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Yoo, Jin Young,Yang, Seung-Ho,Lee, Jung Eun,Cho, Deog Gon,Kim, Hoon Kyo,Kim, Sung Hwan,Kim, Il Sup,Hong, Jae Taek,Sung, Jae Hoon,Son, Byung Chul,Lee, Sang Won M. Nijhoff ; Kluwer Academic Publishers 2012 Journal of neuro-oncology Vol.109 No.2
<P>It remains unclear whether patients with non-small-cell lung cancer (NSCLC) develop brain metastasis during or after standard therapy. We attempted to identify biological markers that predict brain metastasis, and investigated how to modulate expression of such markers. A case-control study of patients who were newly diagnosed with NSCLC and who had developed brain metastasis during follow-up was conducted between 2004 and 2009. These patients were compared with a control group of patients who had NSCLC but no evidence of brain metastasis. Immunohistochemical analysis of expression of Ki-67, p53, Bcl-2, Bax, vascular endothelial growth factor, epidermal growth factor receptor, caspase-3, and E-cadherin was conducted. The methylation status of the genes for O(6)-methylguanine-DNA-methyltransferase, tissue inhibitor of matrix metalloproteinase (TIMP)-2, TIMP-3, and death-associated protein-kinase was also determined, by use of a methylation-specific polymerase chain reaction. A significantly increased risk of developing brain metastasis was associated with the presence of primary tumors with low E-cadherin expression in patients with NSCLC. We also investigated the effects of pioglitazone, a peroxisome proliferator-activated receptor γ-activating drug, in tumor-bearing mouse models. We found that E-cadherin expression was proportional to pioglitazone exposure time. Interestingly, pioglitazone pretreatment before cancer cell inoculation prevented loss of E-cadherin expression and reduced expression of MMP9 and fibronectin, compared with the control group. E-cadherin expression could be a predictor of brain metastasis in patients with NSCLC. Preventive treatment with pioglitazone may be useful for modulating E-cadherin expression.</P>
( Sung Jun Chung ),( Tae Yeob Kim ),( Sun Min Kim ),( Min Roh ),( Mi Yeon Yu ),( Jung Hoon Lee ),( Chang Kyo Oh ),( Eun Young Lee ),( Seung Lee ),( Yong Cheol Jeon ),( Kyo Sang Yoo ),( Joo Hyun Sohn ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: The incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years. Methods: Overall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), midto- late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis. Results: The seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s. Conclusions: The number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population. (Clin Mol Hepatol 2014;20:162-167)
( Kyo Sang Yoo ),( Kyung Hun Lee ),( Kyung Rim Huh ),( Won Sub Choi ),( Gang Jeon ),( Jun Wook Ha ),( Kyoung Oh Kim ),( Cheol Hee Park ),( Tae Ho Hahn ),( Sang Hoon Park ),( Jong Hyeok Kim ),( Choong The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.1
Acute pancreatitis may complicate viral hepatitis B, as well as the other causes of viral hepatitis. There have been reports of acute pancreatitis complicating acute exacerbations of chronic hepatitis B virus infection, most of which were related to immunosuppressive treatment or organ transplantation. However, acute pancreatitis complicating spontaneous acute exacerbation of chronic hepatitis B virus infection is rare. We report a case of acute pancreatitis that developed while a spontaneous acute exacerbation of chronic hepatitis B virus infection was underway in a healthy carrier. (Gut and Liver 2009;3:64-66)
Influence of additional etching on shear bond strength of self-etching adhesive system to enamel
Yoo, Sun-Jin,Kim, Young-Kyung,Park, Jeong-Won,Jin, Myoung-Uk,Kim, Sung-Kyo 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.4
