것은 valine, aspartic acid, threonine, isoleucine, leucine등이었다. 열풍 건조중 유리아미노산의 질적 변화는 없었으며. 원료육 유리아미노산에 대하여 건조중 유리아미노산양이 20% 증가하였다. In this paper, the changes of nucleotides and their related compounds and free amino acid composition of Alaska Pollack muscle during hot-air dehydration and storage for three months were determined. The results showed that the contents of inosine and IMP in defrosted sample were 13.5 and 5.1 μmole/g respectively on dry base, and followed by hypoxanthine in order. ATP, ADP and AMP was very low in content. IMP and inosine tended to degrade rapidly during hot-air dehydration while hypoxanthine increased about five times. But the quantitative changes of nucleotides and their related compounds in the muscle of hot-air dehydrated Alaska Pollack during storage were not detected. Taurine was abundant in the muscle extracts, showing 40% of the total amino acid content and followed by alanine, glycine and glutamic acid. Lysine, serine and histidine were low in content respectively, and valine, aspartic acid, threonine and leucine were very poor. The qualitative change in the pattern of free amino acid composition of muscle extracts was not observed during hot-air dehydration. The increase of the total free amino acid during hot-air dehydration was approximately 20%.