Graves 병 환자에서 항갑상선제 투여에 의한 TSH 수용체 항체의 변동에 관한 연구 : 치료 용량 및 기간에 따른 차이 및 임상상과의 관계 its relation to dose and duration of treatment~and clinical features

이문호,조보연,문대혁,고창순,민헌기,서교일 대한내과학회 1986 대한내과학회지 Vol.30 No.3

We undertook a prospective study of 59 patients with Graves' disease in order to clarify the influence of antithyroid drug on the immunological indices and to determine the association of the changes of TSH receptor antibodies activities with drug dosage, duration of treatment and clinical features according to mode of antitbyroid drugs treatment. Patients were divided into two groups. High dose group included 28 patients and conventional dose group 31 patients. We measured TBII activities, antimicrosomal antibodies, and the size of goiter every 3 months, comparing them with clinical features and laboratory findings. TBII activities declined from R months until 9 months following drug treatment. Therafter no significant change of TBII activities were observed. Antimicrosomal antibodies showed the same pattern of change. There was no statistically significant difference of declining rate of TBII activities, antimicrosomal antibodies, and reduction of size of thyroid between two treatment groups. TBII activities fell into normal range in 15 patients among those 44 patients who had been followed for more than 9 months (8 high dose group, 7 conventional dose group). In those 15 patients, TBII activities and frequency of exophthalmos were less than those whose TBII activity did not normalized. We conclude that TSH receptor antibodies activities and antithyroid autoantibodies are diminished by antithyroid drug treatment in patients with Graves disease and there is no relationship between dose of drug and declining of TBII activities. We suggest that changing levels of TBII activities might be secondary phenomenon which can be achieved by control of thyroid function by antithyroid drug rather than direct immunosuppressive effect of antithyroid drug per se.

Using XML for Describing Sensing Data

Ki Chang Park,Im Chul Kang,Young Hyuk Ko,Byung Ki Kim 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12

The SDK (Software Development Kit) of each device is required in developing contents using TUIs (Tangible User Interfaces). Generally, it is used to adapt a specific sensor to the UIs of contents, which causes duplicated and time-consuming efforts in developing contents if the contents development platform is changed. In this paper, we propose a method which describes signal information of TUIs using XML and show the example of contents development over Virtools and XNA platform using a proposed method. The proposed method allows the sensing data exchange between a device module and a contents module and reduces module coupling between them.

Comprehensive Transcriptomic Analysis of Cordyceps militaris Cultivated on Germinated Soybeans

Yoo Chang-Hyuk,Sadat Md. Abu,Kim Wonjae,Park Tae-Sik,Park Dong Ki,Choi Jaehyuk 한국균학회 2022 Mycobiology Vol.50 No.1

The ascomycete fungus Cordyceps militaris infects lepidopteran larvae and pupae and forms characteristic fruiting bodies. Owing to its immune-enhancing effects, the fungus has been used as a medicine. For industrial application, this fungus can be grown on geminated soy- beans as an alternative protein source. In our study, we performed a comprehensive tran- scriptomic analysis to identify core gene sets during C. militaris cultivation on germinated soybeans. RNA-Seq technology was applied to the fungal cultures at seven-time points (2, 4, and 7-day and 2, 3, 5, 7-week old cultures) to investigate the global transcriptomic change. We conducted a time-series analysis using a two-step regression strategy and chose 1460 significant genes and assigned them into five clusters. Characterization of each cluster based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases revealed that transcription profiles changed after two weeks of incubation. Gene mapping of cordycepin biosynthesis and isoflavone modification pathways also confirmed that gene expression in the early stage of GSC cultivation is important for these metabolic pathways. Our transcrip- tomic analysis and selected genes provided a comprehensive molecular basis for the cultiva- tion of C. militaris on germinated soybeans.

Diagnostic Significance of Brainstem Auditory Evoked Potentials in Microvascular Decompression of Patients with Hemifacial Spasm or Trigeminal Neuralgia

( Sang-koo Park ),( Sung-hyuk Lim ),( Chan-woo Park ),( Jin-woo Park ),( Sung-ho Chang ),( Keun-hye Park ),( Hae-ja Park ),( Ji-hye Song ),( Dong-ok Uhm ),( Ki-bong Kim ) 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.1

The purpose of this study was to analyse brainstem auditory evoked potentials (BAEP) wave change data during microvascular decompression (MVD). The nerve function of Cranial Nerve VIII is at risk during MVD. Intraoperative monitoring of BAEP can be a useful tool to decrease the danger of hearing loss. Between January and December 2009, 242 patients had MVD for hemifacial spasm (HFS) and trigeminal neuralgia (TN). Among intraoperative BAEP changes, amplitude of V-V’ was the most frequently observed during cerebellar retraction and decompression step of the MVD procedure. 138 patients (57%) had no BAEP change while 104 patients (42.98%) had BAEP change. 69 patients (28.5%) had Type A-I, 16 patients (6.6%) had Type A-II, 5 patients (2.1%) had Type B, and 13 patients (5.37%) had Type C. MVD is a surgical procedure to relieve the symptoms (e.g. pain, muscle twitching) caused by compression of a nerve by an artery or vein. During BAEP intraoperative monitoring, the surgical step is important in interpreting the changes of wave V. Several potential mechanisms of injury may affect the cochlear nerve, and complete loss of BAEP is often associated with postoperative hearing loss. Intraoperative BAEP monitoring may provide an early warning of hearing disturbance after MVD.

