심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

급성신부전증 이환견에 대한 복막투석 치료 1례

김건우,이병희,김유수,심재현,김지용,이영원,김덕환,송근호 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A fourteen-month-old intact female Poodle was referred to the Veterinary Teaching Hospital, College of Veterinary Medicine, Chungnam National University. The patient was presented with history of vomiting, inappetence, ataxia, insomnia, tachypnea and convulsion for 5 days. Biochemical examination revealed BUN (254.2 mg/dl), creatinine (9.22 mg/dl) and phosphate (14 mg/dl). Epithelial cells of urinary tract, neutrophils, macrophages, a large number of gram negative and smaller number of gram positive bacteria were presented on urine test. Ultrasonographic findings show hyperechogenic kidney and indistinguishableness of renal cortex and medulla. Based on the results of examination described above, this case was diagnosed as acute renal failure with interstitial nephritis by urinary tract infection (UTI). Treatments with fluids therapy, diuretics, and peritoneal dialysis during hospitalization showed good results with no clinical signs.

구강 편평세포암종에서 E-cadherin 및 β-catenin 발현의 변화 : Correlation with Histologic Features and p53 Expression

서진건,권창석,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Altered expression of cell adheion molecules is associated with biologic behavior of tumor. The aim of this study is to evaluate the expression pattern of E-cadherin, β-catenin and p53 protein according to histologic grade and invasion pattern of squamous cell carcinoma of the oral cavity and the relationship between E-cadherin, β-catenin and p53 protein expression. Methods and Material : The materials were fifty seven cses of squamous cell carcinoma, and clinicl parameers such as age, sex, tumor location, stage and recurrence were recorded. Histologic review was done based on histologic grade and invasion pattern(nodular vs infiltrative). Immunohistochemical stains for E-cadherin and β-ca tenin were interpreted based on staining pattern as los of membranous expression and cytoplasmic expression and p53 protein expression was defined as positive if more than 10% of nuclei were reactive. Statistical analysis between E-cadherin, β-catenin and p53 protein expressions and histologic grade and invasion pattern and the relationship between E-cdherin, β-catenin and p53 protein expressions were perfomed. Results : There wa positive correlation between higher histologic grade and infiltrative pattern. Loss of membranous expression and cytoplasmic expression of E-cadherin were noted in 33.3% and 57.9%, respectively, and loss of membranous expression of E-cadherin showed increaing tendency in poorly differentiated carcinomas, however, there was no significant difference of cytoplasmic expression rate of E-cadherin according to histoogic grade. Altered expression of E-cadherin was more frequent in poorly differentiated carcinomas. Loss of membranous expression and cytoplasmic expression of E-cadherin were more frequent in carinomas with infiltrative pattern than in carcinomas with nodular pattern, but their diferences were not significant, Loss of membranous expression and cytoplasmic expression of β-catenin were observed in 19.3% and 80.7%, respectively. Loss of membranous expression of β-catenin howed no positive correlation according to histologic grade and invasion pattern, but cytoplasmic expression rate of β-catenin was higher in poorly differentiated carcinomas and in carcinomas with infiltrative pettern. p53 protein expression rate was 45.6%, and showed invreasing tendency in poorly differentiated carcinomas, but no significant relationship with invasion pattern. There was an inverse relationship of loss of membranous expression and cytoplasmic expression of E-cadherin and β-catenin. Altered expression of E-cadherin was related to cytoplasmic expression of β-catenin, however, there were no significant relationship between altered expressions of E-cadherin and β-catenin and p53 protein expression. Conclusion : In squamous cell carcinomas of the oral cavity, altered expression of E-cadherin and β-catenin was more frequent in poorly differentiated carcinomas and in carcinomas with infiltrative pattern and there was positive correlation betwween altered expression of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cadherin and β-catenin may have a role in the development of squamous cell carcinomas with aggressive biologic behavior. but altered explosions of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cdherin and β-catenin my have a role in the development of squmaous cell carcinomas with aggressive biologic behavior. But altered expression of E-cadherin and β-catenin might not be related to p53 protein expression. Further study on genetic mutation related to altered expression of E-cadherin and β-catenin will be needed

일제시대의 검도에 대한 의미

김영학,이인희,허건식 龍仁大學校 武道硏究所 1998 武道硏究所誌 Vol.9 No.1

An mentioned above, Korean Kumdo may be considered that Japanese Kendo as a sport has been introduced and popularized here. Some argue that a conservative way of thought due to the principle of Confucianism here interrupted a continuity of Korean Kumdo until the open-door period. But it is high probable that at that time Japanese Kendo has been already introduced and performed here to educate army or police without any difficulty. And it can not dendy that a continuity of Korean traditional Kumdo might be interruped long before the open-door period. A ter the Japanese annexation of Korea. the encouragement of military arts by the political intention of Japan played a remarkable role on the introduction of Japanese Kendo into Korea. and also Kendo was used to maintain public peace and order as a game of national defence, and the common here could not easily contact with Japanese Kendo. That is why then Kendo was started just for the Japanese for the purpose of fostering a Japanese sprit, used as a means to emphasize Japanese Imperial civilians as a colony policy. In the end, it is possible that them many civilians would experience Japanese Imperial civilian gymnastics.

