RBL-2H3 세포에서 Spermine에 의한 히스타민 유리와 칼슘유입에 미치는 상백피의억제효과

채옥희,강경진,신인호,김영기,이무삼,전병득 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.2

열분해 가스화 용융시설 부산물의 재활용성에 관한 고찰

신대윤,문옥란,신찬기 조선대학교 환경공해연구소 2007 環境公害硏究 Vol.20 No.1

The incineration process has commonly used for wastes amount reduction and thermal treatments of pollutants as the technologies accumulated. It investigated the recycling characteristic of the fusion slag which is a last by-product which occurs from 3 facilities which are developed with Municipal waste heat decomposition gasification fusion facility of domestic. We investigated the surface characteristic of 3 melting facility slag with SEM. Therefore we found the surface is soft by cooling water. Also the surface is tough and has small air bubble by cooling air. Ca/Si ratio for alkalinity is high from the slag of the S type melting facility. The slag of T type contents contains much Fe. The melting slag has heavy metals whose contents are Cr 312.1㎎/㎏, Cd ND. Cu 105.9㎎/㎏ and Pb 3.0㎎/㎏. Each heavy metal reduction ratio is Cr 10.72%, Cd 100%, Cu 95.9%, Pb 99.9%. The amount of heavy metals contained fly ash is highly reduced through a heat decomposition fusion process re-in scattering. The Dioxin contents of fusion slag is as following: S type 2.92 pg-TEQ/g, T type 0.87 pg-TEQ/g and P type 0.21 pg-TEQ/g These are very low level comparing with the Dioxin standard 3ng-TEQ/G of Japan. Leaching rate is very low. This satisfies the recycling standard of Germany and the Dioxin Standard of Japan. Therefore we concluded that the possibility of secondary contamination may not happen.

玄胡索중 3級鹽基成分의 分離와 定量에 관한 硏究

嚴東玉,金基德,李來洪,梁在憲,申台容 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

A new application of specrophotometry for the isolation and determination of tertiary base in Corydalis Tuber was investigated. In order to establish the method for isolation and determination of tertiary base in the Corydalis Tuber. Tertiary base was isolated from Corydalis Tuber by organic solvent. When tertiary base was added to a solution containing cobaltous ion and excess thiocyan ion, yellowish-green, 1,2-dichloroethane-solube(base)_2Co(SCN)_4 precipitate. Supportive evidence for identification could be obtained by complexation with tetrathiocyanatocobaltate(Ⅱ) ion. The ultraviolet-visible spectrum of complex vompound in 1,2-dichloroethane exhibits maxima at 282nm and 624nm. The tertiary base was isolated from compex compound and identified as glaucine by UV-Visible spectrum and TLC. A tertiary base in 1,2-dichloroethane scanned from 200nm to 400nm qualitatively exhibits the same absorbance characteristics at identical wavelength as does isolated and concomitantly measured solution of a complex compound. The tertiary base components present in comples compound have been resolved on an absorbance solvent. And it is studied that the differential determination of tertiary base in Corydalis Tuber by spectrophometry. The tertiary base is determined by absorbance of colored products that is produced to reaction of tetrathiocyanatocobaltate(Ⅱ) ion under determination of tertiary base was possible to the range of glaucine 0.100mg/ml-1.000mg/ml in 1,2-dichloroethane. (maximum wavelength; 624nm) The calibration curve showed that the coefficient of variation was 0.9999% for glaucine. Also reproducibility tests showed that the coefficient of variation was 0.9999%. Arepid, specific and precise method using UV-Visible spectrophotometry and TLC has been developed for the isolation and determination of tertiary base in the Corydalis Tuber. The method was applicable to the isolation and determination of tertiary base in Corydalis Tuber or it's extract.

Wolff-Parkinson-White증후군의 임상상 및 전기생리학적 소견

안신기,이문형,장양수,오동진,최인석,하종원,임세중,김병옥,정남식,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

