정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology.

Phi, Ji Hoon,Wang, Kyu-Chang,Park, Sung-Hye,Kim, Il Han,Kim, In-One,Park, Kyung Duk,Ahn, Hyo Seop,Lee, Ji Yeoun,Son, Young-Je,Kim, Seung-Ki M. Nijhoff ; Kluwer Academic Publishers 2012 Journal of neuro-oncology Vol.106 No.3

<P>Pediatric infratentorial ependymomas are difficult to cure. Despite the availability of advanced therapeutic modalities for brain tumors, total surgical resection remains the most important prognostic factor. Recently, histological grade emerged as an independent prognostic factor for intracranial ependymoma. We retrospectively reviewed the treatment outcome of 33 pediatric patients with infratentorial ependymoma. Progression-free survival (PFS) and overall survival (OS) rates were calculated and relevant prognostic factors were analyzed. Fourteen patients (42%) were under the age of 3 at diagnosis. Gross total resection was achieved in 16 patients (49%). Anaplastic histology was found in 13 patients (39%). Adjuvant therapies were delayed until progression in 12 patients (36%). Actuarial PFS rates were 64% in the first year and 29% in the fifth year. Actuarial OS rates were 91% in the first year and 71% in the fifth year. On univariate analysis, brainstem invasion (P = 0.047), anaplastic histology (P = 0.004), higher mitotic count (P = 0.001), and higher Ki-67 index (P = 0.004) were significantly related to a shorter PFS. Gross total resection (P = 0.029) and a greater age at diagnosis (P = 0.033) were significantly related to a longer PFS. On multivariate analysis, anaplastic histology alone was significantly related to a shorter PFS (P = 0.023). Gross total resection (P = 0.039) was significantly related to a longer overall survival (OS) on multivariate analysis. Anaplastic histology and gross total resection were the most important clinical factors affecting PFS and OS, respectively. Anaplastic histology, mitotic count, and Ki-67 index can be used as universal and easily available prognostic parameters in infratentorial ependymomas.</P>

유동화제와 시멘트 풍화에 따른 콘크리트 유동특성과 강도특성

한재원, 한상훈, 홍기남 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

Recently as construction industry become large-sized and complex, construction type of the saving-energy is recommended. So, practical technology of high-flowabillity concrete to solve placabillity and workability is more attracted. This study is regarding the series of experiment carried out to identity effect on flowing and compressive strength due to super plasticizer and cement weathering. As a result of flow test to identify fluidity of cement, cement fluidity increase as the cement weathering increase. However, the fluidity after 1 hour was not measured in all cases except the cement paste using the polycarbonate. The results of compressive tests of concrete show that early compressive strength is extremely decreased with the cement weathering. Especially, strength loss of the 4th step of cement weathering is more then 65%, compared to the strength of concrete using the fresh cement. Polycarbonate produces higher 1 day compressive strength then others and Naphthalene sulphonate produces higher 38 day compressive strength then others.

셀룰로오스 섬유를 혼입한 고성능 콘크리트의 폭열방지 특성

한천구,황인성,김경민,김기훈 청주대학교 산업과학연구소 2005 産業科學硏究 Vol.22 No.3

This paper is to investigate the spalling resistance of high performance concrete with the contents of cellulose fiber. According to test results, the use of CL lead to decrease in fluidity. For compressive strength, the use of CL had no influence on compressive strength. For spalling properties, plain concrete showed a severe spalling failure. The use of CL protected from spalling of concrete, but most specimens had scale failure and partial destruction of specimens. This is due to the insufficient fiber length and diameter of CL fiber, which was unable to discharging the internal vapour pressure. For this reason, CL fiber can not be used to protect from spalling oh high performance concrete. Residual strength was observed to 5~7% of original strength, RC column after fire test showed 20% in plain concrete, 25% in CL fiber concrete.

성견의 치근 이개부병변에서 합성골이식시 교원막의 치유효과에 관한 비교연구

한기훈,임성빈,정진형 단국대학교 치의학연구소 1993 논문집 Vol.5 No.-

After periodontal surgery, the potential healing responses were occurred by interaction among junctional epithelium, gingival connective tissue, alveolar bone and periodontal ligament. The aim of this study was to evaluate the effects of collagen membrane in conjunction with nonresorbable hydroxyapatite in the grade Ⅱ bifurcation involvement of dogs. Experimental periodontitis was created in bifurcation area of 4 mongolian dogs with bone removal and gutta percha packing after 6 weeks later, the gutta percha were removed and experiment was perfomed divided by 2 groups. Flap operation with hydroxyapatite grafting, flap operation with hydroxyapatite grafting and collagen membrane were done. Experimental dogs were serially sacrificed at 2,4,8,16weeks and the specimens were prepared with hematoxylin-eosin stainning for light microsopic study. The results were as follows. 1. The hydroxyapatite particles were surrounded by dense connective tissue and formed new alveolar bone. 2. Dense new alveolar bone was formed in experimental group than control. 3. Infalmmatory cell infiltration was decreased in control group, as time lapsed, there was no inflammatory cell infiltration in the connective tissue of control group at 8 weeks, but was in experimental group. 4. Collagen menbrane was influenced the bone forming activities during 16 weeks

