Erratum to: Occurrence and surgical treatment of massive Morel-Lavallée lesion after large-volume liposuction: A rare clinical case

Byeong Jun Kim,Chul Hoon Chung,이승준 대한미용성형외과학회 2020 Archives of Aesthetic Plastic Surgery Vol.26 No.1

We have noticed an error in our published paper above. In the title, the order of “Byeong Jun Kim, Chul Hoon Chung, Seung Jun Lee” should be “Byeong Jun Kim, Seung Jun Lee, Chul Hoon Chung.” We sincerely apologize for the inconvenience that this may have caused.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA

Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus

沙上地域 産業體 勞動者의 職場體育 參與擴大 方案

安永弼,鄭琮勳,鄭三鉉,金海禮,趙在基,朴俊東,金垠利,張禎允,金福善,孔庚鎬 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-

집속이온빔을 이용한 3차원 마이크로스케일 몰드 제작 및 폴리머 복제

김충수,안성훈,장동영 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

Focused ion beam (FIB) sputtering was used to fabricate a low microscale mold having a circular curved structure, as well as variable sizes. Experimentally, in this work, a continuous slicing method, which was modified from two-dimensional slice-by-slice approach developed by Fu, was tested with the aim of excluding the material redeposition phenomena by repeating the discrete slicing process with a combination of spiral scans as part of an overall vector scan. Three types of fabrication strategies, including scan strategy, ion beam condition, and processing parameter, were defined and the mould was fabricated as a function of ion dose for specific dwell times. Through replication technique from fabricated moulds, polymeric microstructures were replicated from polydimethy-lsiloxane (PDMS) and polyurethane acrylate (PUA) and compared with the mould dimension. Furthermore, micro-lens arrays was also fabricated and replicated.

직렬 리액터를 이용한 계통연계형 태양광 발전 시스템

金大均,鄭春炳,全基英,李丞煥,吳鳳煥,李勳九,金容珠,韓慶熙 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Since the residential load is an AC load and the output of solar cell is a DC power, the photovoltaic system needs the DC/AC converter to utilize solar cell. In case of driving to interact with utility line, in order to operate at unity power factor, converter must provide the sinusoidal wave current and voltage with same phase of utility line. Since output of solar cell is greatly fluctuated by insolation, it is necessary that the operation of solar cell output in the range of the vicinity of maximum power point. In this paper, DC/AC converter is three phase PWM converter with smoothing reactor. And then, feedforward control used to obtain a superior characteristic for current control and digital PLL circuit used to detect the phase of utility line.

건물내장재(석고보드,합판)의 화재성능평가

김충환,김종훈,김운형,하동명,이수경 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.3

본 연구는 국내와 외국의 건물 내장재 화재성능평가방법을 고찰하고 국내에는 도입되지 않은 실대 화재 실험인 Room Corner Test를 국내 내장재중 석고보드와 합판을 대상으로 그 적용성을 위한 실험을 진행하였다. 현재 국내 내장재의 평가규정은 Bench-Scale Test에 의존하고 있으나, 미국, 일본 유럽등에서는 Room Corner Test를 적용한 실질적인 재료의 화재성능평가를 시행하고 있다. 실험 결과, NFPA 265에 의한 석고보드 및 ISO 9705에 의한 합판의 성능은 양호한 것으로 판단되었다. 현재 국내 내장재에 적용되는 등급분류의 평가방법은 재료의 실제 화재성능 평가에 한계가 있으므로 향후 Room Corner Test의 적용과 더불어 Bench-Scale Test 결과를 토대로 화재성능을 예측하는 화재모델을 이용하는 평가 방법의 도입이 필요하다. The fire performance evaluation methods in Korea and overseas for interior finish materials were analysed and tested with gypsum board and plywood by using room corner test not adopted by domestic code until now. The results of gypsum board (thickness: 8 mm) and plywood (thickness: 4 mm) applying NFPA 265 and ISO 9705 test respectively are satisfied the assessment criteria. To assess a actual fire performance and classify fore hazard levels for interior finish materials, room-corner test and flame spread models should be adopted in building code and fire code to overcome limitations of current bench-scale test method. Keywords : Fire performance evaluation, Room corner test, Gypsum board, Plywood

