내시경적 점막절제술 후 발생한 위천공의 성공적인 보존적 치료 1예

양정채,박은하,이준행,이풍렬,김재준,백승운,이종철 대한내과학회 2004 대한내과학회지 Vol.66 No.5

위장관 천공은 내시경적 점막절제술 후 발생할 수 있는 중대한 합병증으로 현재까지 이에 대한 치료 방법은 정립되지 않은 상태이다. 본 증례는 점막층에 국한된 위선암에 대한 내시경적 점막절제술 후 위천공이 발생한 경우로서 아주 작은 미세천공(microperforation)이었고, 최근 시도되고 있는 내시경적 클립 시술의 적응이 되지 못했다. 하지만 임상적인 복막염 발생 및 진행의 징후가 보이지 않아 금식, 광범위 항생제 투여 등의 보존적 요법으로 치료를 시행하였고, 시술 일주일 후 복막염의 발생이나 진행 없이 호전되어 퇴원하였다. 본 증례는 내시경적 점막절제술 후 발생한 미세 천공의 제한적인 경우에 한하여 수술이나 내시경적 치료를 하지 않고 보존적 요법만으로 성공적인 치료를 시행한 예로 문헌고찰과 함께 보고하는 바이다. The serious complication after endoscopic mucosal resection (EMR) was bleeding and perforation. Most of bleedings could be controlled by endoscopic procedure. However, the strategy of treatment for perforation was not established. A 60- year-old man was admitted to our center for EMR of gastric adenomatous lesion. After EMR, perforation in stomach was detected by peumoperitoneum on plain upright chest X-ray. We treated with conservative management such as withholding of oral intake, adminstration of broad-spectrum antibiotics, parenteral nutrition and close monitoring. There were no worsening clinical sings of peritoneal inflammation except mild leukocytosis during the in-hospital course. On the third hospital day after EMR, the patient resumed oral intake. The seventh hospital day, he was discharged. Our experience showed that selected small microperforation in stomach after EMR could be treated by not endoscopic procedures or surgical interventions but conservative management.

원관 주위의 대류 열전달에 대한 원둘레 방향의 열전도의 영향

이승홍,이억수,정은행 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

원관축의 수직방향으로 유체가 유동하는 경우에, 가열되는 수평 원관 주위에서 원둘레 (θ)방향으로 비대칭적으로 균일하지 않게 온도가 분포하기 때문에 원둘레 방향으로의 전도 열전달이 존재하고 비균일 대류 열전달 현상이 생긴다. 본 연구에서는 공기와 물을 작동유체로 하고 직교 유동내에 있는 수평 원관의 열전달 실험에서 국소 대류 열전달에 대한 원둘레 방향 열전도의 영향에 대하여 연구하였다. 에너지 방정식에서 유도된 무차원 수가 반경방향에 대한 원둘레 방향의 열전도의 영향을 나타내는 무차원 수로 사용되었다. 4가지 모델을 직접 전기저항 가열방식으로 가열하고, 원관 표면의 온도를 직접 측정하여 2차원 온도분포의 경계조건으로 사용하여 원관의 단면 내부에서 2차원 온도분포 T(r,θ) 를 보여준다. With uniform heat generation in a horizontal cylindrical heater placed in a cross flow boundary condition, heat flow that is conducted along the wall of the heater creates a non-isothermal surface temperature and heat flux distribution. In the present investigation, the effects of circumferential wall heat conduction on convection heat transfer is investigated for the case of forced convection around horizontal cylinder in cross flow of air and water. Non-dimensional conjugation parameter which can be deduced from the governing energy differential equation should be used to express the effect of circumferential wall conduction heat transfer. Two-dimensional temperature solutions T(r,θ) distribution is presented. The influence of circumferential wall heat conduction is demonstrated on graph of local Nusselt number.

HCV : PE-095 ; The regional prevalence of non-alcoholicfatty liver disease among Korean workers living in Seoul and Gyeonggi-do

