늑막삼출 환자에서 혈청과 늑막액의 Adenosine Deaminase ( ADA ) 와 Lysozyme 활성치의 임상적 의의

이재익(Jae Yik Lee),박종선(Jong Seon Park),유영훈(Young Hoon Yuh),이정미(Jung Mee Lee),이두하(Du Ha Lee),노진우(Jin Woo Roh),이충기(Choong Ki Lee),정진홍(Jin Hong Chung),이관호(Kwan Ho Lee),이현우(Hyun Woo Lee) 대한내과학회 1991 대한내과학회지 Vol.41 No.5

N/A To evaluate the diagnoostic value of ADA and lysozyme activity of serum and pleural fluid, we measured the ADA and lysozyme activity of serum and pleural effusions in 50 cases of pleural effusions due to tuberculosis (n=33), malignancy (n=13), and congestive heart failure (n=4). The results were as follows: 1) The mean value of serum ADA activity of tubercu-lous effusion was 45.533,3 U/L and was significantly higher than that of nontuberculous effusion(p<0,05). 2) The mean value of pleural ADA activity of tuber-culous effusion was 11.7±47.9 U/L and was significantly higher than that of nontuberculous effusion(p<0.005). 3) The mean value of the pleural and serum ADA ratio of tuberculous effusion was 2.9±1.4 and was significantly higher than that of nontuberculous effusion (p<0.05). 4) The serum lysozyme activity was not significant between tuberculous and nontuberculous effusions. 5) The mean value of pleural lysozyme activity of the tuberculous effusion was 18.0±10.3 μg/ml and was significantly higher than that of nontuberculous effusion. 6) The mean value of the pleural and serum lysozyme ratio of tuberculous effusion was 1.8±1.1 and was significantly higher than that of nontuberculous effusion. The ratio above 1.2 had a sensitivity of 70% and a specificity of 100% when used as a screening test for tuberculous effusion compared with malignant effusion. In conculusion, the measurements of serum and pleural ADA, lysozyme and their ratios were useful in the differential diagnosis between the tuberculous and nontuberculous pleural effusions.

S-426 Association between Nailfold Capillary Abnormalities and Diabetic Nephropathy in Type 2 Diabetes

( Jae Yik Lee ),( Sang Joon Park ),( Jae Hyuk Lee ),( Mi Kyung Kwak ),( Hye Jeong Kim ),( Dong Won Byun ),( Kyo Il Suh ),( Myung Hi Yoo ),( Hyun Sook Kim ),( Hyeong Kyu Park ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Introduction: Several capillary changes detected by finger nailfold capillaroscopy have been shown to correlate with microvascular complications in type 1 diabetes. However, there are few reports on the relationship between nailfold capillary abnormalities and microvascular complications in type 2 diabetes (T2DM). Herein, we investigated whether nailfold capillary microscopic changes are associated with diabetic nephropathy in patients with T2DM. Methods: We conducted a cross-sectional study in patients with T2DM diagnosed within 20 years (duration of diabetes: 6.4±6.0 years). The nailfold capillaroscopy can visualize the capillary network in fingers and is a non-invasive test. The presence of morphological abnormalities, including avascular areas, giant capillaries, dilated, tortuous, or ramified capillaries, hemorrhages and capillary architectural derangements, in finger nailfold capillaroscopy image was assessed by a single rheumatology specialist. The severity of nailfold capillary change (0 : no change, 1 : capillary change/mm <33%, 2 : capillary change/mm between 33-66%, 3 : capillary change/mm >66%) was scored. Statistical analyses were performed using Pearson correlation or Spearman rank correlation as appropriate Results: A total of 63 patients with T2DM were enrolled. Both capillary architectural derangements and avascular areas in nailfold capillaroscopy showed significant correlations with albuminuria measured by spot urine or 24-hour urine collection after adjusting for sex, age, body mass index, duration of diabetes, hemoglobin, and HbA1C. Moreover, architectural derangements and avascular areas in nailfold capillaries were significantly associated with urinary albumin excretion rate in T2DM patients diagnosed within 10 years. Conclusions: These findings have shown that nailfold capillary abnormalities are independently associated with albuminuria in patients with T2DM of moderate duration, suggesting a role of capillary changes in the pathogenesis of diabetic nephropthy.