Cyclosporin-A가 흰쥐 자궁선상피세포의 미세구조에 미치는 영향

김훈기,정호삼,김원규 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

Cyclosporin은 11개의 아미노산을 가지고 있는 cyclic oligopeptide로서 면역억제작용으로 인하여 오늘날 장기 이식후 나타나는 거부작용의 억제제로서 혹은 자가면역질환의 치료제로서 사용되고 있으나 신독성, 간독성, 암발생, 임파조직의 종대 및 신경독성 등의 여러 부작용을 유발한다고 알려져 있다. 또한 cyclosporin은 세포내 핵산 및 단백질 합성을 억제하므로 cyclosporin을 흰쥐에 투여하면 흰쥐의 자궁선상피제포가 손상을 받을 것으로 사료되어 저자는 흰쥐에 cyclosporin을 투여하여 자궁선 상피세포내 소기관에서 일어나는 형태적인 변화를 관찰하기 위하여 본 실험을 시도하였다. 실험동물로는 체중 200gm 내외의 Sprague-Dawley계 자성흰쥐을 사용하였으며 체중 ㎏당 500㎎의 cyclosporin-A를 생리적 식염수 0.2cc에 희석하여 1일 1회씩 2주간 복강내로 투여하고 최종 주사후 6시간, 12시간, 24시간 및 72시간 후에 경동맥사혈로 희생시키고 개복하여 자궁을 적출한 후 일반적인 전자현미경 표본제작법에 따라 두께 600∼800Å의 초박절편을 제작한 후 uranyl acetate와 lead citrate로 이중 염색하고 Hitachi H-600 투과형 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. Cyclosporin 투여군 흰쥐의 발정전기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 대조군 흰쥐의 미융모에 비하여 다소 파괴된 양상을 보였고, 핵의 형태가 불규칙해졌으며, 일부 사립체에서 사립체막과 사립체릉이 파괴되었고, 조면내형질세망의 일부 소조가 낭상화, 확장 및 단절되었으며, 막부착 ribosome도 탈락되었고, Golgi 복합체는 위축되었으며, 또한 자식공포, 다소포체 및 식소체 등이 다수 관찰되었다. 2. Cyclosporin 투여군 흰쥐의 발정기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 파괴되고 단절 및 위축된 양상을 보였고, 핵의 형태가 불규칙해졌고, 일부의 사립체에서 사립체막과 사립체릉이 파괴되었으며, 특히 12시간 및 24시간 경과군의 흰쥐 자궁선상피세포에서 조면내형질세망의 소조가 심하게 낭상화, 확장 및 단절되었고, 막부착 ribosome도 탈락되었으며, Golgi 복합체는 위축되었고, 다수의 자식공포 및 식소체가 관찰되었다. 3. Cyclosporin 투여군 흰쥐의 발정후기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 파괴 및 단절된 양상을 보였고, 핵의 형태가 불규칙해졌으며, 일부 사립체의 사립체막과 사립체릉이 파괴되었고, 조면내형질세망의 일부 소조가 낭상화, 확장 및 단절되었으며, 막부착 ribosome이 탈락되었고, Golgi 복합체는 위축되었으며, 식소체, 다소포체 및 자식공포가 다수 관찰되었다. 4. Cyclosporin 투여군 흰쥐의 발정간기 자궁선상세포에서는 자궁선 내강으로 돌출한 미융모가 단절 및 위축된 양상을 보였고, 핵의 형태가 불규칙해졌고, 일부 사립체의 사립체막과 사립체릉이 파괴되었으며, 조면내형질세망의 일부 소조는 낭상화, 확장 및 단절되었고 막부착 ribosome도 탈락되었으며, Golgi 복합체는 위축되었고, 식소체, 다소포체 및 자식공포가 다수 관찰되었다. 이상의 결과를 종합 검토한 바 cyclosporin은 흰쥐 자궁선상피세포의 세포내 소기관에 손상을 일으키는 것으로 사료된다. Cyclosporin, a potent immunosuppressive agent, is produced from culture broth of soil fungus, Tolypocladium Gams or Gylindrocarpon ludidium Booth. It is used for immunosuppressive drugs in organ transplantation or therapeutic agent in autoimmune diseases such as Hashimoto's thyroiditis, type I diabetes mellitus, rheumatoid arthritis, etc. Though the mechanism of