수종의 피부종양에서 Proliferating Cell Nuclear Antigen과 Ki - 67 의 표현에 관한 비교 연구

황선욱(Sun Wook Hwang),원영호(Young Ho Won),전인기(Inn Ki Chun),박창수(Chang Soo Park) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.3

Background : Both PCNA and Ki-67 have been used as marker for cellular proliferation. The drawback of Ki-67 antibody in immunohistochemistry was that it can be labelled only on fresh tissue, however, MIB1 is a newly developed Ki-67 antiboc which can be labelled on formalin-fixed tissue. Objective : The purpase of the present study is to compir the stainability of the Ki-67 antibody with that of the ICNA antibody on formalin-fixed, para fin embedded tissues. Methods : Using MIE1, the newly developed Ki-67 antibody and PC10(PCNA antibody), speci mens of squamous cell carcinoma(SCC), Bowens disease(BL), actinic keratosis(AK) and basal cell epithelioma(BCE) were stained by one hour immunocytial, mistry using a Microprobe immuno/DNA stainer. Results : The labelling indices (LI) of MIB1 were 82.6%, 37.4%, 38.3% & 81.1% respectively in SCC, BD, AK & BC, while the LI of PC10 were 77.69%, 26.6% & 64.4%. The labelled cells of both antibodies differed in distribution patterns on turmor tissues. Conclusion : MIBI cain be used to be an alternative m.rl r for proliferating cells. MIBI PC10, when used together, will be mutually compensatory the study of proliferating cell kinetics. (Kor J Dermatol 1995;33(3): 453-458)

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

코호트 효과를 고려한 주택연금 수요 추정

박상수(Sang-Soo Park),심미령(Mi-Ryung Sim),이충기(Chung-Ki Lee) 한국경제연구학회 2017 한국경제연구 Vol.35 No.3

2007년부터 시행되고 있는 한국의 주택연금제도는 정부가 보증하는 역모기지 프로그램이다. 한국주택금융공사가 매년 실시하고 있는 연간 설문 자료를 이용하여 미래에 주택연금을 이용할 의향이 있는 가구들에 대해 주택연금에 대한 수요를 추정하였다. 본 논문에서는 이충기․박상수(2014)의 연구를 확장하여 미래 기대와 코호트 효과를 고려하여 순서형 로짓 모형을 설정하였다. 설문에서 진술된 가구의 의향이 미래에 대한 기대에 근거하고 있다는 점을 적절하게 평가하기 위해 몇 가지의 가정을 바탕으로 미래의 기대형성 과정을 계량경제학적으로 모형화하여 주택연금 수요를 예측하고자 하였다. 주택연금에 대한 수요 추정 결과에 따르면, 주택연금 프로그램에 대해 후세대들이 보다 덜 긍정적인 경향이 나타난 반면 저소득 계층은 보다 긍정적으로 나타났다. The J ooTaekYeonKeum is the government guaranteed reverse mortgage program that Korean Government has been implementing since 2007. We extended Lee and Park’s(2014) demand estimation for the reverse mortgage loans in Korea using the yearly survey data, conducted by Korea Housing Financing Corporation, for household’s intention to use J ooTaekYeonKeum in the future. In order to appropriately appreciate the fact that the stated intentions in the survey were based on households’ expectations for their future, we adopted an econometric procedure that incorporated expectations explicitly as well as cohort effects. Our findings include: demands for reverse mortgage loans are estimated similar to that of Lee and Park(2014); later generations tend to be less positive for having the reverse mortgage program; lower income groups are more positive for the program.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

경희대학교 수원캠퍼스 노천극장 주변 공원 기본계획

김동찬,이윤수,권오원,민창기,김태현,박경모 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1

We, Kyung-hee University in Suwon has planned to build an open-air theater behind the building of natural science, and feel the need of creating places for cultural life and recreation. As the origin aim of this construction and landscape, university students can use this facilities and place for their daily relaxation and cultivation of emotion, and they also can utilize them for places of their meetings and events. Concerning the following completion of the UN Peace Park, our theater and the surrounding places will expectingly play important roles for the park because the open-air No-cheon theater is included in the full site of the UN Peace park. The focused elements of this basic plan are maintaining the basic plan of the UN Peace Park, forming the visually creative background, of the open-air theater cultural and recreational places, balancing and integrating human, nature, and the useful facilities.

Tetrahydroisoquinoline Alkaloids가 쥐의 동맥과 뇌균등질의 α-Adrenoceptors에 미치는 영향

이현석,백선하,황수현,박인성,김은상,정진명,한종우,장기철,장기철 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.1

Silibinin Inhibits Tumor Growth through Downregulation of Extracellular Signal-Regulated Kinase and Akt <i>in Vitro</i> and <i>in Vivo</i> in Human Ovarian Cancer Cells

Cho, Hyun Jin,Suh, Dong Soo,Moon, Soo Hyeon,Song, Yong Jung,Yoon, Man Soo,Park, Do Yoon,Choi, Kyung Un,Kim, Yong Keun,Kim, Ki Hyung American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.17

