모 주물공장 근로자의 작업공정별 분진폭로량, 자각증상 및 건강진단판정 비교

이범식,조영채,변정식,김동현,원선혜,김정윤 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-

The relationship among dust exposure dose, special health diagnosis results and subjective symptom questionaire survey for 109 casting foundry workers supervised by a local laber office has been studied from august to october 1993. Subjective symptom, dust exposure dose and health examination evaluation of respective working processes have been analized and concluded as follows; 1. Metal fume concentration in melting process measured 3.21±1.46㎎/㎥ is under threshould limit value(TLV;5.0㎎/㎥), casting sand dust measured in molding and desanding process is 5.8 ±3.41㎎/㎥ and 9.69 ±2.64㎎/㎥ which is 3-5 times higher than TLV(2.0㎎/㎥), metal fume, welding fume and metal dust in finishing process measured 9.34 ±1.32, 13.73 ±16.97 and 10.17 ±3.50㎎/㎥ respectively, which are also 2-3 times higher than TLV(5.0㎎/㎥). 2. The complain rate subjective symptoms appeal evaluated for finishing process are 35.9%, 46.2%, 27.2% and 42.2% for eye smptoms, respiractory, skin, general symptom respectively and the rates above express the highest values and the complain rates for melting process are 24.4%, 37.5% and 35.7% for eye smptoms, respiratory and mental system respectively and for molding and desanding it is 24.3%. 3. Perceived occupational disease rate is found 0.9% with are out of 109 worker surveyed who have been exposed in metal fume of finishing process. 4. 33.0% of workers surved are found to require close examination, the worker of hepatopathy suspected are 21.4% which is the highest and 3.7% for circulatory disturbance suspected. 5. The statistically significant variables in general chracteristics that affect health examination evaluation are smoking(P<0.001), respirator put-on (P<0.05) and working career(P<0.05). 6. Cough(P<0.001), "headache"(P<0.05) and "easily skin exchange by slight stimulation" (P<0.05) are statistically significant to the subjective symptom variables affect health examination evaluation.

랫트의 생체내 카드뮴 단독투여 및 카드뮴과 셀레늄 병용투여에 따른 필수원소의 변화

김동현,변정식,조영채,이범식,김광환,김정윤 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-

This study was performed to find out the changes of essential elements as Cu, Fe, Zn, and Ca in blood, liver, kidney and testis of rats. The experimental rats were divided into 4 groups that were consisted of control group(groupⅠ), 3.0㎎Cd/kg group(groupⅡ), 3.0㎎Cd +1.0㎎Se/kg group(groupⅢ) and 3.0mgCd+2.5mgSe/kg group(groupⅣ). Each group was intraperitoneal injection with difference dose of cadmium and selenium such as 3.0mgCd/kg, 3.0mgCd+1.0mgSe/kg and 3.0mgCd+2.5mgSe/kg. Rats were killed at the time of 3 day and 28 day, and Cd, Se, Cu, Zn and Ca concentration in several organs were determined by Atomic Absorption Spectrophotometry and inductively Coupled Plasma. Cadmium content in blood, liver, kidney and testis were significantly increased in the Cd alone injection group than Cd mixed with selenium injection groups. But, copper content were not significantly differences in control and each experimental group. Iron content were significantly increased in the Cd alone injection group than others groups. Zinc and calcium content were significantly decreased in the Cd alone injection group than other groups. On the other hand the essential element content in Cd mixed with selenium injection group were almost equaled with those of control group than Cd alone injection group.

The Korean Association of lnternal Medicine : Poster Session ; PS 1357 : Nephrology ; Age is the Strongest Effector for the Relationship between Estimated Glomerular filtration Rate and Coronary Artery Calcifi cation in Apparently Healthy Korean Adults

( Hyun Beom Chae ),( Eun Jung Rhee ),( Hae Jung Park ),( Min Kyung Lee ),( Won Seon Jeon ),( Se Eun Park ),( Cheol Young Park ),( Won Young Lee ),( Ki Won Oh ),( Sung Woo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Cardiovascular disease (CVD) is a major clinical problem and the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). Coronary artery calcifi cation (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects. Methods: In 23,617 participants in the health screening program in Kangbuk Samsung Hospital health screening program from January 2010 to December 2011, estimated glomerular fi ltration rate (eGFR) was assessed by Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured by multi-detector computed tomography (MDCT). Subjects were divided into 3 groups according to the CKD Staging system with eGFR grade; stage 1: eGFR = 90 mL/min/1.73 m2, stage 2: eGFR 60-89 mL/ min/1.73 m2, stage 3: eGFR 30-59 mL/min/1.73 m2. Results: Mean age of the participants was 41.4 years, and mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed weakly negative but signifi cant association with CACS in bivariate correlation analysis (r=-0.076, p<0.01). Mean CACS signifi cantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC signifi cantly increased from CKD stage 1 to 3. Although odds ratio for CAC signifi cantly increased from stage 1 to 3 after adjustment for confounding factors, this signifi cance was inversed when age was included in the model. Age was the strongest factor that affects CAC. Conclusions: This study performed in young Korean subjects with relatively normal renal function, age was the mostly strongest effector on the association between eGFR and the degree of CAC.

