과두과증식을 동반한 안면비대칭 환자에서 과두절제술의 적용과 효과

임경섭,차정열,황충주 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

과두과증식은 하악의 3차원적인 골격적인 비대가 일어나는 병적인 상태이다. 이러한 과두과증식의 원인은 호르몬의 작용, 외상, 감염, 유전, 태아기 때의 요인, hypervascularity 등의 요인으로 알려져 있다. 과두과증식의 진단 시 가장 중요한 것은 과두과증식 상태가 아직도 활성화 상태인지 판단하는 것이다. 이러한 과두과증식의 상태에 따라서 안면비대칭 환자의 치료는 이환측 과두의 성장 부위를 제거하는 과두절제술을 시행하는 방법, 성장이 완료될 때까지 기다렸다가 통상적인 악교정 수술만을 시행하거나 과두절제술을 병행하는 시술방법이 있다. 과두과증식의 활성화 상태를 판단하는 것은 치료 안정성에 매우 중요한 요인이며, bone scan이나 주기적인 3차원 컴퓨터 단층촬영이나 정모두부방사선사진 등을 통하여 확인할 수 있다. 본 보고에서는 과두과증식을 동반한 안면비대칭 환자를 과두절제술을 이용하여 개선한 증례를 소개하고자 한다. Condylar hyperplasia is a pathologic condition showing 3-dimensional skeletal hyperplasia of the mandible. The reason for condylar hyperplasia is not yet known, but the effects of hormone, trauma, infection, genetics, fetal condition, and hypervascularity are known as possible reasons. When we diagnose a patient as having condylar hyperplasia, it is important to decide if it is in progress or not. Treatment for facial asymmetry due to condylar hyperplasia are decided accordingly, including condylectomy, that is removal of growth site of the affected condyle, and conventional orthognathic surgery only or condylectomy with orthognathic surgery after the completion of growth. Therefore, it is important to determine the growth state of condylar hyperplasia in treatment stability. This is verified through bone scan and regular check-ups with 3D CT or PA cephalogram. This case report introduces an improved case of facial asymmetry with condylectomy together with orthognathic surgery.

Doppler ultrasound를 이용한 교정적 치아 이동 시 치수 혈류량의 변화의 측정 : 예비실험

임경섭,배영민,차정열,유형석,황충주 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.6

교정적 치아 이동 시 지속되는 압력에 의해 혈류변화가 발생하게 되며, 이러한 변화양상에 있어서 선학들의 연구 방법 및 그 결과의 다양성이 존재하였다. 본 연구에서는 Doppler ultrasound를 이용하여, 교정치료 전과 교정치료 시작 3주, 6주 후 치수 혈류량의 연속적인 변화를 알아보고자 하였다. 만 15세 이상 환자 18명을 연구대상으로 Doppler ultrasound를 이용하여 상, 하악 6전치 중 경도의 총생(2 mm 미만)을 보이는 치아(총생측정: required space-available space)와 인접치아를 포함한 3개의 치아를 대상으로 치수 혈류량의 변화를 알아보았다. 연구결과 부위별(상, 하악), 치아별, 기간에 따른 치수 혈류량의 변화는 교정 치료 시작 전과 시작 후 3주, 6주 혈류량에 유의한 차이가 없었다. 또한 치수 생활력 상실의 내재적 위험성을 비교하고자 교정 치료 시작 전 치아별로 치수혈류량을 비교하였을 때, 상악에서는 측절치, 하악에서는 견치에서 통계학적으로 유의한 차이는 나타나지 않았지만, 모든 항목에서 적은 값을 나타냈다 (p > 0.05). 본 연구의 결과는 이후에 진행될 Doppler ultrasound의 치아이동유형, 환자의 연령을 고려한 세부적인 실험 시 방법론적인 기초 자료로서 뿐만 아니라, 교정치료 시 치수 생활력의 상실에 대한 참고 자료가 될 수 있을 것이다. Objective: This study was to change of pulp blood flow among maxillary and mandibular anterior tooth with mild crowding and adjacent teeth using Ultrasound Doppler graphy. Methods: The change of pulp blood flow was measured three times using Ultrasound Doppler graphy; before the attachment of brackets, after 3 week, and after 6 week. The sample consists of 15 year old eighteen patients. Results: Before the attachment of brackets, after 3 weeks, and after 6 weeks, there were no significant differences in the change of pulp blood flow in each part (maxilla and mandible) and each tooth according to period. In addition, to compare internal dangerousness of loss of the pulp vitality, when pulp blood flow is compared in each tooth before orthodontic treatment, there were no statistically significant differences in maxillary lateral incisor and mandibular canine but it showed low values in all measurement items (p > 0.05). Conclusions: Results of this study can be not only methodological preliminary data in further study such as tooth movement type of Ultrasound Doppler graphy and particular study considered the patient age, but also reference materials for the loss of pulp vitality in orthodontic treatment.

