학생청소년의 불안성향과 문제행동 유형간의 상관분석

김헌수,이재우,나철,김영돈,김민호,김은희,권지란,박광식,이길홍,민병근 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.4

The purpose of the present study was to examine the relationship between their problem behavioral pattern and anxious trends among Korean student adolescent. Zung's measurement of anxiety level undergone through used of the self-rating anxiety scale. the data were collected through the questionaire survey which was conducted on Dec.1, 1983. Subjects served for this atudy consisted of 1,404 syudents in Korea, randomly sampled from Korean student population by means of census method. The data were analysed by CDC-174 computer of KAIST, using SPSS pogram. Statistical methods empoyed were χ^2 test and Eta measures. the results of this study were as follows. 1. It showed that students psychological anxious trends had greatest significant correlation with adolescent student's problem brhavioral pattern, but the cardiovascular, respiratory, gastrointestional and genitourinary anxious trends has not significantly related with student's problem behavioral pattern. 2. Students group with undersocialized aggressive, undersocialized nonaggressive,undersocialized school-norm avoidant, or socialized nonaggressive behavioral patterns were less anxious, whereas those with socialized latent aggressive, socialized sexual, or socialized modellong behavioral patterns were higher anxious.

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.

말기신부전 환자에서 혈액투석 전후의 QT간격분산 비교

강대웅,정지용,윤나라,안치용,김종오,신병철,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Background: Some cases of QT interval, corrected QT interval (QTc), QT dispersion (QTd) and corrected QT dispersion (QTcd) have been reported in ESRD, but these results are variable and the influence of a hemodialysis is still controversial, In this study, we investigated the effect of hemodialysis on QT and QTc interval and QT and QTc dispersion in patients with ESRD 15 min before and 15 minute after each hemodialysis. Methods: Sixty-seven patients with ESRD (men 33 & women 34) on three-times stable hemodialysis (>3 months) were randomly enrolled. Fifty control subjects with a similar age and normal renal function were enrolled from this hospital. Routine biochemical studies were measured pre- and post dialysis, at the time of the ECG. Plasma Na+, K+, BUN, creatinine, ionized calcium and phosphate were checked. Twelve-lead electrocardiographs were performed at 10㎜/mv and 50㎜/s using a HewIett-Packard Pagewriter 100, before and after a single hemodialysis session.The QT interval was measured from the onset of the QRS complex to the end of the T wave. If the end of the T wave was not clear in a particular lead then it was excluded from analysis. When U waves were present, the end of the T wave was taken as the nadir between the T and U waves. Each QT interval was corrected for heart rate using Bazett's formula (QTc==QT/√(RR)) (ms). The difference between maximal and minimal QT interval duration was defined as QT dispersion (QTd) in each of the 12 leads. Result: This study demonstrates that QT, QTd, QTcd is higher in hemodialysis patients compared with control subjects, and QT and QTd rise postdialysis to levels comparable to those seen acutely following myocardial infarction, when patients are at greatly increased risk of potentially fatal ventricular arrhythmias, Conclusions: QT interval and QT dispersion, markers of risk for arrhythmias and sudden death, are elevated in hemodialysis patients, and rise postdialysis. QT interval and QT dispersion is an easily obtainable, noninvasive, simple, inexpensive, and widely available method of risk stratification in uremic patients receiving chronic dialysis. Additional studies are needed to clarity whether increased postdialysis QT dispersion results in an increased occurrence of arrhythmias.

혈액투석중인 말기신부전 환자에서 Fludrocortisone acetate (FCA) 투여 후 혈청 칼륨 저하 효과

류봉관,강대웅,정지용,윤나라,신병철,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background: Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (fludrocortisono acetate) on serum potassium level in the serum of hyperkalemic end-stage renal disease patients. Methods: Fourteen patients on hemodialysis receiving fludrocortisone acetate (FCA) 0.1 mg/day were observed for 2 months periods. Consecutive monthly biochemical profiles were compared for the druration of the pre-and post-treatment of FCA. Result: Fourteen patients with mean age (±SE) of 51.5 years (4 males and 10 females) and mean hemodialysis period of 51.9 months were studied. Mean serum potassium levels significantly fell (p<0.05) during the post-FCA period (5.2±0.66 mEq/L) compared with potassium levels during the pre-FCA (5.8±0.43 mEq/L) period. Pre-and post-FCA values were not different for sodium, chloride, protein, albumin, AST/ALT, glucose, blood nitrogen, creatinine, phosphate and calcium. Conclusions: FCA appears to decrease serum potassium value in patients with end-stage renal disease. These results suggested that FCA could be effective to treat hyperkalemia without any adverse effect in patients undergoing hemodialysis.

