지속성 외래 복막투석 환자의 복막염

신영태,황평주,김종학,강민규,구영선,양종오,장윤경,이강욱 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

CAPD has established itself as an effective method maintaining the patients with end stage renal disease. CAPD peritonitis is one of the most important complication of peritoneal dialysis. We analyzed the incidence, pathogens, and outcome of the peritonitis, of the 95 patients who underwent CAPD at CNUH from January 1993 to July 1998. The result were as follows : 1) A total of 72 episodes of peritonitis occurred during this periods. The incidence of peritonitis were 0.64/patient/year. 2) The first episode of peritonitis was occurred within a year in 75%, within two year in 95.8%. 3) The rate of positive and negative culture were 27.8% and 72.2% respectively. Gram positive organisms were cultured in 60%, Gram negative organisms in 40%. S. aureus were most prevalent organisms(30%). 4) The cure rate were 83.3% in Gram positive organisms and 62.5% in negative organisms. 5) Peritoneal catheter were removed in 18 cases. Among them, 7 cases are due to peritonitis. In conclusion, improved technology and increasing patients' effort to careful management of catheter will reduce the incidence of peritonitis.

전신성 홍반성 낭창의 임상적 고찰

신영태,김종학,장윤경,양종오,구영선,강민규,황평주,나기량,이강욱,서광선 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The epidemiology, diagnostic criteria, clinical features, symptoms and signs laboratory findings, kidney pathology, and clinicopathologic correlation of systemic lupus erythematosus(SLE) were analyzed. The 63 patients studied were managed at the Department of Internal medicine, CNUH, from January 1983 to December 1997. Kidney biopsy was performed in 53 patients out of 63 patients with SLE. The results were as follows: 1. The ratio of male to female was 1:26. They were 12 to 71 years old and mean age was 32.1 years old. The peak age incidence was 4th decades(30%). 2. The most frequent chief complaint on admission was generalized edema. Most patients complain two or more symptoms. 3. Immunologic and renal disorders were the most frequently observed in the ARA criteria of SLE. And the positive ANA, hematologic disorder, malar rash, and arthritis, were observed in order of frequency. 4. Among the 53 patients with renal biopsy, 30 patients revealed class Ⅳ lupus nephritis(56%), class II in 12 patients(23%), class V in 8 patients(15%) and class III in 2 patients(6%). 5. The cases of lupus nephritis represented as nephrotic syndrome were high in the class IV with 68% and class V with 86%. 6. Of 30 patients who can be followed up, 5 patients resulted in death(17 % of mortality). They "were 14 to 57 years old and mean age was 28 years old. Follow up duration were from 1 month to 6 years and 3 months, and mean duration was 1 year and 1 month, but 3 cases 7. The causes of death were as follows: Two cases were due to seizure and coma resulted from CNS involvement. One was sepsis due to miliary the & pneumonia. One was dilated cardiomyopathy and heart failure due to cardiac ac involvement. And the other one was sepsis and acute renal failure resulted from cellulitis. 8. Prednisolone was used in all patients basically, and methyl-prednisolone pulse therapy, antimalarials and alkylating agents were used in some cases. In the cases of combined therapy, the activity of SLE was well controlled.

양방향성 형상기억합금을 이용한 초소형 공작물 클램핑 장치 개념설계

신우철,박형욱,노승국,박종권 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

In this paper, a micro workpiece clamping device, which is possible to be applied in micro machine-tools, based on a shape memory alloy is introduced. Especially, the train procedure to transform a commercial one-way shape memory alloy into a two-way shape memory alloy is described. Also, it is experimentally verified that through the train procedure, the applied shape memory alloy ring exhibits two-way shape memory behavior of 220㎛ deformation. In addition, a conceptual design and a basic configuration of the work-piece clamping device using the two-way type shape memory alloy are suggested.

