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Bone formation with alloplastic graft substitutes in critical-sized rat calvarial defects
( Ki Pyo No ),( Su Gwan Kim ),( Ji Su Oh ),( Jong Won Jung ),( Sung Soo Yang ),( Sung Yong Lee ),( Jin Sung Park ),( Sung Chul Lim ),( Mi Ae Jeong ) 조선대학교 치의학연구원 2011 Oral Biology Research (Oral Biol Res) Vol.35 No.2
The purpose of this study was to evaluate whether the level of bone formation differed according to the ratio of the hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) components. Materials and Methods: In the cranial area of 60 rats, bone grafts were performed using four bone graft materials with different ratios of HA/β-TCP: (1) unfilled defect, (2) HA (100%), (3) HA (70%)/β-TCP (30%), (4) HA (30%)/β-TCP (70%), and (5) β-TCP (100%). The rats were sacrificed after 4 weeks or 8 weeks, and the bone formation area was evaluated under a light microscope. Results: In the 4-week groups, the bone formation area in the rats grafted with β-TCP (100%) was 0.75±0.21 mm2, and slightly larger bone formation areas were observed than in other groups; nonetheless, these values were not statistically significant in comparison with the other groups. Similarly, significant differences were not shown among any other groups. In the 8-week groups, in the rats grafted with HA (100%) and HA (30%)/β-TCP (70%), bone formation was observed to be 2.60±1.03 mm2 and 2.56±0.93 mm2, respectively. Thus, more abundant bone formation was observed in these two groups than in the other three groups, and this difference was statistically significant. Conclusion: Based on the results, the amount of new bone formation is greatest when bone grafts are performed using the graft materials HA 100% or HA (30%)/β-TCP (70%); thus, good bone formation outcomes are expected when using these materials in humans.