토오크 양에 따른 세라믹 브라켓의 파절 저항성

한정흠,장민희,임용규,이동렬 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.4

근적외선을 이용한 두개강내 혈종의 진단

박정율,홍기선,김상대,김세훈,임동준,조태형 대한체열학회 2003 대한체열진단학회지 Vol.3 No.1

Feature Article : Topographic Control of Cell Response to Synthetic Materials

( Jung Yul Lim ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.1

How to control cell behavior at cell-biomaterial interfaces is a critical task in today`s implant science, tissue engineering, and regenerative medicine. Various biomaterial surface modification techniques, either chemical or topographical, have been introduced to induce optimal regulation of cell behavior. Among them, topographic control of cell behavior has long been recognized, for example, cells align to the anisotropic direction of ridge and groove topographies(contact guidance). In this review, cell sensing and response to substratum surface topographies will be reviewed in terms of anisotropic vs. isotropic topographies and microscale vs. nanoscale topographies. It is clear that anisotropic topographies induce morphological cell reaction(cell orientation) and then downstream cell responses. On the other hand, isotropic topographies do not induce contact guidance while influencing collective cell functions(such as degree of adhesion, proliferation rate, degree of differentiation, etc). For both topographies, there exist threshold topographic scales from which specific cell sensing and response occur. Clear understanding of cell response to substrate topographies would be very helpful for developing novel regenerative medicine protocols.

Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide

Jung‑Woo Bae,Kyung‑Yul Oh,So‑Jung Yoon,Hyo‑Bin Shin,Eui Hyun Jung,Chang‑Keun Cho,Chang Woo Lim,Pureum Kang,Chang‑Ik Choi,Choon‑Gon Jang,Seok‑Yong Lee,Yun Jeong Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.11

Metoclopramide inhibits the central and peripheralD2receptors and is frequently prescribed in adults andchildren as an antiemetic or a prokinetic drug to controlsymptoms of upper gastrointestinal motor disorders. Metoclopramideis predominantly metabolized via N-dealkylationand it is primarily mediated by CYP2D6 which is highlypolymorphic. Thus, the effects of CYP2D6 genetic polymorphismon the pharmacokinetics of metoclopramide wereevaluated in this study. All volunteers were genotyped forCYP2D6 and divided into four different genotype groups(CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10). Each subjectreceived a single oral dose of metoclopramide 10 mg. Plasma concentrations of metoclopramide were measuredby using HPLC-UV. Compared to CYP2D6*wt/*wt, AUC infof CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10significantly increased by 1.5-, 2.3-, and 2.5-fold, respectively. Cmaxalso increased significantly in comparison toCYP2D6*wt/*wt across all genotype groups, with 1.5-, 1.7-, and 1.7-fold increases seen in CYP2D6*wt/*10,CYP2D6*10/*10, and CYP2D6*5/*10 groups, respectively. The CL/F of metoclopramide decreased in CYP2D6 genotypegroups with decreased function alleles, as decreasesof 37%, 56% and 61% were observed in CYP2D6*wt/10,*10/10, and *5/*10 genotype groups in comparison to theCYP2D6*wt/*wt group. In conclusion, the genetic polymorphismsof CYP2D6 significantly affected metoclopramidepharmacokinetics.

The Distribution of Fetal Nuchal Translucency Thickness in Normal Korean Fetuses

Han Jung Yul,Kim Moon Young,Choi Kyu Hong,류현미,Chung Jin Hoon,Yang Jae Hyug,Song Mi Jin,Cho Jeong Yeon,Lee Young Ho,Park So Yeon,Choi June Seek,Kim Joo Oh,Shin Joong Sik,Ahn HyunKyong,Lim Ha Jung,Moon 대한의학회 2004 Journal of Korean medical science Vol.19 No.1

The aim of present study was to establish normative data for the distribution of nuchal translucency (NT) thickness in normal Korean fetuses. The data were collected from pregnant women with singleton pregnancies in whom fetal ultrasound was performed and the fetal NT thickness was measured between 11 and 14 weeks of gestation. Among them, a total of 2,577 fetuses with a known normal outcome were included in this study. The distribution of multiple of median (MoM) values of the NT thickness with crown-rump length (CRL) in 10-mm intervals and the 95th percentile of MoM were calculated with the linear regression method. The present study showed that NT measurements increase with increasing CRL and a false positive rate increases with increasing gestational age. Therefore, a fixed cut-off point through the first tri-mester was not appropriate and each NT measurement should be examined accord-ing to the gestational age. The present study offers normative data of the fetal NT thickness in a Korean population, which can be used as reference for screening chro-mosomal aberrations or other congenital abnormalities in the first trimester.

