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Haiming Jin,Zengjie Zhang,Chengui Wang,Qian Tang,Jianle Wang,Xueqin Bai,Qingqing Wang,Majid Nisar,Naifeng Tian,Quan Wang,Cong Mao,Xiaolei Zhang,Xiangyang Wang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains unclear. Here, EPCs were isolated from the bone marrow of mice. Treatment of EPCs with melatonin alleviated advanced glycation end product (AGE)-induced apoptosis and cellular dysfunction. We further examined autophagy flux after melatonin treatment and found increased light chain 3 (LC3) and p62 protein levels in AGE-treated EPCs. However, lysosome-associated membrane protein 2 expression was decreased, indicating that autophagy flux was impaired in EPCs treated with AGEs. We then evaluated autophagy flux after melatonin treatment and found that melatonin increased the LC3 levels, but attenuated the accumulation of p62, suggesting a stimulatory effect of melatonin on autophagy flux. Blockage of autophagy flux by chloroquine partially abolished the protective effects of melatonin, indicating that autophagy flux is involved in the protective effects of melatonin. Furthermore, we found that the AMPK/mTOR signaling pathway is involved in autophagy flux stimulation by melatonin. An in vivo study also illustrated that melatonin treatment ameliorated impaired wound healing in a streptozotocin-induced diabetic wound healing model. Thus, our study shows that melatonin protects EPCs against apoptosis and dysfunction via autophagy flux stimulation and ameliorates impaired wound healing in vivo, providing insight into its mechanism of action in diabetic wound healing.
( Cong Wang ),( Yul-lye Hwang ),( Xue Mei Li ),( Soo Jung Kim ),( Ming Ji Zhu ),( Jeung-hoon Lee ),( Ri-hua Jiang ),( Chang Deok Kim ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.3
Background: Sebocytes are the major cells of sebaceous gland. The essential role of sebocytes is the production of sebum, a specific lipid mixture, that covers the body surface and provides the barrier function. At puberty, sebum production increases under the effects of various stimuli including androgens and insulin-like growth factor-1 (IGF-1). Excessive sebum production changes the microenvironment surrounding hair follicle, often leading to the onset of acne. Objective: We previously performed screening test using cultured human sebocytes, and found that bilobetin had a potential for inhibiting lipid production. The aim of this study is to demonstrate the effects of bilobetin on IGF-1-induced lipogenesis in sebocytes. Methods: We pretreated simian virus 40 T (SV40T)-transformed sebocytes with bilobetin then stimulated with IGF-1. Effects of bilobetin on lipogenesis of sebocytes were examined by thin layer chromatography and Western blot. Results: Bilobetin markedly inhibited IGF-1- induced lipid production in sebocytes, especially in terms of production of squalene and wax ester. Supporting these results, bilobetin showed significant inhibitory effect on squalene synthase promoter activity. In addition, bilobetin significantly down-regulated lipogenic transcription factors such as sterol response element binding protein (SREBP)-1 and SREBP-2. To delineate the possible action mechanism, we investigated the effect of bilobetin on intracellular signaling. As a result, bilobetin inhibited IGF-1-induced phosphorylation of AKT. Conclusion: Together, these results suggest that bilobetin has an inhibitory potential on sebum production in sebocytes, being applicable for acne treatment. (Ann Dermatol 31(3) 294∼299, 2019)
On the receding contact plane problem for bi-FGM-layers indented by a flat indenter
Cong Wang,Jie Yan,Rui Cao 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.5
The major objective of this paper is to study the receding contact problem between two functional graded layers under a flat indenter. The gravity is assumed negligible, and the shear moduli of both layers are assumed to vary exponentially along the thickness direction. In the absence of body forces, the problem is reduced to a system of Fredholm singular integral equations with the contact pressure and contact size as unknowns via Fourier integral transform, which is transformed into an algebraic one by the Gauss–Chebyshev quadratures and polynomials of both the first and second kinds. Then, an iterative speediest descending algorithm is proposed to numerically solve the system of algebraic equations. Both semi-analytical and finite element method, FEM solutions for the presented problem validate each other. To improve the accuracy of the numerical result of FEM, a graded FEM solution is performed to simulate the FGM mechanical characteristics. The results reveal the potential links between the contact stress/size and the indenter size, the thickness, as well as some other material properties of FGM.