혈청 HBsAg 양성인 사구체신염의 임상상 및 신조직 소견

신영태,구영선,강민규,황평주,김종학,이강욱,서광선 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Hepatitis-B-associated glomerulonephritis is one of the immunologically mediated disorders associated with chronic Hepatitis B virus(HBV) infection. The frequency of HBsAg infection has been high in East Asia and it is one of the most important etiologic factors of the secondary glomerulonephritis. We reviewed the clinical and pathologic features of 29 patients with glomerulonephritis and HBs antigenemia, who were admitted to Chungnam National University Hospital from January 1988 to Febuary 1999. The results were as follows : 1) The average age of the patients was 33.8±10.4(mean±SD) and male to female ratio was 3.8. Proteinuria was present in 27 patients(93%), hematuria in 20 patients(69%) and hypertension in 17 patients(59%). Two patients(7%) manifested with renal insufficiency and 8 patients(28%) with nephrotic syndrome. 2) Renal pathology revealed membranous nephropathy(41%), membranoproliferative glomerulonephritis(21%), mesangial proliferative glomeulonephritis(21%), minimal change nephritis (14%) and focal segmental glomerulonephritis(3%). 3) The pathologic findings of liver were chronic active hepatitis(68%), chronic persistent hepatitis(38%) and liver cirrhosis(8%). 4) During the follow-up period(average:49.4 months), 7 patients(68%) presented persistent proteinuria, 5 patients(21%) progressed to renal failure and 2 patients(8%) resolved clinically. 5) The treatment was done with prednisolone to 3 patients, and with alpha-interferon to 3 patients. One patient treated with prednisolone resolved clinically, but this resolution did not coincide with disappearance of the hepatitis B antigens.

글 속에서 사건의 중요도와 인지적 흥미가 그 사건의 회상에 미치는 영향

신현정,서종욱 심리과학연구소 2002 심리과학연구 Vol.3 No.-

Interest can be conceptualized as an emotional state which results from stimuli imterpretation and comprehension, and also as motivator which leads an individual to a specific behavior, although it is generally accepted that interest plays an importance role interpreting stimuli, selecting information, deciding processing priority, and allocating attention in the process of learning and cognition, there has been no systematic approach on the effect of importance and cognitive interest within the field of cognitive psychology. Two experiment were conducted in order to test the event recall on importance of a event and cognitive interest in a story. In Experiment, it was found that 'seductive detail' is vary important role on the story recall and important information recall for the event very well. 본 연구는 글 속에서 사건의 중요도와 인지적 흥미가 그 사건의 회상에 미치는 영향에 대한 것이다. 중요도와 흥미도는 글을 읽는 독자의 이해와 기억에 영향을 미치는 주요소로서 기존의 연구에서 중요도와 흥미도가 높은 글을 내용을 보다 많이 회상한다. 그러나 중요도와 흥미도가 일치하지 않는 경우에는 예상 밖의 결과를 얻었다. 즉, 흥미롭기는 하지만 중요하지 않은 정보의 경우 중요정보와 간섭을 일으켜 오히려 중요정보의 회상을 방해하는 것이다. 이처럼 두 요인을 함께 조작한 연구에서는 흥미가 글 이해와 회상에 더 강한 예측변인으로 작용하는 것을 알 수 있다. 본 연구에서는 글을 읽는 독자가 느끼는 중요도와 흥미도가 글 이해와 기억에 미치는 영향에 대한 Hidi 등(1982)과 Gamer 등(1989)의 결과를 재검증하였고(실험 1), 깊은 수준의 처리가 흥미롭지 않은 중요정보의 회상을 증진시킬 수 있는 지를 검증해 보았다(실험 2). 실험 1에서는 중요도와 흥미도를 각각 조작하여 4가지의 실험 조건을 만들고, 각 조건에서 회상량을 보았다. 실험의 결과 흥미로운 중요정보는 흥미롭지 않은 중요정보보다 회상량이 많았고, 예상했던 흥미로운 사소장보가 흥미롭지 않은 중요정보보다 망각이 더 빨리 되는 것을 알 수 있었다. 실험 2에서는 실험 1과 동일한 재료를 사용, 보다 깊은 수준의 처리를 가능하게 하는 2가지 조작조건(요약, 돌발조건)이 통제조건과 비교해서 차이가 나는 지에 대한 것이었다. 실험 2의 결과 2가지 조작조건 중 요약조건에서의 흥미롭지 않은 중요한 정보의 회상이 통제조건의 회상량보다 많다는 것을 알 수 있었다.