immunosuppression of this drug is not exactly known, it may inhibit the proliferation and activation of cytotoxic T lymphocytes, the response of precusor cytotoxic T lymphocytes to interleukin-2 and inactivation of calmodulin to mitogen stimulation. Cyclosporin is very effective agent to graft recipient patients, many adverse effects including nephrotoxicity, hepatotoxicity and neurotoxicity, however, may be occured. So the morphological changes of uterine glandular cells by cyclosporin that the author has taken this study to investigate the effects of cyclosporin on the fine structure of cytoplasmic organelles in the uterine glandular epithelial cells of the albino rats at different stages of the estrous cycle according to time course. Cyclosporin-A(Sandimmun : 50㎎/㎏) was given intraperitoneally once for a day to the animals of the experimental group and normal saline to those of the control group for 14 days. All the animals were sacrificed on the 6, 12, 24 and 72 hours after initial injection, and specimens were obtained from the corpus uteri. Ultrathin section(600∼800Å in thick) made from each specimens were stined with uranyl acetate and lead citrate and observed with electron microscope(Hitachi 600). In the uterine glandular cells of cyclosporin treated rats at the proestrous stage, the following changes were observed : destruction or segmentation or atrophy of microvilli, disorganization of mitochondrial cristae and disruption of the mitochondrial membrane, sacculation, dilatation or fragmentation of the cisternae of the rough endoplasmic reticulum associated with detachment of the membrane-bound ribosomes, and appearance of numerous secondary lysosomes such as autophagic vacuoles, multivesicular body, phagosomes. Similar changes in ultrastructure of the uterine glandular cells were identified in the cyclosporin treated animals at the estrous stage. All the changes induced by cyclosporin in the fine structure of organelles of these cells at the metestrous and diestrous stages were not much different from those produced at the estrous stage. It is demonstrated that cyclosporin causes degenerative changes in the uterine glandular cells of rats in all stages of the estrous cycle.

