개 아토피성 피부염 장기치료 1례

박은정,윤기영,박정호,이왕희,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 7-year-old male castrated Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for severe pruritus. On physical examination were confirmed systemic erythema and alopecia, crust on the neck and flank region. Tape strip test identified numerous degenerative neutrophils and severe Malassezia infection. Treatment for severe pruritus was applied with systemic antihistamine therapy and topical therapy with antimicrobial shampoos. For the finding of appropriate treatment of atopic dermatitis, it was chosen six immune-related treatments. And clinical sign scores were evaluated by investigator with CADESI-03 after each application of six treatments. Application of human immunoglobulin G and leflunomide showed the remarkable regression of lesions.

Hair growth promoting effects of different alternating- current parameter settings are mediated by the activation of Wnt/β-catenin and MAPK pathway

( Ki Min Sohn ),( Kwan Ho Jeong ),( Jung Eun Kim ),( Young Min Park ),( Hoon Kang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: There are clinical studies demonstrating the positive effect of electrical stimuli on hair regrowth. However, the underlying mechanism and optimal parameter settings are not clarified. Objectives: To investigate the effects of different parameter settings of electrical stimuli on hair growth by examining changes in human dermal papilla cells (hDPCs) in vitro and by observing molecular changes in animal tissue. Methods: In vitro, cultured hDPCs were electrically stimulated with different parameter settings. Cell proliferation was measured by MTT assay. The Ki67 expression was measured by immunofluorescence. Hair growth-related gene expressions were measured by RT-PCR. In animal model, different parameter settings were applied to the shaved dorsal skin of rabbit for 8 weeks. Expression of hair-related genes in the skin of rabbit was examined by RT-PCR.Results: At low voltage power (3.5V) and low frequency (1MHz or 2MHz) alterating current, in vitro proliferation of hDPCs was successfully induced. A significant increase in Wnt/モ-catenin, Ki67, p-ERK and p-AKT expression was observed. In animal model, hair regrowth was observed in the entire stimulated areas and expression of hair-related genes in the skin significantly increased. Conclusion: There are optimal conditions for electric stimulated hair growth and they might be different in the cells, animal, and human tissue. Electric stimuli induces mechanisms such as activation of Wnt/モ-catenin and MAPK pathway in hair follicles.

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

The fate of spinal schwannomas following subtotal resection: a retrospective multicenter study by the Korea spinal oncology research group.

Sohn, Seil,Chung, Chun Kee,Park, Sung-Hye,Kim, Eun-Sang,Kim, Ki-Jeong,Kim, Chi Heon M. Nijhoff ; Kluwer Academic Publishers 2013 Journal of neuro-oncology Vol.114 No.3

<P>The fate of residual spinal schwannomas needs to be estimated in order to plan further management after subtotal removal. Our aim was to evaluate the growth rate of residual spinal schwannomas and compare results in regrowth and no regrowth groups by using data collected from the Korea Spinal Oncology Research Group database. From January 1989 to August 2011, 27 patients with residual spinal schwannomas were selected. Patients with at least two follow-up magnetic resonance image (MRI) studies after subtotal resection were included. The mean period of MRI follow-up was 62.4 months. A tumor size increase of over 2 mm in the maximal diameter was considered indicative of regrowth. Age, sex, size at initial diagnosis, postoperative tumor size, and Ki-67 labeling index were compared between regrowth and no regrowth groups. Eight residual schwannomas regrew (29.6 %), and 19 (70.4 %) did not regrow. Average growth rate of the regrowing tumors was 1.0 4.4 mm/year. The mean percentage increase in tumor size during follow-up was 10.0 28.8 %. The Ki-67 labeling indices were significantly different between regrowth and no regrowth groups (P = 0.014). Two patients underwent a revision operation for significant tumor regrowth. Nineteen cases (70.4 %) among 27 residual spinal schwannomas did not regrow significantly, but further surgical treatments were necessary in 2 patients due to significant regrowth. The Ki-67 labeling index was higher in the regrowth group. Earlier follow-up MRI is recommended for patients whose tumors have higher Ki-67.</P>