버텍스에 의한 숫자패턴 인식

辛烘圭,姜英鎭,朴鍾旭 圓光大學校 1987 論文集 Vol.21 No.2

본 논문에서는 도형 패턴의 윤곽선에 대한 버텍스 결정 방법을 도입하여 필기체 숫자 패턴을 인식하는 방법을 보였다. 본 방법은 입력 패턴의 윤곽선에 대한 버텍스의 관계로 부터 연결 링크와 접촉 링크를 추출하고, 패턴의 디스크립터를 유도하여 인식하는 방법이다. 그 결과 필기자의 관습에 의한 변형에 영향이 적고 인식 파라메타 수가 감소되었다. 또한 실험 결과 인식율이 대단히 높고 처리 시간도 세선화 방법에 비하여 30(%) 정도 빠르다는 것을 확인한다. In this paper, it is showed to recognize the Arabic numeral patterns by vertices decision from the contour line. This method is extracted links by vertices relation for input pattern and is recognized by inducing description function from the links. In this results, the affection of deformation due to the way of writters and the number of parameter for recognition are reduced, and experimental results show that recognition for hardwritten numeral patterns are effected and access time is reduced about 30 (%) compared with the conventional method using thinning process.

다층 신경망을 이용한 PID제어기의 자기 동조에 관한 연구

신종욱,채창현 金烏工科大學校 1996 論文集 Vol.17 No.-

In this paper, we studied on self-tuning of PID controller using Multi-layered neural Networks. The whole system structure is closed-loop that RNN can be learned on-line with back-propagation algorithm by the error between reference and plant output. The characteristics of the proposed structure is on-line adaptive learning in spite of the variation of feedback signal. Control performances is compared with that of Neural Network PID controller proposed by K. Iwasa te al. Computer simulation results show that the proposed controller is effective in controlling of unknown nonlinear plants.

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.