이뇨제를 사용한 급성 신손상 환자에서 FEUrea의 진단적 유용성

임대훈 ( Dae Hun Lim ),정지민 ( Ji Min Jeong ),오슬현 ( Seul Hyun Oh ),이형철 ( Hyung Chul Lee ),최준석 ( Joon Suk Choi ),김민지 ( Min Jee Kim ),박정우 ( Jeong Woo Park ),배은희 ( Eun Hui Bae ),마성권 ( Seong Kwon Ma ),김남호 ( Na 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.3

목적: 임상적으로 FENa가 일과성 신손상 (T-AKI)과 지속성 신손상 (P-AKI)을 감별하는 데 많이 사용되지만 이뇨제를 사용한 환자에서 FENa는 유효 혈류량 결핍 상태에서도 증가하게 되어 진단적 정확성이 떨어진다고 알려져 있다. 본 연구에서는 이뇨제 투여상황에서 FE(Na)와 비교하여 FE(Urea)의 진단적 유용성에 대하여 알아보고자 하였다. 방법: 107명의 급성 신손상 환자를 임상적 특성에 따라 일과성과 지속성 신손상 군으로 나누고 이를 다시 이뇨제 투여 유무에 따라 재분류하였다. ROC 곡선에 따라 계산된 cutoff value에 따라서 일과성 신손상을 정의하였고 이뇨제 투여로 인한 cutoff value의 변화에 따른 민감도와 특이도를 비교하였다. 결과: AKI가 발생한 107명의 모든 환자중 검사 이전에 경험적으로 이뇨제를 사용한 경우가 67명으로 63%를 보였고, 일과성 신손상군의 경우는 52명 중 27명으로 52%를, 지속성 신손상군의 경우는 55명 중 45명으로 73%를 보였다. ROC curve에 따라 cutoff value를 FE(Na)≤1.5 FE(Urea)≤30으로 하였을 때 T-AKI를 진단하는 데 사용된 두 값의 민감도와 특이도는 모든 환자군에서 FE(Na)가 81%, 98%를, FE(Urea) 가 94%, 82%를 보였다. 이뇨제 비투여군에서는 FE(Na)가 96 %, 100%를, FEUrea가 92%, 87%를 보였으며, 이뇨제 투여군에서는 FE(Na)가 63%, 98%를, FE(Urea)가 96%, 83%를 보였다. 결론: 이뇨제를 사용한 경우 P-AKI를 진단하는데 FE(Urea)도 FE(Na) 정도의 진단적 유용성을 가진다. Purpose: Although fractional excretion of sodium (FE(Na)) has been used to distinguish transient-acute kidney injury (T-AKI) from persistent-AKI (P-AKI), the availability of FE(Na) in the diagnosis of T-AKI is reported low in patients with diuretics use. We compared the diagnostic performance of fractional excretion of urea (FE(Urea)) with that of FE(Na) in patients with diuretics use. Methods: One hundred seven AKI patients were classified as having T-AKIor P-AKI according to the clinical context. Each group was again subdivided according to exposure to diuretics. According to the cut off value generated by receiver operating characteristic (ROC) curves, sensitivity and specificity of FE(Na) and FE(Urea) were compared with each other. Results: The numbers of patients administered with diuretics were 67 out of total 107 AKI patients (63%), 27 out of 52 (52%) of T-AKI patients, and 40 out of total (65) 55 (73%) of P-AKI patients. When the cutoff value of T-AKI was defined as FE(Na) ≤1.5 and FE(Urea) ≤30 according to the ROC curves, sensitivity and specificity of FE(Na) were 96% and 100% in non-diuretics group, and 63% and 98% in diuretics group, respectively. Sensitivity and specificity of FE(Urea) were 92% and 87% in non-diuretics group, and 96% and 83% in diuretics group, respectively. Conclusion: FE(Urea) is as good as FE(Na) at distinguishing T-AKI from P-AKI in patients administered with diuretics.

