정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

형상기억복합재료에 대한 온라인 모니터링 시스템 개발

이동화,박영철,이민래,이동화,이규창 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

형상기억복합재료를 제조하기 위하여 핫프레스 방법을 이용하여 최적의 제조조건을 도출하였으며 냉간압연에 의해 기지재와 강화재의 계면접합을 강화하여 강도를 증가시켰다. 이러한 방법에 의해 제조된 형상기억복합재료에 대하여 외부 하중에 의한 손상정도와 균열의 발생을 감지하여 균열 발생 및 진전을 억제하는 온라인 모니터링 시스템을 개발하고자 한다. 이를 위하여 음향방출 신호의 파라미터를 이용하여 손상에 따른 최적의 AE 파라미터를 도출하였으며 가열시스템을 이용하여 형상기억합금을 가열함으로써 형상기억합금의 수축에 의한 복합재료 내부에 균열진전을 억제시키는 시스템을 개발하였다. A hot press method was use for the optimal manufacturing condition for a shape memory alloy(SMA) composite. The bonding between the matrix and the reinforcement within the SMA composite by the hot press mothod was strengthened by cold rolling. In this study, the objective was to develop an on-line monitoring system for the prevention of the crack initiation and propagation by shape memory effect of SMA composite. Shape memory effect was used to prevent the SMA composite from cracking. For the system to be developed, an optimal AE parameter should be determined based on the degree of damage and crack initiation. When the SMA composite was heated by the plate heater attached at the composite, the propagating cracks appeared to be controlled by the compressive force of SMA.

기종성 신우신염 1례

이재욱,구정태,서정일,양창헌,이정호,이동철,이영현,이활,이경섭 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

기종성 신우신염은 주로 당뇨병환자나 폐쇄성 요로질환을 가진 환자에 발생하며 특징적으로 신실질 및 그 주위조직에 가스를 형성하면서 심한 조직괴사를 일으키는 매우 드문 급성 화농성 신감염으로 사망률이 높은 질환이다. 이 질환은 1989년 Kelly와 MacCallum에 의해 처음 보고된 이래 외국문헌에 약 90례 정도가 보고되어 있으며 국내에는 28례가 보고되어 있다. 수액 및 전해질 보충, 인슐린 투여를 통한 적절한 혈당조절 및 항생제 투여등의 내과적 치료와 절개배농 및 신적출술등의 수술적 치료 방법이 있다. 내과적 치료로 가스의 감소가 없는 경우에는 즉각적인 수술적 치료를 시행하여야하므로 이 가스변화에 대한 추적관찰이 중요하다 하겠다. 본 저자들은 당뇨병환자에서 발생한 기종성 신우신염 1례를 내과적 요법을 치험하였기에 문헌고찰과 함께 보고하고자 한다. Emphysematous pyelonephritis is rare, life-threatening infection of the renal parenchyma and perirenal tisseue. This disease is characterized by the production of intrarenal and perirenal gas and is frequently encountered in patients with diabetes mellitus or urinary obstruction. We experienced a case of emphysematouse pyelonephritis in a 62 years old women with poorly controlled diabetes mellitus who had been managed with medical theraphy. So we report this case with a review of the referenced literatures.