Diagnostic Significance of Brainstem Auditory Evoked Potentials in Microvascular Decompression of Patients with Hemifacial Spasm or Trigeminal Neuralgia

Park, Sang-Koo,Lim, Sung-Hyuk,Park, Chan-Woo,Park, Jin-Woo,Chang, Sung-Ho,Park, Keun-Hye,Park, Hae-Ja,Song, Ji-Hye,Uhm, Dong-Ok,Kim, Ki-Bong 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.1

The purpose of this study was to analyse brainstem auditory evoked potentials (BAEP) wave change data during microvascular decompression (MVD). The nerve function of Cranial Nerve VIII is at risk during MVD. Intraoperative monitoring of BAEP can be a useful tool to decrease the danger of hearing loss. Between January and December 2009, 242 patients had MVD for hemifacial spasm (HFS) and trigeminal neuralgia (TN). Among intraoperative BAEP changes, amplitude of V-V' was the most frequently observed during cerebellar retraction and decompression step of the MVD procedure. 138 patients (57%) had no BAEP change while 104 patients (42.98%) had BAEP change. 69 patients (28.5%) had Type A-I, 16 patients (6.6%) had Type A-II, 5 patients (2.1%) had Type B, and 13 patients (5.37%) had Type C. MVD is a surgical procedure to relieve the symptoms (e.g. pain, muscle twitching) caused by compression of a nerve by an artery or vein. During BAEP intraoperative monitoring, the surgical step is important in interpreting the changes of wave V. Several potential mechanisms of injury may affect the cochlear nerve, and complete loss of BAEP is often associated with postoperative hearing loss. Intraoperative BAEP monitoring may provide an early warning of hearing disturbance after MVD.

뇌의 Orexin 발현과 운동 : 스트레스 조절 인자로서의 역할

장혁기 서울대학교 스포츠과학연구소 2008 스포츠과학리뷰 Vol.2 No.1

Orexins (Orexin A & B) are hypothalamic peptides of brain most recognized for their significant effects on feeding and arousal. Physiologically the orexin system has been implicated in the regulation of behaviours that are associated with wakefulness, locomotion, and stress. Central orexin activates hypothalamo-pituitary-adrenal (HPA) axis and may be involved in stress-induced activation of the HPA axis, resulted in a dose-dependent elevation of circulating adrenocorticotropin (ACTH) and corticosterone related with stress regulation. Both Orexin 1 receptor and 2 receptor have been found in the general area of the hypothalamus, but their localizations are region-specific : OX-2R mRNA is predominant in the paraventricular hypothalamic nucleus (PVN) region. The PVN area is innervated by OX-A and OX-B immunoreative projections, which both originate from the lateral hypothalamic area and perifornical nucleus. Those projections suggest an action of endogenous orexin on ACTH release, either by neuromodulatory effects in the PVN, or by neuroendocrine actions in the pituitary gland following release into the median eminence. Swimming and running exercise in rats activated orexin neuron in the brain and central administration of Orexins increased physical activity. Orexins is important not only stress regulating but also physiological regulator about exercise. But, the study of orexin about exercise is not enough for knowledge of the mechanism. Orexin은 중추 섭식 조절인자로서 밝혀진 이래에 뇌의 시상하부에서의 다양한 조절인자로서 역할하는 것이 많은 연구를 통해서 밝혀졌다. 그 조절로는 섭식조절을 비롯하여 수면·각성 조절, 자율신경계 조절, 스트레스 조절 등이 있다. 특히, 생체가 스트레스를 받으면 시상하부로부터 시작되는 HPA축이 활성화하는데 이를 조절하는 상위레벨의 조절인자로 Orexin이 발견되었다. 이 Orexin 의 발견으로 스트레스 기전의 새로운 개념도가 형성되었고, 운동 스트레스시에도 관련되며, 그 조절 인자로서의 역할에 대해 연구되기 시작되었다. Orexin은 식욕을 조절하는 뇌의 외측시상하부에서 발현하는 단백질로 뇌의 여러 부위에 그 수용체가 존재하는 것으로부터 생리적으로 복잡하고 많은 조절에 관여한다. 스트레스 호르몬인 ACTH 분비를 자극하는 CRH가 많이 존재하는 부위인 PVN에 Orexin 수용체가 존재함으로써 HPA축의 조절에 중요한 역할을 하는 것으로 여겨져 그 연구가 시작되었다. 최근의 몇몇 연구를 통하여서는 수영 및 런닝 운동이 뇌의 Orexin 신경을 활성화시키는 것을 밝혀내었으며, 쥐에게 외인성 Orexin의 투여가 자발적 신체활동을 증가시켰다. 이처럼, 운동학적으로 Orexin은 스트레스뿐만 아니라 운동에 대해 생리적으로 중요한 조절 인자임이 밝혀지고 있다. 하지만, 아직 운동 분야에서 Orexin이 역할과 관련성에 대한 연구는 미비한 실정이다.

