정신분열병과 22번 염색체 인터루킨-2 수용체 β-chain 유전자의 연관성

김용구,이민수,김 인,곽동일,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3

연구배경 : 정신분열병이 유전적이라고 제시하는 많은 역학 연구와 유전자 연구에도 불구하고, 이 질환의 유전방식과 질병유전자는 밝혀져 있지 않다. 본 연구에서는 정신분열병과 22번 염색체 장완의 11.2-12부위에 위치한 Interleukin-2수용체 β chain 유전자간에 유전적 연합을 조사하고자 정신분열병 환자 93명과 정상대조군 97명 대상으로 중합효소연쇄반응을 이용하여 Interleukin-2 수용체 β chain (IL-2Rβ) 유전자의 다형성 분포를 조사하였다. 연구방법 : 환자군은 DSM-Ⅲ-R 진단기준에 따라 임상아형(망상형, 붕괴형, 미붕괴형, 잔류형)으로 분류하였다. 음성 및 양성 정신분열병으로 분류하기위해 Positive and Negative Syndrome Scale(PANSS)을 사용하였다. Genomic DNA를 전혈 임파구에서 추출한 후, IL-2Rβ 유전자좌를 분석하기 위해 dinucleotide(GT)n 염기배열순서를 중합효소연쇄반응을 이용하여 증폭시켰다. 연구결과 : IL-1Rβ의 대립유전자는 모두 8가지 종류이고, guanine-thymine의 반복된 149 염기쌍을 시작으로 151, 153, 155, 157, 159, 161, 163 염기쌍의 형태를 보였다. 정신분열병 환자군과 정상대조군간에 도형접합체 및 이형접합체 빈도의 유의한 차이는 없었다. 환자군과 정상대조군의 대립유전자 분포의 빈도는 통계적으로 유의한 차이가 없었다. 더욱이 각각의 대립유전자 분포에서도 양군간 유의한 차이는 없었다. 또한 동질의 아형으로 분류해 보기위해 임상아형, 양성 및 음성증상군, 가족력의 유무에 따라 비교적 동질적인 표현형을 가진 집단으로 나눈 후 대립유전자 분포를 비교해 보았으나 통계적으로 유의한 차이를 보이지 않았다. 결 론 : 본 연구에서는 Interleukin-2 수용체 β chain 유전자가 정신분열병의 병인론에 관련된다는 가설을 지지할 만한 긍정적 소견을 얻지 못했다. Background : While a significant genetic predisposition to schizophrenia has been proposed, the mode of inheritance or nature of etiological factors is unknown. Previous reports of a genome-wide survey for schizophrenia susceptibility genes have indicated a possible region of linkage on chromosome 22. In order to test the possibility that the interleukin-2 receptor β chain(IL-2Rβ) gene on chromosome 22 is of etiological importance in schizophrenia, a case-control association study was conducted. Methods : Subjects were ninety-three schizophrenic patients with a diagnosis of schizophrenia by DSM-Ⅲ-R criteria and ninety-seven normal controls, Schizophrenic patients were divided by clinical phenotypes such as DSM-Ⅲ-R diagnostic subtypes, positive and negative symptoms, and family history so as to increase the homogeneity of schizophrenics. Genomic DNA was extracted from whole blood lymphocytes according to standard procedures. The DNA was used to study a dinucleotide repeat in the IL-2Rβ gene. To reveal the dinucleotide polymorphism. genomic DNA of subjects was amplified by polymerase chain reactions(PCR). Results : At the IL-2Rβ gene locus, all the previously reported alleles(eight different alleles) of a dinucleotide polymorphism were identified. There was no significant difference between number of heterozygosity in schizophrenic patients and in normal controls. There was no significant difference in the distribution of frequencies of alleles between schizophrenics and normal controls. In addition, there was no significant difference in the allele frequencies among subtypes of schizophrenic patients according to DSM-Ⅲ-R diagnostic subtypes, positive and negative symptoms, and family history. Conclusion : The present study did not detect a difference in frequencies of alleles of a dinucleotide polymorphism at the IL-2Rβ gene locus between schizophrenic patients and normal controls. These results do not supports an evidence that IL-2Rβ gene plays, a major role in the etiology of schizophrenia.

