고방(古方)으로 치료한 두드러기 환자 39례의 임상보고(臨床報告)

탁명림,김미보,변석미,고우신,윤화정,Tark, Myoung-Rim,Kim, Mi-Bo,Byun, Seok-Mi,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3

Objectives : This study was designed to investigate the chronical features of urticaria and the effects of urticaria treatment with Ko-Bang(古方). Methods : We treated 39 patients for urticaria with Ko-Bang(古方), who visited to care urticaria at the Dept. of Dermatology Oriental medical hospital Dong-eui university from Jan, 2008 to Sep, 2009. This study was assessed using the chart analysis and the follow-up survey by telephone. Results & Conclusions : 1. 39 outpatients were surveyed, who were 20 males and 19 females. And patients who were ages 21-30 were the largest group, 11(28.21%). Among the 39 patients, acute urticaria patients were 8(20.5%), chronic urticaria patients were 31(79.5%), and contraction of a disease period between 6 weeks with 3 months was 17.9%. 2. The causes of urticaria were measured unknown 37.5%, foods 37.5%, drugs 25% in acute and unknown 35.5%, a change of temperature 29%, foods 16% in chronic. And suspected provocation factors were measured unknown and foods each 12 cases. The most of accompanied symptoms was itching sign(34 cases), the second most was self-conscious fever(10 cases). 3. Out of treat prescription(Ko-Bang,古方), Injinho-Tang(茵蔯蒿湯) was used most in 5 cases, Daehwanghwangryunsasim-Tang(大黃黃連瀉心湯), Hwangryun-Tang(黃連湯), Daesiho-Tang(大柴胡湯) were used in each 4 cases, Galgeun-Tang(葛根湯), Chijadaehwangsi-Tang(梔子大黃?湯), Sosiho-Tang(小柴胡湯) were used in each 3 cases, Gaemagakban-Tang(桂麻各半湯), Chijasi-Tang(梔子?湯),Oryeongsan(五笭散) were used in each 2 cases. 4. When the processes of treatment were classified by one poison(一毒), there were the 19 cases (48.7%) which was caused by Bun(煩), the 12 cases(30.8%) by Water(水) and the 4 cases(10.3%) by Gyur(結).

말초성 안면마비 입원환자 250례에 대한 임상적 고찰

강나루,탁명림,변석미,고우신,윤화정,Kang, Na-Ru,Tark, Myoung-Rim,Byun, Soek-Mi,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.3

Objectives : This study was performed to analysis the effect of oriental medical care for inpatients with facial paralysis that had visited Dept. of Otolaryngology Oriental medical hospital Dong-eui university. Methods : From January 2008 to September 2010, a clinical study was done on 250 inpatients who were treated as facial nerve paralysis at the Dept. of Otolaryngology Oriental medical hospital Dong-eui university. This study was assessed using the chart analysis. Results : 1. The distribution of sex : female 54.8%, male 45.2%. The distribution of age was pregented that fifty to sixty was the most in 67 cases(26.8%). 2. The distribution of the period of admission : female 12.5 days, male 9.9 days. 3. The distribution of past history : hypertention(18.8%), diabetes-mellitus(10.85%), facial paralysis(9.25%), cerebrovascular disease(4.4%), liver disease(5.6%), hyperlipidemia(1.2%), otitis media(1.2%), herpes zoster(1.2%), cardiac disease(2.45%), thyroid disease(1.2%). 4. The distribution of the region of facial paralysis : Rt(55.36%), Lt(56.52%). 5. Check the mastoid pain : 66.8%(female 73.91%, male 58.04%). 6. Out of prescription(Ko-Bang, 古方), Galgeun-Tang(葛根湯) and Gaejigeogaegayoungchul-Tang was used most in each 34 cases, Daesiho-Tang(大柴胡湯) 30 cases, Galgeungabanha-Tang(葛根加半夏湯) 27 cases, Sihogaeji-Tang(柴胡桂枝湯) 14 cases, Hwanggigaejiomul-Tang 12 cases, Odu-Tang(烏頭湯) 10 cases, Chijadaehwangsi-Tang 10 cases, Gaejigagalgeun-Tang(桂枝加葛根湯) 7 cases, Banhasasim-Tang(半夏瀉心湯) 5 cases, Injinho-Tang(茵蔯蒿湯) 5 cases in order. 7. The distribution of herb group : Mahwang-Jae(麻黃劑) 31.72%, Gaeji-Jae(桂枝劑) 26.00%, Siho-Gae(柴胡劑) 20.70%, Chija-Gae(梔子劑) 7.49%, Buja-Jae(附子劑) 4.41%, Banhahwanggeum-Gae(半夏黃芩劑) 3.08%, Daehwang-Gae(大黃劑) 2.64%, Bockryeong-Gae(茯笭劑) 1.76%, Jisil-Gae(枳實劑) 1.32%, Insam-Gae(人蔘劑) 0.88% in order. 8. The distribution of House-Brackmann grade of admission : Gr Ⅳ 74.85%, Gr.III 13.6%, Gr.V 11.6% in order. 9. The distribution of House-Brackmann grade of discharge : Gr.III 56%, Gr.IV 38.4%, Gr.II 5.6% in order. 10. The average number of OPD follow up is 6.46. Conclusion : This results indicated that oriental medical treatment with Ko-bang(古方) can be an effective way to treat facial paralysis. The more patients we treat with Ko-bang(古方), the more clinical report is accumulated. Then it would be helpful to map out a systematic treatment on facial paralysis.

