http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
난치성 급성 혼합형 백혈병 환자에 동반된 수포성 괴저성 농피증 1예
강희정,이재련,이경희,현명수,신동훈,박진우,조희순 대한내과학회 2004 대한내과학회지 Vol.66 No.2
괴저성 농피증(pyoderma gangrenosum)은 드물게 발생하는 궤양성 피부질환으로 반수이상에서 궤양성 대장염, 류마티스성 관절염, 코론병, 만성 활동성간염 및 백혈병 같은 전신질환을 동반한다. 저자들은 난치성 급성 혼합형 백혈병에 동반한 수포성 괴저성 농피증의 드문 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated acute leukemia. We report a case of pyoderma gangrenosum associated refractory acute biphenotypic leukemia wherein the malignant cells show a phenotype specific for myelogenous and lymphocytic leukemia. Histopathologic examination revealed moderate perivascular infiltrate consisting mainly of neutrophils and lymphocytes without involvement of leukemic cells in the skin lesions. Treatment with systemic steroid was followed by a characteristically rapid healing of the skin lesions.
이재련(Jae Lyun Lee),신창진(Chang Jin Shin),강희정(Hee Jeong Kang),오현아(Hyun Ah Oh),이구(Gu Lee),최재혁(Jae Hyuk Choi),배성화(Sung Hwa Bae),이경희(Kyung Hee Lee),현명수(Myung Soo Hyun),신세원(Sei One Shin),류헌모(Hyun Mo Ryoo) 대한내과학회 2002 대한내과학회지 Vol.62 No.4
목적 : 전이성 뇌종양은 성인 악성 종양환자의 흔한 합병증이다. 저자 등은 전이성 뇌종양의 임상적인 특징, 치료 효과, 생존에 영향을 미치는 예후 인자를 알아보고자 하였다. 대상 및 방법 : 1991년 1월부터 1997년 12월까지 본원에서 전이성 뇌종양으로 진단 받은 97예의 환자를 대상으로 하여 후향적으로 분석하였다. 결과 : 뇌전이의 원발종양으로는 폐암 (61예, 63%)이 가장 흔하였으며 그 외 원발 불명 전이성 뇌암 (15예, 16%), 위장관암 (13예, 13%), 유방암 (6예, 6%), 신장암 (2예, 2%) 순이었다. 단일성 뇌전이는 44예 (45%)였으며 다발성 뇌전이는 53예 (55%)였다. 치료 유무 및 종류를 고려하지 않을 경우 중앙생존기간은 3개월이었으며 1년 생존율은 8%였다. 생존율에 영향을 미치는 유의한 예후인자로는 진단당시 활동능과 신경손상의 정도 (p< 0.01)였다. 어떠한 치료도 시행하지 않는 군에 비해 스테로이드를 포함한 치료를 시행한 군에서 유의한 생존기간의 증가를 관찰할 수 있었다 (1.1개월 대 3.7개월). 스테로이드 단독 치료에 비해 전뇌 방사선 조사를 추가한 군에서 유의하게 생존기간이 연장되었다 (2.2개월 대 4.8개월). 추가적인 항암화학요법은 유의한 생존기간의 향상을 가져오지는 못하였다. 수술적 절제술을 시행한 군의 중앙생존기간은 8.8개월로 스테로이드와 전뇌 방사선치료만 시행한 군에 비해 유의한 생존기간의 증가를 보였다. 결론 : 전이성 뇌종양 환자에서 전뇌 방사선치료와 스테로이드는 유용한 완화치료 방법이며 진단 당시 활동능과 신경손상의 정도가 중요한 예후 인자로 분석되었다. 후향적인 연구로 인해 결과 해석에 한계가 있으나 수술적 절제 및 항암화학요법이 일부 선택된 환자 치료시 중요한 수단이 될 것으로 사료된다. Background : Brain metastasis is a common complication in cancer patients. We evaluated the clinical characteristics, treatment outcome and prognostic factors for patients with metastatic brain tumor. Methods : The records of 97 patients with metastatic brain tumor during the period from January 1991 to November 1997 were reviewed retrospectively. Results : The most common primary tumor is lung cancer (61 cases, 63%) followed by metastatic cancer unknown primary site (15 cases, 16%), gastrointestinal cancer (13 cases, 13%), breast cancer (6 cases, 6%) and renal cancer (2 cases, 2%). There were 44 patients with a single brain metastasis and 53 patients with multiple brain metastases. The median survival was 3.0 months and one-year survival rate was 8% irrespective of treatment. Favorable prognostic factors which affect survival were ambulatory status (p<0.01) and functional neurologic class 1, 2 (p<0.01). Median survival was 3.7 months for patients with steroid therapy and 1.1 months with no therapy (p<0.01). Median survival was 4.8 months for patients with steroid therapy plus whole brain radiotherapy (WBRT) and 2.2 months with steroid therapy alone (p<0.01). Additional chemotherapy did not appear to affect the survival. The patients treated with surgery had median survival time of 8.8 months compared with 2.5 months for patients treated with steroid therapy plus WBRT (p<0.05). Conclusion : In present study, we confirmed that whole brain irradiation and corticosteroid administration are effective palliative treatment for patients with metastatic brain tumor. Initial performance status and neurological function were identified as important prognostic factors. Although confounded by the limitations of retrospective study, more aggressive treatments including surgery and chemotherapy could be regarded to have a significant role to achieve better treatment outcome in some selected cases.(Korean J Med 62:444-452, 2002)