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

契約終了後의 附隨義務 : 독일에 있어서 契約의 餘後效理論과 관련하여

朴正基 釜山水産大學校 1994 論文集 Vol.50 No.-

It is difficult to fix the definite point of contractual termination actually. Even after main duties of contract terminate with performance, regular incidents(Nebenpflicht) subsequent to them are sometimes laid on the parties concerned so that they can function effectively as a whole. Therefore, it becomes an issue how to explicate the duties remaining between the parties theoretically when the contract terminates with appropriate performance. Civil Law has accepted 'Treu und Glaube(bona fide)' for the duty in the individual type as 'Employment' so far, but the entire review on it has not been fulfilled. This paper examines the contents and legal characteristics of the incidents(Nebenpflicht) subsequent to contractual termination with reference to 'After-affect(Nachwirkung)' of contract in Germany. The constitution is as follows : Ⅰ. Introduction Ⅱ. 'After-affect(Nachwirkung)' Theory in Germany Ⅲ. Representative Cass in Germany Ⅳ. Classification and Arrangement by Main Theories Ⅴ. Reexamination Ⅵ. Conclusion

契約上의 附隨的인 義務에 관한 履行請求의 可能性에 관하여 : Sturner의 見解를 중심으로 Unter Berucksichtigung der Auffassung Sturners

朴正基 釜慶大學校 1998 釜慶大學校 論文集 Vol.3 No.1

AuBer den Hauptleistungspflichten, die den Typus eines Schuldverhaltnisses bestimmen, gibt es die parteinen vielfaltige Nebenpflichten. Wahrend es fur die Hauptleistungspflichten vollig selbstverstandlich ist, daB der Pflichtigkeit des Schuldners ein klagbarer und damit erzwingbarer Anspruch des Glaubigers entspricht, ist die Klagbarkeit der Nebenpflichten auBerordentlich zweifelhaft. Die Literatur versuchte stets Kriterien zu entwickeln, welche die Nebenpflichten, Verhaltenspflichten oder Schutzpflichten ohne korrespondierendem Anspruch von den Nebenleistungspflichten mit korrespondierendem Anspruch unterscheiden sollten. Der Grundtenor des heutigen Meinungsstandes laBt sich etwa folgendermaKen zusammenfassen: anspruchskorrespondierende Nebenlesitungspflichten setzen eine konkretisierbare Pflicht voraus, die neben der geschuldeten Hauptlesitung einem eigenstandigen Zweck dient. Oft wird auf den Parteiwillen verwiesen, der jede Pflicht zu einer anspruchskorrespondierenden Nebenleistungspflicht erheben konne.Ganz uberwiegend sind die Klagbarkeit einer Pflicht und ihre synallagmatische Verknupfung in gegenseitigen Vertragen als verschiedene, voneinander unabhangige Kategorien erkannt. Die in den Lehrbuchern skizzierten Kriterien eines Erfullungsanspruchs sprechen ohne Zweifel die richtigen Gesichtspunkte an. Weil sie aber M. E. etwas undifferenziert sind, lohnt der Versuch, die Voraussetzungen des Anspruch auf Erfullung von Nebenpflichten scharfer einzugrenzen. Neben der Bedeutung der gesetzlich geregelten Falle fur eine Gesamtlosung und dem EinfluB des Parteiwillens auf das Entstehen eines Anspruchs erscheint vor allem das Problem der Konkretisierung der Nebenpflichten naherer Betrachtrung wert. Der Anspruch verlangt eine Konkretisierung des gewunschten Verhaltens ex ante und nicht erst ex post.

