한중록의 국어학적 고찰

李氣銅(Lee Ki-dong) 고려대학교 한국학연구소 2009 한국학연구 Vol.30 No.-

본 연구의 목적은 『한중록』이라 불리는 작품의 이본인 李氣銅本과 一?本을 국어학적으로 비교하여 李氣銅本의 간행 연대를 추정하는 것이다. 『한중록』은 『한중만록』, 『읍혈록』 등의 명칭으로 불리며 지금까지 21종의 이본을 확인할 수 있다. 그러나 현재까지 원본으로 확정된 것은 없다. 본고에서는 여기에 새로운 1종을 추가하여 李氣銅本이라고 하고 이를 一?本과 비교하여 李氣銅本의 간행 연대를 추정한다. 이를 위해 두 이본 사이에서 관찰되는 연철ㆍ중철ㆍ분철, 합용병서, ‘ㅎ’종성체언, 높임법의 주격 표지, 음운변화 등의 표기 경향을 살폈다. 李氣銅本의 표기는 근대국어의 일반적 표기 경향에 가까우면서도 궁중에서 만들어진 작품이라는 성격 때문에 근대국어 이전의 표기 경향도 반영하는 보수성을 보여주고 있다. 이에 비해 一?本은 근대국어의 표기경향을 따르면서도 근대국어 후기의 성격도 반영하고 있다. 그러므로 두 이본의 비교를 통해 李氣銅本이 적어도 一?本보다 앞선 시기의 작품으로 판단할 수 있다. The purpose of this study is to compare the Lee Ki Dong-version Hanjungrok with the IlSa-version linguistically and to estimate the age of publication. The Hanjungrok has 21 versions and various names such as Hanjungmanrok, Uephyoelrok. But, up to now, there is no version identified as the original. In this paper one version called Lee Ki Dong-version is added to the versions of Hanjungrok and then compared with IlSa-version to estimate age of publication. For that, this paper investigated the notational tendency of both versions. On the one hand the notation of the Lee Ki Dong-version resembles Modem Korean notational tendency, but on the other shows the conservativeness that reflects the notational tendency of Middle Korean because of the particularity as Court literature. In comparison, the IlSa-version reflects the notational tendency of not only Modem Korean but also Late Modem Korean. As a result, the comparison between the Lee Ki Dong-version and the IlSa-version suggests that the former is earlier at least than the latter.

간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

족저압력분포 측정장비를 이용한 골프 스윙시 족저압 분석

이동기,이중숙,이범진,이훈식,김용재,박승범,주종필 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

D. K. LEE, J. S. LEE, B. J. LEE, H. S. LEE, Y. J. KIM, S. B. PARK, J. P. JOO. PIantar foot pressure analysis during golf swing motion using plantar foot pressure measurement system. Korean Journal of Sport Biomechanics, Vol. 15, No. 1, pp. 75-89, 2005. In this study, weight carrying pattern analysis and comparison method of four foot region were suggested. We used three types of club(driver, iron7, pitching wedge). This analysis method can compare between top class golfer and beginner. And the comparison data can be used to correct the swing pose of trainee. If motion analysis system, which can measure the swing speed and instantaneous acceleration at the point of hitting a ball, is combined with this plantar foot force analysis method, new design development of golf shoes to increase comfort and ball flight distance will be available. 1. Address acting, forces concentrated in rare foot regions and lateral foot of right foot. Back swing top acting, relatively high force occurred in medial forefoot region of left foot and forefoot region of right foot. Impact acting, high force value observed in the lateral rarefoot region of left foot and medial forefoot region of right foot. Finish acting, force concentration observed on the lateral region and rarefoot region of left foot. 2. Forces were increased in address of right foot with clubs length increased. All clubs, back swing top acting, high force value observed in the lateral forefoot region of right foot. All clubs, in impact, high force value observed in the lateral rarefoot region of left foot and medial forefoot region of right foot. Finish acting, force concentration observed on the rarefoot region in driver and lateral foot region in iron on left foot. 3. Right foot forces distribution were increased in address, back swing top and left foot force distribution were increased in impact, finnish

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

광선각화증, 보웬병, 편평상피세포암에서 Ki-67, Cyclin A, p53, p16의 발현 양상

이효진 ( Hyo Jin Lee ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),김기홍 ( Ki Hong Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4

