[P8-108] In vitro and Cellular Antioxidant Activities of Smilax China Extracts

Dong―Su Kim,Chong-Ik Kim,Gyo-Nam Kim,Hyun-Mi Jeong,Hae-Dong Jang 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

전류제어형 PWM컨버터를 이용한 동기발전기용 여자시스템에 관한 연구

장수진,류동균,서민성,김준호,원충연,이진국 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

동기발전기 출력전압은 여자시스템의 계자전류 제어에 의해 일정하게 유지된다. 고주파 PWM 컨버터(전류제어모드 buck컨버더)형태의 여자시스템은 부하변동이 발생하였을 때 동기발전기의 계자전류를 제어하게 된다. 이 논문은 정상상태 및 과도상태에서의 안정화를 개선하기 위하여 여자시스템의 설계 및 실험에 대해 다루었다. 시뮬레이션 및 실험 결과는 제안된 여자시스템이 50kW 동기발전기의 DVR에 의해 응답시간이 개선되었음을 보여주었다. The output voltage of synchronous generator is regulated constantly by field current control in excitation system. High frequency PWM converter (current control mode buck conveter) type excitation system for synchronous generator is able to control exciter current when the load change happened. This paper deals with the design and evaluation of the excitation system for a synchronous generator to improve the steady state and transient stability. The simulation and experimental results show that the proposed excitation system is able to improve the response time by the DVR(digital voltage regulator) of 5O[kW] synchronous generator.

청계천 주변에 조성된 전통도시숲의 복원에 관한 연구

장동수 한경대학교 2005 論文集 Vol.37 No.-

The Korean traditional urban forest is a intentionally planted forest around a urban area because of some special reasons. People usually regard the forest as a symbol of their pride of city. The goal of this study is to restore traditional urban forests around the bank of CheongGyeCheon stream. Results of this study can be summarized as follows; Traditional urban forests around the bank of CheongGyeCheon Stream are the forests on the CheongGyeCheon stream bank, ChoSan, SuGuMaKi, pool bank, and bank around CheonGwan pasture. The flood prevention forest make a river bank stable because trees hold together the stone and soil by roots and decrease the speed of running fluid for the heavy flood by trunks. ChoSan is a unique convex mountain to be artificially made near SuGu. SuGu means a floodgate(the exit of the river from the city on the narrow throat of it) in Korea. The forest planted on the edge of the traditional city or a gorge in which wind blows is called SuGuMaGi. This SuGuMaGi not only played an important part in protection against cold wind in winter and the storm in summer but also controlled internal temperature and humidity. The pool that is usually located in front, performs a very practical function. In addition there were some pools on the urban edge. In the case of Seoul, the capital of Korea, four pools in ChoSun dynasty were located near the outside of the four gates of the citadel in Seoul. These kinds of pools and forests on those banks play a role in prevention against fire and draught, and in providing agriculture water. The forest on the bank around CheonGwan pasture functions as a fence for horses to go out. These kinds of Korean traditional urban forests form a green network which links and divides urban regions. The forest framework that embraces surrounding mountains and ridges is able to play an important ecological role in forming and maintaining ecological networks and can create ecological corridors conditioning the city and its water balance. The construction of the Korean traditional urban forest is one of best ecological methods to construct a friendly environment.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