여자 중학생들의 슬관절 근육의 등속성 운동평가

한기훈,김환순 한국운동역학회 2003 한국운동역학회지 Vol.13 No.2

Han, K-H and Kim, H-S. Isokinetic Evaluation of Knee Muscles in Female Youth Group. Korean Journal of Biomechanics, vol. 13, No. 2, pp. 1-12. This study was performed to provide normative isokinetic strength of knee muscles of middle school non-athletic and athletic populations for rehabilitation and pre-season screening for injury prevention. Seven non-athletic subjects and 8 hockey players participated in this investigation. Each subject was tested at speeds of 60°/sec, and 300°/sec. The free weight of lower leg was measured at speed of 60°/sec to take gravity effect into consideration when peak torque of knee muscles occurred. The results showed that the relative peak torque production of knee flexors did not change but the relative peak torque of knee extensors decreased significantly. Hamstring/quadriceps rations increased mainly due to significant decreases in knee extensors torque production. No significant differences were found between groups. The hamstring/quadriceps rations for both groups were significantly lower when the gravity effect was not eliminated.

스포츠 행정조직 구성원의 조직동일시와 이직의도의 관계

한기훈,유원용 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

In this research, targeting 144 members of the sports administration, we've surveyed and analyzed their organizational identification and job changing intention with a standard of social-demographic features. The purpose of this study is not only to grow the organizational identification of the members, but also to show some basic data for more efficient job changing management. Using SPSS 10.0 version, we ran a t-test and a one-way ANOVA(Analysis of variance) to investigate the relationship between the social-demographic features and the organizational identification, and ran a Scheffe-test in the case of meaningful differences. The relationship of the organizational identification and the job changing intention is, with being conducted a simple regression analysis, followed as : 1. The relationship between the social-demographic features and the organizational identification 1) The level of the organizational identification of members of the sports administration is resulted to be meaningful according to their age. (p<.05) 2) The level of the organizational identification of members of the sports administration is resulted to be meaningful according to their post. (p<.05) 3) The level of the organizational identification of members of the sports administration is resulted to be meaningful according to their school career. (p<.05) ④ The level of the organizational identification of members of the sports administration is resulted not to be meaningful according to their sex, personal history, and monthly income. 2. The relationship between the organizational identification and the job changing intention. The result was proved to be meaningful statistically(p<.001), with the constant being 47.752, β, which refers to the organizational identification being -.668. And R² which refers to the model's explanation was .446.

서혜부 탈장으로 오인된 inguinal sparganosis 1례

장상훈,한병규,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Sparoganosis is a parasitic infestation of human by a lavel form of an animal tapeworm, genus spirometra. ingestion of raw or undercooked flesh of numerous intermediate hosts results in human infection. Sparganum is usually found in the subcutaneous tissues of various parts of the body, but other sites, such as orbit, brain, and the abdominal viscera, have been recorded. we experienced a case of sparganosis it the spermatic cord.

결장 직장암 환자에서 근치적 절제술 후 혈청 CEA치의 변화에 대한 임상적 의의

김영훈,배병노,김기환,한세환,김홍주,김영덕,김홍용 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.6

수직적 안모형태와 치아성숙도의 상관관계에 대한 연구

구용한,현홍근,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구는 수직적 안모형태와 치아성숙도의 관계를 평가하고 이러한 연관성에 대한 사춘기 성장의 영향을 평가하기 위한 것이다. 이번 연구를 위해 7세에서 9세, 13세에서 15세 환자 1306명을 Ricketts의 VERT index를 이용하여 수직적 안모 형태를 분류하였고 환자들의 치령을 Demirjian법으로 평가하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 치령이 역령과 비교 시 통계적으로 유의한 수준에서 크게 측정되었다. 2. 사춘기 연령군에서 brachyfacial type의 경우가 dolichofacial type 보다 치아성숙도가 크게 나타나는 경향을 보였다. 여성의 경우는 통계적으로 유의성있게 차이가 나타났으며, 남성의 경우는 통계적 유의성은 보이지 않았다. 3. Brachyfacial type의 경우 사춘기전 군들과 비교 시 사춘기 군들에서 치아성숙도가 유의성있게 높게 나타났으며, dolichofacial type의 경우는 연령층간 치아성숙도의 차이를 보이지 않았다. The purpose of this investigation was to study the relationship between vertical facial pattern and dental maturation in children in pubertal and pre-pubertal periods. The material consisted of lateral head films and panoramic radiographs of 1306 patients. The subjects were selected according to Ricketts's VERT index and other including criteria. These subjects were divided by VERT index to brachyfacial group and dolichofacial group. In each selected subject, dental age was determined according to Demirjian's dental maturity score. All subjects were distributed according to age, vertical facial type and sex, mean and standard deviation of chronological age, dental age and age difference were determined in each group. And the data were analysed to find the difference of tooth maturation by facial pattern. Findings of this study include: 1. In all groups, dental age was determined higher than chronological age in statistically significant level. 2. Compared by vertical facial pattern, in pubertal age groups, it seems that subjects with brachyfacial type presented the tendency to have an advanced dental maturation, only in female group. 3. Compared by pubertal period, brachyfacial groups presented more advanced dental maturation in pubertal groups than pre-pubertal groups.