Background: Actinic keratosis (AK) and bowen`s disease (BD) are pre-cancerous diseases, and are regarded as an early squamous cell carcinoma (SCC). AK and BD can be progressed into SCC. In this process, tumor suppressor and cell proliferative proteins may play important roles. Objective: To investigate the differences of expression patterns of the immunohistochemical (IHC) staining and useful markers for differential diagnosis in AK, BD and SCC. Methods: Biopsy had proven 17 cases of AK, 20 cases of BD and 17 cases of SCC, which were all selected. IHC staining for Ki-67 and cyclin-A, as cell proliferative markers, p53 and p16 as tumor suppressor markers, were performed. Labeling index (LI) and distribution pattern of IHC expressions were measured. Results: LI of Ki-67 in AK, BD and SCC were 30.6%, 60.2% and 54.8%, respectively. LI of cyclin-A in AK, BD and SCC were 9.2%, 24.4% and 24.1%, respectively. LI of p53 in AK, BD and SCC were 20.7%, 37.9%, and 39.9%, respectively. LI of p16 in AK, BD and SCC were 10.6%, 38.3% and 39.9%, respectively. Lower 1/3 was the most frequent distribution pattern in AK in all IHC stains, full thickness lower 2/3 were the most frequent distribution pattern in BD and SCC in all IHC stains. Conclusion: LI and distribution pattern of Ki-67, cyclin-A, and p16, as well as the distribution pattern of p53 may be useful markers to differentiate AK from BD and SCC. Higher degree and full-thickness distribution pattern IHC expressions in all stains may be helpful in the diagnosis of BD, rather than AK. (Korean J Dermatol 2012;50(4):290∼298)

가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

북한의 방언구획에 대한 고찰

이기동 고려대학교 한국학연구소 2001 한국학연구 Vol.15 No.-

This study centers round dialect division in the realm of dialectology which is studied mainly in North Korea. The study of language which had been worked in North Korea was not pure sense but supplementary means to perform social and political purpose. The such cognition of the study of language shows well from dialectology, and the dialect is understood in North Korea so-called 'what has to be gone in the process of centering round Mun-Hwa Language'. Despite of the such view about dialect, when we analyze the dialectology general, it is not very different from boundary of dialectology itself. It was worked relatively for many dialectologists to study of dialect division in dialectology. The early of dialect division study, it was arrangement stage of the study which is established by native and foreign dialectologists. After this, it was centering round large dialect area. It was a similar tendency in even South Korea, but since then the study in South Korea was converted to the study centering round small dialect area. It is not too much to say that dialect North Korea is Seo-Buk dialect, Dong-Buk dialect and Yukjin dialect. To be remarkable phonological feature in Seo-Buk dialect, there is no palatalization. Vowel 'ㅡ' is very unstable in Seo-Buk dialect, and it is lost of opposition to vowel 'ㅜ'. In Dong-Buk dialect, the important feature is that the inflection of the declinable word which stem ends in consonant 'ㅅ, ㅂ' is regular. In addition, the vowel sometimes nasalizes with falling of nasal consonant. To be the feature related to vowel, there is the 'umlaut' that realizes powerfully, there is a view that Yukjin dialect is regarded as 'isolated island' of Dong-Buk dialect, but it was understood in individual dialect area. Because we can see the distinguished individual system and phonological phenomena between Yukjin dialect and Dong-Buk dialect, though Seo-Buk dialect and Dong-Buk dialect share with some phonological phenomena. Especially, it is quite notable single vowel 〈+〉 that characterized central high vowel in this dialect. The studies of dialect division in North Korea have been working centered around national scale data on the whole, they present a contrast to the tendency centering round small dialect area in South Korea dialectology.

Lightweight Printed Dipole Antenna Array With 3×2 Beamforming Network for Wide UAV Communication Coverage

Dong‑Geun Seo,Jeong‑Soo Park,Gun ‑Ki Lee,Wang‑Sang Lee 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4

In this paper, a lightweight printed dipole antenna array with 3×2 beamforming network for wide unmanned aerial vehicle (UAV) communication coverage is presented. The proposed antenna consists of an upper substrate, a lower substrate, and two supports with a microstrip feeding. The upper substrate has a two-element printed dipole antenna array, and the lower substrate includes a beamforming feeding circuit and a ground plane as a refector of the proposed antenna array for gain improvement. For wide beam coverage, the proposed feeding network consists of three RF switches, one Wilkinson power divider, and one 90° hybrid coupler, and generates the wide beam using one broadside beam and two end-fre beams. Measured impedance bandwidth, peak gain, and half-power beamwidth (HPBW) of the proposed array operated from 5.03 to 5.15 GHz are approximately 2 GHz, 4.3 dBi, and 155°, respectively.

인(仁)문화의 원류와 동이(東夷)와의 관계

이기동 ( Ki Dong Lee ) 한국유교학회 2008 유교사상문화연구 Vol.32 No.-