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( Hyun Gwoo Lee ),( Ae Jin Choi ),( Gum Yong Kang ),( Hyung Soon Park ),( Hyung Chan Kim ),( Hyun Jung Jade Lim ),( Hye Won Chung ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.5
Age-related macular degeneration (AMD) is the leading causeof blindness in the world. Evidence indicates that thesuppression of the ubiquitin-proteasome system (UPS) contributesto the accumulation of toxic proteins and inflammation inretinal pigment epithelium (RPE), the functional abnormalitiesand/or the degeneration of which are believed to be theinitiators and major pathologies of AMD. To identify newprotein associations with the altered UPS in AMD, we usedLC-ESI-MS/MS to perform a proteomic analysis of the aqueoushumor (AH) of AMD patients and matched control subjects. SixUPS-related proteins were present in the AH of the patients andcontrol subjects. Four of the proteins, including 26S proteasomenon-ATPase regulatory subunit 1 (Rpn2), were increasedin patients, according to semi-quantitative proteomic profiling. An LC-MRM assay revealed a significant increase of Rpn2 in 15AMD patients compared to the control subjects, suggesting thatthis protein could be a biomarker for AMD.[BMB Reports 2014; 47(5): 292-297]
위장관 ; 절제 불가능한 Stage IV 진행성 식도암의 치료방법에 따른 효과 비교
이규진 ( Gyu Jin Lee ),박무인 ( Moo In Park ),구상건 ( Sangeon Gwoo ),정현주 ( Hyun Joo Jung ),김주훈 ( Joo Hoon Kim ),박선자 ( Seun Ja Park ),문원 ( Won Moon ),김형훈 ( Hyung Hun Kim ),김양수 ( Yang Soo Kim ),박성달 ( Sung Dal P 대한소화기학회 2012 대한소화기학회지 Vol.59 No.4
Background/Aims: The aim of this study was to compare palliative treatments such as chemotherapy, chemoradiotherapy or radiotherapy with best supportive care in patients with inoperable advanced esophageal cancer. Methods: A total of 67 patients with inoperable advanced esophageal cancer visiting Kosin University Gospel Hospital between January 2000 and July 2010 were included in a retrospective analysis. Patients were categorized as having palliative treatment or best supportive care to compare their prognosis. Results: The median survival was 6.4 months in 67 patients. There was significant difference in median survival between the palliative and best supportive treatment (9.8 months vs. 4.5 months, p=0.01). The patients who underwent palliative treatment had superior 1-year and 3-year overall survival rate than those with best supportive treatment (27%, 10% vs. 5%, 5%, respectively). The 1-year and 3-year overall survival rate of palliative treatment was 18% (1-year overall survival rate) in chemotherapy, 33% (1-year overall survival rate) in radiotherapy, 45% and 9% in concurrent chemoradiotherapy, and 20% and 20% in sequential chemoradiotherapy, respectively. Conclusions: These results may suggest that palliative treatments are more effective than best supportive care. Further prospective studies are still needed to elucidate beneficial effect of palliative treatments on inoperable advanced esophageal cancer. (Korean J Gastroenterol 2012;59:282-288)