지방간에서 발생한 폐 지방색전증의 병리학적 및 임상적 의의에 대한 연구

권태정,강현욱 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

Fat embolism is the presence of fat globules in the peripheral circutation and in the lung, brain, kidney, pearl, and so on -not in the fine emulsion of a metabolic lipemia but in globules large enough to obstruct arterioles and capillaries. The fat droplets can deride from fractures of long bone due to disruption of the fatty marrow from extensive bruising of the soft tissue, and from fat tissue in burns. Fat embolism has also been reported in patients suffering from various diseases including alcoholism, fatty liver, diabetes mellitus and pancreatitis. We investigated 19 autopsies with fatty liver of varying degrees to establish a correlation between fatty change of limier and pulmonary fat embolism. Among 19 cases, 3 cases with moderate to severe fatty change of elver, and 1 case with submassive hepatic necrosis and mild fatty change showed Grade II pulmonary fat embolism. In histologic section with Sudan III stain, the arteries and capillaries of lung were occupied and distended by round, oval, or staghorn fat globules. The alveoli may contain edema fluid and blood Although the pulmonary fat embolism occuring in the presented cases didn't cause death on its own, one should be aware that a life-threatening mobilization of fat into the lungs and ever into the systemic circulation is possible In fatty fiver and submassive hepatic necrosis.

A Study on DNA Sequences and Mutation of Integrase Region of Korean-type Bovine Leukemia Virus (BLV) pol Gene

권오식,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Bovine leukemia virus (BLV) is a causative agent for lymphoma disease in cattle including cows worldwide. BLV shares similar virion structure and characteristics with other retroviruses. The pol gene of the BLV genome produced reverse transcriptase (RT) and integrase (IN) for important roles for BLV genome integration into host cell chromosomes that is known to be coded in the 3' side of the BLV pol gene (one third portion). In this study, we have sequenced 978 bp in the 3'side of the BLV pol gene from BLV 10C3 in order to determine the BLV IN region of it. And we compared it to the nucleotide sequences of an Australian BLV isolate. As a result, nucleotide sequences of the IN region of the Korean-type BLV pol gene were mutated at a rate of 3.7%. We can confirm that the typical mutations are such as Arg (AGG) → Lys(AAG), Thr (ACG) → Met (ATG), Ile (ATT) → Val (GTT), Asn (ACC) → His (CAC), Phe (TTT) → Leu (TTG) and Asn (ACC) → Asp (GAC). From the analysis of the sequencing data, we were able to determine the zinc-finger-like "HHCC" motif in the amino terminus of BLV IN, that was H-X_(3)-H-X_(25)-C-X_(2)-C. It was also found the DD35E motif in the IN catalytic domain as D-X_(56)-D-X_(35)-E. It fits very well to the consensus sequences of retroviral IN as well as HHCC motif.

영상 처리 기법을 이용한 OMR 답안지 판독

권갑현,서정상 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

In this paper, a method for scoring OMR exam sheets using image processing techniques is suggested. In many schools, the special-purpose OMR card reader is used to score OMR exam sheets, but it is very expensive and foreign-made as well. Jn this method, a PC and a digital camera are used, so it is relatively low-priced. In addition, the intermediate images produced in this procedure can be stored easily in the computer storage media. Therefore, the necessary store space can be significantly reduced, and the specific card image can be easily retrieved.

청주시 소비자의 그린마케팅에 대한 인식과 그린제품 구매의도

권소영, 박혜영, 최혜미, 최현미, 유현정 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

The purpose of this study was to analyze consumers' perception of green marketing and purchase intention of green products. Questionnaire survey was conducted from 9 August to 29 August 2010. We have surveyed 298 consumers who were living in Cheongju area. Major findings are as follows. First, consumers' environment perception and involvement, awareness of green marketing, evaluation for green products, purchase intention of green products were generally positive. It means that Korean consumers have a positive attitude and behavioral intention for green consumption. Second, consumers responded high perception level for necessity of green marketing and purchase intention of green products. On the other hand, consumers think that green product manufacturers need to more protect our environment. Consumers evaluated the quality of green products is good but its price is high. Third, insufficient information was the most common response of the items asked for the resistance of the whole process for the production of green products. For benefit part, high quality and symbolic value of green consumer were given answer highly. Fourth, there were differences among the consumer groups from environment perception, awareness of green marketing, evaluation for green products, and purchase intention of green products by consumers' characteristics. Old aged group were high involved on environment and student group showed relatively low environment perception and involvement of green consumption. Four million won or less income groups were relatively higher interest in green products and eco-conscious consumer groups have a high degree of purchasing intention of green products.

