Effects of Herbal Extracts Used in Oriental Medicines on Heme Oxygenase-1 Expression

Jeong, Gil-Saeng,Oh, Seung-Hwan,Kang, Dae-Gill,Lee, Ho-Sub,Kim, Youn-Chul The Physiological Society of Korean Medicine and T 2006 동의생리병리학회지 Vol.20 No.5

Effects of twenty-three aqueous herbal extracts used in oriental medicines on heme oxygenase (HO)-1 expression were estimated in a mouse hippocampal cell line, HT22. HO-1 is one of the cytoprotective enzymes activated various stimuli, and Western blot analysis was used for evaluated HO-1 expression. Six aqueous extracts such as Rhei Rhizoma, Paeoniae Radix, Uncariae Ramulus et Uncus, Theae Folium, Prunellae Spica, and Coptidis Rhizoma significantly increased HO-1 expression in HT22 cells at the concentration of 300 ${\mu}$g/ml. In Addition, four aqueous extracts including Eucommiae Cortex, Moutan Cortex Radicis, Ginseng Radix Rubra, and Scutellariae Radix moderately increased HO-1 expression. These results would be usefulfor the isolation and identification of their neuroprotective principles.

Sauchinone Suppresses Pro-inflammatory Mediators by Inducing Heme Oxygenase-1 in RAW264.7 Macrophages

Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyoung-Su,Kang, Dae-Gil,Lee, Ho-Sub,Jeong, Gil-Saeng,Kim, Youn-Chul Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.10

<P>Sauchinone, a biologically active lignan isolated from the roots of <I>Saururus chinensis</I> (L<SMALL>OUR</SMALL>.) B<SMALL>AILL</SMALL>. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to a reduction in COX-2-derived prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. Present study also demonstrates the effects of sauchinone in inducing heme oxygenase-1 (HO-1) expression and an increase in heme oxygenase (HO) activity in RAW264.7 macrophages. The effects of sauchinone on LPS-induced PGE<SUB>2</SUB>, NO, tumor necrosis factor-α (TNF-α) and interlukine-1β (IL-1β) production were partially reversed by the HO-1 inhibitor Tin protoporphyrin was also seen in this study. In addition, we found that treatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) reduced sauchinone-induced HO-1 expression. Sauchinone also increased ERK phosphorylation. These results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 <I>via</I> ERK pathway.</P>

강제치환 거동특성에 관한 원심모형실험

이종호,박병수,정길수,유남재 강원대학교 산업기술연구소 2003 産業技術硏究 Vol.23 No.A

This thesis is results of centrifuge model experiments to investigate the behavior of replacement method in dredged and reclaimed ground For experimental works. centrifuge model tests were carried out to investigate the behavior of replacement method in soft clay ground. Basic soil property). tests were performed to find mechanical properties of clay soil sampled from the southern coast of Korea which was used for ground material in the centrifuge model tests Reconstituted clay ground of model was prepared by applying preconsolidation pressure in 1g condition with specially built model container. Centrifuge model tests were carried out under the artificially accelerated gravitational level of 50g Replacing material of leads having a certain degree of angularity was used and placed until the settlement of embankment of replacing material was reached to the equilibrium state. Vertical displacement of replacing material was monitored during tests. Depth and shape of replacement. especially the slope of penetrated replacing material and water contents of clay ground were measured after finishing tests Model tests of investigating the stability of embankment after backfilling were also performed to simulate the behavior of the dike treated with replacement and backfilled with sandy material. As a result of centrifuge model test. the behavior of replacement, the mechanism of the replacing material being penetrated into clay ground and depth of replacement were evaluated

컴퓨터 모의실험을 이용한 Stop-and-wait ARQ 기법 성능 평가

이용학,이호준,최길용,장재신 인제대학교 2012 仁濟論叢 Vol.27 No.1

ARQ schemes are commonly used in various communication areas, for instance TCP protocol, to combat communication packet errors and there are three different types of ARQ protocol. In this paper, the performance of stop-and-wait ARQ scheme is evaluated with computer simulation and then compared with analytical results. Two different traffic generation modes are considered: the first one is the saturated traffic model and the other one is periodic arrival model based on exponential distribution. For performance measures, link utilization and average packet delay are used in this paper. According to numerical results, it is known that performance results from computer simulations coincide well with those by mathematical analysis. For the further study, we will continue to carry performance evaluations of two other ARQ schemes, go-back-N ARQ and selective repeat ARQ schemes.

자연파열된 신혈관근지방종 2례

이길호,선판일,성영훈,최영석,조철희,김철성,장대수 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Renal angiomyolipoma is an uncommon benign tumor of the kidney that consists of smooth muscle, blood vessels and mature adipose tissues. The most common benign renal tumor associated with spontaneous non-traumatic perirenal hemorrhage is angiomyolipoma, because of high vascularity. The ultrasonographic and computed tomographic images are sufficiently characteristic to permit accurate preoperative diagnosis. We report 2 cases of renal angiomyolipoma with spontaneous perirenal hemorrhage which were managed with nephrectomy.