Cong, Wang,Fang, Zhang,Nam-Young, Kim Science Press 2010 CHINESE PHYSICS LETTERS Vol.27 No.7
<P>We report the fabrication of high breakdown voltage metal-insulator-metal (MIM) capacitors with 200-nm silicon nitride deposited by plasma-enhanced chemical vapor deposition with 0.957 SiH<SUB>4</SUB>/NH<SUB>3</SUB> gas mixing rate, 0.9 Torr working pressure, and 60 W rf power at 250° C chamber temperature. Some optimized mechanisms such as metal source wiping, pre-melting and evaporation rate adjustment are used for increasing the yield of the MIM capacitors. N<SUB>2</SUB> annealing and O<SUB>2</SUB>/H<SUB>2</SUB> plasma pre-deposition treatment is proposed to increase the reliability of the MIM capacitors in high-temperature, high-pressure, and high-humidity environments. A 97% yield and up to 148 V breakdown voltage of a 13.06 pF MIM capacitor with 0.04 mm<SUP>2</SUP> die area can be fabricated.</P>
High Performance Wilkinson Power Divider Using Integrated Passive Technology on SI-GaAs Substrate
Cong Wang,Cheng Qian,De-Zhong Li,Wen-Cheng Huang,Nam-Young Kim 한국전자파학회JEES 2008 Journal of Electromagnetic Engineering and Science Vol.8 No.3
An integrated passive device(IPD) technology by semi-insulating(SI)-GaAs-based fabrication has been developed to meet the ever increasing needs of size and cost reduction in wireless applications. This technology includes reliable NiCr thin film resistor, thick plated Cu/Au metal process to reduce resistive loss, high breakdown voltage metalinsulator-metal(MIM) capacitor due to a thinner dielectric thickness, lowest parasitic effect by multi air-bridged metal layers, air-bridges for inductor underpass and capacitor pick-up, and low chip cost by only 6 process layers. This paper presents the Wilkinson power divider with excellent performance for digital cellular system(DCS). The insertion loss of this power divider is ?0.43 ㏈ and the port isolation greater than ?22 ㏈ over the entire band. Return loss in input and output ports are ?23.4 ㏈ and ?25.4 ㏈, respectively. The Wilkinson power divider based on SI-GaAs substrates is designed within die size of 1.42 ㎟.
Mechanical Properties Improvement of Nanoclay Addition Epoxy 3D Orthogonal Woven Composite Material
Cong Wang,Xiaoping Gao,Yonggui Li 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7
In this study, the influence of nanoclay on mechanical properties of epoxy/3D orthogonal glass fiber wovencomposite was studied. The DK2 polymer-grade organic nanoclay modification composite specimen reinforced with 3Dorthogonal woven fabric/epoxy was manufactured by means of Resin Infusion under Flexible Tooling (RIFT) process. Firstly, the modification mechanism with nanoclay was characterized by means of Fourier transform infrared spectroscopy(FT-IR), X-ray diffraction (XRD) and transmission electron microscope (TEM). Secondly, as far as the tensile behaviorbetween the fiber/matrix of the composite was concerned, the modification process was optimized by means of nonlinearleast square fitting. The results show that the bonding strength between the fiber and matrix was improved and thedelamination and debonding between fiber and matrix was retarded and shifted to cohesive failure of the matrix due to thenanoclay modification with respect to results from FT-IR, XRD and TEM. The tensile strength and modulus of compositewere increased by 23.32 % and 16.42 % respectively due to 3 of nanoclay addition. The contact angle also shows that thedispersion effect and wettability at this state. The tensile stress-strain curve was fitted by applying nonlinear fitting. It can beconcluded that there has a good modification effect with 3 wt% of nanoclay addition.
