Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

비선형 웹 이송 시스템의 장력제어

윤석찬,백승훈,정진태,한창수 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.5

This paper presents the study of the tension control in a web transfer system. In this study the sliding mode controller is applied to a time-varying nonlinear mathematical model. The model was derived to consider the effects of changing the roll rad;us in tension variation during winding and unwinding. The uncertainty in modeling may be due to unmodelled dynamics, on variations in system model. Designed sliding mode controller made the system error always staying in the suggested surface from the beginning. Through this, system is maintained to be robust against a disturbance and uncertainty. To verify the designed controller has a good performance, various inputs such as desired velocity, step input, and trapezoidal input are applied. When the sliding mode controller was used, the system(the tension control) performance was improved comparing to the PID controller. The robustness of the controller with respect to an estimation error was verified through simulations.

산지하천의 강우특성에 의한 부유물질 유출에 관한 연구

윤인규,박수진,최한규 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

In this research, we have selected the region of Jawoon river that is the area of high land vegetable growing in the upper Soyang Reservoir and we have observed actual floating materials that generate negative nutrition and turbidity of the Reservoir water and the changes of water quality by raining of each month for one year of 2005 in order to monitor the relationship of pollution sources by the outflow of rain water. In addition, we also have conducted statistical inspection methods such as correlation analysis and regression analysis on strength of raining force and rain continuance time among the elements affecting the outflow of floating materials.

유치원과 초등학교의 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지

한윤경,김희진 이화여자대학교 교육과학연구소 2000 교육과학연구 Vol.31 No.3

본 연구의 목적은 유치원과 초등학교의 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지도와 그 두 요소간의 관계를 알아보는 것이다. 연구대상은 서울 시내에 소재 한 유치원에 재직 중인 교사 179명과 초등학교에 재직 중인 교사 201명이었으며, 연구를 위하여 유치원 교사용 설문지와 초등학교 교사용 설문지를 사용하였다. 연구결과 연계교육에 대한 교사의 인식은 유치원 교사가 초등학교 교사보다 연계교육의 정의, 필요성, 개선 및 증진방안에 대한 인식에서 높게 나타났으며, 연계교육에 대한 교사의 인식과 상대교육과정에 대한 인지도는 관계가 있는 것으로 나타났다. The purpose of this research was to investigate teachers´ perceptions of the educational continuity between kindergarten and elementary school and their understanding of the curriculum of the counterpart.The subjects were 179 kindergarten teachers and 201 elementary school teachers. The results of this study are summarized as follows: First, there were differences between the perceptions of kindergarten teachers and that of elementary school teachers.Second, there weren´t any significant differences between the kindergarten teachers´ understanding of the elementary school curriculum and the elementary school teachers´ understanding kindergarten curriculum, Third, there were relationship between teachers´ perception of the educational continuity and their understandings of the counterpart´s curriculum.This means that the higher the degrees of teachers´ perception of the educational continuity, the better their understandings of the curriculum of the counterpart.

초등실과 전기기구 다루기 단원의 CD-ROM 개발과 수업에의 적용 효과

윤정한,김동연,김진수 韓國實科敎育硏究學會 2001 實科敎育硏究 Vol.7 No.1

The purposes of this study was to develop CD-ROM on manipulating the electric appliances unit for the fourth grade students in elementary practical arts curriculum, and to verify the effect of it for helping students acquire the basic knowledge of manipulating the electric appliances and teachers improve teaching method. The developed CD-ROM title had the following features. 1.The learning content of this CD-ROM title was consisted around manipulating the electric appliances unit for the fourth grade students in elementary practical arts curriculum. 2.This CD-ROM title was developed using various graphics, photos, movable image and animation to motivate elementary school students and to raise the effect of learning. 3.The learning content of this CD-ROM title was consisted around the fourth grad practical arts text in elementary school to utilize this CD-ROM title in class effectively. 4.This CD-ROM title was developed with authoring tool, Tool Book 5.0 of Asymetrix. 5.The basic learning topic of this CD-ROM title was composed of five specific topics for consideration of learner's interest. The results of application of this CD-ROM title were as follows: 1.There was a meaningful difference(p<0.05) between experimental group and control group on the effect of achievement. 2.There was a meaningful difference in girl students, but not a meaningful difference in boy students on the effect of achievement.

식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

인터넷 쇼핑몰 의류상품 구매자의 불평행동 특성에 관한 연구

최윤영,이진영,오희선,서용한 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.5

This study is to investigate complaining behavior of consumers who purchase fashion products on the inter-net, as well as to find how the complaining behaviors are related to the consumers' characteristics. The subjects of this study are limited to the consumers who have experienced dissatisfaction when purchasing fashion products through the internet. The questionnaires were administered to male and female respondents using the internet shopping mall. The results can be summarized as follows: The factor analysis shows that consumer complaining behaviors are fitted well into four factors(direct complaining behavior, private complaining behavior, third-party complaining behavior, and no response). In the difference analysis by consumer's complaining behavior styles and gender, private complaining and third-party complaining behavior were significant statistically. In the difference analysis between consumer's complaining behavior styles and internet self-efficacy. Internet self-efficacy was significantly different according to consumer's complaining behavior styles, especially for direct complaining, third-party complaining and no response. Private complaining behavior, third-party complaining behavior and no response were negatively related to consumer retention, while direct complaining behavior was not.