新聞에 揭載된 韓國人 自殺記事 內容 分析

박동철,이영식,박두병,곽동일,이길홍 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.4

To analyze the suicide patterns of Koreans, a research study was conducted from the suicide cases taken from the Dong-A Newspaper from 1981 to 1990. Four hundred and eleven cases were obtained from the collected data, which were composed of 275 cases of males and 136 cases of fe-males. The age groups were classified into 6 groups for convenience, 10's, 20's, 30's, 40's, 50's, and 60's. The group differences were then compared for analysis. The characteristics in relation to the socio-demographics and family environment were conpared for analysis. Suicide types compared and analyzed by gender and age group in terms of frequency, type, time, place, method, motivation, location and size of articles, and risk factors for suicide. Sta-tistical analysis used SPSS/PC^+ for cross-tabulation analysis. 1. In relation to the rate of Koreans' suicide, male suicide rate was at least double that of fe-male(2.02 : 1). The age group of the 20's(118 cases) and 30's(96 cases) accounted for a pre-dominant rate of 52.6% of the sample. 2. The distribution of occupation of suicides showed that most were students(22.5%), followed by the unemployed(17.8%) and housewives(12.7%), retrospectively. In relation to the residency of those that had committed suicide, residents who lived in large cities accounted for the greatest number as 70.3%, Especially, females and cases in their 40's were more likely to live in large cities. In the marital status, singles were in the lead(144 cases, 33.0%). With respect to marital status by age group, cases in their 40's(17.4%) tended to have an unstable status such as divorce, separation, co-habitation, remarriage, or widowed, In birth order, the first child were the highest ones as 22.1%. 3. In relationship to the family structure, data revealed that nuclear families were the most(163 cases). Especially, males and cases in their 40's were likely to be form a nuclear familiy, while those in their 60's were from and extended family. In relation to parental survival, data showed that both parents dead were at the highest frequency as 264 cases. In case of female, loss of both parents were more frequent. 4. With respect to the frequency of recurrent suicide, data presented that 6.3% of the cases ex-perienced recurrent suicide. In case of the recurrent suicide of male(8.0%), the rate was about 2.3 times higher than of female(2.9%) 5. For the relationships of homicide and suicide, data showed that 128cases(31.2%) hurt others and attempted suicide. Among them, 96 cases(23.4%) attempted co-suicide and 32 cases(7.8%) attempted homicide others. Analyzed by the characteristics of gender and age group, 10's males were more likely to commit solo-suicide, women in their 30's or 40's commit co-suicide, and 50's commit suicide after homicide. Among the victims of homicide, family members were the most(42 cases). Analysis by age difference between the suicide partners, the cases of 30's or 40's were with family members, 20's with lovers, and 10's with their peers. 6. In relation to the annual distribution of frequency of suicide, data revealed that most cases of suicide were reported in 1990(95 cases), 70 case in 1981, 45 cases in 1982, 44 in 1983, 30 in 1986, 1987, 1989, each, the fewest cases were in 1985(14 cases). In terms of the trend of sui-cide, recently the rate of male and old cohorts over 50's has been increasing. A great number of suicide were in 1981∼1982 and 1989∼1990, the period of a treat political-economical up-heaval. On the other hand, the number of suicide was low during the period of political-economical stability of 1985 and of political thawing in 1988. These fact demonstrated that there were some relationships between political-economical change and the rate of suicide. 7. For the month of suicide, data showed that the highest frequency of cases were in May and June(21.7%), followed by 44(10.7%) in September. For the season of suicide, the fewest cases were in winter(78 cases). The cases of 10's or 20's were more likely to suicide in May and June, and those of older aged group above 50's in fall, weekend, between 1 : 00∼6 : 00 A.M. 8. With respect to the place of suicide, data presented that in most cases suicide was attempted at home(210 cases). Compared by gender, the rate of femal's suicide at home(71.3%) was remarkably higher than that of male's(41.4%). On the other hand, the rate of male's suicide in indoors was much higher(36.4%) than that of female's(15.4%). Analyzed by age groups over 50's were more likely to attempt suicide at home, 30's in indoors, 20's in the office or outdoors. 9. For the methods of suicide, 31.9% resort to intoxication followed hanging(21.9%), jumping(13.1%), burning(10.2%), CO poisoning(6.1%), gunshot(3.9%) or drowning(2.9%), Compared by gender, while females were more likely to take such passive methods as intoxication or CO poisoning, males were more likely to take rather fatal methods such as hanging, burning, gunshot. 10. In relation to the general motives of suicide, data showed that economic poverty was the lead(20.9%), followed by emotional conflict(19.2%), marital conflict(16.1%), demonstration(8.5%), health problem (6.3%), school problems(5.8%), and job problems(5.6%). Analyzed by age group, in case of 10's adolescent conflicts such as school problems, scolding of parents of teachers, mockery, and frustration were the major motivations of their suicide, in the cases of 20's hetero-sexual problems, job and demonstration were their motivators. In case of 30's marital and legal problems were the motivators, economic problems in the age of 40's, loss of objects in 50's and health problems in 60's were their major motivations of suicide. 11. Analyzed by subtypes of suicide in the socio-psychological perspective, data showed that fatalistic suicide was the most frequent(30.2%), followed by anomic suicide(29.4%), egoistic suicide(21.7%), altruistic suicide(11.2%). Whereas in case of males altruistic and egoistic suicide were relatively more frequent, in case of females fatalistic and egoistic suicide were relatively more frequent. Analyzed by age group, fatalistic suicide in the 60's, anomic suicide in the 40's, egoistic suicide in the 10's adolescents and altruistic suicide in the 20's were more frequent. 12. For the psychodynamic factors of suicide, data revealed that most cases were escape from despair and loneliness(28.5%), followed by revenge toward the objects that hurt him or her(14.8%), inferiority(12.7%), escape from a conflict situation(11.4%), altruistic(7.8%), self-punishment for guilt(6.8%), pessimism(3.9%), reunion fantasy(1.0%), and other(13.1%). Whereas the psychodynamic factors of males were altruistic and inferiority, those of females were despair and revenge. Analyzed by age group, incase of old age groups over 50's despair and loneliness were the major fcators, revenge in the 30's and 40's, altruistic in the 20's inferiority and escape from a conflict situation in the 10's were more frequent psychodynamic factors. 13. With respect to the suicide risk rescue factors, data showed that as the helpers at the time of trying suicide, family members were the most(111 cases). Family members as helpers were more frequent in the case of females and in those of 10's or 60's. While passerbys were more frequent in the case of males and in those of 50's. For the suicide notes, 17.3% left the notes behind and those in their 60's males were more likely to have a relatively higher rate of leaving motes behind. 14. In relation to the experience rate of the suicide risk factors, data demonstrated that 16.8% had a history of depression which comprised the highest rate, followed by an alcoholism history(10.0%), unemployment and retirement(7.1%), recent death of intimates and separation(4.6%), health change(3.2%). Analyzed by gender and age groups, males were more likely to have an alcoholism or depression history, those in their 40's were more likely to have an alcoholism history than those of any other age group cohorts.

