Caerulein과 총담췌장관 결찰에 의한 급성췌장염 모델의 특징

심상수,김현준,이윤혜,박진형,이승준,김창종 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-

To investigate the difference in acute pancreatitis experimentally induced by common bile-pancreatic duct (CBPD) ligation and caerulein iv infusion, we measured amylase activity, pancreatic edema and phospholipase A_2 activity in pancreatic tissue and serum. In acute pancreatitis induced by CBPD ligation and caerulein infusion, tissue edema and tissue phospholipase A_2 activity significantly increased as compared with normal group. Also experimental acute pancreatitis significantly increased the levels of serum protein, serum amylase activity and serum phospholipase A_2 activity. In the comparison of two experimental models, the symptom of acute pancreatitis induced by CBPD ligation was more severe than that induced by caerulein infusion. These results indicate that the increase of phospholipase A_2 activity in pancreatic tissue and serum may be one of the parameters for the diagnosis of acute pancreatitis.

대기압 플라즈마 처리와 접착력 강화 : 고무 소재의 접착력 향상

심동현,설수덕 東亞大學校附設 生産技術硏究所 2007 生産技術硏究所硏究論文集 Vol.12 No.-

An atmospheric plasma pre-treatment method was applied to Rubber material to improve its contact angle and adhesion. In order to investigate the optimum reaction condition of plasma treatment, type of reaction gas (nitrogen, argon, oxygen, air), rate of gas flow (30~100mL/min), and reaction time(0~30sec) were examined in a plate plasma reactor. The result of the surface modification with respect to the treatment procedure was characterized by using SEM and ATR-FTIR. Due to a decrease of the contact angle of polyurethane foam, the greatest adhesion strength was achieved at a flow rate of 100 mL/min and at a reaction time of 10s for N2 gas. Consequently, the atmospheric plasma treatment reduced the contact angle of the Rubber material and also resulted in the improvement of the peel strength.

저장기간에 따른 3개 수종의 종자 및 발아 특성 변화

한심희,김찬수,장석성,이현주,탁우식 한국농림기상학회 2004 한국농림기상학회지 Vol.6 No.3

This study was conducted to examine the changes in the seed physical characters and germinative properties of three tree species at three different storage times in order to determine the most suitable storage time and condition. Seed physical characters and germinative properties were examined from seeds of Fraxinus rhynchophylla, Zanthoxylum schinifolium and Staphylea bumalda that were stored at -18C for 1, 3 and 10 years, and the growth performance and physiological characters of their seedlings were analyzed. Seed physical characters and germinative properties showed significant differences between three storage times as well as three tree species. Seed moisture content of F. rhynchophylla and S. bumalda and seed fresh weight of Z. schinifolium decreased with increase of storage time. Storage time represented negative correlation with moisture content and fresh weight (r = -0.822, p < 0.01). Seed percent germination of Z. schinifolium and S. bumalda stored for 3 and 10 years decreased less than 15% and 10.7% respectively. Mean germination times for seed of F. rhynchophylla, Z. schinifolium and S. bumalda were delayed 11.9, 5.7 and 9.7 days after a storage time of 10 years, respectively. However the growth and viability of seedlings didn't show a special pattern for storage time and tree species.

후복막섬유증 5례의 임상적 고찰

정충식,김수현,안병수,심대성,박도영,김철성,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Retroperitoneal fibrosis is a fibrotic process of the retroperitoneum that frequently produces ureteral obstruction. It can occur as an idiopathic disease or in association with various non-malignant and malignant condition. In the early phase of the retroperitoneal fibrosis ; symptoms originate from the disease process itself, while in the late state the clinical features represent the effect of obstructive uropathy and renal failure. Treatment consist of steroid therapy, urinary diversion and ureterolysis with jntraperitonealization or lateralization or wrapping with omentum. Herein we present 5 cases of retroperitoneal fibrosis.