도시 거주 노인 수면 습관 및 불면증상의 요인 : 인구학적,질병 및 정신증상의 관련성

홍진표,안준호,윤영국,박종익,이소영,함봉진,김장규,한오수,조맹제 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 본 연구는 국내 노인의 습관을 조사하고 불면 증상과 연관 있는 인구학적, 질병학적 요인을 알고자 했다. 방 법 : 1997년 12월부터 1998년 1월까지 약 1개월에 걸쳐 2단계 층화집락표본추출의 역학조사법을 통해 선정된 3개 4개동 거주의 만 65세 이상 노인을 대상으로 수행되었다. 대상자 중 723명에서 등답을 받았으며 응답률은 73.8였다. 대학생인 설문조사요원들을 훈련시킨 뒤, 이들로 하여금 대상지역의 노인거주가정을 방문하여 개개 노인을 대상으로 반구조화된 면담으로 수면습관 및 불면증상 설문을 실시하였으며 그 외 한국어판 노인정신장애평가척도, 삶의 질 척도를 이용한 설문조사와 과거 질병력을 청취조사하게 하였다. 결 과 : 국내 노인들은 평균 오후 10시 16분에 자리에 누워 오전 5시22분에 일어나서 총 7시간 6분의 수면시간을 보였다. 노인의 11.7%가 거의 매일 밤 불면증을 14.8%가 간헐적 불면증을 호소하였다. 남자에서는 연령이 증가할수록 침상에 누워있는 시간이 증가하고, 또, 입면시까지 소요되는 시간과 수면 중의 각성회수가 증가되었으나 여성에서는 명확하지 않았다. 단변수 분석에서 요통, 중풍 병력의 환자에서 불면증상이 심했다. 다변량분석 결과 불면 증상과 관련 깊은 요인으로 남자에게서는 고령과 우울증상이 여자에게서는 남자의 위험요인에다 신체통증과 피부병력이 추가로 관련이 있었다. 결 론 : 지역 거주 노인에서 불면 증상은 매우 흔한 증상이며 우울증상과 명확한 상관관계를 보이고 있었다. 불면증을 극복하기 위해 불면증 위험요인의 인과관계에 대한 추후 연구가 필요하다. Objectives : The purpose of this study is to analyze sleep habit and investigate the association between insomnia and demographic, health and psycho-behavioral symptomatology in Korean urban elderly Method : A total of 723 community residents aged 65 years or older were surveyed by two stage, random cluster sampling method. The response rate was 76.2%. Interviewers performed door to door visits and administered a questionnaire about sleep, past medical history, and several scales as the Psychogeriatric Assessment Scale(PAS), the short form Quality of Life Scale (SF-36) and etc. Results : The mean scores are as follows : retiring time was ten-sixteen p.m., wake-up time was five twenty two a.m., duration of sleep was seven hours and six minutes. Among the elderly, 11.6% and 14.8% of the subjects reported chronic and intermittent difficulty in sleeping, respectively. The patients with back pain and history of stroke complained of more insomnia symptoms in univariate analysis. In ANCOVA analysis, insomnia symptoms were associated with an old age, depressive symptoms in male. Bodily pain and history of dermatologic disease were additional risk factors in female. Conclusions : The data suggest insomnia is one of most common health problems among elderly Koreans living in the community. Strong positive relationship between depressive symptoms and insomnia were found. Further research is needed to explore the causal relationship between insomnia and risk factors.

텅그스텐鋼에 形成된 炭化物의 Ostwald ripening에 대한 定量組織學的 分析

金漢軍,李相允,崔鎭源 東亞大學校 大學院 1987 大學院論文集 Vol.12 No.-

This study has been carried out to determine the structural characteristics and growth kinetics in thungsten steels. the results obtained from the the experiment are summerized as follows; 1. Microstructure of carbide particles spheroidization treated after quenching has been finely dispersed along grain boundary when tungsten content is increased. 2. The value obtained by mean redius of carbide particle and spherodizing treatment analysis has been calculated to be 0.27 and the growth of these carbide particles occurs by diffusion-controlled mechanism. 3. The value of activation energy obtained by particle number measurements and spherodizing time analysis has been calculated to be 69.6Kcal/mole and the coarsening phenomina of these carbide particles in tungstem steels occurs by the interdiffusion mechanism of iron, tungsten and carbon atoms. 4. The tungsten carbides in which W : C atomic ratio is 0.12 change to M₃C+MC but tungsten steels in which atomic ratio is 0.25 and 0.36 change to the stable M₃C+MC type caride after the process of the metastable M?C?+M?C type carbide. 5. Hardness measurements have revelaed that hardness during the spheroidization of tungsten steels varies as the Hall-Petch type relation, impact value has increased with th increasing of W content in range of 125 hours spheroidizing treatment time and 3% tungsten content.

사마귀류 추출물의 생물학적 활성 비교

허진철,황재삼,강석우,윤치영,이상한 慶北大學校農業科學技術硏究所 2007 慶北大農學誌 Vol.25 No.-

In order to investigate the availability of insect resources for agrobiotechnological or medical purposes, we examined antioxidant (DPPH and FRAP assay) and cell viability by oxidant stress and NO inhibition assay by treatment of the extracts of Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll. We found that Tenodera angustipennis Saussure and Tenodera aridifolia Stoll extract (DW, etanol, methanol) had high levels of anti-oxidant activity, whereas Tenodera aridifolia Stoll extract showed increased cell viability by hydrogen peroxide and inhibition of NO production. These findings suggest that Statilia maculata Thunberg, Tenodera angustipennis Saussure and Tenodera aridifolia Stoll, extract have potentials to be developed for agrobiotechnology or medicinal use, indicating that mechanistic study including inhibition against molecular inflammation will show a possibility for the development of useful insect resources.