소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구

김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.

[18F]FDG PET을 이용한 강박증 환자에서 뇌 포도당 대사의 이상에 관한 연구

권준수,이동우,이재성,최정임,이동수,정준기,조맹제,이명철,류인균 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 강박증에 대한 기능적 뇌영상 연구들에서 강박증 환자들의 안와전두엽과 미상핵의 대사율 증가 소견이 비교적 일과되게 발표되어 왔으며, 전두-피질하 회로의 이상이라는 이론이 수립되기도 하였다. 그러나 기존의 연구들은 강박증의 유병기간에 따른 구분없이 시행된 연구였고, 영상분석 방법에 있어서도 관심영역 방법을 이용했다는 한계를 지니고 있다. 본 연구의 목적은 첫째, 강박증의 유병기간에 따라 환자군을 구분하여 PET 영상소견을 분석함으로써 유병 기간에 따른 차이가 있는지를 조사하였으며, 둘째, 강바증 환자의 포도당 양전자방출 단층촬영(18-Fluor-deoxyglucose Positron Emission Tomography : FDG-PET) 영상분석에 통계적 매개변수 지도법(Statistical Parametric Mapping : SPM)을 이용함으로써 강박증의 병인기전 및 강박증상과 뇌기능 간의 관계를 명확히 규명하고자 하였다. 방법: 구조적 면담도구(Structured clinical interview for DSM-IV : SCID-IV)를 적용하여 진단된 12명의 강박증 환자들과 10명의 정상 대조군에 대해 FDG-PET을 촬영하여 SPM으로 분석하였다. PET 촬영 전 적어도 4주 동안에는 약물복용을 하지 않은 상태였다. 결과: 1) 환자군과 대조군의 비교 : 강박증 환자군은 대조군에 비해 양측 두정 영역의 대사율이 유의하게 감소되어 있었으며(P<0.01). 대사증가를 보인 영역은 없었다. 강박증의 유병기간이 10년 이상인 만성강박증 환자 4명은 양측 안와전두엽에서 유의한 대사증가 소견을 보였으며(P<0.01), 양측 두정영역에서 유의한 대사감소 소견을 보였다 (P<0.01), 유병기간이 10년 이하인 환자에서는 전체 환자군의 분석에서와 마찬가지로 대조군에 비해 유의한 대사증가 소견을 보인 영역은 없었으며, 양측 두정엽 부위에서 유 의한 대사 감소 소견을 보였다.(P<0.01). 2) 강박증상의 심각도와의 상관관계 분석 : 우측 두정엽의 대사율은 강박장애 척도 점수와 유의한 음의 상관관계를 보였으며(p<0.01), 양측 시상 영역의 대사율은 예일-브라운 강박장애 척도의 강박장애척도 점수와 유의한 양의 상관관계(p<0.01)를 보였다. 결론: 본 연구는 결과는 기존의 연구들에서 보고된 안와전두엽의 대사 증가 소견이 강박증의 만성화로 인해 나타나는 2차적 장애이며, 두정엽의 대사 저하가 보다 1차적인 장애일 가능성을 시사한다. Baxter가 수립한 전두-피질하 회로 이론은 두정엽의 이상을 포함하는 전두-두정엽 복합체 이론으로 확장되어야 할 것이다. Objectives: Functional imaging studies on obsessive-compulsive disorder(OCD) subjects have repeatedly reported increased metabolism in orbitofrontal lobes and caudate nucleus, resulting in the "frontal-subcortical" circuit abnormality theory. Limitations of the previous studies to date include little consideration for the duration of illness, and the use of regions of interest methods, as an image analysis method. Our study objectives are 1) to include the duration of illness as an important study variable, and 2) to use Statistical Parametric Mapping(SPM) method in order to tap relations between the brain function and the psychopathology and symptoms of OCD. Methods: The [18] fluorodeoxyglucose positron emission tomography(FDG-PET) scans of OCD subjects and normal comparison subjects, as diagnosed by the Structured Clinical Interview for DSM-IV(SCID-IV), were analyzed using SPM. Results: 1) Comparison of OCD and control groups : OCD subjects had significantly decreased metabolism in both parietal lobes and didn't have any areas of increased metabolism in comparison to comparison subjects(p.<0.01). four OCD subjects with the illness duration of 10 years or longer, had significantly increased metabolism in both orbitofrontal lobes<p<0.01). OCD subjects whose illness duration is shorter than 10 years didn't have any areas of increased metabolism and had significantly decreased parietal lobe metabolism, as in the analyses of all subjects(p<0.01). 2) Correlation analysis between areas and symptom severity : Metabolism of both thalamic sreas showed significant positive correlation with Yale-Brown Obsessive-Compulsive Scale(Y-BOCS) scores(p<0.01). Metabolism of right parietal area showed significant negative corre lation with Y-BOCS scores(p<0.01). Conclusions: The current findings suggest that the increased metabolism in orbitofrontal lobe, previously rported, may be a secondary phenomenon due to the extended illness dur- ation and that decreased metabolism in the parietal lobes are primary abnormality in OCD subjects. Thus Baxter's fronto-subcortical circuit theory should be extended into "fronto-pari-etal" complex theory, which includes the parietal lobes.