최근 많이 소개되고 있는 자가산부식 접착제는 상아질에 대한 접착은 우수한 것으로 알려져 있지만 법랑질에 대한 접착은 인산에 비해 낮은 산도로 인해 충분한 부식이 일어나는지에 대한 논란이 되고 있다. 본 연구에서는 서로 다른 산도를 가진 1단계 혹은 2단계의 자가산부식 접착제에서 부가적인 산부식이 법랑질과 복합 레진 사이의 전단결합강도에 미치는 영향을 평가하고자 하였다. 90개의 발거된 우치의 순면을 물기가 있는 상태에서 #600 사포로 표면을 연마하여 평활한 법랑질을 노출시킨 후, 임의로 6군으로 분류했다. 사용재료는 Clearfil SE Bond^(®), Adper^(TM)Prompt L-Pop, 그리고 Tyrian SPE^(TM)를 사용하였으며, 각 재료에 추가적인 산부식을 시행한 군과 그렇지 않은 군으로 나누어 표현 처리한 후, 제조사의 지시대로 접착과정을 시행하였다. 각 시편에 복합레진을 2 ㎜ 두께로 충전하고, 40초간 광중합을 하였다. 그 후 시편을 37℃, 100% 상대습도에서 24시간 보관 후 전단응력 접착강도를 측정하였다. 결과치는 independent t - test 를 이용하여 통계분석 하였으며 그 결과는 다음과 같이 나타났다. Clearfil SE Bond^(®)에서 부가적인 산부식을 시행한 군이 그렇지 않은 군보다 유의하게 높은 접착강도를 나타내었다 (p < 0.01). Adper^(TM) Prompt L-Pop과 Tyrian SPE^(TM)에서는 부가적인 산 부식이 결합강도에 통계적인 유의차를 나타내지 않았다.(p >0.01). 본 연구의 결과로 보아, 강산을 함유하고 있는 접착제를 사용할 경우에는 부가적인 부식 처치가 접착력을 증가시키지 않으나, 약산을 함유하고 있는 접착제의 경우에는 부가적인 산부식이 접착력을 증진시키는 것으로 사료된다. Recently, self-etching adhesive system has been introduced to simplify the clinical bonding procedures. It is less acidic compared to the phosphoric acid, thus there is doubt whether this system has enough bond strength to enamel. The purpose of this study was to investigate the influence of additional etching on the adhesion of resn composite to enamel. Ninety extracted bovine permanent anterior teeth were used. The labial surfaces of the crown were ground with 600-grit abrasive paper under wet condition. The teeth were randomly divided into six groups of 15 teeth each. Clearfil SE Bond^(®), Adper^(TM) Prompt L-Pop and Tyrian SPE^(TM) were used as self-etaching primers. Each self-etching primers were applied in both enamel specimens with and without additional etching. For additional etching groups, enamel surface was pretreated with 32% phosphoric acid (UNI-ETCH, Bisco, Inc., Schaumburg, IL, USA). Hybrid resin composite Clearfil APX, (Kuraray Co., Ltd., Osaka, Japan) was packed into the mold and light-cured for 40 seconds. Twenty-four hours afer storage, the specimens were tested in shear bond strength. The data for each group were subjected to independnt t - test at p < 0.01 to make comparisons among the groups. In Clearfil SE Bond^(®), shear bond strength of additional etching grop was higher than no additional etching group (p < 0.01). In Adper^(TM) Prompt L-Pop and Tyrian SPE, there were no significant difference between additional etching and non-etching groups (p < 0.01). In conclusion, self-etching adhesive system with weak acid seems to have higher bond strength to enamel with additional etching, while self-etching adhensive system with strong acid seems not.〔 Kor Acad Cons Dent 31(4):263-268, 2006〕
Yoo, Ik-Dong,Kim, Sung-Hoon,Seo, Ye-Young,Oh, Jin-Kyoung,O, Joo-Hyun,Chung, Soo-Kyo The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Purpose : To decrease the risk of recurrence or metastasis in differentiated thyroid cancer (DTC), selected patients receive radioactive iodine ablation of remnant thyroid tissue or tumor. A low iodine diet can enhance uptake of radioactive iodine. We compared the success rates of radioactive iodine ablation therapy in patients who followed two different low iodine diets (LIDs). Materials and Methods : The success rates of postsurgical radioactive iodine ablation in DTC patients receiving empiric doses of 150 mCi were retrospectively reviewed. First-time radioactive iodine ablation therapy was done in 71 patients following less strict LID and 90 patients following very strict LID. Less strict LID restricted seafood, iodized salt, egg yolk, dairy products, processed meat, instant prepared meals, and multi-vitamins. Very strict LID additionally restricted rice, freshwater fish, spinach, and soybean products. Radioactive iodine ablation therapy was considered successful when follow-up $^{123}I$ whole body scan was negative and stimulated serum thyroglobulin level was less than 2.0 ng/mL. Results : The success rate of patients following less strict LID was 80.3% and for very strict LID 75.6%. There was no statistically significant difference in the success rates between the two LID groups (p=0.48). Conclusions : Very strict LID may not contribute to improving the success rate of initial radioactive iodine ablation therapy at the cost of great inconvenience to the patient.
