http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zero-order Delivery of Alfuzosin Hydrochloride with Hydrophilic Polymers
Park, Jun-Bom,Hwang, Chang-Hwan,Noh, Hyung-Gon,Chae, Yu-Byeong,Song, Jun-Woo,Kang, Chin-Yang The Korean Society of Pharmaceutical Sciences and 2010 Journal of Pharmaceutical Investigation Vol.40 No.5
Manufacturing a multi-layered tablet such as Xatral XL$^{(R)}$ is more complex and expensive than monolayered tablets, but mono-layered tablets may have less favorable release properties depending on the pharmacodynamics and pharmacokinetics of the active ingredient. We therefore sought to develop a monolayer tablet with a similar dissolution profile to the commercial alfuzosin sustained-release triple layered tablet (Xatral XL$^{(R)}$). We prepared four different mono-layered alfuzosin tablets with different concentrations of hydroxypropyl methycellulose and PVP K-90. Fomulation III with alfuzosion/mg-stearate/ HPMC/ PVP K-90 (10/5/110/95 mg/tab) has a similar dissolution rate to Xatral XL$^{(R)}$, with a similarity factor score of 81.4. However, the swelling and erosion rates of the two formulations were different, and NIR analysis showed differences in the mechanisms of drug release. Thus, although formulation III and Xatral XL$^{(R)}$ show similar dissolution rates, the mechanisms of drug release are different.
Park, Jun-Bom,Park, Chulhun,Piao, Zhong Zhu,Amin, Hardik H.,Meghani, Nilesh M.,Tran, Phuong H.L.,Tran, Thao T.D.,Cui, Jing-Hao,Cao, Qing-Ri,Oh, Euichaul,Lee, Beom-Jin Elsevier 2018 Journal of drug delivery science and technology Vol.46 No.-
<P>The aims of this work were to design pH-independent controlled release (CR) tablet containing nanonizing solid dispersion (SD) adsorbed on hydrophilic silica (Aeroperl((R)) 300/30). Valsartan (VAL) was chosen to simultaneously modulate solubility and release rate due to its poor water solubility in low pH condition and short elimination half-life. Based on extensive equilibrium solubility and compatibility studies, poloxamer 407 was selected as a SD carrier. The melted mixtures of drug and poloxamer 407 were adsorbed onto hydrophilic fumed silica (Aeroperl((R)) 300/30). Ternary SD system changed crystalline drug into an amorphous state and had intermolecular hydrogen bonding as confirmed by FT-IR with poloxamer 407. The dissolution rate of SD system was markedly enhanced as compared with pure VAL or commercial Diovan((R)) tablet in simulated gastric fluid (pH 1.2). Interestingly, the particle size of SD system was gradually nanonized for 2 hr, ranging from 600 nm to 150 nm during dissolution process. The SD-loaded CR (SD-CR) tablets using hydroxypropylmethylcellulose (HPMC 4000) showed pH-independent zero-order release and good stability at accelerated conditions for six months. The SD-CR tablet showed minimized inter-subject variation of maximum plasma concentration as compared with commercial Diovan((R)) tablets in healthy human volunteers.</P>
박준범(Park, Jun-Bom) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.11
본 이 연구의 목적은 부유 기술을 이용하여 제형이 위에 더 오래도록 머무르면서 약물을 지속적으로 방출하는 이중정 을 개발하는 것이다. 실험방법으로는 메트포르민을 주 약물로 선정하였는데, 그 이유는 메트포르민은 주로 소장 상부에서만 흡수되는 좁은 흡수 영역 대를 가지고 있는 점, 용해도가 매우 높아 약물 방출을 조절하는 것이 쉽지 않은 점 등 때문이다. 정제의 부유를 위한 가스를 생성하는 부분과 약물의 방출을 조절하는 부분의 간섭을 최소화하기 위해 이중정 타정 기를 사용 해 이중정으로 제조하였으며, 정제의 모양, 질량 및 경도를 측정하였고, 부유정의 중요한 요소인 부유 촉발시간과 부유유지 시간을 평가하였다. 또, 약물의 방출 조절을 평가하기 위해 용출시험을 시행하였으며, 그 결과를 시판되고 있는 메트포르민 서방성 제제인 Glucopharge XR® 과 비교평가 하였다. 그 결과, 부유 촉발제인 NaHCO₃ 및 약물 방출 조절제인 hydroxypropyl methylcellulose (HPMC)의 사용량에 따라 13초의 부유 촉발시간, 10시간 이상의 부유 유지시간 및 시판 제제와 매우 유사한 약물 방출 거동을 확인할 수 있었다 (f2: 89.6). 