고내열 Polyester-imide Resin의 합성 및 열적 성질

박이순,하기룡,도정회 경북대학교 산업기술연구소 1993 産業技術硏究誌 Vol.21 No.-

Methylene dianiline(MDA)와 trimellitic anhydride (TMA)를 반응시켜 diacid diimide (DID)를 합성하고 이를 과량의 ethyleneglycol과 반응시켜 bishydroxyethylbisimide(BHEI) 중간체를 합성하였다. 다음 dimethylterephthalate와 ethyleneglycol를 에스테르 교환 반응시켜 bishydroxyethyl terephthalate(BHET)중간체를 합성하였고 이를 BHEI와 280℃, 감압(1~3 ㎜Hg)의 용융상태에서 축합 중합하여 polyester-imide를 얻었으며 GPC 및 ^1H-NMR로 분자량 및 공중합체 조성을 구하였다. 생성된 공중합체는 imide단위가 2-10 mole% 함유됨에 따라 PET단독중합체(T_g=78.9℃)보다 내열성(공중합체 T_g=81.9-91.6℃) 이 증가됨을 확인하였다. Methylene dianiline(MDA) was reacted with trimellitic anhydride(TMA) to give diacid diimide(DID) and then DID was reacted with excess of etyleneglycol to give bishydroxyethylbisimide(BHEI) intermediate. Dimethylterephthlate was reacted with ethyleneglycol by ester interchange reaction to give bishydroxyethylterephthalate(BHET) intermediate. BHET and BHEI was cocondensed in the melt state at 280℃ under reduced pressure (1~3 ㎜Hg) to give polyester-imide type copolymer. The molecular weight and composition of copolymer was determined by GPC and ^1H-NMR. The resulting copolymer showed increased thermal stability (T_g=81.9-91.6℃ with imide unite content of 2-10 ㏖%) compared to homopolymer (PET, T_g=78.9℃).

남원군 산내면 일대에 분포하는 편마암류의 미량성분에 의한 그 기원암에 관한 연구

박정관,조규성,남기상 全北大學校 基礎科學硏究所 1989 基礎科學 Vol.12 No.1

This research aims to study origin by trace elements (Cu, Cr Pb, Ni, Mn, Li,Zn) of 225 samples of the gneisses that receive high metamorphism in sannae-myeon area, Namwon-gun. I have studied average abundance, abundance range and frequency distribution of each elements, and considered geochemical feature of the trace elements in the shale and granite. Abundance of Cu, Cr, Ni, in the shale of sedimentary origin is higher than that in the granite of igneous origin. Abundance of the trace elements in the porphyroblastic gneiss, granitic gneiss and pegmatitic gneiss is very similar to the that in the shale with the biotite gneiss, but that in the leucocratic gneiss is less than in the shale and it is similar to the granite. Frequency distribution of the rocks of sedimentary origin is irregularly widely dispersion, but that of igneous origin is distributed narrowly around maximum frequency. Therefore the porphyroblastic gneiss, granitic gneiss and pegmatitic gneiss is paragneiss with the biotite gneiss, and the Leucocratic gneiss is orthogneiss. This result is in accord with geological field survey and study on the metamorphism(Kim O.J. etal.,1964;Kim H.S., 1970,1973; Lee S.M., 1980,1981)

혈관화 두개골 외층골피판을 이용한 두개안면부 재건

정주성,김기영,김창룡,박문성,정숭룡,유선열,이승호 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Vscularized calvarial bone flaps have been useful tools in the reconstuction of different type of bone defects in craniofacial surgery Vascularized bone transfer are often preferred to nonvascularized bone grafts because nonvascularized bone grafts are less resistant to infection, mot as mechanically strong, and do not survive well in a poorly vascularized bed. Potential advantages of vascularized outer table cavarial bone flap include proximity to the operative feild, membranous origin similar to that of the facial skeleton, maleability which allows for a variety of shapes and sizes, inconspicous donor sit scar. The following are the case reports of two patients who underwent craniofacial reconstruction suing vasularized outer table calvarial bone flap.