전위된 상악 견치 및 하악 측절치의 치험례

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

Tooth transposition is an anomaly of eruption characterized by the interchanged positions of two adjacent teeth, which is divided into complete and incomplete transposition. There are three common approaches for treating transposition: aligning the involved teeth in their transposed positions, moving them to their correct anatomic position in the arch and extracting one of the transposed teeth. Considerations in treatment plans are esthetic, function, risk of jeopardizing the roots and damaging the supporting structures, position of the root apex, developmental stages of teeth and expected compliance. The presented case reports described one maxillary canine-the first premolar transposition and two mandibular lateral incisor-canine transpositions. The former transposed teeth were arranged in their transposed position, and the latter transposed teeth were rearranged into their normal position. 치아전위란 인접한 두 치아의 위치가 서로 바뀐 치아 위치 이상을 말하며, 치관과 치근의 위치에 따라 완전전위와 불완전전위로 나눌 수 있다. 하악보다는 상악에 편측성으로 호발하며, 특히 상악 견치에서 자주 발생한다. 전위는 발견 시기와 전위된 양상에 따라 치료방법이 달라질 수 있다. 본 증례는 상악 견치와 제1소구치 간의 전위가 일어난 10세 7개월의 환아와 하악 측절치와 견치 간의 전위가 일어난 8세 11개월 환아와 8세 9개월 환아의 교정치료에 대한 것으로 양호한 치료 결과를 얻었고, 증례 별로 치료방법의 차이점에 관한 고찰을 하였기에 이를 보고하는 바이다.

EDM 가공 공정에서 세장비 극대화를 위한 미세구멍의 최적가공 조건 결정

정종혁,이현욱,권원태 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Demand of micro holes has been increased fast, especially in the area of inkjet nozzle, micro turbine and optical parts. However, the micro hole with 40㎛ exit diameter and aspect ratio of 10 has yet to be reported. In this study, an endeavor was made to manufacture the micro hole under over 40㎛ exit diameter at stainless steel plate with 40㎛ thickness. To accomplish the goal, the relationship between machining parameters and machined result was identified. It was found that the entrance clearance was proportional to the discharge power, when discharge energy was kept constant and resistance had to be as high as possible at the given condition to minimize the machining time. 40㎛ average diameter of the micro hole with over 10 aspect ratio was achieved under the condition of 60V, 680pF, 500Ω, 1.5㎛ and 1500rpm.

유치 수복물에 따른 주변 법랑질의 탈회 저항성 : QLF를 이용한 연구

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구에서는 유치 수복물의 불소 방출 여부에 따른 주변 법랑질의 탈회 저항성과 재광화 효과를 살펴보고자 하였다. 건전 유전치 48개를 16개씩 임의로 세 군으로 나누어, FiltekTM Z250(1군), F2000(2군), KetacTM N100(3군)을 사용하여 제조사의 지시에 따라 충전하였다. 3일 동안 인공 우식 병소를 유발한 후, 14일 동안 인공 타액에 담가 재광화를 유발하였다. Quantitative light-induced fluorescence(QLF)를 이용하여 실험 단계와 시간에 따른 무기질 소실량(ΔQ)의 변화를 관찰한 결과는 다음과 같다. 1. 탈회가 일어난 인공 우식 병소의 ΔQ 값은 3군, 2군, 1군 순으로 작게 나타났고, 이 중 3군은 1군에 비해 유의한 탈회 저항성을 보였다. 2. 1군, 2군, 3군 모두 재광화 1일 후부터 초기 인공 우식 병소의 ΔQ 값과 비교 시 유의한 차를 보였으며, 관찰 기간 동안 지속적인 증가 양상을 나타내었다. 3. 재광화 속도를 의미하는 Δ(ΔQ)/일 값은 각 군에서 처음 1일 동안 유의성 있게 크게 나타났으며, 그 이후 급속히 감소하였다. 4. 수복 재료에 따른 재광화 정도는 각 군 간에 유의한 차이가 없었다. The objective of this in vitro study was to detect and monitor demineralization and remineralization of primary teeth according to restorative materials using quantitative light-induced fluorescence (QLF). A single bur hole was drilled on the each sound forty eight primary anterior teeth, and the specimens were divided into three groups. The cavity was restored with FiltekTM Z250(Group 1), F2000(Group 2), KetacTM N100(Group 3) following the manufacturer's instructions. The teeth were subjected to the demineralizing buffer for 3 days, and then subjected to a remineralizing buffer for 14 days. The change of mineral loss(ΔQ) according to the stages was evaluated by QLF and the following results were obtained: 1. When demineralization was done, ΔQ was increased as follows. : Group 1 (-110.79 ± 27.77) < Group 2 (-104.84 ± 28.95) < Group 3 (-90.16 ± 21.87) : Resistance to demineralization was statistically significant in Group 3. 2. There was a statistically significant increase in ΔQ of all groups since 1st day of remineralization 3. The rate of remineralization, Δ(ΔQ)/day, showed significant high value in each group on the 1st day then decreased rapidly. 4. There was no statistically significant difference in the degree of remineralization among restorative materials.