<P>Anticancer activity of silibinin, a flavonoid, has been demonstrated in various cancer cell types. However, the underlying mechanisms were not elucidated in human ovarian cancer cells. The present study was undertaken to examine the effect of silibinin <I>in vitro</I> and <I>in vivo</I> on tumor growth in human ovarian cancer cells. Silibinin decreased cell viability in a dose- and time-dependent manner. Silibinin caused an increase in reactive oxygen species (ROS) generation, and the silibinin-induced cell death was prevented by the antioxidant <I>N</I>-acetylcysteine (NAC). Western blot analysis showed silibinin-induced downregulation of extracellular signal-regulated kinase (ERK) and Akt. Transfection of constitutively active forms of MEK and Akt prevented the silibinin-induced cell death. Oral administration of silibinin in animals with subcutaneous A2780 cells reduced tumor volume. Subsequent tumor tissue analysis showed that silibinin treatment induced a decrease in Ki-67-positive cells, an increase in transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, activation of caspase-3, and inhibition of p-ERK and p-Akt. These results indicate that silibinin reduces tumor growth through inhibition of ERK and Akt in human ovarian cancer cells. These data suggest that silibinin may serve as a potential therapeutic agent for human ovarian cancers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-17/jf400192v/production/images/medium/jf-2013-00192v_0008.gif'></P>

폐결핵으로 오인된 역형성 거대세포 림프종 1례

현동우,박재용,강태경,박기수,박태인,김창호,손상균,권건영,이규보,정태훈,권삼,Hyun, Dong-Woo,Park, Jae-Yong,Kang, Tae-Kyung,Park, Ki-Soo,Park, Tae-In,Kim, Chang-Ho,Sohn, Sang-Kyun,Kwon, Kun-Young,Lee, Kyu-Bo,Jung, Tae-Hoon,Kweon, Sam 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

저자들은 발열, 체중감소 등의 증상과 흉부 X-선 사진상 폐경화의 소견이 있었던 환자에서 폐의 병변이 역형성 거대세포 림프종으로 추측되는 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Anaplastic large cell lymphoma(ALCL) is a recently recognized large cell lymphoma characterized by large pleomorphic cells, with prominent nucleoli, expressing the CD30(Ki-1) antigen. It is often misdiagnosed as metastatic carcinoma, malignant histiocytosis or Hodgkin's disease. Primary pulmonary ALCL is extremely rare although it frequently involves extranodal sites, e.g. skin, bone, gastrointestinal tract, soft tissue and lung. We report a case of ALCL suspected as primarily involving lung.

半導體 PbS 薄膜의 活性化硏究

朴東秀,孫基洙,李元植 慶北大學校 物理化學硏究所 1984 硏究論文集 Vol.5 No.-

Auger electron spectroscopy has been used in conjunction with argon ion sputtering in a study of the chemical structure of the surface, bulk and interface region between chemical deposited PbS and the glass substrate, thermally oxidated PbS and the glass substrate and thermally oxidated PbS and the SiO_2. All these PbS films were activated by means of oxidation in various conditions. In the result of the present study, we showed that our experiments are coincidence with theoretical mechanism "minority-carrier model" of photoconductivity of PbS film. The principal features in the Auger electron of a complex spectra from a SiO_2, carbide and graphite surface are presented. They occured when some of the electrons involved in this Auger process are valence electrons. It was found that these complex spectra serve as a fingerprint for the identification of the form of the carbon, oxygen at surfaces. We found the chemical structure of the surface, bulk and interface of a 1-2μ PbS chemical deposited on SiO_2 and simultaneous activation effect of SiO_2-PbS interface.

실온에서 Al-SiO_2-Si(100)_p형 계의 경계면 반응

박동수,손기수,이원식,박봉두 慶北大學校 物理化學硏究所 1985 硏究論文集 Vol.6 No.-

실온에서 알루미늄 산화층(SiO_2)-반도체〔Si(100)_p형〕 소자의 경계면 반응을 Ar^+이온 sputter총을 부착한 AES로 수행했다. SiO_2-Si 경계면은 Si-Si 결합, Si-O 결합의 두 가지 상태를 갖고 있으며, 경계면 넓이는 약 30Å였다. Al-SiO_2-Si 반도체 소자의 경계면 반응은 SiO_2 속의 자유 실리콘이 알루미늄 표면으로 확산되고, 알루미늄과 SiO_2 경계면에 대량의 자유 실리콘이 존재한다. Al-interfacial layer(SiO_2)-semiconductor Si(100)_p-type structures were investigated by the Auger Electron Spectroscopy. The results of depth profiling Ar^+ -ion sputtering are presented for the SiO_2-Si(100)_p-type cell. In the interface, Silicon exists in only two distinct bonding states: Si-Si or Si-O bonding. The exact width of the interface is known as indefinite, but here we estimate it approximately 30Å. The results of depth profiling Ar^+ -ion sputtering are also presented for the Al-SiO_2-Si(100)_p-type cell. Metal(Si) atoms from deposited interfacial oxide layer were observed on the Al surface. The interfacial reaction takes place between Al and the interfacial layer at the room temperature. The diffusion of metal(Si) atoms from the interfacial layer towards the Al surface is suspected to play a role in degradation effect in the MIS solar cells.