한국 전통도시조경에 대한 소고 : 전통도시숲의 문화와 생태

장동수 안성산업대학교 2002 論文集 Vol.34 No.-

The Korean traditional urban forest is not a natural forest but a intentionally planted forest around a urban area. There were people' public activities something like an urban park. So most of forests have been planted the center and boundary of the city. People usually regard the forest as a symbol of home town and a source of pride. The goal of this study is to review cultural meaning and ecological concept of the forest and to propose some guidelines to contemporary park planning. First, the forest is usually located around the meaningful space in a city. So the forest has a lot of cultural meanings which play a more important role as a communication media. Second, the Korean traditional urban forest serves as a conspicuous visual element that enhances the sense of place in a city, because it locates in a center and enclosing surroundings in a city. So the forest become generally known as a famous place. A center located forest enhances a sense of authority for those people at the high class. Otherwise, a boundary located forest enhances the feeling of enclose and serves as the symbol of peoples' status and hierarchy by the region. Third, the Korean traditional urban forest of the center(the main ridge of the guardian hill around administrative buildings and facilities) and enclosing boundary(river banks, floodgates, ridges) of the city is to accomplish the green network which links and divides urban area. It is the most ecological method of urban planning to construct friendly environment in Korea. Essentially, the forest completed a traditional urban topography encircled on all sides without opening. It was built in order to fence off a floodgate(the place where water flows into or flows out), a gorge, and a ridge around the city. This type of forest not only played an important part in protection against cold wind in winter and storm in summer, but also controlled internal temperature and humidity.

이용후평가 방법론에 관한 연구

장동수 안성산업대학교 1997 論文集 Vol.29 No.2

POE is a last phase in the environmental planning and design process that follows the sequence of planning, programing, design, construction, and use of a project. Most of POEs are usually used for collection and analyzing some inquiries into select aspects of the evaluated project, documentation of successes and failures of it, feedback to it for purposes of immediate problem solving, and generalization of POE information for updating and improving design criteria and guideline for the environmental planning and design profession. This paper is organized as follows; The next section reviews the backgrounds, the history of POE. Section 3 explains the significance, the definition, goals, the content, and characteristics and categories of POE. Section 4 summarizes the findings of this study and studies some restrains and possibilities in order to apply POE into environmental planning and design.

동기발전기 여자시스템용 고주파 PWM 컨버터 설계

장수진,류동균,원충연,이진국,배기훈,김수석 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

A synchronous generator is equipped with an automatic voltage regulator(AVR), which is responsible for keeping the output voltage constant under normal operating conditions at various levels. The output voltage of Synchronous Generator is regulated constantly by field voltage control in excitation system. High frequency PWM converter (Buck converter) type excitation system for synchronous generator that can sustain proper output voltage level even at the fault condition happened. The proper operation of the proposed excitation system was verified through the simulations and the experiments.

Cervical Headgear와 Anterior bite plate를 이용한 Ⅱ급 부정교합의 치험례

손동수,이상훈,장기택,박윤정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The headgear is an extraoral appliance which used to distal movement of the teeth, inhibition of maxillary growth and reinforcement of anchorage. In case of treatment of Class Ⅱ malocclusion, however, it is not sufficient to simply restrict the horizontal growth of maxilla but to need treatment on mandibular retrusion. Generally, the combination theraphy of activator and headgear is conventional, but other study about combination therapy with other intraoral removable appliance is done. In this case, theatments were done by the combination therapy of headgear and anterior bite plate. The results were followed: 1. Reduction of SNA, upper lip to esthetic plane and lower lip to esthetic plane were observed. 2. 1 to FH plane angle was corrected. 3. Severe overbite, large overjet, and deep curve of spee was corrected. 4. Class Ⅱ molar relation was changed by class Ⅰ.

시지각분석에 따른 수원민자역사에서의 공간인식과 개선제안 연구

이수동,장성준 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

The goals of the study is to investigate the spatial perception of station complex and to verify the problems of space and to suggest direction for improvements. The case study is conducted on Suwon Station Complex, a newly constructed with mixture of railroad and subway station and several commercial facilities, ie. Department store, office block, cinema blocks. For the analysis of space, the Visual Structure Analysis(ISOVIST) was applied. The spaces in concern in the station complex was Front Gate(east side and towards city center), Rear Gate(west side and toward fringe area), and concourse hall. Space is organized into length, width and also perceived by finishing material and level's difference. We found that Suwon Station Complex has a big problem in the main circulation space: it provided not any clue to attract and to guide the people as they are inside a station, but a sense of department store We have to deal with various angles of outcome and additional analyses present public station making further efforts.

정신분열병과 Neuregulin 1 유전자의 연합연구

박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.