허혈성 심질환에 있어서 아데노신 급속 정맥투여후 관동맥압의 변화에 관한 연구

봉종대,오종용,배성한,신원용,김철현,이광희,최태명,현민수,김성구,권영주 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Background: Adenosine interacts with A1 receptors present on the extracellular surface of cardiac cells, activating K+channels in a fashion. It produces coronary vasodilatation and AV nodal block. The half-time is one to six second and has ultra-short action. In ischemic heart disease, fractional flow reserve(FFR) can be achieved safely with intravenous adenosine infusions at a rate of 150㎍/kg/min which cause maximal coronary hyperemia. Purpose: We investigated the patients who have had ischemic heart disease(n=8). After adenosine intravenous administration(150㎍/kg/min), the effect cause maximal hyperemia of coronary artery. During peak maximal hyperemia, we reported clinical findings, coronary hemodynamics and electrocardiogram findings. Methods: After diagnostic coronary angiography and left ventriculography, catheter was advanced into the ostium of coronary artery. We investigated coronary hemodynamics such as systolic coronary artery pressure, diastolic coronary artery pressure, mean coronary artery pressure and heart rate. To assess the use of adenosine for determination of fractional flow reserve, hemodynamics and electrocardiogram were measured at basal state and during peak maximal hyperemia. Results: Symptoms developed 1.5-2 minute after adenosine intravenous administration and each symptom disappeared 2-2.5 minute after adenosine administration. Two patients represented asymptomatic appearance and six patients complained of flushing, chest pain, palpitation and headache. In eight patients with ischemic heart disease, 1.5 minute after venous administration of 150㎍/kg/min of adenosine, coronary artery pressure decreased and heart rate increased significantly. Conduction abnormalities after administration of 150㎍/kg/min of adenosine were transient 2nd degree AV block 2 cases(25%). Conclusions: Adenosine is a potent ultra short-acting vasodilator. Although coronary artery pressure decreased and heart rate increased and mild cardiovascular symptoms occurred after continuous infusion of 150㎍/kg/min of adenosine, it is useful as an agent for determination of fractional flow reserve.

接觸酸化法을 利用한 LAS 除去效率에 關한 硏究

오종민,구태회,진현오,윤동선,박재영 경희대학교 환경연구소 1997 環境硏究 論文集 Vol.7 No.-

This study was performed to know LAS concentration in the small urban stream and estimate the LAS removal efficiency when apply to natural purification method with variable media. When we used gravel and concrete as media, the average LAS concentration of influent was 819.7㎍/ℓ (112.0 ∼ 1671.0 ㎍/ℓ). The average LAS concentration of effluent gravel media reactor was 58.5 ㎍/ℓ (0 ∼ 158.4 ㎍/ℓ) and average removal efficiency was 93.8%. The average LAS concentration of effluent concrete media reactor was 33.1 ㎍/ℓ (0 ∼ 136.8 ㎍/ℓ) and average removal efficiency was 96.1%. And when we used tire and scrubber, the average LAS concentration of influent was 693.7 ㎍/ℓ (241.5 ∼ 1330.3 ㎍/ℓ). The average LAS concentration of effluent tire media reactor was 88.4 ㎍/ℓ (47.8 ∼ 131.8 ㎍/ℓ) and average removal efficiency was 83.9%. The average LAS concentration of effluent scrubber media reactor was 26.1 ㎍/ℓ(0 ∼ 58.9 ㎍/ℓ) and average removal efficiency was 95.3%.

심근 경색증을 동반한 좌측 단일 관상동맥 1례

김성구,온영근,현민수,권영주 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Anomalous origin of the right coronary artery is uncommon in patient undergoing coronary angiography. Especially single coronary artery is a rare congenital anomaly. Most coronary anomalies did not result in signs, symptoms, or complications, and usually were discovered as incidental finding at the time of coronary angiography. However, some anomalies may be associated with malignant courses such as myocardial infarction, syncope or sudden cardiac death. This report describes a 65-year-old man who had right coronary artery originating from left circumflex artery with unusual type of isolated single coronary artery and myocardial infarction.