트랙션 시브의 마모특성 연구

이강용,이길호 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.2

A laboratory testing machine is manufactured to examine the relationship between wear amount and hardness. Wear characteristics are observed with the traction sheaves of BHN 211-245 and wire rope of BHN 370 using acoustic emission method. The empirical relations between wear amount and hardness as well as between total acoustic emission count and wear amount are obtained. The empirical results show that the relationship between wear amount and hardness is not inversely proportional and the one between total acoustic emission count and wear amount is linear. The wear amounts of traction sheave T1 and T2 are the minimum and nearly constant in the ranges of BHN 235-245 and BHN 225-245, respectively.

한국인에서 다변성 D12S391 유전좌의 집단유전학적 연구

이용욱,김성민,구태완,이혜린,강일호,한길로,이혜승,황적준 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

The hypervariable short tandem repeat(STR) locus D12S391 was investigated in a Korean population. A total of 14 alleles were detected by size under denaturing conditions in 517 unrelated individuals. To confirm all of the alleles detected in a Korean population, a total of 34 fragments were sequenced. Prior to allele designation, we constructed the allelic ladders containing 11 alleles sequenced in this study. Allele 18 is the most common with a frequency of 0.281 in Koreans, and one variant allele 19.3 which have been confirmed by sequencing, was detected. The observed heterozygosity, the power of discrimination (PD), and the mean exclusion chance (MEC) for the locus D12S392 is 0.781, 0.946 and 0.652 , respectively. No deviation from Hardy-Weinberg equilibrium was observed in a Korean population (p=0.557). In the 424 meioses in 105 Korean families confirmed using other 17 STR loci, no mutation was detected in locus D12S391. The STR locus D12S391system is useful both for the analysis identification and parternity.

육상 100m 달리기 지도 및 기록향상을 위한 기술분석

이상철,오봉석,유호길 龍仁大學校 1998 용인대학교 논문집 Vol.16 No.-

This study was performed to analyze the technique of 100m sprint running and to offer profitable information related to sprint running to trainer and sprinter. To this purpose the technique of 100m sprint running was divided into four phase, that is, start phase, acceleration phase, maximum speed phase and finish phase. The following is summary. 1. In the 'set' position the most effective fore-leg and near-leg angle is 90 ˚, 120 ˚ respectively. Backbone angle is 27 ˚, shoulder position is on 10cm ahead of starting line. The head and neck are naturally as an extension of the trunk. The sprinter needs maximum concentration for the first action of the arms and legs. When the starting pistol fires the a straight line can be drawn from the toes of extended driving leg to the sprinter's head. 2. During the acceleration phase the body will gradually rise from a pronounced to a slight forward lean. The arms must be harmony with the legs. The hands are lifted not much higher than shoulder level. 3. During the maximum speed phase when the driving leg land below of gravity center the knee must be somewhat bended for reduction of the landing brake. Recovery leg heel moves to the buttocks to reduce the length of plumb and to increase the number of pitch. Arms must swing with 90 degrees at the elbow. 4. During the finish phase the sprinter must do the exact finishing techniques at exact timing. That is, it is disadvantageous for the sprinter to do the finish technique on excessive tension and to do jumping. A forward dip finish method during the last stride before the finish line is the most commonly used technique.

간경변 환자에서 콜히친 사용에 의한 호중구성 백혈구감소증 1예

이호찬,이헌주,김용길,박재현,김성준,박준석 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.2

Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and in patients with many liver diseases. Therapeutic oral doses of colchicine may cause nausea, vomiting, abdominal pain and diarrhea. The adverse effect of colchicine associated with the dose is bone marrow suppression, and especially neutopenia. Neutropenia has often been reported in patients have taken an overdose of colchicine. We describe a 64-year-old female liver cirrhosis patient with neutropenia that was induced by a therapeutic dose of colchicine.

레이온회사 퇴직근로자에서 이황화탄소에 의한 건강영향평가 : 직업병 인정여부에 따른 자각증상과 관련 요인 Subjective Symptoms and Related Factors According to Compensation for CS_2 Poisoning

이경재,김주자,최현림,양길승,김호,임상혁,이윤근 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.2