Anti-oxidative and Anti-inflammatory Effects of Protulaca Oleracea on the LPS-stimulated AGS Cells

Chae Hyun Kim,Pyeong Beom Park,Seung Ryeol Choe,Tae Heon Kim,Jong Kil Jeong,Kwang Gyu Lee,Chang Hyun Lee,Han Sol Jeong 한의병리학회 2009 동의생리병리학회지 Vol.23 No.2

Hardware In-the-Loop Simulation의 다중 코어 연산시 발생할 수 있는 연산 오류 및 연산속도 저하를 해결하기 위한 회로 구성 기법 제안

채범석(BEOM-SEOK CHAE),전재현(JAE-HYUN JEON),김경수(KYUNG-SUE KIM),오현석(HYUN-SEOK OH),박철현(CHEOL-HYUN PARK),이정준(JEONG-JOON LEE) 전력전자학회 2020 전력전자학술대회 논문집 Vol.2020 No.8

Anti-oxidative and Anti-inflammatory Effects of Protulaca Oleracea on the LPS-stimulated AGS Cells

Kim, Chae-Hyun,Park, Pyeong-Beom,Choe, Seung-Ryeol,Kim, Tae-Heon,Jeong, Jong-Kil,Lee, Kwang-Gyu,Lee, Chang-Hyun,Jeong, Han-Sol The Physiological Society of Korean Medicine and T 2009 동의생리병리학회지 Vol.23 No.2

Protulaca oleracea, a widely distributed weed, has been reported to exhibit different health promoting effects. The objective of this study was to evaluate the anti-oxidative and anti-inflammatory effects of P. oleracea on LPS-stimulated AGS cells. The cytotoxicity of P. oleracea in AGS cells was examined by MTT assay. The anti-oxidative effects of P. oleracea were examined by DPPH assay. RT-PCR was carried out to examine the effect of P. oleracea in the mRNA expression of different inflammatory mediators. MTT assay revealed that P. oleracea have almost no cytotoxity in AGS cells. DPPH radical scavenging activities were better than butylated hydroxyl toluene (BHT). The mRNA expression of different endogenous anti-oxidative enzymes (SOD2, GPx3 and catalase) were preserved by P. oleracea in AGS cells. The nitric oxide production and expression of iNOS in LPS stimulated RAW264.7 were suppressed in P. oleracea treated groups. Based on these findings, P. oleracea has protective anti-oxidant and anti-inflammatory effects.

궤양성 대장염에서 진단시기별 예후의 차이

채현범 ( Hyun Beom Chae ),정윤숙 ( Yoon Suk Jung ),박동일 ( Dong Il Park ),이창균 ( Chang Kyun Lee ),허규찬 ( Kyu Chan Huh ),신정은 ( Jeong Eun Shin ),김재학 ( Jae Hak Kim ),김유선 ( You Sun Kim ),정윤호 ( Yun Ho Jung ),정성애 ( S 대한소화기학회 2014 대한소화기학회지 Vol.64 No.2