캔음료중 epichlorohydrin 의분석법에 관한 연구

이광호,곽인신,최재천,전대훈,김형일,강경모,최병희,김귀정,이철원 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

캔식품중에 잔류하는 epichlorohydrin을 분석하기 위한 pu링e & trap-Cc/uf통D 분석법을 확립하여 캔의 lacauer 코팅제에서 식품으로 이행되어 잔류하는 epichtorohydfn을 측정하고, 식품유사용매에 의한 용출시험을 통해 일일추정섭취량을 산출하였다. epichlorohydrin의 검량선은 y=0.0006x+0.OO6?(R큰0.9983)의 직선성·라 0.05#ga의 검출한계를 나타내었다. 각종 음료 및 식품유사용매에 일정량의 epichlorohydrin을 첨가한 후 분석하였을 때 회수을은 72~91%였으며, 실제 시판되는 f5건의 캔음료 중 잔류하는 epichlorohydrin을 측정한 결과 모든 캔음료에서 검출한계(0.1#94) 이하였다. 제관업체에서 구입한 modifed epoxy, epoxy phenolic, vinyl organosol, epoxy phenol ester 등의 BADGE(bisphenol A diglycidyt ether)형 에폭시수지로 lacquer 코팅된 식품용 캔에 식품윤사용매인 10% 또는 95% 에탄올을 층L진한 후 90~121'c의 드라이오븐에서 30분~2시간동안 용출시켰을 패 캔의 lacquer 코팅재에서 식품유사용매로 이행되는 epichBorollydirn은 코팅재질, 그리고 가열온도 및 시간에 문관하게 모든 캔에서 검출한계(0.4#ga)이하 였다. 위의 용출결과를 FD.f_의 "Recommendation for Chemistry Data for Indirect Food Additive Petition" 윽 일일추정섭취량 산출법에 적용하여 얻은 epichtorohydrin의 일딜추정 섭 취 량은 0.2r조persorday이하였다. A sensitive ana1?~7tical method based on gas cl)romatogFapy~mass spectrometry with a selected ion monitoring (GE/hfS-Slhf) and the purge-and-trap concentrator ))·asdeveloped for determining ot'epicillorohydrin in canr;ed be)#erages coated with eporl· resin. Thecalibration rurve in the ranre of 0.j ~50nr had'correlation coefficient of 0.9983 and detection limit of 0.Osrga. Recoveries of epichlorohydrin spiked to beverages were in the range of 72 ~91% with detection limits of 0.1 #ga. fn survey of epichlorohydff in twenty commercialcanned beverage samples, epichlorohydrin was not found in all the samples with the detectionlimit of 0.1 r9a. In migration test of various cans coated with BADGE-based coating cans;modifed epoxy, epoxy phenolic, vinyl organosol, epox?· phenol ester were exposed to the foodsimulants of 10% ethanol and 95% ethanol. flfo delectable epichlorohydrin migrated to foodsiHulants was found in aTl the cars with detection Jimit of 0.4 #9/L. Using the miEration data,along uTith the applicstion of food and beverage cans complied with FDA's "Recommendationfor Chemlstry Data f,3r Indirect Food Additive Petition" , the potential dietary exposure toepichlorohydrin was estlmated to be under 0.2rf/person/day.

Effects of Home Exercise Program and Manual Therapy on Shoulder Function and Quality of Life in Patients with Adhesive Capsulitis

( Kwang- Il Kwak ),( Bum-jin Choi ),( Young-jeoi Yoon ) 대한물리치료학회 2016 대한물리치료학회지 Vol.28 No.5

Purpose: This study was conducted to identify the effects of home exercise programs and manual therapy on shoulder function and quality of life in patients with adhesive capsulitis. Methods: A total of 31 patients were enrolled in the study. All subjects were randomly assigned to a home exercise group (n=15) or a manual therapy group (n=16). Both groups performed each intervention program three times a week for four weeks. After four weeks, both groups performed a home exercise program continuously until week 12. Shoulder function was evaluated using the Korean Shoulder Scoring (KSS) system, while quality of life was evaluated using the WHO Quality of Life-BREF (WHOQOL-BREF) before and 4, 8, and 12 weeks after the intervention. Data were analyzed using two-way repeated measures analysis of variance (ANOVA). Results: There were significant differences in KSS before intervention and 4, 8, and 12 weeks after intervention for both the home exercise group and manual therapy group (p<0.001). There was also a significant difference in KSS at 4, 8, and 12 weeks when compared to the home exercise group and manual therapy group (p<0.001). Moreover, there was a significant difference in WHOQOL-BREF before and 4, 8, and 12 weeks after intervention in the home exercise group and manual therapy group (p<0.001). Conclusion: Home exercise and manual therapy improved shoulder function, but manual therapy led to a greater improvement in shoulder function better than home exercise. Home exercise and manual therapy improved quality of life, but there was no significant difference between groups.