Radiofrequency Partial Dorsal Root Ganglionotomy For Persistent Low Back and Leg Pain Following Lumbar Surgery

Park, Jung-Yul,Kim, Sung-Dae,Kim, Se-Hoon,Lim, Dong-Joon,Suh, Jung-Keun 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objective: The effect of percutaneous partial radiofrequency(PRF) lesioning on dorsal root ganglion was studied in patients with persistent back and leg pain after surgery to validate its role in management of such patients. Materials & Methods: A total of 90 patients with persistent back and leg pain(52 males, 38 females, mean age 46.2 years) for more than 6 months of duration following lumbar surgeries were enrolled into study. These patients were reevaluated to make sure they did not have ongoing compressive lesions that were clearly indicated for conventional surgery. Also, patients with postoperative infection, bleeding tendency, and uncontrolled hypertension were also excluded. PRF procedures, the partial dorsal root ganglion lesioning, were percutaneously done under local anesthesia with C-arm guidance and adjustments from physiologic monitorings(e.g., impedance, sensory and motor responses). Assessments included the clinical symptoms, signs and changes of thermographic pattern before and after PRF procedure. Various clinical variables such as age, sex, bilaterality, duration of symptoms, number of previous operations, types of pathology, and types of operations were also studied to determine the prognostic factors. Minimal follow up period was 6 months. Results: All patients tolerated the RF procedures well. PRF procedure provided substantial improvement of pain(>50% pain reduction) in 46(76.7%) and 42(70%) at I and 6 months following procedures. Thermographic findings before procedures were agreeable to clinical and radiographic findings in 54(90%) of patients, and in 49(81.7%) of patients, they seemed to correlate with clinical improvements. However, 11 patients(18.3%) showed no significant thermographic changes despite clinical improvement. Clinical factors that were statistically significant(p<0.05) for good outcome(>50% of pain relief at 6 month post-treatment) were unilateral pain, less number of operations, and no instrumentation. There were no complications from procedures. Conclusion: These results indicate that PRF lesioning on dorsal root ganglion seems to be effective, at least for 6 month period, in majority of patients who continuously experience even after surgeries. Thus, it is considered a useful armamentarium in management failed back patients with persistent back and leg pain. As for the thermography, it may have a role in evaluating in these patients, especially for comparing the clinical status before and after treatment.

Effect of Transforaminal Dorsal Root Ganglion and Epidural Block in Herniated Lumbar Disc Disease : Results from Minimum of 6-Month Follow-up 6개월 이상의 추적 결과

Park, Jung-Yul,Lee, Chang-In,Kim, Sang-Dae,Kim, Se-Hoon,Lim, Dong-Jun,Suh, Jung-Keun 대한척추신경외과학회 2004 Neurospine Vol.1 No.1

Objective: This study is aimed to determine and validate the therapeutic value and long-term effects of transforaminal dorsal root ganglion(DRG) andepidural block in patients with refractory back and radicular leg pain due to herniated lumbar disc disorders. Methods: Patients who met our inclusion criteria received the fluoroscopy guided, transforaminal DRG and epidural blockstargeted directly at the level and side of their documented pathology. Patients were evaluated by an independent observer and received sequential questionnaires before and after injection to document level of pain, level of activity, and amount of satisfaction. Results: Two hundred and fifty-four patients met our inclusion criteria and were followed for a minimum period of 6 months(average 35 weeks, range 24-50 weeks). Two hundred and twenty-one(87.0%) had a successful long-term outcome, reporting at least a 50% reduction between pre- and post-injection pain scores, and were able to return to or near to their previous levels of functioning after an average of 2.2 injections(range 1-3). Onlynine(3.5%) of the remaining 33 patients underwent an operation. Twenty-four patients showed recurrence of symptoms, but obtained beneficial effects, similar to earlier blocks, from subsequent injections. Of our patients, 85.0% were satisfied with their outcomes. There was no worsening of symptoms or complications from the procedures. Conclusion: The fluoroscopy guided transforaminal DRG and epidural blocks appear to be an effective nonsurgical treatment option for patients with lumbar herniated nucleus pulposus and radiculopathy for whom conservative treatments are not effective, and should be considered before surgical intervention.

In Vitro Mass Propagation of Lilium lancifolium Bulbil Treated by Hormone

Min-Jung Jung,Islam MD Mazharul,Yesmin Reshma,Hong-Yul Kim,Ki-Byung Lim 한국화훼학회 2020 한국화훼학회 정기총회 및 학술발표회 자료집 Vol.28 No.1