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease
( Kyo-sang Yoo ),( Ho Soon Choi ),( Dae Won Jun ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Kyeong Geun Lee ),( Seung Sam Paik ),( Yong Seok Kim ),( Jin Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.5
Background/Aims: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterolassociated gallbladder disease and evaluated the relationship between mucin and bacterial infection. Methods: The present study involved 20 patients with cholesterol stones with cholecystitis, five with cholesterol stones with cholesterolosis, six with cholesterol polyps, two with gallbladder cancer, and six controls. Canine GBECs treated with lipopolysaccharide were also studied. MUC3, MUC5AC, MUC5B, and MUC6 antibodies were used for dot/slot immunoblotting and immunohistochemical studies of the gallbladder epithelial tissues, canine GBECs, and bile. Reverse-transcription polymerase chain reaction was performed to evaluate MUC3 and MUC5B expression. Results: MUC3, MUC5AC, MUC5B, and MUC6 were expressed in the normal gallbladder epithelium, and of those, MUC3 and MUC5B exhibited the highest expression levels. Greatly increased levels of MUC3 and MUC5B expression were observed in the cholesterol stone group, and slightly increased levels were observed in the cholesterol polyp group; MUC3 and MUC5B mRNA was also upregulated in those groups. Canine GBECs treated with lipopolysaccharide also showed upregulation of MUC3 and MUC5B. Conclusions: The mucin genes with the highest expression levels in gallbladder tissue in cholesterol-associated diseases were MUC3 and MUC5B. Cholesterol stones and gallbladder infections were associated with increased MUC3 and MUC5B expression. (Gut Liver 2016;10:851-858)
Yoo, Ran Ji,Lee, Ji Woong,Lee, Kyo Chul,An, Gwang Il,Ko, In Ok,Chung, Wee Sup,Park, Ji Ae,Kim, Kyeong Min,Choi, Yang-Kyu,Kang, Joo Hyun,Lim, Sang Moo,Lee, Yong Jin 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
$^{64}Cu$-labeled diacetyl-bis($N^4$-methylthiosemicarbazone) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the study, we confirmed hypoxia regions in VX2 tumor implanted rabbits with injection $^{64}Cu$-ATSM and $^{18}F$-FDG using positron emission tomography (PET)/computed tomography (CT). PET images with $^{18}F$-FDG and $^{64}Cu$-ATSM were obtained for 40 min by dynamic scan and additional delayed PET images of $^{64}Cu$-ATSM the acquired up to 48 hours. Correlation between intratumoral $O_2$ level and $^{64}Cu$-ATSM PET image was analyzed. $^{64}Cu$-ATSM and $^{18}F$-FDG were intravenously co-injected and the tumor was dissected and cut into slices for a dual-tracer autoradiographic analysis. In the PET imaging, $^{64}Cu$-ATSM in VX2 tumors displayed a specific uptake in hypoxic region for48 h. The uptake pattern of $^{64}Cu$-ATSM in VX2 tumor at 24 and 48 h did not match to the $^{18}F$-FDG. Through ROI analysis, in the early phase (dynamic scan), $^{18}F$-FDG has positive correlation with $^{64}Cu$-ATSM but late phase (24 and 48 h) of the $^{64}Cu$-ATSM showed negative correlation with $^{18}F$-FDG. High uptake of $^{64}Cu$-ATSM in hypoxic region was responded with significant decrease of oxygen pressure, which confirmed by $^{64}Cu$-ATSM PET imaging and autoradiographic analysis. In conclusion, $^{64}Cu$-ATSM can utilize for specific targeting of hypoxic region in tumor, and discrimination between necrotic- and viable hypoxic tissue.