목적: 이 연구는 이황화탄소 취급 사업장에서 근무한 경력이 있는 퇴직 근로자들을 대상으로 이황화탄소에 의한 건강영향을 조사함으로써, 이황화탄소 노출 후의 건강영향 파악 및 이황화탄소 노출 근로자에 대한 건강관리 기준 마련 등에 중요한 기초자료를 제공하고자 하였다. 방법: 이 연구는 우리나라 모 레이온회사에 근무한 경력이 있는 퇴직 근로자 중에서 1998년 12월까지 직업병 여부를 확인하기 위해 건강진단을 신청한 1,702명 중에서 이미 사망한 40명을 제외한 1,662명을 대상으로 하여 이 연구 목적에 대한 설명문을 우편으로 발송하여 참여 의사를 밝힌 258명을 면접대상으로 하여 최종적으로 177명을 분석 대상으로 하였다. 결과: 연구대상자는 남자가 147명, 여자가 30명이었고, 평균 연령은 55.4세이고 입사시 연령은 29.1세였다. 근무부서별로는 고폭로부서에 근무한 군이 156명으로 88%를 차지하였으며, 인정받은 군이 103명(58.2%), 받지 못한 군이 74명(41.2%)이었다. 평균 총폭로지수는 38.96(±31.18)이었고, 인정받은 군에서 받지 못한 군 보다 유의하게 높았고 (p=0.000). 고폭로부서군에서 저폭로부서군보다 높게 나타났다(p=0.000). 퇴사전후 시간에 따른 호소 증상들을 분석한 결과, 퇴사전후 시간 흐름에 따라 호소하는 증상들이 차이는 있지만 호소하는 증상들이 퇴사전과 퇴사후 5년 이내에 비해 퇴사후 5~10년인 경우에는 인정받은 군과 받지 못한 군 간에 유의한 차이를 보이는 호소 증상들이 적어지는 경향을 보였다. 그러나 퇴사 10년 이상인 경우에는 퇴사후 5~10년 이내에 비해 오히려 호소하는 증상들은 많아진 반면, 인정받은 군보다 받지 못한 군에서 유의하게 높았다. 따라서 이는 퇴사후 10년 이상이 되면 그 이전 기간에 비해서 호소하는 증상들은 직업병 인정에 올바른 영향을 미치지 않을 수도 있다고 생각되고 이러한 결과에 영향을 미칠 수 있는 여러 가지 요인들을 생각해 볼 필요가 있다고 생각된다. 인정받은 군에 대해서 직업병 인정시점을 기준으로 인정전후에 호소 증상의 변화를 비교한 결과, 대부분 직업병 인정전에 비해 인정후에 호소하는 증상이 감소하는 경향을 보이고 있어 직업병 인정후에 의료기관으로부터 증상관리가 이루어지는 것이 증상호소를 줄이는 데 기여한 것으로 생각되며 이밖에도 직업병 인정으로 인한 심리적인 보상도 영향을 미칠 수 있을 것으로 생각된다. 직업병 인정여부에 영향을 주는 요인에 관하여 분석한 결과, 총폭로지수와 퇴사후 최종 건강진단을 받을 때까지의 시기가 유의한 요인으로 나타났으며, 퇴사후 직업병 인정을 받을 때까지의 시간에 대한 Cox의 비례위험 회귀분석을 한 결과, 총폭로지수와 입사연령, 고폭로부서의 근무여부가 의미있는 요인으로 나타났다. 결론: 이 연구를 통하여 이황화탄소 취급 사업장에서 근무한 퇴직 근로자들을 대상으로 직업병 인정에 따른 호소 증상을 분석하고 직업병 인정에 영향을 주는 요인을 분석해 봄으로써 이황화탄소 노출에 의한 건강영향을 파악하고 폭로 이후의 증상변화를 예측 관리할 수 있는 자료를 마련하고자 하였으며 이는 이황화탄소 노출 근로자들에 대한 건강관리에 기초자료로 의미를 가질 것으로 생각된다. Objectives: To investigate the chronological subjective symptoms and related factors in exworkers who were occupationally exposed to Carbon disulfide. Methods: One hundred and seventy-seven subjects(147 males and 30 females) were randomly selected among ex-workers and interviewed by well trained doctors, who filled out a structured questionnaire developed by authors on the subjective symptoms. The questionnaire was composed of symptoms in the head and neck, and those of the neuro-psychological, respiratory, endocrine, musculoskeletal, and reproductive systems. Other factors such as general and occupational characteristics including work department, work duration, duration since cessation of exposure, and compensation for occupational disease were also investigated. Results: The mean subject age was 55.4 years. The mean cumulative exposure index (CEI) was 38.96±31.18. CEI was significantly higher in the compensated group(47.61±32.51) than in the non-compensated group(26.81±24.75)(p=0.000). Symptom complaints were significantly higher in the compensated group in all organ systems, and their incidence increased gradually until 10 years after cessation of work, and then decreased. The mean duration for cessation of exposure at the time of compensation was 10.97 years. The significantly different factors between the compensated group and the non-compensated group were total cumulative exposure index and the time interval between the cessation of work and the time of compensation. Conclusion: Our findings suggest that total cumulative exposure index and the time interval between the cessation of work and the time of compensation may be important factors affecting the compensation for occupational disease. Therefore, further studies will be necessary.