결론적으로 메트포르민을 함유한 위 체류 이중정을 성공적으로 개발할 수 있었으며, 그로 인해 메트포르민의 치료효과도 극대화 할 수 있을 것으로 예상된다. The aim of this study was to develop gastric retentive bi-layered tablet using floating drug delivery technique. Metformin was selected as a model drug due to its narrow absorption window as well as very highly water solubility. These properties of metformin led to be difficult controlling the drug release. The bi-layered tablet was prepared with bi-layered compression machine to minimize interference between floating part and controlling part. The tablet weight, appearance and hardness were evaluated after compression process. The times of 'time to floating' and 'Floating duration' were tested for floating ability and drug release study was also carried out to understand drug release behavior. Furthermore, the drug release of bi-layered tablet was compared with marketed metformin tablet with sustained release pattern (Glucopharge XR®).The floating ability and drug release behaviors were well controlled by changing amounts of NaHCO₃ (floating substance) and hydroxypropyl methylcellulose (HPMC; release control material). Bi-layered tablet had 13s of time to float, over 10h of floating duration and very similar drug release behavior compared with Glucopharge XR®(f2: 89.6). Consequently, the bi-layered tablet with floating ability was successfully prepared and these properties can maximize the efficacy of metformin.
Kang, Yun Pyo,Lee, Won Jun,Hong, Ji Yeon,Lee, Sae Bom,Park, Jeong Hill,Kim, Donghak,Park, Sunghyouk,Park, Choon-Sik,Park, Sung-Woo,Kwon, Sung Won American Chemical Society 2014 JOURNAL OF PROTEOME RESEARCH Vol.13 No.9
<P>To better understand the respiratory lipid phenotypes of asthma, we developed a novel method for lipid profiling of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS with an internal spectral library and high-throughput lipid-identifying software. The method was applied to BALF from 38 asthmatic patients (18 patients with nonsteroid treated bronchial asthma [NSBA] and 20 patients with steroid treated bronchial asthma [SBA]) and 13 healthy subjects (NC). We identified 69 lipids, which were categorized into one of six lipid classes: lysophosphatidylcholine (LPC), phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylserine (PS), sphingomyelin (SM) and triglyceride (TG). Compared with the NC group, the individual quantity levels of the six classes of lipids were significantly higher in the NSBA subjects. In the SBA subjects, the PC, PG, PS, SM, and TG levels were similar to the levels observed in the NC group. Using differentially expressed lipid species (<I>p</I> value < 0.05, FDR < 0.1 and VIP score of PLS-DA > 1), 34 lipid biomarker candidates with high prediction performance between asthmatics and controls were identified (AUROC > 0.9). These novel findings revealed specific characteristics of lipid phenotypes in asthmatic patients and suggested the importance of future research on the relationship between lipid levels and asthma.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2014/jprobs.2014.13.issue-9/pr5002059/production/images/medium/pr-2014-002059_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr5002059'>ACS Electronic Supporting Info</A></P>
Park, Ki Seong,Song, Ho-Chun,Cho, Sang-Geon,Kang, Sae-Ryung,Kim, Jahae,Jun, Haeng Man,Song, Minchul,Jeong, Geum-Cheol,Park, Hee Jeong,Kwon, Seong Young,Min, Jung-Joon,Bom, Henry Hee-Seung The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3