P088 : An epidemiological and mycological study on 6,250 patients infected with Trichophyton mentagrophytes during the last 21- year-period (1992~2012)

( Hyun Bo Sim ),( Soo Yuhl Chae ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Mi So Kim ),( Seok Jong Lee ),( Do Won Kim ),( Yong Jun Bang ),( Jae Bok Jun ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Trichophyton (T.) mentagrophytes is the second common dermatophyte in Korea. But there were rare reports on epidemiological and mycological analysis of T. mentagrophytes with long term and large scale study in Korea. Objectives: The aim of this study is to explain epidemiological and mycological characteristics of T. mentagrophytes in Korea. Methods: During the 21-year-period from 1992 to 2012, 6,250 patients with T. mentagrophytes were surveyed with respect to annual incidence, the distribution of the subjects according to age, sex, season, involved sites and a place of residence. Patients with T. mentagrophytes infection were clarified with fungal culture. In addition, we classified the colony appearance of T. mentagrophytes into granular, persicolor, powdery and downy colony. Results: In an epidemiological analysis, annual incidence reached its peak in 2005, and then gradually decreased. T. mentagrophytes was most common in July at monthly distribution. It was also found predominantly in middle-aged adults, especially in forties in age. In a mycological analysis, powdery colony was most common, followed by persicolor and granular colony. Clinically, tinea pedis was the most common T. mentagrophytes infection, followed by tinea unguium and tinea facieii. Conclusion: This massive, long term study on T. mentagrophytes infection leads us into epidemiological and mycological information in Korea.

Effect of Cholera Toxin Administered Supraspinally or Spinally on the Blood Glucose Level in Pain and D-Glucose Fed Animal Models

Sim, Yun-Beom,Park, Soo-Hyun,Kang, Yu-Jung,Kim, Sung-Su,Kim, Chea-Ha,Kim, Su-Jin,Jung, Jun-Sub,Ryu, Ohk-Hyun,Choi, Moon-Gi,Choi, Seong-Soo,Suh, Hong-Won The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.2

In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment with CTX alone for 24 h dose-dependently increased the blood glucose level. However, i.c.v. treatment with CTX for 24 h did not affect the blood glucose level. When mice were orally fed with D-glucose (2 g/kg), the blood glucose level reached to a maximum level at 30 min and almost returned to the control level at 120 min after D-glucose feeding. I.c.v. pretreatment with CTX increased the blood glucose level in a potentiative manner, whereas i.t. pretreatment with CTX increased the blood glucose level in an additive manner in a D-glucose fed group. In addition, the blood glucose level was increased in formalin-induced pain animal model. I.c.v. pretreatment with CTX enhanced the blood glucose level in a potentiative manner in formalin-induced pain animal model. On the other hand, i.t. pretreatment with CTX increased the blood glucose level in an additive manner in formalin-induced pain animal model. Our results suggest that CTX administered supraspinally or spinally differentially modulates the regulation of the blood glucose level in D-glucose fed model as well as in formalin-induced pain model.

P196 : Home-use microneedle in the treatment of pattern hair loss: efficacy and safety Department of Dermatology

( Soo Yuhl Chae ),( Hyun Bo Sim ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Hyun Ho Son ),( Hong Dae Jung ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Microneedle devices have been useful tools to reduce scarring and wrinkling. In addition, microneedle devices have been used in the treatment of pattern hair loss. Objectives: To investigate the efficacy and safety of home-use microneedle for the treatment of pattern hair loss. Methods: A total of 29 patients were enrolled. They were randomized into 3 groups; 5% minoxidil group, home-use microneedle group and their combination group. They were used twice a week. This study was evaluated through macrophotographic hair count, folliscope hair count, investigator`s global assessment (IGA), subject satisfaction score (SSS) and side effects at 0, 1, 3 and 6 months. Results: In all groups, a significant improvement was not shown in macrophotographic hair count (p>0.05) but in folliscope hair count (p<0.05). There was no statistically significant difference in hair count among the three groups (p>0.05). IGA was increased in three groups and 5% minoxidil group showed a statistically significant increase in IGA (p<0.05). SSS showed an improvement in a combination group. Mild and transient pruritus occurred in one patient of home-use microneedle group. Conclusion: Our study showed that a combination of home-use microneedle and 5% minoxidil is not inferior to 5% minoxidil. Home-use microneedle twice weekly is considered as a safe therapeutic modality to stimulate hair growth and to enhance transdermal delivery.