Development of Field Joining Method for Micro-Pile

Lee Jae-Yik(이재익),Noh Myung-Hyun(노명현),An Dong-Wook(안동욱),Chang Kyung-Ho(정경호) 한국지반신소재학회 2015 한국토목섬유학회 학술발표회 Vol.2015 No.4

해양구조물 장수명화를 위한 효과적 방식 시스템

이재익(Jae-Yik, Lee),박종원(Jong-Won, Park),임성우(Sungwoo, Im) 한국해양환경·에너지학회 2013 한국해양환경공학회 학술대회논문집 Vol.2013 No.11

9%Ni강 용접에 발생되는 과도변형율의 특성

이재익(Jae-Yik Lee),노명현(Myung-Hyun Noh),김응수(Eung-Soo Kim) 대한용접·접합학회 2019 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2019 No.5

부유식 해상풍력발전시스템의 현수준

이재익(Jae Yik Lee) 한국강구조학회 2014 韓國鋼構造學會誌 Vol.26 No.6

Diagnostic Value of AFP, AFP-L3, and PIVKA-II and Their Combinations for Hepatocellular Carcinoma: Single center, Case-control Study

( Sang Joon Park ),( Woo Jin Jung ),( Jae Yik Lee ),( Hee Jeong Lee ),( Jae Young Jang ),( Soung Won Jeong ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang-woo Cha ),( Young Seok Kim ),( Young Deok Cho ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Background and Aim: Alpha-fetoprotein (AFP), Lens culinaris agglutinin- reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for diagnosis of hepatocellular carcinoma. This study aimed to perform a head-to-head comparison of the diagnostic value of AFP, AFP-L3 and PIVKA-II as single or in combination to find the best biomarker or panel. Methods: Seventy nine patients with newly diagnosed HCC and 77 non-HCC liver cirrhosis control patients were enrolled. Plasma AFP, AFP-L3, PIVKA-II levels were measured by ELISA, and receiver operating characteristic curve analyses were performed for each biomarker and for every combination of the markers. Results: Among three single biomarkers, AFP showed the highest area under the curve (0.751, 95 % confidence interval0.683-0.818). The diagnostic performance (sensitivity/specificity) of each single biomarker was 68.35 %/81.82 % with AFP (AFP>40 ng/mL), 70.89 %/70.13 % with PIVKA-II (PIVKA-II > 40 mAU/mL), and 50.63 %/83.12 % with AFP-L3 (AFP-L3>10 %), respectively. In case of combination of the biomarkers, ‘PIVKA-II > 40 mAU/mLand AFP>40 ng/mL’ showed the highest AUC (0.765, 95 % CI:0.708-0.823), and its sensitivity and specificity were 55.70 % and 97.40 % each. Compared with combination of ‘PIVKA-II > 40mAU/mL and AFP>40 ng/mL and AFP-L3>10 %’ (sensitivity 40.51 %, specificity 98.70 %, AUC 0.696), it had better sensitivity (55.70 % vs. 40.51 %, p=0.001) and AUC (0.765 vs. 0.696, p=0.001) and similar specificity (97.40 %vs. 98.70 %, p=0.001). The combination of ‘PIVKA-II > 40 mAU/mLor AFP>40 ng/mL or AFP-L3>10 %’ showed the highest sensitivity (sensitivity 84.81 %, specificity 51.95 %, AUC 0.684), but compared to combination of ‘PIVKA-II > 40 mAU/mLor AFP>40 ng/mL’(sensitivity 83.54 %, specificity 54.55 %, AUC 0.690), there is no statistical significant difference ( p=0.549). Conclusions: AFP showed the best diagnostic performance as a single biomarker for diagnosing HCC. Furthermore, when AFP combined with PIVKA-II, its diagnostic value could be maximized. However, AFP-L3 did not contribute to distinguish between HCC and non-HCC liver cirrhosis.

일부 공단주변 국민학생의 뇨중 중금속 함량에 관한 연구

이재형,손위익,황인담 의과학연구소 1987 全北醫大論文集 Vol.11 No.3

This study was to analyse the levels of heavy metals in the urine of school children living in the industrial areas and to compare the results with those of agricultural areas. Kinds of analysed heavy metals were lead, cadmium, copper and zinc. The sample collection and analysis were done from September to December in 1986 from 7 to 9 years old children in Seoul(47 cases), Iri(64 cases) industrial areas and Chinan(56 cases) agricultural area. The results were as follows : 1) The concentrations of urinary lead were 28.7±17.7 ug/I in Seoul, 25.3±7.5 ug/I in Iri and 19.3±5.2 ug/I in Chinan. 2) The concentrations of urinary cadmium were 1.5±0.8 ug/I in Seoul, 1.4±0.5 ug/I in Iri, and 0.9±0.3 ug/I in Chinan. 3) The concentrations of urinary copper were 12.8±7.0 ug/I in Seoul, 10.5±8.4 ug/I in Iri, and 10.0±4.5 ug/I in chinan. 4) The concentrations of urinary zinc were 383±279 ug/I in Seoul, 329±133 ug/I in Iri, and 267±181 ug/I in Chinan. 5) In lead, cadmium and zinc concentrations of children, there were statistical differences between the industrial area and the agricultural area. 6) There were no statistically significant difference between the sex. 서울 구로공단지역 47명, 전북 이리 공단지역 64명, 진안 농업지역 56명, 총167명의 7~9세까지의 조사 가능한 어린이를 대상으로 뇨중 중금속 합량을 원자흡광도법으로 분석하여 다음과 같은 결과를 얻었다. 1. 납의 평균농도는 서울 28.7±18.6㎍/ℓ, 이리 25.3±7.5㎍/ℓ, 진안 19.3±5.2㎍/ℓ로 서울과 이리 지역이 진안 지역보다 높았다(p<0.01). 2. 카드뮴의 평균 농도는 서울 1.5±0.8㎍/ℓ, 이리 1.5±0.5㎍/ℓ, 진안 0.9±0.3㎍/ℓ로 서울과 이리 지역이 진안 지역보다 높았다(p<0.01). 3. 구리의 평균 농도는 서울 12.8±7.0㎍/ℓ, 이리 10.5±8.4㎍/ℓ, 진안 10.0±4.5㎍/ℓ로 서울과 이리 지역이 높았으나 통계학적 유의성은 없었다. 4. 아연의 평균 농도는 서울 383±279㎍/ℓ, 이리 329>133㎍/ℓ, 진안 267±181㎍/ℓ로 서울과 이리 지역이 진안 지역보다 높았다(p<0.05). 5. 남녀별 농도 차이는 남자에서 높았으나 통계학적 유의성은 없었다.