목적: 궤양성 대장염 환자에서 infliximab 사용이 승인된 2006년을 기준으로 infliximab 사용이 증가하면서 그 이전과 이후에 진단된 환자들의 질병의 예후 및 치료약제의 사용이 어떻게 달라졌는지 알아보고자 하였다. 대상 및 방법: 1987년부터 2012년까지 12개 병원에서 궤양성 대장염을 진단받은 1,422명을 대상으로 후향적 연구를 시행하였다. 진단 연도에 따라 두 군(A군: 1987-2005, B군: 2006-2012)으로 나누어 진단 당시 나이, 성별, 추적기간, 이환기간, 질병의 위치, 질병과 관련된 입원과 수술, 약물 사용에 차이를 보이는지 등에 대해 통계적 분석을 시행하였다. 결과: 진단 당시의 평균 연령은 42.2세였고, 평균 추적기간은 4.7년이었다. Infliximab을 사용한 환자는 89명으로 전체의 6.3%였다. 단변량 분석에서 B군에서의 infliximab 사용이 통계적으로 유의하게 많았고(4.5% vs. 7.6%, p=0.016), 경구 스테로이드의 사용은 유의하게 적었다(60.1% vs. 53.3%, p=0.009). 궤양성 대장염에 관련된 입원(45.8% vs. 40.1%, p=0.031)과 수술(6.4% vs. 3.5%, p=0.010)은 B군에서 통계적으로 유의하게 낮았다. 수술적 치료를 받은 환자군과 받지않은 환자군과의 단변량 분석을 시행한 결과, 수술적 치료를 받은 환자군에서 전대장염의 비율이 높았고(p=0.026), 경구 스테로이드의 사용이 많았다(p=0.007). 다변량 분석에서는 경구 스테로이드 사용만이 유의한 차이를 보였다(OR 1.85, 95% CI 1.03-3.30, p=0.039). 결론: 2006년 이후 진단된 궤양성 대장염 환자에서 2006년 이전 진단된 환자들에 비하여 infliximab 의 사용이 유의하게 증가하였고, 수술률도 유의하게 낮은 것으로 나타났다. 또한, 스테로이드 불응성 궤양성 대장염 환자에서 infliximab의 사용이 효과적인 치료로 사용될 수 있을 것으로 생각된다. Background/Aims: Infliximab was approved for the treatment of ulcerative colitis (UC) in 2006 and has recently been used as rescue therapy in steroid-refractory UC. The aim of this study was to investigate the differences of medication use and prognosis in UC patients according to the periods of diagnosis. Methods: From 1987 to 2012, a total of 1,422 patients with UC were retrospectively reviewed in 12 hospitals. The study population was divided into two groups according to the periods of diagnosis as follows, group A: 1987 2005, group B: 2006-2012. Analyzed variables were compared by using chi-square test and logistic regression analysis. Results: Mean age of the subjects was 42.2 years, and the mean follow-up period was 4.7 years. In univariate analysis, the use of infliximab in group B was significantly higher than group A (4.5% vs. 7.6%, p=0.016), and UC related hospitalization (45.8% vs. 40.1%, p=0.031) and UC-related surgery (6.4% vs. 3.5%, p=0.010) in group B was significantly lower than that of group A. The use of oral steroid in surgery group was significantly higher than non-surgery group in multivariate analysis (OR 1.85, 95% CI 1.03-3.30, p=0.039). Conclusions: Infliximab might play an important role for the treatment of steroid-refractory UC. Well designed prospective trials based on the efficacy and safety of infliximab are required in the future. (Korean J Gastroenterol 2014,64:93-97)

Diagnostic accuracy and safety of 16α-[¹⁸F]fluoro-17β-oestradiol PET-CT for the assessment of oestrogen receptor status in recurrent or metastatic lesions in patients with breast cancer: a prospective cohort study

Chae, Sun Young,Ahn, Sei Hyun,Kim, Sung-Bae,Han, Sangwon,Lee, Suk Hyun,Oh, Seung Jun,Lee, Sang Ju,Kim, Hee Jeong,Ko, Beom Seok,Lee, Jong Won,Son, Byung Ho,Kim, Jisun,Ahn, Jin-Hee,Jung, Kyung Hae,Kim, Elsevier 2019 LANCET ONCOLOGY Vol.20 No.4

