The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

公共支出과 經濟活動

李之舜 서울大學校 經濟硏究所 1988 經濟論集 Vol.27 No.4

봉산탈춤 학습이 신체적 자기개념에 미치는 영향

송지영,이강순 한국문화교육학회 2008 문화예술교육연구 Vol.3 No.1

본 연구는 봉산탈춤 학습이 신체적 자기개념에 미치는 영향을 알아보는 데 목적을 두고 초등학교 4학년 학생들로 구성된 실험집단에 봉산탈춤 프로그램을 차시별로 적용하였고, 통제집단은 정규체육수업을 실시하였다. 본 연구 결과는 다음과 같다. 첫째, 신체적 자기개념의 심리적인 요인(봉산탈춤 유능감, 자기 존중감)에서 봉산탈춤 유능감과 자기 존중감 요인 모두 실험집단과 통제집단 간 차이가 나타났다. 둘째, 신체적 자기개념의 외적인 요인(체지방, 외모, 건강)에서 체지방, 외모, 건강 요인 모두 실험집단과 통제집단 간 차이가 나타났다. 셋째, 신체적 자기개념의 체력적인 요인(유연성, 지구력, 근력)에서는 유연성 요인에서 실험집단과 통제집단 간 차이가 나타났다. 넷째, 신체적 자기개념의 활동적인 요인(신체활동, 신체전반)에서는 신체활동과 신체전반 요인 모두 실험집단과 통제집단 간 차이가 나타났다. This study aims to examine the effects of Bongsan Mask Dance on elementary students' physical self-concept, focused on explaining the relation between Bongsan Mask Dance learning and physical self-concept. For this purpose, the data was collected from 74 male and female 4th-graders at G Elementary School in Incheon Metropolitan City and conducted a pretest and a posttest using a questionnaire with proved reliability and validity. The Bongsan Mask Dance learning program was applied to the experimental group for 6 weeks from September to October, 2007, 2 sessions per week and a total of 12 sessions, and 40 minutes per session. The control group had regular physical education classes with their class teacher while the experimental group was participating in the program. After the experiment, a posttest was performed. According to the results, the mean scores of the pretest was not significantly different between the experimental group and the control group(p<.05), which shows that the two groups were homogeneous. In the mean scores of the posttest, the experimental group and the control group were significantly different in 8 sub-factors of physical self-concept such as Bongsan Mask Dance competency, body fat/ slenderness, appearance, health, physical activity, self-esteem, flexibility and overall physical condition(p<.05). but were not significantly different in muscular strength and endurance.

녹차보리죽의 저장기간과 해동방법에 따른 품질 특성

이종미,최남순,오지은 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.1

This study was conducted to determine the desirable thawing method and storage time of Nokchaborijook(gruel made of barley, rice powder and Green tea) which made of optimum conditions as the 5.8% Green tea and 15 seconds grinding time. Decision on desirable storage time(10, 20, 30, 40, 50days), thawing method(water bath, microwave oven) of frozen Nokchaborijook were determined by sensory evaluation and physicochemical attributes. As the storage time became longer, moisture and flavonoid contents were decreased. Viscosity, the ratio of water seperation, spreadability of Nokchaborijook which stored at 30 days showed great differences between the two thawing method. Among the sensory characteristics, desirability for overall, flavor, and texture were decreased as the storage time became longer. As a result of consumer test, Nokchaborijook thawed at water bath was more desirable than Nokchaborijook thawed at microwave oven. According to the results, frozen Nokchaborijook can be using as a supplement of dietary fiber and flavonoid for the health and be using convenience food.