무대미술의 관례성 : 맨션(Mansion)에서 '임의의 궁전'에 이르기까지 des mansions au palais a` volonte´

권현정 한국 프랑스어문교육학회 2003 프랑스어문교육 Vol.15 No.-

Comme tout art, le the´a^tre a un mode de fonctionnement spe´cifique et ne peut se contenter de copier la re´alite´, me^me s'il exploite des donne´es (personnages, fiction, espace, temps, langage) qui appartiennent au monde de l'expe´rience. Mais ce monde de l'expe´rience ne peut se transporter tel quel sur la sce`ne; l'espace sce´nique, du fait me^me de ses dimensions, ne peut donner qu'un aperc¸u, qu'un concentre´ des lieux e´voque´s par les fictions. De la` naissent des conventions qui sont des modes de fonctionnement fonde´s sur l'accord du spectateur. La de´coration-type est une des conventions essentielles qui couvre la longue pe´riode qui va du Moyen a^ge au the´a^tre classique du 17e`me sie`cle. Que ce soit sur la sce`ne simultane´e ou sur la sce`ne unique, cette convention repose sur l'espace neutre qui fait nai^tre une autre convention, celle du jeu de l'acteur qui demande a` son tour une grande complicite´/re´ceptivite´ de la part du spectateur. Les acteurs du Moyen Age utilisent l'espace sce´nique place´ devant les mansions de fac¸on tout a` fait arbitraire, comme une sorte de lieu de´veloppe´ en prolongement des diffe´rentes mansions. Ne´anmoins ces conventions-la` sont admises sans difficulte´s par le public. Mais au 17e`me sie`cle, les conventions vont devenir progressivement a` la fois plus pre´cises et plus codifie´es du fait de l'intervention des doctes. Ces conventions provoquent des discussions, du moins des remaniements de la part des cre´ateurs car elles entrent en conflit avec un autre grand principe, celui de la vraisemblance. D'autre part, les conventions sont changeantes et de´termine´es par la mentalite´ des spectateurs. De la sce`ne simultane´e a` la sce`ne unique, des mansions au palais a` volonte´ en passant par la pluralite´ des lieux ou le lieu composite des tragi-come´dies ou des pastorales on n'assiste pas seulement a` l'e´volution de l'esthe´tique de la sce´nographie conventionnelle. Il s'agit aussi d'une forme de mentalite´ : pour les gens du Moyen Age, tout signe exte´rieur vaut une re´alite´ palpable auquel on croit sans mettre en doute sa perception imme´diate. On pourrait parler alors d'une convention spontane´e. Pour les Franc¸ais des anne´es 1630-50, la sce´nographie simultane´e est une manifestation de l'esprit baroque, fait de fantaisie, de liberte´ et d'imagination : le spectateur se prome`ne en imagination en divers lieux situe´s pourtant, de fac¸on totalement invraisemblable, co^te a` co^te sur la sce`ne exigue¨ de l'Ho^tel de Bourgogne. Sans doute a` la sortie de la pe´riode trouble´e de la Fronde, dans les anne´es 1660, il n'est pas e´tonnant qu'on e´volue d'un gou^t anarchique vers l' n'est pas e´tonnant qu'on e´volue d'un gou^t anarchique vers l'unite´ de lieu qui n'est d'autre qu'une maifestation du de´sir de rationaliser, d'organiser aussi bien l'espace fictif du plateau que le monde lui-me^me. Pourtant, ce de´sir de se rationaliser a commence´ a` se faire sentir me^me en ces temps de liberte´. Un signe caracte´ristique de ce changement de mentalite´ est donne´ par l'usage des tapisseries : ces rideaux de tissu descendus des cintres masquent les compartiments dont on ne se sert pas a` tel ou tel moment de l'action sce´nique ; on tend au vraisemblance par l'utilisation de tapisseries qui ont pour but de re´duire l'arbitraire. On imagine par la` le combat, qui va durer plusieurs ge´ne´rations, entre des conventions de moins en moins bien accepte´es et un besoin de vraisemblance qui finira par s'imposer a` la sce´nographie du 19e`me sie`cle sous le nom de re´alisme sce´nique puis de naturalisme. Pourtant, au moment ou` la sce`ne d'illusion se perfectionne jusqu'au de´tail avec le naturalisme, la convention renai^t et se renouvelle : 'la convention consciente' veut de´voiler le fonctionnement propre du the´a^tre ; elle devient le signe de reconnaissance de la the´a^tralite´. Par tous ces e´le´ments de´libe´re´ment propose´s comme arbitraires, la sce´nographie fait comprendre au spectateur qu'il est au the´a^tre, qu'il assiste a` un jeu dont on ne cherche plus a` masquer le me´canisme. Ainsi nai^t une nouvelle vision du monde et du the´a^tre : plus c'est faux, plus c'est vrai ; en multipliant les signes visibles de l'artifice du the´a^tre, on essaye de s'approcher de la ve´rite´ des choses...