메타 전자 쇼핑몰의 설계 및 구현

신민화,김승희,배상현,김판구 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.1

최근 전자상거래의 상업성이 부각되면서 많은 기업들과 개인사업자들이 독자적인 웹서버를 구축하고 자사의 상품 또는 기업에 대한 광고 내용을 인터넷을 통해 서비스를 하고 있다. 그러나 소비자들에게 인지도가 낮은 기업이나 전국의 각 지방의 특산품과 토산품 관련 웹사이트들은 소비자에게 홍보가 부족하고, 상품의 종류와 정보의 부족으로 외면을 당하고 있는 것을 많이 본다. 본 논문에서는 이러한 기업들의 카탈로그를 수집하여 재구성한 후, 한 사이트에서 여러 기업의 상품을 검색할 수 있도록 하여 소비자의 접근과, 각 기업의 상거래 사이트를 활성화 할 수 있는 메타 전자 쇼핑몰 개발에 관해 기술한다. 본 시스템의 특징은 로봇이 자동으로 데이터 베이스를 구축하여 소비자가 쉽게 검색 할 수 있도록 주제어 검색과 디렉토리 검색 및 폴더형맵 검색 인터페이스 구성을 가지고 있다는 점이다.

불균질한 지하수대 내에서의 오염물질 이동에 관한 시뮬레이션 시 적률들의 안정화

서병민,이현구 충남대학교 기초과학연구소 2005 忠南科學硏究誌 Vol.32 No.1

Three dimensional Monte-Carlo simulations of non-ergodic transport of a non-reactive solute plume by steady-state groundwater flow under a uniform mean velocity in isotropic heterogeneous aquifers were conducted. Ensemble averages of the second spatial moments of the plume, <S_(ij)'(t',l')>, plume centroid variances, R_(ij)'(t',l'), and one particle displacement variance or second spatial moment of an ergodic plume, X_(ij)'(t') were simulated with 3200 Monte Carlo runs for five variances of log K, σ^(2)_(Y)=0.1, 0.25, 1.0, 2.5, and 5.0, and a constant dimensionless length of line plume sources (l^(2)'=1) normal to the mean velocity. The simulated moments are increased in larger σ^(2)_(Y) of random fields and the plumes are spreaded more in strongly heterogeneous aquifers. The simulated moments are stabilized while the number of simulated random fields are increased, and the transverse moments need more random fields than the longitudinal moments to be stabilized (M>1600). The stabilization of the moments has strong correlation with the number of random fields but doesn't show clear correlation with the degree of heterogeneity of the random fields.

파노라마방사선사진 지수와 임플란트 실패와의 관계에 관한 연구

조현정,이원진,허민석,안창현,이진구,이삼선,최순철 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : Several panoramic indices have been suggested to assess bone quality from the morphology and width of mandibular cortex on panoramic radiography. The purpose of this study was to compare dental implant failure group with control group in panoramic mandibular index (PMI), mandibular cortical index (MCI), and gonion index (GI) and to determine the effect of these panoramic indices on dental implant failure. Materials and Methods : A case-control study was designed. Test group (n = 42) consisted of the patients who had their implants extracted because of peri-implantitis. Control group (n = 139) consisted of the patients who retained their implants over one year without any pathologic changes and had been followed up periodically. They had dental implants installed in their mandibles without bone augmentation surgery from 1991 to 2001. The following measures were collected for each patients: 1) PMI, MCI, and GI were measured twice at one-week interval on preoperative panoramic views; and 2) age, sex, implant length, implant type, installed location, occluding dentition state, and complication were investigated from the chart record. Results : The PMI showed moderate level of repeatability. The intra-observer agreement of MCI and GI were good. There was statistically significant difference in PMI between two groups. There were significant different patterns of distribution of MCI and GI between two groups. Among the panoramic indices, PMI and MCI showed significant correlation with dental implant failure. Conclusion : Panoramic indices can be used as reference data in estimating bone quality of edentulous patients who are to have implants installed in their mandibles.