유기용제 폭로가 여성 근로자들의 월경에 미치는 영향

김대환,이채관,김휘동,강동묵,문덕환,김정호,손병철,이창희,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

유기용제는 산업장에서 널리 사용되고 있다. 특히 여성근로자들의 폭로기회가 증가하고 있으며 이로 인한 자연유산, 수태능력 감소, 월경이상 등이 보고되고 있다. 따라서 유기용제 폭로가 여성근로자들의 월경에 미치는 영향을 보기 위해 설문조사와 월경주기별 여성생식 호르몬(progesterone, estrogen) 분석을 하였다. 그 결과 폭로군에서 progeterone의 억제효과가 유기용제에 폭로되는 여성근로자들의 다양한 월경이상을 초래할 가능성이 있는 것으로 생각된다. ■ Objectives This study was conducted to evaluate the effects of menstrual function in female workers exposed to organic solvents. ■ Methods Rates of menstrual disorders were studied in 87 female workers with exposure to organic solvents(Cn/Hn-value 0.713) in a factory manufacturing shoes and compared with 83 general female workers who had no exposure to organic solvents, Detailed menstrual and reproductive histories were obtained by personal interview using structured questionnaire, and plasma concentrations of progesterone and estrogen were assayed by radioimmunoassay(RIA). ■ Results The rates for menstrual irregularity, menstrual duration, blood clot in menstrual flow and dysmenorrhea were not significantly different in both groups. Number of using menstrual pad was significantly higher and the plasma level of progesterone during 6-11th day of menstrual cycle was significantly lower in the exposed group compared with non-exposed group(P<0.05). ■ Conclusions It seemed to be suppression effect of organic solvents on the reproductive hormones(progesterone and estrogen) in female workers. But there was no evidence that menstrual disorder was likely to result from exposure to organic solvents, because other behavioral, psychological and work related factors may also affect menstrual function.