Purpose Closed-mouth bone scintigraphy (CM scan) and closed-mouth single-photon emission computed tomography (CM SPECT) are used for conventional evaluation of osteoarthritis of the temporomandibular joint (TMJ). However, the adequacy of open-mouth bone scintigraphy (OM scan) has not yet been evaluated. Therefore, the purpose of this study was to compare the diagnostic performance of CM scan, CM SPECT, and OM scan. Methods Thirty-six patients with suspicion of an abnormality of the TMJ and who underwent a $^{99m}Tc-HDP$ CM scan, CM SPECT, and an OM scan were enrolled. The scans were assessed visually for the presence of positive focal uptake in the TMJ. Osteoarthritis was defined as arthralgia plus crepitus or radiologic signs of arthrosis. Results Of 72 TMJs, 21 (29.2 %) were diagnosed with osteoarthritis. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 90.5 %, 49.0 %, 42.2 %, 92.6 % and 61.1 % for the CM scan, 81.0 %, 58.8 %, 44.7 %, 88.2 % and 65.3 % for CM SPECT, and 81.0 %, 82.4 %, 65.4 %, 91.3 % and 81.9 % for the OM scan, respectively. The accuracy of the OM scan was higher than that of CM SPECT and the CM scans (p = 0.004 and p < 0.001, respectively). Conclusions The OM scan was more accurate than the conventional CM scan and even CM SPECT for diagnosing TMJ osteoarthritis.
범희승,박성욱,오승준,문대혁,이희경,홍명기 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.2
Restenosis remains a major limitation of percutaneous coronary interventions. Numerous studies including pharmacological approaches and new devices failed to reduce the restenosis rate except coronary stenting. Since the results of BENESTENT1) and STRESS2) studies came out, coronary stenting has been the most popular interventional strategy in the various kinds of coronary stenotic lesions, although the efficacy of stenting was shown only in the discrete lesion of the large coronary artery. The widespread use of coronary stenting has improved the early and late outcomes after coronary intervention, but it has also led to a new and serious problem, e.g., in-stent restenosis. Intravascular radiation for prevention of restenosis is a new technology in the field of percutaneous coronary intervention. Recent animal experiments and human trials have demonstrated that local irradiation, in conjunction with coronary interventions, substantially diminished the rate of restenosis. This paper reviews basic radiation biology of intracoronary radiation and its role in the inhibition of restenosis. The current status of intracoronary radiation therapy using Re-188 liquid balloon is also discussed.
( Bom Bi Lee ),( Bong Jun Sur ),( Jin Hee Park ),( Sung Hun Kim ),( Sunoh Kwon ),( Mi Jung Yeom ),( In Sop Shim ),( Hye Jung Lee ),( Dae Hyun Hahm ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.5
The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and infl ammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of rats. The effects of GRg3 on proinfl ammatory mediators in the hippocampus and the underlying mechanisms of these effects were also investigated. Injection of LPS into the lateral ventricle caused chronic infl ammation and produced defi cits in learning in a memory-impairment animal model. Daily administration of GRg3 (10, 20, and 50 mg/kg, i.p.) for 21 consecutive days markedly improved the LPS-induced learning and memory disabilities demonstrated on the step-through passive avoidance test and Morris water maze test. GRg3 administration signifi cantly decreased expression of pro-infl ammatory mediators such as tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. Together, these fi ndings suggest that GRg3 signifi cantly attenuated LPS-induced cognitive impairment by inhibiting the expression of pro-infl ammatory mediators in the rat brain. These results suggest that GRg3 may be effective for preventing or slowing the development of neurological disorders, including Alzheimer`s disease, by improving cognitive and memory functions due to its anti-infl ammatory activity in the brain.