H9c2 심근 세포주에서 외인성 nitric oxide가 허혈에 의한 세포 독성에 미치는 영향

정성구,장현용,김명천,고영관,정주호,배영미,박원서,김대중,유영민,김성수,임성빈 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Nitric oxide(NO) is known to have protective effects on an ischemic heart and to exert triggering effects on ischemic preconditioning. However, the effects of NO during the ischemic period have not been investigated. To investigate the role of exogenous nitric oxide in a model of ischemic heart cell death, we studied the effects of ischemic preconditioning and ischemia in a normal and an ischemic buffer. Methods: Rat cardiac myoblast cells(H9c2) were cultured in a normal and an ischemic buffered medium. For the ischemic culture of heart cells, the cells were cultured in a dessicator with GasPak for 5 hrs. In ischemic preconditioning, the cells were pretreated with ischemic buffer for 5 min and then perfused with normal medium for 30 min. For the measurement of the cytotoxicity, a MTT(3-4-Sdimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide) assay was performed. A DAPI(4',6-diamidino-2-phenylindole dihydrochloride) staining procedure and a flow cytometry analysis were performed to confirm apoptotic cell death by ischemia. Results: Cell viability, as determined by using a MTT assay, showed that the preconditioned group treated with NO showed more cell death than with the not-preconditioned groups in both normal and ischemic buffers. But, In normal medium and not-preconditioned groups, NO showed protective effect according to the concentrations(100,1000μM) . No treatment with NO produced the different results. In normal medium, the protective effect of ischemic preconditioning was demonstrated, but no protective effect of ischemic preconditioning could be seen in the case of the ischemic buffer. The DAPI staining and flow cytometry analysis of heart cells showed characteristic apoptotic features. Conclusion: NO added in the ischemic phase had deterious effects on heart cells. Ischemic preconditioning was more harmful than ischemia alone. The toxicity of the cells was characteristic apoptosis.

가교화 쌀 전분의 이화학적 특성

최현욱,정구민,김정호,문태화,박천석,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

디지탈 影像處理를 爲한 畵像表示 시스템에 關한 硏究

박규태,박명구,신태민,강현철 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2

A digital image display system is studied. A TV set is used for a display unit. The system is designed to display 256x212 pixels in a frame and 8 bit gray levels. A microcomputer system is utilized for the image processing which has a Z-80A cpu and s-100 bus. A image processing system which includes a refresh memory system is designed. Images taken by the input system are processed. The image sharpening techniques are introduced. The image edges are found and sharpend using Robert cross operator of spatial differentiation technique. The images are also processed to eliminate noise utilizing the neighbourhood averaging method.

흉통의 양상에 따라 분류한 불안정형 협심증 환자의 임상적 소견의 비교

김명수,김성구,정호석,온영근,신원용,김철현,최태명,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background and aims : The clinical syndrome unstable angina pectoris that encompasses a variety of symptoms and clincal presentations of transient episode of myocardial ischemia, was devided to several subgroups. Also, it has variable pathophysiologic factors to cause myocardial ischemia. According to clincal presentation, coronary angiographic finding and prognostic factor, the result of unstable angina pectoris is variable. In fact, there were a few data reported on the prognosis of wide spectrum of patients with unstable angina. However, the precise risk of subgroups according to classitication has not been established because it was difficult to compare between studies. We classified unstable angina pectoris by clinical nature of chest pain, and performed to establish and compare the clinical presentations, coronary angiographic findings, treatement and prognosis of patients with unstable angina within subgroups of classification. Methods : Retrospenctive data for 164 unstable angina pectoris patients admitted to the Internal Cardiology Division of Soon Chun Hyang University Hospital from May 1996 to July 1999 was analyzed. The patients were classified into one of the following categories: Class I, new onset of severe angina; Class II, acceleration of previous chronic stable angina; Class III, angina at rest. Clinical presentations, echocardiographic findings, coronary angiographic findings, treatment and prognosis were compared. Results : From the total 164 patients, the subjects of classes were as follows : Class I, 46 cases (28.1%); Class II, 74 cases (45.1%); Class III, 44 cases (26.8%). In view of age distribution, the 7th decade had the highest incidence, and then, 6th, 8th decades were followed. There was no baseline differences among the 3 classes with respect to gender, number of risk factors. Significantly, class II showed more severe findings in abnormal Q wave 15 cases (20.8%), total occclusive lesion 10 cases (20.8%) and three vessel coronary disease 11 cases (22.9%) than other classes. The change of ST segment was significantly apparent (p<0.02) among class I 28 cases (60.8%), class III 26 cases (59.0%), comparing with class II 30 cases (40.5%). Class III had the higher incidence of one vessel coronary artery disease than class I and III. The heparin treatment was performed in 99 cases (60.1%). The incidence of nonfatal myocardial infarction was much more in class I and III, each 4 cases (8.7%, 9.8%) than in class II 1 cases (1.4%). In-Hospital death was occurred in class I and II, each 1 case. Conclusion : The patients with the acclerated angina from chronic stable angina had more severe coronary artery disease than other classes, but they had better in-hospital prognosis.