Effect of simultaneous therapy of arthrocentesis and occlusal splints on temporomandibular disorders: anterior disc displacement without reduction

Hye-Sung Lee,Hyun-Su Baek,Dong-Suk Song,Hee-Chul Kim,Hyo-Geun Kim,Bok-Joo Kim,Myung-Soo Kim,Sang-Hoon Shin,Sung-Hee Jung,Chul-Hoon Kim 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.1

Objectives: This study sought to evaluate the effect of simultaneous application of arthrocentesis and occlusal splint. Materials and Methods: A retrospective study of 43 patients (3 males, 40 females) whose symptoms had improved was conducted at the Department of Oral and Maxillofacial Surgery, Dong-A University Hospital between 2008 and 2010. Subjects were divided into three groups: Group A (17 patients with arthrocentesis and occlusal splints simultaneously applied), Group B (13 patients whose symptoms did not improve with occlusal splints, undergoing arthrocentesis after occlusal splint use for 8 weeks), and Group C (13 patients that only used occlusal splints). We compared these groups in maximum comfortable opening (MCO) and the visual analogue scale of pain and noise. Follow-up was performed at 1 week, 1 month, 3 months, and 6 months. Results: The improvement of symptoms was noted in all three groups, but Group A had a quicker improvement than the other groups, in terms of pain reduction and MCO increases. Conclusion: The simultaneous application of arthrocentesis and occlusal splints can reduce patient discomfort more quickly.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.

장애학생 체육활동에 대한 부모의 신체활동 가치 인식

노형규 ( Hyoung Kyu Roh ),이동철 ( Dong Chul Lee ) 한국체육대학교 체육과학연구소 2013 스포츠사이언스 Vol.30 No.2

본 연구는 장애학생 신체활동프로그램에 참여하는 부모가 자녀의 신체활동에 대한 가치를 어떻게 인식하고 있는지 분석하여 향후 장애학생 신체활동프로그램의 효과적인 운영전략을 위한 정보를 제공하는데 그 목적이 있다. 연구대상은 전국 5개 대학에서 운영하는 장애학생 신체활동프로그램 참가 부모 148명으로 설문조사를 실시하였으며, 조사도구로는 Lee와 Dummer(2003)가 개발하고 이범진(2005)이 번안한 “Physical Activity Values and Concern Survey”을 수정ㆍ보완하여 사용하였다. 자료처리는 SPSSWIN Ver 18.0을 이용하여 측정도구에 대한 신뢰도 검증, 빈도분석(Frequency analysis), 기술통계, 독립표본 t-검정, oneway-ANOVA을 실시하였다. 본 연구의 기술통계 결과 부모의 신체활동 중요도 가치는 즐거움, 심리적효과에서 가장 높게 나타났으며, 신체활동 참여 가치에서는 즐거움, 운동기능 향상의 순으로 나타났다. 또한 집단 간의 차이검정결과 신체활동 참여 가치 영역의 자녀 성별에서 통계적으로 유의한 차이가 나타났으나, 다른 변인들의 결과에서는 집단간 평균차가 통계적으로 유의한 차이가 없는 것으로 나타났다. 본 연구결과로 알 수 있는 것은 장애학생 신체활동프로그램에 참여하는 장애 부모는 자녀가 신체활동 참여를 통해 즐거움을 느끼고 심리적ㆍ사회적으로 안정감을 찾으며, 건강 증진과운동 기능을 향상시키는 것에 대해 가치를 두고 있다는 것을 확인할 수 있었다. The purpose of this study was to understand parent``s perceptions of physical activity value about students with disability participating adapted physical education and supported effective strategy to manage adapted physical activity. To achieve this goal, 148 parents of 5 university who take part in adapted physical activity program in Korea. The tool was developed by Lee and Dummer(2003) and re-modification by Bum-Jin Lee(2005) as "Physical Activity Values and Concern Survey". T-test, oneway-ANOVA, Frequency analysis, and reliability were conducted by using SPSS 18.0. The results indicated that parents had perception physical activity effected their children``s enjoyment and emotion. And while the children were participating in the physical activity, the priority value for parents was enjoyment and improvement of motor skill. The difference in the test results between parents groups raising boys or girls showed a statistically significant value participating physical activity, but the other group was not showed statistically significant difference. This result can suggests that parents whose children take part in adapted physical education tends to think the students can get enjoyment through participation in physical activity, and stability from the psychologically and sociologically, furthermore, health promotion and exercise that enhances the functionality, and their effects are evaluated highly.