( Eun Haeng Jeong ),( Yong Kyun Cho ),( Seung Ho Ryu ),( Dae Won Jun ),( Seung Min Lee ),( Eun Chul Jang ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: The prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing in Korea recently. Regional differences in NAFLD prevalence and characteristics need to be investigated. Methods: From January 2009 to December 2010, the Seoul and Gyeonggi-do residents who had checked up health exam at our institution 161,941 participants were enrolled in this cross-sectional study. After exclusion criteria, 141,660 subjects (men 80,977, women 60,683) were analyzed. NAFLD was presented by ultrasonographic findings. Results: 1. Both the prevalence of obesity (BMI≥25, kg/m2) and NAFLD were higher in Gyeonggi-do (29.2, 26.8%) than in Seoul (28.7, 25.1%) respectively (p=0.045, p<0.001). 2. The prevalence of Obesity was higher in Kangbuk than Kangnam area (29.6 vs 27.7 % p<0.001), regardless of gender (men in Kangbuk 39.9 vs. men in Kangnam 38.8%, p<0.033; women in Kangbuk 16.3 vs. women in Kangnam 13.0%, p<0.001). There were no difference in prevalence of NAFLD between Kangbuk and Kangnam area, but among women, Kangbuk was higher than Kangnam (13.8 vs 12.5% p=0.001). 3. There were no difference in prevalence of NAFLD between Kangbuk and 3 distincts in Kangnam (Kangnam-gu, Seocho-gu, Songpa-gu), but among men, 3 distincts in Kangnam was higher than Kangbuk (35.5 vs. 33.8%, p=0.006), and among women, Kangbuk was higher than 3 distincts in Kangnam (13.8 vs. 10.9%, p<0.001). Conclusions: There was difference of regional prevalence of the NAFLD in Seoul and Gyeonggi-do in Korea. The further study will be needed about the cause of the difference of regional prevalence.

HCV, Alcoholic : PE-095 ; The regional prevalence of non-alcoholic fatty liver disease among Korean workers living in Seoul and Gyeonggi-do

( Eun Haeng Jeong ),( Yong Kyun Cho ),( Seung Ho Ryu ),( Dae Won Jun ),( Seung Min Lee ),( Eun Chul Jang ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing in Korea recently. Regional differences in NAFLD prevalence and characteristics need to be investigated. Methods: From January 2009 to December 2010, the Seoul and Gyeonggi-do residents who had checked up health exam at our institution 161,941 participants were enrolled in this cross-sectional study. After exclusion criteria, 141,660 subjects (men 80,977, women 60,683) were analyzed. NAFLD was presented by ultrasonographic findings. Results: 1. Both the prevalence of obesity (BMI≥25, kg/m2) and NAFLD were higher in Gyeonggi-do (29.2, 26.8%) than in Seoul (28.7, 25.1%) respectively (p=0.045, p<0.001). 2. The prevalence of Obesity was higher in Kangbuk than Kangnam area (29.6 vs 27.7 % p<0.001), regardless of gender (men in Kangbuk 39.9 vs. men in Kangnam 38.8%, p<0.033; women in Kangbuk 16.3 vs. women in Kangnam 13.0%, p<0.001). There were no difference in prevalence of NAFLD between Kangbuk and Kangnam area, but among women, Kangbuk was higher than Kangnam (13.8 vs 12.5% p=0.001). 3. There were no difference in prevalence of NAFLD between Kangbuk and 3 distincts in Kangnam (Kangnam-gu, Seocho-gu, Songpa-gu), but among men, 3 distincts in Kangnam was higher than Kangbuk (35.5 vs. 33.8%, p=0.006), and among women, Kangbuk was higher than 3 distincts in Kangnam (13.8 vs. 10.9%, p<0.001). Conclusions: There was difference of regional prevalence of the NAFLD in Seoul and Gyeonggi-do in Korea. The further study will be needed about the cause of the difference of regional prevalence.

Original Article : Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea

( Eun Haeng Jeong ),( Dae Won Jun ),( Yong Kyun Cho ),( Young Gil Choe ),( Seung Ho Ryu ),( Seung Min Lee ),( Eun Chul Jang ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3

Background/Aims: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Korea has increased recently. The aim of the present study was to determine the regional differences in the prevalence and characteristics of NAFLD. Methods: From January 2009 to December 2010, 161,891 Seoul and Gyeonggi-do residents receiving a health examination at our institution were enrolled in this cross-sectional study. After applying exclusion criteria, the data of 141,610 subjects (80,943 males, 60,667 females) were analyzed. The presence of NAFLD was established by ultrasound examination. Results: The overall prevalence of NAFLD was 27.3% (38.3% in men, 12.6% in women). When standardized according to age, area, and sex, the prevalence of NAFLD was 25.2%. The age and area standardized prevalence of NAFLD was higher for men (34.4%) than for women (12.2%; P<O.OOl). The overall prevalence of NAFLD was higher in Gyeonggi￢do (27.7%) than in Seoul (26.9%; P<O.OOl). Among the men, the prevalence of NAFLD was higher in Gyeonggi-do (39.2%) than in Seoul (37.4%; P<O.OOl), while for the women it was higher in Seoul (13.2%) than in Gyeonggi-do (12.0%; P<O.OOl). Conclusions: The regional prevalence of NAFLD differed between Seoul and Gyeonggi-do. Further studies are needed to establish the etiology of this difference. (Clin Mol HepatoI2013;19:266-272)

Characterization of Transgenic Cucumber Plants Producing High Levels of Superoxide Dismutase

Suk Yoon Kwon,Haeng Soon Lee,Sang Soo Kwak,Hyun Sook Kim,Eun Jeong Kwon,Yu Jeong Jeong,Eun Mo Lee,In Shik Woo 한국육종학회 2001 한국육종학회 학술발표회 발표요지 Vol.2001 No.9