Effects of Home Exercise Program and Manual Therapy on Shoulder Function and Quality of Life in Patients with Adhesive Capsulitis

Kwak, Kwang-Il,Choi, Bum-Jin,Yoon, Young-Jeoi 대한물리치료학회 2016 대한물리치료학회지 Vol.28 No.5

Purpose: This study was conducted to identify the effects of home exercise programs and manual therapy on shoulder function and quality of life in patients with adhesive capsulitis. Methods: A total of 31 patients were enrolled in the study. All subjects were randomly assigned to a home exercise group (n=15) or a manual therapy group (n=16). Both groups performed each intervention program three times a week for four weeks. After four weeks, both groups performed a home exercise program continuously until week 12. Shoulder function was evaluated using the Korean Shoulder Scoring (KSS) system, while quality of life was evaluated using the WHO Quality of Life-BREF (WHOQOL-BREF) before and 4, 8, and 12 weeks after the intervention. Data were analyzed using two-way repeated measures analysis of variance (ANOVA). Results: There were significant differences in KSS before intervention and 4, 8, and 12 weeks after intervention for both the home exercise group and manual therapy group (p<0.001). There was also a significant difference in KSS at 4, 8, and 12 weeks when compared to the home exercise group and manual therapy group (p<0.001). Moreover, there was a significant difference in WHOQOL-BREF before and 4, 8, and 12 weeks after intervention in the home exercise group and manual therapy group (p<0.001). Conclusion: Home exercise and manual therapy improved shoulder function, but manual therapy led to a greater improvement in shoulder function better than home exercise. Home exercise and manual therapy improved quality of life, but there was no significant difference between groups.

Effects of Dual Task Training on Balance and Functional Performance in High School Soccer Players with Functional Ankle Instability

Kwak, Kwang-Il,Choi, Bum-Jin 대한물리치료학회 2016 대한물리치료학회지 Vol.28 No.4

Purpose: This study was conducted to identify the effects of dual task training on balance and functional performance in high school soccer players with functional ankle instability. Methods: Twenty high school soccer players with functional ankle instability were randomly assigned to a single task training group and a dual task training group. One participant who did not participate regularly in the training was excluded. The single task training group (n=9) received balance training on an unstable surface. The dual task training group (n=10) received balance training on an unstable surface and had to catch thrown balls during the balance training. Both groups were trained for 4 weeks, 3 days a week. The balance and functional performance of both groups was measured before and after training. Balance was measured using an anterior-posterior and medio-lateral balance. Functional performance was measured based on a figure-of-8 hop test, up-down hop test, and a single hop test. All data were analyzed by repeated two-way ANOVA tests. Results: A time by group interaction effect was not observed in the medio-lateral balance test, figure-of-8 hop test, or single hop test (p>0.05). A time by group interaction effect was observed in the anterior-posterior balance and up-down hop test (p<0.05). Conclusion: These results suggest that dual task training improved balance and functional performance better than single task training for some items.

Effects of Dual Task Training on Balance and Functional Performance in High School Soccer Players with Functional Ankle Instability

( Kwang-il Kwak ),( Bum-jin Choi ) 대한물리치료학회 2016 대한물리치료학회지 Vol.28 No.4

Purpose: This study was conducted to identify the effects of dual task training on balance and functional performance in high school soccer players with functional ankle instability. Methods: Twenty high school soccer players with functional ankle instability were randomly assigned to a single task training group and a dual task training group. One participant who did not participate regularly in the training was excluded. The single task training group (n=9) received balance training on an unstable surface. The dual task training group (n=10) received balance training on an unstable surface and had to catch thrown balls during the balance training. Both groups were trained for 4 weeks, 3 days a week. The balance and functional performance of both groups was measured before and after training. Balance was measured using an anterior-posterior and medio-lateral balance. Functional performance was measured based on a figure-of-8 hop test, up-down hop test, and a single hop test. All data were analyzed by repeated two-way ANOVA tests. Results: A time by group interaction effect was not observed in the medio-lateral balance test, figure-of-8 hop test, or single hop test (p>0.05). A time by group interaction effect was observed in the anterior-posterior balance and up-down hop test (p<0.05). Conclusion: These results suggest that dual task training improved balance and functional performance better than single task training for some items.

한국 노인의 신체활동 정도와 의료이용과의 관련성

곽광일(Kwak, Kwang-Il),백창희(Baek, Chang-Hee),류소연(Ryu, So Yeon) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.1