측백나무 추출물의 Monoamine Oxidase 저해활성

이문순,오지훈,이학수 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.2

Monoamine oxidase (MAO) exists in the outer membrane of mitochondria and contained a flavin adenine dinucleotide (FAD). MAO is classified into two forms, A-type (MAO-A) and B-type (MAO-B) on the basis of their different specifications toward substrates and inhibitors. This study was carried out to identify inhibitory components on MAO from Thuja orientalis seed extract by bioassay- guided isolation. The seeds of Thuja orientalis was extracted with 80% MeOH, and the MeOH extract was fractionated with n-hexane, chloroform, ethylacetate and n-butanol successively. The n-hexane and chloroform fraction showed relatively high inhibitory activity on MAO. Among the fractions from n-hexane layer through silicagel column chromatography, the fractions 2, 3 and 4 showed strong inhibitory activity on MAO

財政支出 增加의 物價上昇效果에 關한 硏究

李之舜 서울大學校經濟硏究所 1998 經濟論集 Vol.37 No.2

이 논문은 재정지출의 규모 및 그 구성 내역의 변화가 소비, 투자, 생산 등에 직접적으로 영향을 미치는 貨幣經濟 模型을 활용하여, 재정정책의 변화가 물가에 대해 미치는 영향이 무엇인지를 밝히고 있다. 이 연구는 재정지출을 단순히 총수요의 한 구성 항목으로 취급하여 재정정책의 경제적 효과를 분석하는 기존 거시모형의 단점을 극복한 배로의 財政政策 模型과 화폐가 본질적인 기능을 수행하는 重複世代模型을 결합함으로써 재정과 통화부문의 연결관계를 일관성 있게 고려하는 가운데 일반균형 모형을 활용하여 재정의 정책 효과를 체계적으로 분석하고 있다는 특징을 지닌다.

근세 서양복식에 나타난 두식에 관한 연구

이순홍,이지숙,김정진 誠信女子大學校 生活文化硏究所 2003 生活文化硏究 Vol.17 No.-

The purpose of this study is to find the trend of European headdresses during the period of the 16^th to the 18^th century. The fashion of the headdress, which generally means hairstyle and hat, constitutes a part of the whole fashion style of a time. The fashion style itself represents an aspect of the society at the time. The headdress in the 16^th century, which was also called Renaissance period, had begun to show diversified hairstyles and hats, of men's and women's reflecting the liberal trend of the society of the period. Short hairs and beret represent men's headdress of the period; dyed hairs and various hoods represent women's headdress. The headdress in the 17^th century, Baroque period, showed somewhat exaggerated, complicated and sensitive tendency as a reflection of the trend of the period that tried to express things more artistic ways. Wigs and hats took important position in men's fashion; Fontages hairstyle and tricorn hat partly represent women's headdress. The headdress in the 18^th century, Rococo period, had partly showed the culmination of the fashion in its history in the diversity of style and pursue of beauty. The fashion in the period could almost be called the art itself. Men's wigs evolved more practical style while their hats more decorative; women's headdress became extremely beautiful decorated by corsages and plaits.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

중등교사의 주의력 결핍·과잉 행동장애에 대한 지식, 대처 및 교육적 중재

이정옥,서지민,김정순,전성숙 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : This study investigated the prevalence of middle school students with ADHD and the level of middle school teacher's knowledge, coping strategies, and educational intervention for ADHD. Methods : There were 185 teachers and 6,381 middle school students at the 6 middle schools in Pusan. The data was collected from December 20, 2003 to January 10, 2004. Results : 195 middle school students had ADHD (3.1%). The male students with ADHD made up 4.4% of the total students and the female students with ADHD totaled 1.3%. The mean score of middle school teacher's knowledge about ADHD was 21.86 of the score total 32. The teachers used a negative coping style less than an active and passive coping style. Of the educational interventions, the environmental intervention in the classroom was used more than the educational intervention activity. 61.1% of the teachers responded that they did not know very much about ADHD. 93.5% of the teachers had no educational experience with ADHD. 94.1% felt that they needed an education program about ADHD and over half of them intended to participate in an ADHD education program. Conclusion : Based on the results of this study, we concluded that the middle school teachers felt that they had insufficient knowledge about ADHD. They wanted the opportunity to increase their knowledge of ADHD. Therefore, it is necessary for educational programs about ADHD for teachers to be developed and made available to them.