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성견 2급 치근이개부 병변 치료 시 이종골 이식 및 혈소판 농축 혈장의 골재생에 관한 효과
임성빈,신형식 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1
New techniques for regenerating the destructed periodontal tissue have been studied for many years. Current acceptable methods of promoting periodontal regeneration are basis of removal of diseased soft tissue, root treatment, guided tissue regeneration, graft materials, and biological mediators. Platelet Rich plasma has been reported as a biological mediator which regulates activities of wound healing progress including cell proliferation , migration, and metabolism. The purpose of this study is to evaluate the effects of using the Platelet Rich plasma as a regeneration promoting agent for furcation involvement defect. Five adult beagle were used in this experiment. The dogs were anesthetized with Ketamin HCl (0.1 ml/kg, IV) and Xylazine hydrochloride (Rompun^ⓡ, Bayer, 0.1 ml/kg, IM) and conventional periodontal prophylaxis were performed with ultrasonic scaler and hand instruments. With inrasulcular and crestal incision, mucoperiosteal flap was elevated. Following decortication with 1/2 high speed round bur, degree Ⅱ furcation defect was made on mandibular third(P3), forth(P4) and fifth(P5) premolar, and stopping was inserted, After 4 weeks, stopping was removed, and bone graft was performed. Ca-P was grafted in P3(experimental group I), combination of Ca-P and plasma rich platelet were grafted in P4(experimental group Ⅱ), and P5 was remained at control group. Systemic antibiotics(gentamicin sulfate) and anlgesics(phenyl butazone) were administrated intramuscular for 2 weeks after surgery. Irrigation with 0.1% Chlorhexidine Gluconate around operate sites was performed during the whole experiment period except one day immediate after surgery. Soft diets were fed through the whole experiment period. After 4, 8 weeks, the animals were sacrificed by perfusion technique. Tissue block was excised including the tooth and prepared for light microscope with Gomori's trichrome staining. At 4 weeks after surgery, there were rapid osteogenesis phenomenon on the defected area of the platelet produced by activated osteoblast. Bone formation was almost completed to the formix of furcation by 8 weeks after surgery. In conclusion, Platelet Rich Plasma can promote rapid osteogenesis during healing of periodontal regeneration.
녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험
장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3
목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.
( Hyung-jin Park ),( Chan-yang Lee ),( Hye-jin Ahn ),( June-hyuck Yim ),( Ki-heon Jeong ),( Min Kyung Shin ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
The rate of malignant transformation of all forms of porokeratosis (PK) is approximately 7.5%, and the linear PK is known to have highest rate of malignancy. A 83-year-old-female presented with rapidly enlarging erythematous mass on the left arm. Physical evaluation revealed solitary 1.5 x 2cm sized yellowish to erythematous mass on the left arm, and scattered various sized erythematous scaly patches were found on the left half of trunk and left arm. Additionally generalized various sized brownish annular patches with hyperkeratotic outer ring were found on the face, trunk, back and both arm. Skin biopsy was performed at 3 lesions; yellowish to erythematous mass, erythematous scaly patch and brownish annular patch. The histopathologic evaluation revealed squamous cell carcinoma, actinic keratosis and PK, respectively. The final diagososis is disseminated superficial porokeratosis with linear porokeratosis on the left side of body, actinic keratosis and squamous cell carcinoma confined to the linear porokeratosis lesions. Herein, we report a case which represents the progressive and malignant transformation steps of porokeratosis into squamous cell carcinoma.
Minke whale genome and aquatic adaptation in cetaceans
Yim, Hyung-Soon,Cho, Yun Sung,Guang, Xuanmin,Kang, Sung Gyun,Jeong, Jae-Yeon,Cha, Sun-Shin,Oh, Hyun-Myung,Lee, Jae-Hak,Yang, Eun Chan,Kwon, Kae Kyoung,Kim, Yun Jae,Kim, Tae Wan,Kim, Wonduck,Jeon, Jeon Nature Pub. Co 2014 Nature genetics Vol.46 No.1
The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.