치과용 니켈-티타늄 합금의 갈바닉 부식

최창혁,최기열,이중배 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.1

The purpose of this study was to evaluate the galvanic corrosion behavior of NT by coupling with other dental alloys in artificial saliva. The variation of galvanic current and common potential (mixed potential) were monitored as a function of time, and interpreted in terms of the electrochemical properties of each alloy. The effects of adding some constituents such as acid or chloride to the ordinary composition of artificial saliva were also estimated. For most cases of coupling, the significant current was observed only at early stage for several seconds or several minutes, then gradually diminished. The current value was affected by the excessive amount of acid or chloride added to artificial saliva, depending on their aggressiveness on each alloy ; the current was increased in the couples with HG, LG, VT, and decreased in the couples with AM and G2. The results were more complicated in the couples with AP and TC, where some mixed reaction occurred. The common potential was always between two corrosion potentials of alloys involved in the couple, and did not exceed the breakdown potential of alloy acted as anode except the case of coupling with AM in acid-containing artificial saliva. The coupling with AM was found to be the most susceptible to galvanic corrosion.

리조트 시설의 형태적 특성에 관한 연구

서기영,이성창,이재혁 대한건축학회 2003 대한건축학회논문집 Vol.19 No.6

The purpose of this study is to provide the design method of the resort facilities to give proper visual characteristics. For this purpose, SD(Semantic Differential Scale) technique was conducted as the main research method and SPSS(Statistical package for the Social Sciences) program was applied for statistical analysis. The results are summarized as follows : (1) The visual factors of resort facilities are defined Harmony, Identification, Order, Entertainment, Decoration and Clearness. (2) There visual factors are closely related to Nature, Shape, Formation, Display, Ornament and Material. (3) Therefore, when planning and designing resort facilities, these relationship can be applied very usefully in systematic fashion.

요소 및 포도당 동시 측정용 ISFET다기능 바이오센서

김창수,권대혁,손병기 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

A multi-biosensor for simultaneous detection of urea and glucose was fabricated by using ISFETs and Immobilized enzyme membrane and its performance characteristics were investigated. Detection of urea and glucose was possible in urea concentration range of 1~100mg/dl and glucose concentration range of 5~100mg/dl respectively. The ISFET multi-biosensor with strong advantages, very small size and fast response, showed high Potentials for in-situ measurements.

광섬유를 이용한 고감도 압력센서의 개발

김창원,권대혁,김진섭,이정희,손병기 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

KOH 수용액을 이용하여 실리콘 식각공정기술을 확립하였으며, 이를 이용하여 실리콘 기판 위에 스트레스 균형이 이루어진 150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4 두께를 가지는 구조의 평탄한 3층 유전체 멤브레인을 제작하였다. 본 실험에서 사용되는 파장인 1.3 ㎛ 근방에서 다이아프레임의 광투과도는 약 50 %로 광반사막으로 사용이 불가능하였다. 따라서, 다이아프레임 뒷면에 약 1000 Å의 금을 증착하여 N/O/N/Au박막의 광투과도를 수 %정도로 감소시킴으로써, 센서의 광반사막으로 사용할 수 있었다. source fiber를 단일모드로 했을 때 다이아프레임의 크기에 따라 감도는 각각 0.52㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟)였다. 광손실을 최소화하기 위해 광전송용 다모드 광섬유를 사용하였을 때는, 2×2 ㎟의 다이아프레임의 크기에 대해 0∼800 torr의 넓은 측정범위에서 거의 선형적인 압력특성을 나타내었다. Using KOH solution, silicon etching technology has been established and stress-balanced flat 600 ㎚ thick triple dielectric membrane(150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4) on silicon substrate has been fabricated. At the wavelength of the sensor light source near 1.3 ㎛, the optical transmittance of the diaphragm was about 50 %, it was impossible to be used as a reflecting film. To decrease to a few percents, the back-side of the diaphragm was deposited 1,000 Å thick gold layer, which is sufficient enough to be used as a light reflection layer of the sensor. When was used 8/126 ㎛ single-mode fiber, the respective sensitivities for diaphragm size were 0.52 ㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟). When was used 62/126 ㎛ multi-mode fiber for the light transmission to minimize optical loss, the pressure characteristics was showed almost linearly curve in a wide pressure range, 0 torr∼800 torr, for the 2×2 ㎟ diaphragm in dimensions.