이헌주(Heon Ju Lee),이재련(Jae Lyun Lee),이재춘(Jae Chun Lee),이은정(Eun Jung Lee),김기범(Ki Beom Kim),임상우(Sang Woo Lim),이동준(Dong Jun Lee),전경진(Kyeoung Jin Jeon),조영복(Young Bog Cho),도갑석(Gab Suk Doh),서정일(Jeong Ill Suh) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: 80-90% of the cases of hepatocellular carcinoma(HCC) are associated with cirrhosis. Hepatitis B virus(HBV) is known as a major etiologic factor of HCC and about 10% of Koreans are HBV carriers. And the prevalence of HCC is high in Korea. Early detection of HCC is important for the better treatment especially in the patients with cirrhosis who usually have the decreased functional hepatic reserve. Risk factors for the hepatocellular carcinoma in the korean patients with cirrhosis were evaluated. Methods: Risk factors for hepatocellular carcinogenisis such as age, sex, ascites, alcohol, HBsAg, anti-HCV, AFP, ICG R(15) and risk score were investigated among the 176 patients with cirrhosis and HCC(group I) and 72 patients with cirrhosis(group II) and compared between the two groups. Results: 1) No age difference was noted between group I and group II. 2) Male to female sex ratio were 5.7: 1 and 2.4: 1 for group I and II in each(p<0.01) and the frequency of HCC among cirrhosis was higher in male than female sex(p<0.01). 3) Both HBsAg and anti-HCV positivity were significantly higher in group I than in group II (p<0.01 and p<0.05 respectively). 4) The frequencies of Child-Pugh A, elevated AFP, elevated ICG R(15) and the frequency of super-high risk patient were higher in group I than in group II(p<0.01). 5) The frequency of alcoholic patients was significantly higher in group II than in group I (p<0.05) but no difference was noted between HBsAg positive group I and group II patients. 6) The frequency of abnormal AST with the level of below 100IU was not significantly different between group I and group II. 7) The frequency of the patients with ascites was higher in group II than in group I (p<0.01). Conclusion: Risk factors for hepatocellular carcinogenesis in korean patients with cirrhosis are male, Child-Pugh A, HBsAg positivity, anti-HCV positivity, absence of ascites, higher AFP, lower ICG R15 and higher platelet count.
이석호,손희정,이규택,김재준,강인구,백승운,이종균,이준혁,고광철,이풍렬,오성윤,이종철,최규완,오영륜 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.4
Amyloidosis is characterized by deposition of amyloid, which is resistant to proteolysis & phagocytosis, in intercellular spaces & vascular walls. The amyloid deposition provokes dysfunction of an accumulated organ & displays variable clinical symptoms depending upon the involved organ. A diagnosis is rendered through a biopsy of the affected organ, followed by staining using congo red which reveals an apple greenish refractile birefringence via polarizing microscopy. Using an electro-microscopy specific filaments can be found. Amyloidosis is classified into primary amyloidosis, composed of light chain filaments (AL) and secondary amyloidosis, comprised of A protain (AA). The AL type of amyloidosis shows deposition of amyloid in muscularis mucosa & muscularis externa. Priunary amyloidosis on the other hand, is relatively rare. We experienced primary stornach amyloidosis (AL), which was mistaken for stomch cancer.
Lee, Jae-Lyun,Kim, Jeong Eun,Ahn, Jin-Hee,Lee, Dae-Ho,Lee, Jungshin,Kim, Choung-Soo,Hong, Jun Hyuk,Hong, Bumsik,Song, Cheryn,Ahn, Hanjong The Korean Cancer Association 2010 Cancer Research and Treatment Vol.42 No.1
<P>To assess the efficacy and safety of treating Korean patients with metastatic hormone-refractory prostate cancer (HRPC) using docetaxel plus prednisolone chemotherapy.</P>