Case Reports : Acute Localized Exanthematous Pustulosis on the Face

( Hyun Soo Sim ),( Jung Eun Seol ),( Ji Sung Chun ),( Jong Keun Seo ),( Deborah Lee ),( Ho Suk Sung ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s

Acute localized exanthematous pustulosis (ALEP) is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 26- year-old woman presented with multiple erythematous pustules on her face, which had appeared three days after taking antibiotics. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules were resolved within 2 weeks after the patient discontinued the antibiotics. Herein, we present a case of a woman with a cutaneous drug reaction consistent with ALEP that occurred subsequent to administration of antibiotics. (Ann Dermatol 23(S3) S368~S370, 2011)

A case of lymphatic malformation with an unusual clinical presentation of evolving marginal polycyclic red induration

( Hyun Bo Sim ),( Dong Hyuk Eun ),( Sun Young Moon ),( Soo Yuhl Chae ),( Jin Hyup Lee ),( Myung Im ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok Jong Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lymphatic malformations or lymphangiomas are congenital vascular anomalies characterized by progressive dilatation of anomalous lymphatic vessels. They are classified as microcystic versus macrocystic according to the diameter of the largest cystic cavity, or combined. Sclerotherapy, surgery or laser can be chosen for their management variably according to their subtype. Itscorrect differential diagnosis from other vascular tumors and malformations is mandatory before to decide therapeutic modalities. A 2-month-old female infant came to clinic presenting with large asymptomatic skin colored rubbery diffuse swelling with narrow marginal polycyclic red induration on left upper shoulder and axilla area since birth. As time went by, the lesion grew wider and more prominent marginal induration accordingly spreading. Vascular malformation with a slow flow on USG and lobulated, septated mass on MRI was revealed. Skin biopsy of the central and peripheral area to rule out vascular tumor or malformation revealed variably dilated thin walled vascular channels in whole dermis and subcutis. Diffuse positive reaction of lymphatic endothelial cell to D2-40 and Prox-1 staining was shown. Finally, she was diagnosed as lymphatic malformation with peculiar clinical feature of evolving marginal polycyclic red induration. To the best of our knowledge, there has been no report about lymphatic malformation with extraordinary clinical manifestation.

Accessary nipple-like ectopic salivary gland in the anterior neck

( Hyun Bo Sim ),( Sun Young Moon ),( Soo Yuhl Chae ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Ectopic salivary gland is defined as the situation in which the salivary gland tissue develops at a site where it is not normally found. It occurs in various sites within the head and neck region and has even been found in other anatomical sites including anal mucosa. Though the origin of this entity still remains unclear, some reports insist about hypothesis to be a heteroplasia of the epithelium of the precervical sinus of His. A 13-year-old female presented nipple-like erythematous papule with fistula on her right anterior neck since birth. The lesion was mucoid discharge without other symptoms. Under the clinical impression of bronchogenic cyst, the lesion was totally excised. Histopathological examination revealed glandular elements and ducts in deep dermis and fat layer and the gland composed of multiple mucinous acini. Positive staining of mucinous acini with Periodic acid-Schiff(PAS). As accessary nipple-like ectopic salivary gland in the anterior neck is a rare disease with atypical clinical manifestation, it can be easily misdiagnosed as other conditions such as bronchogenic cyst. However ectopic salivary gland shows positive for PAS stain and has characteristic histopathological findings. So diagnosis of ectopic salivary gland can be easily done by histopathological and immunohistochemical examination. We report an informing case of an accessary nipple-like ectopic salivary gland which occurred on the anterior neck.