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HPLC를 이용한 백삼,홍삼 및 홍삼 농죽액의 Ginsenosides 함량 분석
맹주양;이용구;이숙재;정진아;김상민;김유정;육영난 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2
Commercial White ginseng(WG), Red ginseng (RG), and Red ginseng concentrate(RGC) were analyzed for ginsenosides Rg1, Rb1, and Re by HPLC. The contents of Rg1, Rb and Re were 0.25%, 0.17%, 0.13% in WG, the contents of Rg1, Rb1, and Re were 0.11%, 0.23%, 0.12% in RG, and the contents of Rg1, Rb1, and Re were 0.7%, 0.04%, 0.42% in RGC. In Rg1, the contents were decreased in the order of RGC(O.70%)>WG (0.25%)>RG(O.11%), in Rb1, RG(O.23%)>WG(O.17%)> RGC(O.04%), in Re, RGC(0.42%)>WG(0.13%)>RG(O.12%). The total content s of Rg1, Rb1, and Re were decreased in the order of RGC(1.16%)>WG(0.55%)>RG(O.46%). Overall results demonstrated that The content of Rg1 was higher than those of Rb1 and Re in WG and RGC, while the content of Rb1 was higher than those of Rg1 and Re in RG.
( Jin-sung Yuk ),( Won I. Park ),( Jung Hun Lee ),( Hyeong Sik Ahn ),( Hyun Jung Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: The purpose of this study was to compare treatment success rates, side effects rates and time to resolution between single-dose protocol and non-single-dose protocol (multi-dose protocol and two-dose protocol) of methotrexate (MTX) in treatment of ectopic pregnancy (EP) using randomized controlled trials (RCTs). 방법: We searched MEDLINE, EMBASE, SCOPUS, Web of Science, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, International Clinical Trials Registry Platform and EU Clinical Trials Register. The relative risk (RR) and 95% confidence intervals (CIs) were used for calculating dichotomous outcomes, while mean difference (MD) and 95% CIs were used for calculating continuous outcomes. 결과: We selected 9 RCTs among total 1521 articles. The success rate of single-dose protocol was similar to that of non-single-dose protocol in treating EP [RR (95% CI): 1.02 (0.98~1.06; 9 trials, 891 patients), I2=0%]. Although non-single-dose protocol tended to have a higher side effects compared to single-dose protocol, there was no significant difference in both group, [RR (95% CI): 0.76 (0.58~1.01; 7 trials, 704 patients), I2=12%]. However, in subgroup analysis about tubal pregnancy, non-single dose protocol appeared to have a higher side effects rate than single-dose protocol [RR (95% CI): 0.69 (0.51~0.93; 3 trials, 369 patients), I2=0%]. Single-dose protocol had longer resolution time than non-single-dose protocol [MD (95% CI): 4.5 (0.40~8.60; 5 trials, 528 patients), I2=83%]. 결론: Single-dose protocol has similar success rates to non-single-dose protocol in treating EP, and tends to lower side effects rate than non-single- dose protocol. Also, in treating tubal pregnancy, single-dose protocol has lower side effects rate than non-single-dose protocol. However, single- dose protocol has longer resolution time than non-single-dose protocol.
Yuk, Jin-Sung,Lee, Jung Hun Elsevier 2018 Gynecologic oncology Vol.151 No.1
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The primary objective was to compare the overall survival of women with unsuspected uterine malignancy (UUM), including sarcomas and adenosarcomas, diagnosed after laparotomic versus laparoscopic myomectomy. The secondary objective was to determine the incidence of UUM diagnosed after myomectomy.</P> <P><B>Methods</B></P> <P>We analyzed the national health insurance database, which covers almost the entire Korean population, between 2006 and 2010 to calculate the incidence and mortality of UUM diagnosed after myomectomy. Diagnosis and procedure codes were used to identify women with or without UUM.</P> <P><B>Results</B></P> <P>During the study period, 78,826 patients who underwent myomectomy among women in the database (23 million per year) were enrolled. The women were divided into a laparotomic myomectomy group (<I>n</I> = 56,213) and a laparoscopic myomectomy group (<I>n</I> = 22,613). The incidence of UUM diagnosed after myomectomy was 0.08% in both groups (47/56,213 and 18/22,613 women, respectively). There was no difference in mean age, socioeconomic status, diagnostic code, UUM incidence at 5-year intervals, survival rate, or mean survival time. The 5-year survival rates of women with UUM were 95.7% and 88.9% in the laparotomic and laparoscopic groups, respectively. A Kaplan-Meier survival analysis showed no difference in the overall survival rates according to the surgical method (<I>P</I> = 0.447).</P> <P><B>Conclusions</B></P> <P>The incidence of UUM after myomectomy was 0.08% after laparotomic or laparoscopic myomectomy. Although morcellator use does not reduce the overall survival rate, clinicians should explain the risks of intraperitoneal tumor dissemination to patients and do their best to prevent tumor spillage when using this tool.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The incidence of unexpected uterine malignancy after myomectomy was 0.08%. </LI> <LI> Laparotomic and laparoscopic myomectomy had no difference in the incidence. </LI> <LI> Laparoscopy did not deteriorate the prognosis of the unexpected uterine malignancy. </LI> </UL> </P>
Association between pregnancy and acute appendicitis in South Korea
Jin-Sung Yuk,Yong Jin Kim,Jun-Young Hur,Jung-Ho Shin 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.85 No.2
Purpose: To estimate the prevalence of acute appendicitis and the relationship between pregnancy and acute appendicitis among South Korean women in 2009. Methods: This was a cross-sectional study over 1 year period using a national registry data. We analyzed a national patient sample (n = 1,116,040) from a database complied by the South Korean National Health Insurance in 2009. Results: We identified 15,974 cases of acute appendicitis from 2009. The prevalence rate of acute appendicitis was 228 ± 2 per 100,000 persons. The prevalence in men was higher than in women. The peak prevalence of the disease in both genders occurred in patients aged 10 to 14 years. After that, prevalence declined with age. The prevalence of acute appendicitis in women aged 20 to 39 years was negatively associated with age and pregnancy (P < 0.001) but was not associated with socioeconomic status. The prevalence of perforated appendicitis cases by age is represented by a U-shaped curve. The prevalence was highest in people less than five years of age and in people older than 60 years. Conclusion: We found that the prevalence of acute appendicitis decreased with increasing age after early teens, and that the prevalence of acute appendicitis in pregnant women was lower than in nonpregnant women.
Yuk, Jae-Min,Shin, Dong-Min,Lee, Hye-Mi,Kim, Jwa-Jin,Kim, Sun-Woong,Jin, Hyo Sun,Yang, Chul-Su,Park, Kyeong Ah,Chanda, Dipanjan,Kim, Don-Kyu,Huang, Song Mei,Lee, Sang Ki,Lee, Chul-Ho,Kim, Jin-Man,Song Nature Publishing Group, a division of Macmillan P 2011 Nature immunology Vol.12 No.8
The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxin-induced sepsis. SHP had dual regulatory functions in a canonical transcription factor NF-觀B signaling pathway, acting as both a repressor of transactivation of the NF-觀B subunit p65 and an inhibitor of polyubiquitination of the adaptor TRAF6. SHP-mediated inhibition of signaling via the TLR was mimicked by macrophage-stimulating protein (MSP), a strong inducer of SHP expression, via an AMP-activated protein kinase??dependent signaling pathway. Our data identify a previously unrecognized role for SHP in the regulation of TLR signaling.