The Korean Society of Gastroenterology & SIDDS 2046 : Slide Session ;K-LG-17 : Lower GI Tract ; The Characteristics of Advanced Colorectal Neoplasias in Patients with Positive Fecal Immunochemical Test: A Retrospective Case-Control Study

( Ji Hun Na ),( Hong Jun Park ),( Hyun Soo Kim ),( Hee Man Kim ),( Jae Woo Kim ),( Kyong Joo Lee ),( Jae Hyun Kim ),( Hyun Sik Kim ),( Ji Su Lee ),( Han Nah Jo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The aim of this study was to evaluate the characteristics of advanced colorectal neoplasias in asymptomatic subjects with positive fecal immunochemical test(fiT) Methods: A total of 378 subjects who have undergone colonoscopy were enrolled as fiT positive group. In addition, a total of 378, age-sex matched subjects with negative fiT who have undergone colonoscopy were recruited as well as a control group. Results: Among a total of 756 subjects, 350 subjects had one or more adenomas. On per polyp analysis, a total of 783 colorectal neoplasias were found in both group (448 in fiT (-) vs. 335 in fiT (+), p=0.022). Cancers, HAA and large adenomas more than 10 mm in size were more frequently found in fiT positive group (figure 1). Interestingly, among adenomas more than 10 mm in size, adenomas with advanced histology including HGD or cancer were equally found in both groups (41.4% in fiT (-) vs. 48.9% in fiT (+), p=0.527). However, adenomas less than 9 mm in size with advanced histology including HGD or cancer were signifi cantly more frequent in fiT positive group than those in fiT negative group (7.6% vs. 0.7%, p<0.001, respectively). The site specifi c performance of fiT (right vs. left) for detecting AAs was not different between both groups (p=0.079). Conclusions: Compared to those with fiT negative, asymptomatic subjects with fiT positive on colorectal cancer screening showed similar non-advanced adenomas but higher advanced histologies even a small sized lesion. These results suggest the necessity of more rapid and complete resection for lesion found in asymptomatic subjects with fiT positive lesion. This study was supported by a grant from the National R&D Program for Cancer

Increased hCTLA4-Ig production by regulating feeding time of 4-phenylbutyrate in CHO cell cultures

Ji-hun LEE,Jin-hyuk LIM,Ji-hee LEE,Na-hee KIM,Hye-jin HAN,Dong-il KIM 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.10

Insect Pollinators use in Cypripedium japonicum Thunb.

Ji Hun Na,Jong Chul Jeong,Gun Hye Gang,Jae Hwan Gwon 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04

덕유산국립공원 내 멸종위기 야생생물 Ⅰ급 광릉요강꽃(Cypripedium japonicum Thunb.)의 자생지 보전과 복원기초자 료 축적을 위해 개화기에 찾아오는 곤충을 조사하였다. 그 결과, 5개목 19과 26종의 곤충이 관찰되었지만 꽃 내부로 출입하는 곤충은 벌목 뿐 이었다. 광릉요강꽃 구조상 화분 매개를 위해서는 우수리뒤영벌(Bombus ussurensis)과 호박벌(Bombus ignitus)과 같은 몸체의 두께가 1cm 내외의 꿀벌과가 효과적이다. 그렇지만 꿀벌과 곤충은 꽃이 질 무렵(5월 18일 이후)부터 관찰되었으며, 꽃 내부로 출입하는 비율은 14.3%로 다른 과(Family)에 비해 낮게 나타났다. 광릉요강꽃의 자연수정률이 낮은 원인으로 화분매개곤충의 활동시기와 개화시기가 일치하지 않는 점으로 여겨지 는 바, 개화시기와 화분매개곤충의 유효적산온도와의 상관관계를 연구할 필요가 있다. 더불어 새순이 날 때 진딧물류, 수정된 씨방에서 굴파리(Ophiomyia sp.)가 발견되어 결실율을 높이기 위해서는 이들의 기주식물을 조사해 자생지에서 격리 및 타 기주 내 방제방법 연구가 필요하다.

Increased Biomass Accumulation of Phosphate in MBR Process with Reduced Sludge Production

Ji-Hun Na,Duck-Hyun Nam,Byeong-Gon Ko,Chae-Young Lee,Ki-Hoon Kang 대한환경공학회 2015 대한환경공학회 학술발표논문집 Vol.2015 No.10

Enhancing hCTLA4-Ig productivity by controlling the feeding time of 4-phenylbutyrate in CHO cell cultures

Ji-Hun LEE,Hyun-Myoung CHA,Jin-Hyuk LIM,Ji-Hee LEE,Na-Hee KIM,Dong-Il KIM 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.4