서맥 의존성 완전 방실차단 1례

이재익,김영조,심봉섭,이현우 영남대학교 의과대학 1989 Yeungnam University Journal of Medicine Vol.6 No.2

저자들은 안정 와위시 완전 방실차단을 보이고, 좌위로 체위변동과 아트로핀 투여로 야기된 빈맥시 1도 방실차단으로 호전된 서맥의존성 방실차단의 예를 경험하였으며, 인공심박조율기로 효과적으로 치료하였기에 문헌고찰과 함께 보고하는 바이다. Induction of A-V block by tachycardia is a well-known phenomenon. But there are few case reports of bradycardia-dependent A-V block. We report a case of bradycardia-dependent A-V block with review of literatures. This patient was a 52-year-old female who complained of dizziness and anterior chest discomfort. Electrocardiographic recording demonstrated complete A-V block. Monitor electrocardiographic recordings during sitting position and after atropine administration demonstrated decrease of degree of block from complete A-V block to first degree A-V block. The occurrence of complete A-V block for bradycardia during supine position suggests a phase 4-dependent block. After a permanent ventricular pacemaker was implanted, the patient recovered and was without symptoms during 12 months follow up.

상온접합 본딩이 있는 복합재 날개의 저온 구조시험

하재석(Jae Seok Ha),박찬익(Chan Yik Park),이기범(Kee Bhum Lee) 한국항공우주학회 2015 韓國航空宇宙學會誌 Vol.43 No.10

본 논문에서는 상온접합이 있는 무인기 복합재 날개의 저온 구조시험에 대하여 소개하였다. 본 시험에 사용된 날개구조는 탄소섬유 강화 복합재료로 구성되며, 내부 구조물과 스킨은 상온접착제로 접합되었다. 또한 날개구조의 손상허용성을 검증하기 위하여 육안으로 확인이 거의 불가능한 충격손상을 스킨의 주요 부위에 인위적으로 적용하였다. 무인기 운용 고도의 온도환경을 모사하기 위한 저온 챔버를 특별히 제작하였으며, 날개구조는 챔버내에 고정시키고 챔버 외부에 설치한 유압 작동기를 이용하여 하중을 부가하였다. 구조시험은 변형률 개관시험 및 1배 수명 피로하중 스펙트럼에 대한 손상허용시험으로 구성된다. 변형률 게이지와 광섬유 센서를 이용하여 본딩영역 및 주요 부위의 변형률을 측정하였으며, 압전 구동기/센서를 이용하여 손상의 변화를 모니터링 하였다. 시험결과로부터 날개구조는 1배 수명에 대한 운용환경을 모사한 환경 하에서 구조적 건전성을 보유하고 있음을 확인하였다. This paper presents low temperature structural tests of a UAV wing which has room temperature-curing adhesive bond. The wing structure is made of carbon fiber reinforced composites, and the skins are bonded to the inner structures (such as ribs and spars) using room temperature-curing adhesive bond. Also, to verify damage tolerance design of the wing structure, barely visible impact damages are intentionally created in the critical areas. The attachment fittings of the wing are fixed in a specially designed chamber which can simulate the low temperature environments of the operating altitudes. The test load is applied by hydraulic actuators which are placed outside the chamber. The structural tests consist of strain survey tests and a durability test for 1-life fatigue load spectrum. During the tests, strains of major parts are measured by strain gauges and FBG sensors. The change of the initial impact damages is also monitored using piezoelectric sensors. The 1-life damage tolerance of the composite structure is verified by the structural tests under the simulated environments.