개에서 발생한 폐수종의 치료 증례

김유수,심재현,김건우,김지용,이병희,송근호,이영원,김덕환 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A 9 months intact male American bull dog with chief complaints of dry cough, dyspnea and fever was referred to the Veterinary Teaching Hospital, Chungnam National University. Based on the findings of physical examination, radiological examination, and blood and blood chemical examinations, the present patient was diagnosed into pulmonary edema secondary to primary bacterial and aspiration pneumonia. The patient was hospitalized and treated with buscopan, cephazolin and furosemide for 1 week. His activity and appetite was returned to normal and thoracic radiographs revealed that Jung was recovered to the normal condition after treatment for 7 days. The present patient was a case with pulmonary edema showed favorable therapeutic responses to proper medication.

심장사상충증 이환견의 치료 1례

심재현,김유수,김건우,이병희,김지용,박성준,송근호 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A 4-years old pointer dog was referred to the Veterinary Teaching Hospital of Chungnam National University with chief compliment of anorexia, exercise intolerance, hemoptysis, coughing and ascites. It was diagnosed as heartworm disease (class 3) by physical and laboratory examination, radiography, ultrasonography and electrocardiography. This dog was undertaken by adulticidal therapy. Normal conditions and good appetite after therapy were observed.

防風類의 比較檢討

김미경,김미정,김은영,류건영,이은미,장원희,황선희 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

CONTINUOUS SHADOWING AND INVERSE SHADOWING FOR FLOWS

Keon hee Lee,Man seob Lee,Zoon hee Lee 충청수학회 2007 충청수학회지 Vol.20 No.3

The notions of continuous shadowing and inverse shad-owing for °ows are introduced, and show that an expansive °ow on a compact manifold with the shadowing property has the continu-ous shadowing property. Moreover it is proved that the continuous shadowing property implies the inverse shadowing property.

LAG-3 and TIGIT protein expressions in cutaneous melanoma and their relationship with PD-1 tumor-infiltrating lymphocytes

( Keon Hee Lee ),( Woo Jin Lee ),( Ye Jin Lee ),( Myoung Eun Choi ),( Kyung A Yun ),( Chong Hyun Won ),( Mi Woo Lee ),( Jee Ho Choi ),( Sung Eun Chang ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Lymphocyte activating gene 3 (LAG-3) and T cell immunoglobulin and ITIM domain (TIGIT) are emerging important checkpoint proteins. Objectives: We evaluated LAG-3 and TIGIT protein expression patterns and correlation with programmed death-1 (PD-1) expression, and determined their effects on clinicopathological characteristics and biological responses in melanoma. Methods: Diagnostic tissue from 124 cases of melanoma was evaluated by immunohistochemistry for LAG-3, TIGIT, and PD-1 expression. Clinicopathological features and survivals were analyzed according to the expression of LAG-3, TIGIT, and PD-1. Results: LAG-3 and TIGIT expression on TILs was significantly correlated with that of PD-1 expression, and was also significantly associated with negative prognostic factors: deeper Breslow thickness, lymph node involvement, and advanced stage of disease. However, PD-1 expression was not associated with clinicopathological variables, which are a prognostic index. High expression of either LAG-3 or TIGIT was associated with worse survivals. High expression of PD-1 was not predictive for survivals, but expression of LAG-3 or TIGIT predicted worse survivals in patients with high expression of PD-1. Conclusion: Expression of LAG-3 and TIGIT represents an independent unfavorable prognostic factor in cutaneous melanoma, which suggests the therapeutic value of combined immune checkpoint blockade in melanoma.

Prognostic significance of CD163 expression and correlation with COX-2 and VEGF expression in cutaneous melanoma

( Keon Hee Lee ),( Woo Jin Lee ),( Mi Hye Lee ),( Hak Tae Kim ),( Chong Hyun Won ),( Mi Woo Lee ),( Jee Ho Choi ),( Sung Eun Chang ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: In several cancers, tumor progression is associated with the infiltration of tumor-associated macrophages (TAMs). Objectives: To evaluate the prognostic significance of CD163 and CD68 (TAMs' marker) expression and its correlation with VEGF and COX-2 expression in cutaneous melanoma. Methods: Diagnostic tissues from 102 cases of cutaneous melanoma were evaluated by immunohistochemistry for CD68, CD163, VEGF, and COX-2 expression. Correlations between these proteins were investigated. Clinicopathological features, overall survival, and progression-free survival were analyzed in terms of the expression of these proteins. Results: CD163, but not CD68 expression, correlated with VEGF and COX-2 expression. Positivity for CD163 was associated with a deeper Breslow thickness and advanced stage of disease. Positivity for CD163 was associated with lower overall survival. No significant differences were found in CD68 expression between the clinicopathological variables and overall survival. COX-2 expression was associated with a deeper Breslow thickness and a higher frequency of lymph node involvement. Multivariate analysis revealed that CD163 and COX-2 expression were independent prognostic markers of lower survival outcomes. Conclusion: Our data confirms that CD163 expression provides independent prognostic information in cutaneous melanoma. The correlation of CD163 with VEGF and COX-2 expression suggests various tumor-promoting actions of CD163-positive TAMs.