본 연구는 제 5기 전체(2010~2012)국민건강영양조사 자료를 이용하여 우리나라 노인의 신체활동 정도와 의료이용과의 관련성을 파악하기 위하여 실시하였다. 연구결과에서 비활동적인 신체활동군과 비교하여 활동적 신체활동군의 경우에 입원이용 가능성이 0.54배(OR;95% CI, p<0.001), 외래이용은 0.73배(OR;95% CI, p=0.040), 약국이용은 0.75배(OR;95% CI, p<0.007) 더 낮으것으로 나타났으며, 의료이용 횟수도 감소하는 것으로 나타났다. 또한, 최소 신체활동군의 경우에 비활동적 신체활동군과 비교하여 입원 의료이용 가능성이 0.64배(OR;95% CI, p<0.001) 낮고, 이용횟수도 감소하는 것을 확인하였다. 결론적으로 노인의 신체활동 정도에 따라서 의료이용과의 관련성을 확인하였다는 데 의의가 있으며, 신체활동을 활발하게 실천하는 것이 노인의 건강증진과 삶의 질을 향상시킬 뿐만 아니라 의료비 지출의 감소에도 도움이 될 것으로 사료된다. This study examined the relationship between the physical activity levels and health care utilization in Korean elderly based on the data from The fifth Korean National Health and Nutrition Examination Survey (K-NHANES Ⅴ). As a result, physically active participants were 0.54 times (OR;95% CI, p<0.001) less likely to use inpatient health care and 0.73 times (OR;95% CI, p=0.040) less likely to use outpatient health care and 0.75 times (OR;95% CI, p<0.007) less likely to use drugstores than physically inactive participants, and the frequency of health care use was lower. In addition, physically minimal active participants were 0.64 times (OR;95% CI, p<0.001) less likely to use inpatient health care than physically inactive participants; the frequency of other health care facilities was lower. In conclusion, the relationship between being physically active and lower health care utilization among Korean elderly identified in this study. This suggests that being physically active is helpful to the elderly, not only in health promotion and improving quality of life, but also in reduced medical expenditure.

先天性完全胸部心 脫出症 麻醉1例報告

廉廣元,申光一,金光宇,郭一龍 한국의 현대의학사 1971 한국의 현대의학 Vol.4 No.1

익명화 방법을 적용한 임상진료문서 등록 기법 연구

김일광(Kim Il Kwang),이재영(Lee Jae Young),김일곤(Kim Il Kon),곽연식(Kwak Yun Sik) 한국정보과학회 2007 정보과학회논문지 : 소프트웨어 및 응용 Vol.34 No.10

진료기관 사이뿐 아니라 국가 경계를 넘어선 환자진료 정보 교류에 대한 요구사항이 세계적으로 증가되고 있으며 이에 대한 연구가 활발하게 진행되고 있다. 본 논문에서는 임상진료문서 등록 저장소에서의 임상진료문서 등록, 조회 방법에 관한 두 가지 기법을 제안한다. 그 첫 번째는, 임상진료문서 관련 부속파일에 대한 참조와 처리를 위해 적하목록(Manifest)을 구성하고 사용을 제안하는 것이다. 두 번째는 한층 강화된 임상진료문서 보안전략을 통해 환자 익명성을 제공할 수 있는 방법이다. 전자는 네트워크 장애와 같은 외부요인에도 임상진료문서 관련 부속자료에 대한 로컬 참조를 가능케 하여 끊김 없는 뷰(view)를 구성할 수 있게 한다. 후자는 환자의 신상정보를 담은 임상진료문서 헤더와 진단과 처치 정보를 담은 임상진료문서 바디가 지리적으로 분산된 하나 이상의 저장소에 분리 저장되기 때문에 어느 하나의 저장소가 공격 당하더라도 공격자는 환자의 단편적인 정보만 획득하게 된다. 이는, 결국 환자의 신상정보와 병력정보를 단절시킴으로써 사생활침해의 소지를 줄이고 개인정보보호 효과를 가져올 수 있게 한다. The goal of this paper is to propose a new way to register CDA documents in CDR (Clinical Document Repository) that is proposed by the author earlier. One of the methods is to use a manifest archiving for seamless references and visualization of CDA related files. Another method is to enhance the CDA security level for supporting pseudonymization of CDA. The former is a useful method to support the bundled registration of CDA related files as a set. And it also can provide a seamless presentation view to end-users, once downloaded, without each HTTP connection. The latter is a new method of CDA registration which can supports a de-identification of a patient. Usually, CDA header can be used for containing patient identification information, and CDA body can be used for diagnosis or treatment data. So, if we detach each other, we can get good advantages for privacy protection. Because even if someone succeeded to get separated CDA body, he/she never knows whose clinical data that is. The other way,even if someone succeeded to get separated CDA header; he/she doesn’t know what kind of treatment has been done. This is the way to achieve protecting privacy by disconnecting association of relative information and reducing possibility of leaking private information. In order to achieve this goal, the method we propose is to separate CDA into two parts and to store them in different repositories.

Respiratory and Circulatory Effects of Flnnitrazepam

Kwak, Il Yong,Kim, Yong Lack,Kim, Kwang Woo 최신의학사 1976 最新醫學 Vol.19 No.1