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조광현,성경제,이창우 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.2
Direct immunofluorescent (DIF) starining was performed on biopsy specimens from four patients with pityraasis lichenoides chronica. Deposits of IgM and C3 were foundin the dermal vessel walls of the lesional skin in two patients with pityriasis lichenoides chronic. Deposition of C3 and cytoid bodies were detected along the dermo-epidermal junction in one patient. This supports the view that deposition of immune complexes may play a part in the pathogenesis of pityriasis lichenoides chronica.
S - 100α 및 β 단백질에 대한 단세포군 항체를 이용한 한선종양의 면역조직화학연구
성경제(Kyung Jeh Sung),조광현(Kwang Hyun Cho),서호석(Ho Seok Suh),최지호(Jee Ho Choi),고재경(Jai Kyoung Koh) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4
S-100 protein is a mixture of three proteins, that is, S-100 ao(aa), S-100 a(ab) and, S- 100 b(bb). Twenty-two case, of sweat gland tumors were stained with immunoperoxidase technique (ABC method) for the presence of S-100a and b-subunit. Four syringomas, four eccrine poromas, two eccrine porocarcinomas, two ecerine spirdeiomas, one papillary eccrine adenoma, three clear cell hidradenomas, three mixed tumr rs of the skin, two papillary syringocystadenomas, and one cylindroma were included. All specimens were formalin-fixed and paraffin-embedded. The results were as follows : 1) The staining patterns of anti-S-100a and b-protein antibodies we e simillar to those of anti-S-100 protein antibody except in eccrine poroma and porocare nomal. 2) In eccrine poroma and porocarcinoma, scattered S-100-positive dendritic cells within tumor cell nests were stained by S-100-protein antibody (3/6), but not by anti-S-100a protein antibody. S-100p is present in normal Langerhans cells. Therefore this finding suggests that these cells niay be Langerhans cells. (Kor J Dermatol 1992;30(4):446-453)
성경제(Kyung Jeh Sung),조광현(Kwang Hyun Cho),정홍근(Hong Keun Chung),김성범(Sung Bum Kim),최지호(Jee Ho Choi),고재경(Jai Kyoung Koh) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3
The histogenesis and differentiation of sweat gland tumors are controversial. Twenty-two cases of sweat gland tumors were stained by immunoperoxidase technique (ABC method) for the presence of S-100 protein, CEA, and two kinds of keratin. Four syringomas, 4 eccrine poromas, 2 eccrine porocarcinomas, 2 eccrine spiradenomas, 1 papillary eccrine adenoma, 3 clear cell hidradenomas, 3 mixed tumors of skin, 2 papillary syringocystadenomas, and 1 cylindroma were included. All samples were formalin-fixed and paraffin-erribedded. Two monoclonal cytokeratin ant.ibodies, MA-902 (specific for cytokeratin No. 8) and MA-903 (specific for cytokeratins No.1,5,10,11) were used. In normal eccrine and apocrine glands, MA-902 stains cells of the intradermal duct and secretory portion. While MA-903 stains cells of the intraepidermal and intradermal duct and myoepithelial cells of eccine and apocrine glands, S-100 protein is found in the secretory cells of the intradermalduct and secretory portion, while CEA stains the secretory and ductal cells of eccrine and apocrine glands. All sweat gland tumors we studied stained by 4 antibodies in variable positive rates, Based on these findings, we discuss the histogenesis of various sweat gland tumors. (Kor J Dermatol 1992; 30(3): 303-316)
최지호(Jee Ho Choi),조광현(Kwang Hyun Cho),류병직(byung Jick Ryu),성경제(Kyoung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.5
Background : A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens, Objective : Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases. Method : We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases. Results : S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas. Conclusion : These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system. (Kor J Dermatol 1993;31(5):702-712)
건강성인에서 성별 및 연령별 혈청지질의 정상치 - 특히 이상지혈증의 빈도를 중심으로 -
권삼(Sam Gweon),구성모(Seong Mo Koo),조봉기(Bong Kee Cho),정기제(Gih Jeh Jeong),이중기(Choong Ki Lee),정의룡(Eui Ryong Cheong),류재근(Jae Kean Ryu),이봉렬(Bong Ryeol Lee),채성철(Shung Chull Chae),전재은(Jae Eun Jun),박의현(Wee Hyun 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A mg/dl) in men and women was 36.8 and 44.0%, respectively and that of high LDL-cholesterol(≥160 mg/dl) was 26.6% in men and 35.2% in women. Their frequencies were increased with age in both sexes. 4) There were no significant, differences in the mean values of total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol and atherogenic index by residency. The frequency of high total cholesterol(≥200mg/dl) in Taegu and its rural area was 40.7% and 35.5%, respectively. Conclusion: These findings suggest that the mean concentrations of total cholesterol, triglyceride and LDL-cholesterol in men and women vary with age. The frequency of hypercholesterolemia (≥200 mg/dl) in men and women was about 40%, and increased with age. Values of HDL-cholesterol were not affected by age and sex