양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

청간소요산으로 호전된 설통 환자 3례

김연진,양승보,김정화,이상화,조승연,박성욱,박정미,고창남,Kim, Yeon-jin,Yang, Seung-bo,Kim, Jeong-hwa,Lee, Sang-hwa,Cho, Seung-yeon,Park, Seong-uk,Park, Jung-mi,Ko, Chang-nam 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4

Objectives: This clinical study reports the effects of Cheonggansoyo-san (CSS) on three patients with glossodynia. Methods: Three patients with glossodynia were treated with CSS (i.e., an herbal medicine) and acupuncture. Numeric rating scales (NRSs) for glossodynia and dry mouth and hwa-byung questionnaire scores were evaluated, and the results from heart rate variability (HRV) evaluations were analyzed. Results: After treatment with CSS, three patients' glossodynia symptoms, such as burning sensations, tingling, and numbness of the tongue, were improved. NRS ratings for glossodynia and dry mouth and the hwa-byung questionnaire scores also improved, and HRV parameters were closer to the normal range. Conclusion: Cheonggansoyo-san could be used to treat glossodynia.

우유와 과즙으로 만든 발효유를 동결건조한 제품의 관능성 조사

고영태,오미화 德成女子大學校 1998 德成女大論文集 Vol.29 No.-

Fermented milk was prepared from milk or mixture of milk and apple juice/ grape juice and it was freeze dried. The sensory properties of freeze dried and freeze dried/ reconstitutied fermented milk sample were invesitgated. In case of freeze dried/reconstituted samples, the sensory properties of the mixed sample of fruit juice-milk were better than those of milk sample. Among several different ratios of fruit juice and milk, sample of 15:35 showed the best sensory property. When the sensory properties of freeze dried apple juice-milk sample and those of freeze dried grape juice-milk sample were compared, there was no significant difference (p>0.05). However, hedonic scale score of smaple added with apple juice was slightly higher than that of sample added with grape juice(6.55 vs. 6.28).