Poster Session 1 : Signal Transduction ; Suppression of ERK1/2 signaling pathway by eugenol in murine T Lymphocytes

( Haeng Soon Jeong ),( Eun Jung Kim ),( Chul Ho Yun ),( Dae Hyun Seog ),( Yeong Hong Park ),( Jae Gook Shin ),( Sung Su Yea ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-

Organotin Compounds Act as Inhibitor of Transcriptional Activation with Human Estrogen Receptor

( Eun Min Cho ),( Haeng Seog Lee ),( Jeong Suk Moon ),( Im Soon Kim ),( Sang Hyo Sim ),( Akinori Ohta ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.3

In aquatic invertebrates, particularly marine gastropods, organotin compounds induce irreversible sexual abnormality in females, which is termed imposex, at very low concentrations. Organotin compounds are agonists for nuclear receptors such as RXRs and PPARγ. However, the imposex phenomenon has not been reported to act as an antagonist on estrogen receptors in other species, including vertebrates and invertebrates. In order to gain insights into the antagonistic activity of organotin compounds on estrogen receptors (ERs), we examined the inhibitive effect of these compounds on estradiol-dependent β-galactosidase activity using the yeast two-hybrid detection system consisting of a combination of the human estrogen receptor (hERβ) ligand-binding domain and the co-activator steroid receptor co-activator-1 (SRC1). Tributyltin-hydroxide (TBT-OH) and triphenyltin-chlorine (TPT-Cl) exhibited an inhibitive effect on E2-dependent transcriptional activity, similar to antagonistic chemicals such as 4-hydroxytamoxifen (OHT) or ICI 182,780, at a very low concentration of 10-14M TBT or 10-10 M TPT, respectively. The yeast growth and transcriptional activity with transcriptional factor GAL4 did not exhibit any effect at the tested concentration of TBT or TPT. Moreover, the yeast two-hybrid system using the interaction between p53 and the T antigen of SV40 large did not describe any effect at the tested concentration of OHT or ICI 182,780. However, the interaction between p53 and T antigen was inhibited at a TBT or TPT concentration of 10-9 M, respectively. These results indicate that TBT and TPT act as inhibitors of ER-dependent reporter gene transcriptional activation and of the interaction between hERβ LBD and the co-activator SRC1 in the yeast two-hybrid system. Consequently, our data could partly explain the occurrence of organotin compoundinduced imposex on the endocrine system of mammals, including humans.

A Bacterial Flagellin, Vibrio vulnificus FlaB, Induces Human Dendritic Cell Maturation

Jeong, Byung-Chul,Kim, Soo-Young,Choi, Bo-Hwa,Park, Myong-Suk,Lee, Je-Jung,Rhee, Joon-Haeng,Lee, Shee-Eun The Korean Society for Microbiology 2005 Journal of Bacteriology and Virology Vol.35 No.3

The motile marine bacterium, vibrio vulnificus has a total of six flagellins. Flagellin is a structural component of flagellar filament in various locomotive bacteria and is the ligand of Toll-like receptor 5 (TLR5). TLRs, highly expressed on various types of cells including dendritic cells (DCs), recognize invading microorganisms and finally trigger host immune responses. In this study, we prepared all of six recombinant flagellin proteins and assessed the effect of six flagellins on IL-8 activation through TLR5 recognition. Although showed different activities, five out of the six flagellins stimulated significant IL-8 activation. We also investigated the immunomodulatory roles of Vv-FlaB, the crucial building block of V. vulnificus flagellar filament, on human dendritic cells. Treatment of immature DCs with Vv-FlaB resulted in an increased expression of co-stimulatory molecules and induced strong allo-T cell proliferative activities of the DCs. These results show that the Vv-FlaB may serve an epochal immune adjuvant possessing effective immunomodulatory activities.

Structural and electrical properties of La(Sr,Ca)MnO3 ceramics for NTC thermistors

Eun-Hui Kim,Sam-Haeng Lee,Byeong-Jun Park,Jeong-Eun Lim,Myung-Gyu Lee,Joo-Seok Park,Byung-Cheul Kim,Sung-Gap Lee 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.6

La0.7(Sr0.3-xCax)MnO3 (0.1≤x≤0.25) ceramics were prepared using solid-state sintering. XRD measurements showed that allspecimens showed rhombohedral polycrystalline structures. As the amount of Ca increased from 0.1 mol to 0.25 mol, sintereddensities decreased from 5.8888 g/cm3 to 5.5829 g/cm3. All specimens exhibited excellent NTCR properties of approximately0.445-0.421 %/oC. The TCR property, B25/65 constant, and resistivity at room temperature of the LSMO specimen doped with0.2 mol Ca were 0.439 %/oC, 469 K, and 3.94  104 Ω-cm, respectively.