백서 혈관평활근 세포에서 α-Lipoic acid가 PAI-1 발현, 세포의 증식, 주유능 및 신생내막 형성억제에 미치는 효과

신동우,이동욱,이상준,김혜순,강효경,안종덕,이인규 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:당뇨병의 혈관 합병증의 발생에 있어서 산화스트레스는 중요한 역할을 하는 것으로 알려져 있다. 혈관 평활근세포에서 고혈당은 안지오텐신Ⅱ와 더불어 활성산소족(ROS)을 증가시키며, 산화스트레스에 민감한 전사인자들을 활성화시켜 동맥경화증을 유발하는 것으로 알려져 있다. 이에 저자들은 항산화제로 알려진 알파­리포산이 혈관 평활근세포의 증식속도와 이주에 미치는 영향과 PAI­1발현에 미치는 영향을 조사하였고 이와 동시에 백서의 혈관 손상 모델을 이용하여 알파­리포산이 신생내막 증식을 억제시킬 수 있는지를 알아보았다. 방법:In vitro 실험은 백서의 대동맥 평활근세포를 고농도의 포도당(22mM)과 100nM의 안지오텐신Ⅱ로 4시간 배양하였다. 알파­리포산을 처리 후, PAI­1 mRNA의 발현을 보기 위해 노던 블롯을 시행하였고 평활근세포의 유주능과 증식속도에 미치는 영향을 보기 위해 성장속도의 유주능 분석을 시행하였다. 또한 평활근세포의 유주능에 NF­μB 경로가 미치는 영향을 보기 위해 겔 지연 분석과 NF­μB 보고 유전자 분석을 시행하였다. In vivo 실험으로 백서의 혈관손상 모델을 이용하여 알파­리포산 처리 후 혈관의 신생내막 두께를 비교하였다. 결과:In vitro 실험에서 고농도 포도당과 안지오텐신Ⅱ에 의해 유도된 PAI­1 mRNA 발현증가는 알파­리포산 처리에 의하여 용량에 비례하여 억제되었다(p<0.05). 알파­리포산 처리로 혈관 평활근세포의 유주능은 유의하게 억제되었으나(p<0.01),증식속도는 유의하게 억제되지 않았다. 또한 알파­리포산 처리로 NF­μB 발현도 유의하게 억제되었다(p<0.01). In vivo 실험에서 알파­리포산을 주입한 군에서 혈관손상에 의한 신생내막의 증식이 유의하게 억제되는 것을 보여주었다(p<0.01). 결론:알파­리포산은 백서의 대동맥 평활근 세포의 증식속도는 억제하지 못했으나 유주능은 유의하게 억제하였으며, 혈관 손상 모델에서 신생 내막 증식도 유의하게 억제함을 확인할 수 있었다. 이러한 작용은 알파­리포산에 의한 NF­μB 경로의 억제와 연관이 있는 것으로 사료된다. Background : Exposure to large amounts of glucose causes a characteristic dysfunction and morphologic changes of the endothelium by an increased production of reactive oxygen species(ROS) in diabetes. The plasminogen activator inhibitor-1(PAI-1), which modulates fibrinolysis and cell migration may influence proteolysis and neointimal formation in vascular smooth muscle cells(VSMC). Antioxidants have been proposed to inhibit multiple proatherogenic events. This study investigated the effect of α-lipoic acid on PAI-1 expression and VSMC proliferation and migration both in vivo and in vitro. Methods : In the in vitro study, cultured rat aortic smooth muscle cells(RASMC) were incubated in a medium containing high glucose (22 mM) and 100 nM angiotensin Ⅱ for 4 hour. After α-lipoic acidtreatment, a -migration and growth assay of the RASMC, and a gelmobility shift assay and reportergene analysis for nuclear factor- иB(NF- иB) and northern blot analysis for PAI-1 were performed. In the in vivo study, the effect of α-lipoic acid on neointimal hyperplasia in a rat carotid balloon injury model was evaluated. Results : RASMC migration was inhibited significantly by α-lipoic acid (p<0.01), but their prolife ration was not inhibited. The NF-иB DNA binding activity and NF-иB promoter activity was inhibited by α-lipoic acid significantly (p<0.01). α-lipoic acid inhibited PAI-1 mRNA expression by high glucose and angiotensin Ⅱ in dose dependent manner (p<0.05). In the rat carotid artery balloon injury model, neointimal formation was reduced by α-lipoic acid treatment in a dose dependent manner significantly (p<0.01). Conclusion : α-lipoic acid suppresses migration, but not prolife ration in RASMC. α-lipoic acid also reduce neointima formation in a rat carotid balloon injured model. This effect might be related to the blocking of NF-иB which increase the expression of the genes associated with atherosclerosis including TNF-α, IL-1, IL-6, endothelin-1, MCP-1, VCAM-1, ICAM-1, E-selectin, tissue factor(J Kor Diabetes Asso 25:446~459, 2001).

형상기억합금 기반 공구 클램핑 장치의 원심력 영향 해석

신우철,박형욱,노승국,박종권 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper presents analysis and experimental results for effects of centrifugal force of the SMA-based tool clamping device. First, the corresponding theories of radial deformations resulting from the centrifugal force were described, and based on them, the radial deformations of the contact region between a tool and a tool holder were verified according to rotational speeds. Next, as for 3D-model of the tool holder, analysis of the radial deformations were carried out based on FEM. Finally, the feasibility of the SMA-based tool clamping device at high-rotational speed was experimentally verified by monitoring the clamped tool in mill-machining at 220,000rpm.