첫번째 뇌졸중 환자에서 무증상 뇌경색 : 뇌자기공명영상 소견과 위험인자 MRI Findings and Stroke Risk Factors

윤신구,방차옥,성기범,박형국,신현길 대한신경과학회 1996 대한신경과학회지 Vol.14 No.1

소목(Caesalpina sappan L.) 추출물의 항균성과 김치숙성에 미치는 효과

이신호,최우정,조옥기,손수정 대구효성가톨릭대학교 식품과학연구소 1997 식품과학지 Vol.9 No.-

김치의 숙성을 지연시킬수 있는 천연물질을 검색하기 위하여 소목 ethanol추출물의 항균력을 조사하고 김치제조에 응용할 수 있는 가능성을 검토하기 위하여 소목 추출물 1%를 김치 제조시 첨가하여 10℃에서 숙성시키면서 그 변화를 관찰하였다. 소목 ethanol추출물은 유산균 4종류 7균주에 대하여 성장억제 효과를 나타내었으며 생균수 측정시에도 시험균주 모두에 대해 공히 1~4 log cycle의 항균효과를 나타내었다. 김치 숙성 중 소목 첨가구의 경우 숙성 기간동안 대조구에 비해 pH와 산도가 다소 높은 경항을 나타내었다. 소목 추출물을 첨가한 김치의 관능검사는 대조구와 첨가구간의 유의적 차이를 보이지 않았으며 sour taste의 경우에는 대조구에 비해 첨가구의 수치가 더 낮은 경향을 나타내었다. Antimicrobial effect of ethanol extracts of Caesalpina sappan Linne and its effects on kimchi fermentation were investigated. Antimicrobial activities of the extract against 4 kinds of lactic acid bacteria isolated from kimchi, such as Lactobacillus plantarum, Lactobacillus sake. Leuconostoc mesenteroides and Pedicoccus pentosaceus showed 1~4 log_(10) reduction during incubation for 12 hours. The growth of tested lactic acid bacteria did not occur in Caesalpina sappan Linne containing modified MRS broth except L. plantarum HSU02 and L. mesenteroides HSU14. The pH of kimchi containing 1% of Caesalpina sappan Linne extracts was higher than that of control but titratable acidity, total bacteria and Lactobacilli were lower than that of control during fermentation for 25 days at 10℃. Sour taste of Caesalpina sappan Linne containing kimchi was more weak than that of control. Sensory score of flavor and overall acceptability did not show significant difference between Caesalpina sappan Linne containing kimchi and control during fermentation.

알코올 금단 발작 환자에서 진전 섬망 예방에 대한 Nimodipine과 Chlordiazepoxide의 효과 비교

정두신,양광익,이보람,방차옥,이태경,성기범,안무영,박형국 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background & objectives : An increase of calcium influx during alcohol withdrawal state may contribute to neuronal hyperexitability, which cause delirium tremens(DT). Some investigators have found calcium channel blockers effects in prevention of DT in experimental animals. Therefore we evaluated the preventive effects of calcium channel blocker(nimodipine) and benzodiazepine(chlordiazepoxide) on the development of DT in alcohol withdrawal seizure(AWS) patients. Method : A total 59 patients with AWS were divided into three groups according to the management nimodipine-treated, chlordiazepoxide-treated, and control(no specific medication) groups. We compared the incidence rates of DT in the three groups. Results : Total incidence rate of DT was 30.5%(18 of 59 patients). There were 6 DTs of 18 patients(33.5%) in nimodipine-treated group, 4 of 21 patients(22.5%) in chlordiazpoxide-treated group, and 8 of 20 patients(44.0%) in control. Conclusion : The control group(44.0%) showed the highest incidence rate of DT. And nimodipine-treated(33.5%) and chlordiazepoxide-treated group(22.5%) were followed. However, this result failed to demonstrated statistically significant differences due to small numbers size.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

상부 조기 위암 환자의 복강경하 상부 위절제술 3례 경험

조규석,김형철,박경규,이문수,송옥평,임철완,신웅진,주종우,유기원 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Background : The reported incidence of early gastric cancer located in the upper portion of the stomach has been increasing with the recent advances in its diagnosis and screening. Recently, we have successfully performed laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without pyloroplasty on three patients with early gastric carcinoma localized to the upper third of the stomach. We describe our modification of this procedure in this report. Method : After creating an surgical pneumoperitoneum, the stomach was mobilized using laparoscopic coagulating shears. Upper half of the greater curvature and three-quarters of the lesser curvature were then dissected along with regoinal D2 lymphadenectomy. This was followed by a 5 cm, longitudinal mini-laparotomy in the upper abdomen, and the construction of the exteriorized stomach with a gastric tube measuring 20 cm long and 4 cm wide. Reconstruction with an esophagogastrostomy was performed using a circular stapler. Result : No post-operative morbidity or mortality was observed in this small series of patients. The average operative time was 250 minutes (range 220-300 minutes), and the average blood loss was 150 ml (range 90-180 ml). The mean number of lymph nodes harvested during these laparoscopic proximal gastrectomies was 24 nodes (range 22-25 lymph nodes). The average postoperative hospital stays was 7.5 days (range 7-8 days). Conclusion : Our technique of laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without phloroplasty offers a minimally invasive technique with the potential of impoving the post-operative quality of life patients with an early-stage proximal gastric cancer.