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강원도 함백폐탄광지역에서 생성되는 광산배수의 수질 특성
박천영,정연중,김성구,조갑진 조선대학교 에너지.자원신기술연구소 2001 에너지·자원신기술연구소 논문지 Vol.23 No.2
This study investigated geochemical characteristics of the mine drainage discharged from the abandoned coal mine in the Hamback area. Sampling of stream waters(21) were carried out in the Hamback area. The pH, EC, TDS, Eh and Do contents were measured in field and ions such as Na, K, Mg, Ca, Mn. Fe, S r , Al. Cr, Cu. Zn, Ge, As, Mo, Cd, Sb, Ba, Pb, F, Cl. No₃ and SO₄ were analyzed by GFAAS, AAS, ICP-AES, ICP-MS and IC. In stream waters, pH values increased, whereas total dissolved solids(TDS), electrical conductivity(EC) and dissolved oxygen(D0) values decreased with distance. Eh negative values a t upstream site were found, suggesting that its caused by the organic material in the retention pond, and these value in stream water effluent from the retention pond increased progressively with distance. The concentration of toxic heavy metals and major cations except Na, Cl, No₃, Cu, Mo and Sb decreased rapidly due to retention pond, but the concentration of Na, Cl, No₃, Cu, Mo and Sb increased gradually with distance. The concentration of Na, Cl and No₃ increasing with distance, which indicate by domestic waste. Major ions, such as Na, K, Ca, Mg, F, Cl, SO₄ and HCO₃ were statically analyzed in order to investigate relationship with TDS contents. M is observed that TDS contents have-positive relation with K, Ca, Mg, F, so4 and HC0₃ contents, but negative relationships with Na, Cl and No₃ contents. Most stream surface waters showed a calcium-sulfate and noncarbonate hardness dominating water quality type. In geochemical modeling for stream surface waters, the saturation index of gibbsite were oversaturated with respect to gibbsite.
Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study
이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.
Post - NAFTA Change in Trade Structure of Korea : Implications for Canada - Korea Relations
Jeong, Kap Young 한국캐나다학회 1998 캐나다논총 Vol.4 No.-
Korean economic growth has been extremely dependent on its trade with North America. With the establishment of NAFTA, this dependency has become a major trade issue for Korea and other East Asian economies as their major trading relations may be affected with the status as a non-NAFTA members. This paper will examine the effects of NAFTA on the trade between East Asian economies and North American countries: U.S., Canada and Mexico. The focus will be placed on the Korean economic performance and its relations with the three North American countries, especially Canada. Trade diversion effects of NAFTA on the Korean economy will be estimated using the gravity model, CGE models and comparative statistical analysis. Actual performance of the Korean economy and recent changes in its trade and investment pattern will be reviewed, followed by a discussion of the future prospects of Korean relations with the NAFTA members.