정상교합자의 치열궁 형태

권용철,성정옥,권오원,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 yesrs old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.

국내 혈액질환 환자에서 침습성 아스페르길루스증의 구제치료로서 Voriconazole의 효과와 안전성

권재철,김시현,최수미,최재기,이동건,박선희,최정현,유진홍,신완식 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Invasive aspergillosis (IA) is associated with significant morbidity and mortality in patients with hematologic malignancies. We investigated the efficacy and safety of voriconazole (VCZ) when used as salvage therapy for IA in Korean adults with hematologic malignancies who had not responded to prior antifungal therapy. Materials and Methods: We retrospectively reviewed data, collected from January 2007 to October 2008, from patients with proven or probable cases of IA. All were probable IA cases, except for one proven case. All cases were refractory or intolerant to antifungal therapy prior to administration of VCZ. Efficacy and safety were assessed in patients treated with VCZ for more than 3 days and for more than one dose, respectively. A favorable response [complete (CR) or partial (PR)] was defined by significant improvement of all clinical symptoms, signs, and radiologic abnormalities. Results: Fifty patients who met the inclusion criteria were enrolled. There were 27 male and 23 female patients with mean age of 44.4 years (range, 15-65 years). Underlying diseases were acute leukemia (35 cases), chronic myelogenous leukemia (4 cases), myelodysplastic syndrome (3 cases), lymphoma (3 cases) and other hematologic diseases (5 cases). Twenty-two patients had received chemotherapy and 13 patients had undergone hematopoietic stem cell transplantation. The lung was the main infection site (94%) followed by the sinus (6%). Amphotericin B deoxycholate alone was the most frequent previous antifungal therapy. The mean duration of antifungal therapy prior to VCZ therapy was 13.9±8.8 days (2-44 days). The median duration of VCZ therapy was 19 days (interquartile range, 49 days). Sixteen patients (32.0%) showed favorable responses (CR:PR=8:8) at the end of VCZ therapy. The numbers of patients with stable disease, progression and death were, 6 (12%), 6 (12%) and 22 (44%) respectively. Most of those with unfavorable responses had relapsed underlying malignancies or refractory graft versus host diseases. Twelve patients developed drug-related adverse events but only one patient stopped VCZ treatment prematurely. Conclusions: VCZ demonstrated an acceptable level of toxicity in patients with hematologic malignancies but further studies are required to prove its efficacy as salvage therapy.