원료콩의 증자조건을 달리한 검정콩 간장의 유리당, 유기산 및 지방산의 변화

권선화,최재훈,고영란,손미예,박석규 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

콩의 증자조건에 따른 검정콩 전통간장의 숙성 후 유리당, 유기산, 지방산조성을 조사하였다. pH 값은 5.04~5.32로 시험구간의 큰 차이를 나타내지 않았고, 원료 콩을 상압증자한 검정콩 간장이 가압이나 스팀보다는 약간 높은 수치를 나타내었다. 적정산도는 4.26~7.73mL로 나타났으며, 가압증자한 검정콩 간장(4.26~5.61mL)이 가장 높았으며, 다음으로 상압(7.32mL), 스팀(5.99~6.96mL)의 순으로 나타났다. 환원당은 25.18~194.81㎎%로 나타났고, 상압이 25.18㎎%로 가장 낮았으며, 가압이나 스팀증자한 검정콩 간장의 경우 상호간에는 큰 차이가 없지만, 상압한 것보다는 7~8배 높은 함량을 나타내었다. 주요 유리당은 glucose, fructose, xylose였으며, 스팀증자한 검정콩 간장이 상압이나 가압보다 각각의 유리당 모두가 많았고, 상압증자는 유리당이 극히 미량으로 검출되었다. 주요 유기산은 succinic acid, oxalicaicd, tartaric aic, malic acid, citric acid였고, 총 유기산은 스팀증자 (40.38~76.96 ㎎%)한 검정콩 간장이 상압(55.85㎎%)이나 가압(27.78~34.21)한 것보다 많았다. 증자 처리시간이 길수로 가압과 스팀으로 처리하여 제도된 검정콩 간장은 약간씩 감소되는 경향을 나타내었다. 주요 지방산은 palmitic acid(33.28~43.51%), stearic a창(14.15~19.16%), myristic acid(5.03~19.14%)였으며, 전체 지방산 중에 55.97~72.85% 비율을 차지하였고, 원료 콩에 존재하지 myristic acid가 상당히 많이 존재하였다. pH values in all samples were in the range of 5.04 to 5.32. pH of kanjang prepared with normal pressure(HPK) was higher than that of kanjang prepared with high pressure(HPK) and kanjang prepared with steam(SPK). Titratable acidity(TA) in all samples were found to be 4.26∼7.72 mL. TA in HPK(5.99∼6.96 mL) was lower than that in SPK(4.26∼5.61 mL) and NPK(7.32 mL). Reducing sugar(RS) contents in all samples were in the range of 25.48 to 194.81 ㎎%. Rs contents of HPK and SPK were a similar pattern and were higher than that of NPK. Major free sugars(FS) were glucose, fructose and xylose. In total FS, SPK was higher than that of NPK and HPK. Major organic acids(OA) were succinic acid, oxalic acid, tartaric acid, malic acid citric acid. OA contents in HPK and SPK were decreased slightly according to the heating time of whole black bean. The highest percentage of fatty acid(FA) in all samples was palmitic acid(33.28∼43.51% as area % of GC chromatogram), followed in a decreasing order by stearic acid(14.15∼19.16%) and myristic acid(5.93∼19.14%). The composition ratios of three FA to total FA ranged from 55.97 to 72.85%. In all samples, there was myristic acid that was not contained in raw soybean.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

Evaluation of improved vaccine for type C Foot-and-Mouth Disease in cattle and pigs

Su-Hwa You(Su-Hwa You),Hye-Eun Jo(Hye-Eun Jo),Joo-Hyung Choi(Joo-Hyung Choi),Mi-Kyeong Ko(Mi-Kyeong Ko),Sung Ho Shin(Sung Ho Shin),Min Ja Lee(Min Ja Lee),Su-Mi Kim(Su-Mi Kim),Byounghan Kim(Byounghan K 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-

The convergence rates in the asymmetric laws of large number for negatively associated random fields

( Mi Hwa Ko ) 호남수학회 2012 호남수학학술지 Vol.34 No.2

Convergence rates in the law of large numbers for i i d. random variables have been generalized by Gut [Gut, A, 1978. Marc inkiewicz laws and convergence rates in the law of large numbers for random variables with multidimensional indices, Ann. Probab, 6, 469-482] to random fields with all indices having the same power in the normalization. In this paper we generalize these convergence rates to the identically distributed and negatiely associated random fields with different indices having different power in the normalization.

On the Negative Quadrant Dependence in Three Dimensions

( Mi Hwa Ko ),( Tae Sung Kim ) 호남수학회 2003 호남수학학술지 Vol.25 No.1