<P><B>Summary</B></P> <P><B>Background</B></P> <P>A biopsy of first recurrence or metastatic disease is recommended to re-evaluate oestrogen receptor status in patients with breast cancer and to select appropriate treatment. However, retesting for oestrogen receptor status with rebiopsy is not always feasible, depending on lesion location and the risk associated with biopsy, and in these cases clinicians continue to treat patients according to the oestrogen receptor status of the primary tumour. Consequently suboptimal therapy might be offered to these patients. We assessed the diagnostic accuracy and safety of 16α-[<SUP>18</SUP>F]fluoro-17β-oestradiol (<SUP>18</SUP>F-FES) PET-CT to assess oestrogen receptor status in patients with recurrent or metastatic breast cancer.</P> <P><B>Methods</B></P> <P>We did a prospective cohort study at the Asan Medical Center, Seoul, South Korea. Eligible patients had breast cancer, with first recurrence or metastatic disease at presentation, were 19 years or older, and had an Eastern Cooperative Oncology Group performance status of 0–2. The primary objective was to show the agreement between qualitative <SUP>18</SUP>F-FES PET-CT interpretation and the results of oestrogen receptor expression by immunohistochemical assay, a non-reference standard test. Whole-body <SUP>18</SUP>F-FES PET-CT imaging was done after intravenous injection of 111–222 MBq of <SUP>18</SUP>F-FES, with dosing primarily determined by radiation dosimetry analysis. <SUP>18</SUP>F-FES uptake above background intensity was interpreted as positive. Efficacy was assessed in all patients with histologically confirmed recurrent or metastatic breast cancer who received <SUP>18</SUP>F-FES and had PET-CT images available (intention-to-diagnose analysis), and safety was assessed in all patients who received <SUP>18</SUP>F-FES. This study is registered with ClinicalTrials.gov, number NCT01986569.</P> <P><B>Findings</B></P> <P>Between Nov 27, 2013, and Nov 10, 2016, 93 patients were enrolled. Of the 85 patients included in the efficacy analysis, 47 (55%) were oestrogen receptor-positive and 38 (45%) were oestrogen receptor-negative. Positive status percent agreement between the <SUP>18</SUP>F-FES PET-CT results and oestrogen receptor status by immunohistochemical assay was 76·6% (95% CI 62·0–87·7) and the negative status percent agreement was 100·0% (90·8–100·0). Patients who were oestrogen receptor-positive and had a positive <SUP>18</SUP>F-FES PET-CT result had a significantly higher progesterone receptor expression than those who were oestrogen receptor-positive and had a negative <SUP>18</SUP>F-FES PET-CT result (23 [68%] of 34 patients <I>vs</I> 0 of 11 patients; p<0·0001). The most common adverse event was procedural pain in nine (10%) of 90 patients injected with <SUP>18</SUP>F-FES. No adverse events were related to the study drug except injection site pain in one (1%) patient. No serious adverse events were recorded.</P> <P><B>Interpretation</B></P> <P>The high negative percent agreement between <SUP>18</SUP>F-FES PET-CT and oestrogen receptor status by immunohistochemical assay in this cohort suggests that positive <SUP>18</SUP>F-FES uptake by recurrent or metastatic oestrogen receptor-positive breast cancer lesions could be an alternative to oestrogen receptor assays in this setting. Staging assessment should include <SUP>18</SUP>F-FES PET-CT when retesting oestrogen receptor status is not feasible.</P> <P><B>Funding</B></P> <P>Asan Institute for Life Sciences, Ministry of Health and Welfare, South Korea.</P>

Xenon ventilation CT with a dual-energy technique of dual-source CT: initial experience.

Chae, Eun Jin,Seo, Joon Beom,Goo, Hyun Woo,Kim, Namkug,Song, Koun-Sik,Lee, Sang Do,Hong, Soo-Jong,Krauss, Bernhard Radiological Society of North America 2008 Radiology Vol.248 No.2

<P>Institutional review board approval and written informed consent were obtained. Although xenon (Xe) ventilation CT has been introduced as a potential method with which to depict regional ventilation, quantification of Xe enhancement has been limited by the variability of lung attenuation caused by different lung volumes between scans. The purpose of this study was to assess the feasibility of Xe ventilation CT with a dual-energy technique. Dual-energy CT was performed in 12 subjects after Xe inhalation. With use of a dual-energy technique, the Xe component could be extracted without any influence from lung volume. Dynamic and static regional ventilation function can be displayed with an exact match to the thin-section CT image.</P>

Dual-energy Computed Tomography Characterization of Solitary Pulmonary Nodules

Chae, Eun Jin,Song, Jae-Woo,Krauss, Bernhard,Song, Koun-Sik,Lee, Choong Wook,Lee, Hyun Joo,Seo, Joon Beom Lippincott Williams Wilkins, Inc. 2010 Journal of thoracic imaging Vol.25 No.4

For the assessment of solitary pulmonary nodules (SPNs), a chest computed tomography (CT) is often performed as a combination of a nonenhanced and an enhanced scan. A nonenhanced scan is used for the detection of calcification in the SPN or lymph node, as the presence of calcification is one of the important determinants of benignity. An enhanced scan is informative in providing the degree and pattern of enhancement. In particular, the degree of enhancement of an SPN after iodine injection has been shown to be helpful in distinguishing malignant from benign nodules. Recently introduced dual-energy applications of dual-source CT simultaneously provide a virtual nonenhanced and an iodine-enhanced image from a single scan, after the administration of iodine contrast material. Therefore, a single enhanced dual-energy CT scan allows both measurement of the degree of enhancement and detection of calcifications. It may reduce radiation exposure to patients by avoiding baseline nonenhanced scans and may also reduce measurement error due to different regions of interest during the subtraction of a nonenhanced image from an enhanced image. This technique may have applications in contrast-enhanced dynamic CT and perfusion CT for the differentiation between benign and malignant lesions and the assessment of tumor angiogenesis. In this review article, we sought to address the usefulness of dual-energy CT for the assessment of SPN. In addition, we briefly review the physical principles of dual-energy CT and discuss potential future applications in patients with lung nodules.