Cong Wang,Yongxue Zhang,Hucan Hou,Zhiyi Yuan,Ming Liu 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.1
To improve the energy conversion efficiency and cavitation performance of the ultra-low specific-speed centrifugal pump (ULSSCP), the impeller-volute interaction has been studied. Blade outlet setting angle (β₂), wrap angle (φ), volute inlet width (b₃) and throat area (St) were addressed as the design parameters. The entropy production at 0.5 Q0 and NPSHc (critical net positive suction head) at 1.5 Q0 were selected as the target to characterize the energy loss and cavitation performance. The L9 (3⁴) orthogonal matrix was established via Taguchi method. Results show that the contribution ratio of φ on S/NS is the most vital, followed by b₃ and St, while the influence of β₂ is relatively small, and the design parameter combination with β₂=19°, φ=220°, b₃=12mm and St=190㎟ is the best choice for the lowest entropy production at 0.5Q0 and NPSHc. At last, the optimization design reduces the loss greatly before and after cavitation by alleviation of vortex generation and backflow intensity.
Cong Wang,Dong-Jian Song,Zhi-Li Xu,Shu-Ping Xie,Jun-Hong Hu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
The primary purpose of this study was to explore the short-term efficacy of different cisplatin and fluorouracil-based chemotherapy regimens in the treatment of patients with esophagogastric junctional adenocarcinoma (EGJA) using a network meta-analysis (NMA). Randomized controlled trials (RCTs) related to chemotherapy regimens based on cisplatin and fluorouracil for EGJA were included from the PubMed, EMBASE and Cochrane Library electronic databases (from inception to June 2016). Direct and indirect evidence were combined to calculate the pooled odds ratio (OR) and its 95% confidence interval (95% CI) as well as to draw the surface under the cumulative ranking (SUCRA) curves. This NMA finally enrolled ten eligible RCTs with the following five regimens: cisplatin plus fluorouracil (cisplatin+fluorouracil), cisplatin+fluorouracil-based chemotherapy (cisplatin+fluorouracil+docetaxel/epirubicin/irinotecan), fluorouracil-based chemotherapy (fluorouracil+docetaxel/doxorubicin/ methotrexate/irinotecan), cisplatin-based chemotherapy (cisplatin+docetaxel/epirubicin/irinotecan/capecitabine/s-1) and other drug-based chemotherapy (docetaxel/irinotecan/capecitabine). These results revealed that compared with a cisplatin+ fluorouracil-based chemotherapy regimen, the fluorouracil-based chemotherapy regimen had a lower overall response rate (ORR) and partial response (PR) for EGJA patients (ORR: OR=0.43, 95% CI=0.22–0.86; PR: OR=0.46, 95% CI=0.23–0.91). Cluster analyses suggested that the cisplatin+fluorouracil-based chemotherapy regimen had the best short-term efficacy for EGJA in terms of the complete response (CR), PR, ORR, stable disease (SD) and progression disease (PD). Our results indicated that cisplatin+fluorouracil-based chemotherapy regimens may have the best short-term efficacy in the treatment of EGJA
Adaptive robust target tracking control of marching tank under high-speed maneuvering condition
Cong Li,Guolai Yang,Xiuye Wang,Yuze Ma,Liqun Wang,Quanzhao Sun 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
This paper focuses on the problem of target tracking control of marching tanks under the condition of high-speed maneuver based on sliding mode disturbance observer. First, the dynamic model of marching tank is established by using multi-body dynamics software. The nonlinear factors such as barrel flexibility, clearance between barrel and bushing, and uncertainty sources such as road excitation are considered. Second, the mechatronics model of tank bidirectional stabilization system considering transmission clearance and friction is established in numerical simulation software. Aiming at the tank bidirectional stabilization system, an adaptive robust controller based on sliding mode disturbance observer is designed. Finally, the real-time control and target tracking of the tank bidirectional stabilization system are realized by co-simulation. The results show that the sliding mode disturbance observer improves the stability accuracy of the system by 43.22 %. Comparing the simulation results with the PID control, the controller designed in this paper has the characteristics of rapid tracking speed and high robustness, and the advantage is more obvious under the condition of highspeed maneuver.