알코올중독자의 백혈구탐식능, 림프구아형 및 증식능

김영훈,이정녀,서병배,김용호 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1996 Journal of biomedical laboratory sciences Vol.2 No.2

알코올 중독자의 폐렴관리와 같은 건강관리에 필요한 비특이 면역력, 면역기능을 측정하기 위하여 알코올 중독 의존형으로 입원한 신, 구환자군에 대하여 다음과 같은 결과를 얻었다. 대조군에 대한 알코올 중독증은 MCV, 혈당, ΥGTP를 이용한 생물학적 측정 결과에 의하여 확인 하였으며, 기타 측정 항목은 대조군과 유사한 결과를 나타내었다. 림프구 아형 분석 결과 대조군은 한국인 참고치와 매우 유사하였으며, 실험군 CD4+를 제외한 CD3+, CD8+, CD19+이 감소되었고, CD4+/CD8+ 비율은 통계적으로 유의하게 증가되어 있음을 알 수 있었다. 따라서 실험군의 면역기능과 림프구 증식능은 대조군에 비하여 현저하게 저하되었으며, 탐식세포 탐식능 및 유주능도 대조군에 비하여 현저하게 감소되었다. 탐식세포의 유주능과 CD4+의 증가, CD4+/CD8+ 비율의 증가와 PHA에 의한 림프구 증식능의 감소 및 CD3+, CD19+ 감소등은 상호관련성을 가지고 일치된 결과를 보여 대조군에 비하여 현저하게 저하된 탐식세포의 탐식기능과 함께 알코올 중독자의 비특이 면역계, 면역기능이 현저하게 저하되어 있음을 알 수 있었다. 그러나 알코올 중독 의존형으로 입원한 신, 구환자간의 비교분석 결과 총단밸질, 혈색소, 림프구 증식능, 탐식세포 탐식능, 유주능에서 신환자군에 비하여 구환자군이 대조군에 다소 근접되어가는 결과로부터 치료에 따라 숙주의 세포성, 체액성 면역기능이 회복되어가고 있음을 알 수 있었다. 또한 결과 알코올중독자의 비특이적 면역능의 측정을 위한 탐식세포 탐식능, 유주능은 숙주, 미생물측의 활성화 자극인자가 모두 포함된 phagocytic plaque film법에 의하여 측정함이 의의 있는 평가를 할 수 있을 것으로 보며, CD4+/CD8+ 림프구 아형 비율을 이용한 면역기능의 측정은 알코올 중독자의 건강 관리를 위한 면역력 측정에 유용한 방법이라고 생각된다. Alcoholics increased susceptibility to microbial infection that is associated with decreased immunity. but there has been little experimental evidence to support alcoholics-induced increase of microbial infection directly in non-specific immunity. Therefore, we were used the method of phagocytic-plaque including all the stimulating factors for the phagocytosis, subtypes of lymphocytes and T-lymphocyte proliferation. The experimental groups were divided into 3 groups: (1) alcoholics who were hospitalized less than 1 week (newly hospitalized alcoholics), (2) alcoholics who were hospitalized more than 2 weeks (old hospitalized alcoholics), (3) healthy blood donors. We have studied 98 alcoholics and 35 healthy blood donors and control groups. A physician has checked the biological markers and diagnosed the body-condition alcoholics. The immunity and non-specific immunity on the alcoholics were analyzed by using the simultest kit and flow cytometry. Proliferation of the lymphocytes was analyzed by the phytohemmagglutinine mitogen. Phagocytosis and migration properties of leukocytes were identified on the layer formed by Staphylococcus aureus Cowan I strain. Biological markers of alcoholics and control groups, by such as blood glucose, Υ-glutamyl transpeptidase and mean corpuscular volumes of red blood cells, were determined by biochemical and hematological methods. Compared with control groups, cluster of differentiation (CD)3+, CD8+ and CD19+ in alcoholic were more decreased except CD4+/CD8+ ratio. Proliferation of the T-lymphocytes, phagocytosis and migration properties of the leukocytes in alcoholics were decreased compared with those of control groups. According to the results observed in our experiment, they can be summerized as follows: 1. Cellular, humoral and non-specific immunities, are markedly decreased in alcoholics than those in control groups. 2. It is inferred that Phagocytic plaque formation is a very useful method to evaluate phagocytosis and migration properties of the alcoholic leukocytes 3. It is thought that the subtypes of lymphocytes, especially CD4+/CD8+ ratio, are essential methods to analyzed the alcoholic immunity. 4. Specific and non-specific immunity on the old hospitalized alcoholics was slightly increased, which depends upon the alcoholic medication.

하악전돌증에서 하악지 시상분할골절단 및 Screw고정후 골성회귀에 관한 연구

김명래,최장우,윤정훈,이창국 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Skeletal and dental changes were examined in 38 patients of mandibular prognathism who been treated by a bilateral sagittal split osteotomy(SSRO) and internal fixation using titanium mini-screws. All patients were followed up for over 8 months after the surgeries, and postoperative cephalometric measurements were compared at 2 months and at 8 months. Linear measurements of the “Pog-most posterior screws” and angular measurementsts of “SN-Pog”were compared to figure out the change of bony fragments. The significancy of data were tested by unpaired T-test. The results were as follows : 1. The fixation screws were changed in cephalometric position as little as 0.32 2.51㎜ in SSRO and 0.15 1.00㎜ in SSRO & Le Fort I Osteotomy.(P<0.05) 2. Mandibular set-back over 5㎜ resulted in less stability of the fixation screws and higher relapse tendency. 3. The internal fixation using two screws along the inferior border and one on the superior ridge is considered to be very resistant to postoperative relapse of the repositioned bony segments.