악성 림프종 환자에서 발생한 다형홍반

여운철,조광현,이유신,허대석,이승철 ( Un Cheol Yeo,Kwang Hyun Cho,Yoo Shin Lee,Dae Seog Heo,Seung Chul Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Erythema Multiforme A ssociated with Malignant Lymphoma Un Cheol Yeo, M.D., Kwang Hyun Cho, M.D., Yoo Shin Lee, M.D., Dae Seog Heo*, M.D., Seoung Chul Lee**, M.D Department of Dermatology and Internal Medicine*, College of Medicine, Seoul National University, Seoul, Korea, Department of Dermatology**, College of Medicine, Inha University, Kyung Gi Do, Korea We report a case of erythema multiforme associated with malignant lymphoma. Fifty-six-year-old male patient visited our clinic complaining generalized skin lesions which were compatible with erythema multiforme clinically and histopathologically. The skin lesions were treatment-resistant, recurrent and persistent for 3 years. In consideration of old age, atypical features of erythema multiforme and no other demonstrable etiology of erythema multiforme, we studied for internal malignancy. Malignant lymphoma at the duodenum was revealed by UGI series, abdominal CT, and endoscopic biopsy. After chemotherapy, the tumor mass and active skin lesions were cleared simultaneously. Erythema multiforme may be regarded as one of the paraneoplastic syndromes.

일제의 조선인 강제징발 실상

허종호,리철홍,공명성 한국역사연구회 2003 역사와 현실 Vol.- No.50

This paper surveys the scale and characteristic of the forced arrestment of Koreans by Japanese Imperialist and would call Japan's responsibility for it. Japan's reparation for the forced arrestment of Koreans is the national obligation. It is because the forced mobilization of Koreans was intended and directed by Japan authority and was the national criminal act accomplished under the national direct control. After Sino-Japanese war in 1937, Japanese Imperialist commandeered Koreans with the several form as "compulsory service", "emigration", "collection", "commandeering" and its number was reached as many as 84 hundreds thousand. Characteristic of the forced mobilization by Japanese Imperialist was accompanied by the form of policy to obliterate the Korean nation regardless of regions and social classes. Therefore, Japan's apology and reparation ought to be an unavoidable obligation.

Atropa belladonna 모상근의 생장량과 tropane alkaloid 생산에 관한 연구

허인옥,오순자,한태완,김철수 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.1

Agrobacterium rhizogenes strain R1000에 의해 유도된 Atropa belladonna 모상근을 배지별, NAA, IBA, IAA, 2,4-D를 농도별(0.01-100 mg/l)로 첨가한 NN액체배지에서 생장량과 tropane alkaloid 함량을 HPLC로 이용하여 정량하였다. 모상근 배양 30일째의 각 auxin의 농도별에 따른 생장율은 고농도보다 저농도일때 대체적으로 양호하였으나, 0.1mg/1 2,4-D농도에서는 callus화 하였고 10mg/l 2,4-D, 1mg/l IBA일때 2.96g, 2.36g으로 대조구보다 2.3배의 생장량을 보였다. 농도별에 따른 Tropane alkaloid 함량은 atropine이 대조구 0.141%, 원식물체가 0.059%로 나타났으며, 0.01mg/l NAA와 0.1mg/l IAA에서 배양한 모상근이 각각 1.378%, 1.814%의 생산을 보여 대조구와 원식물체보다 9-30배의 생산을 보였다. 또한 scopolamine 함량은 대조구와 원식물체는 각각 0.109%. 0.050%에 비해 0.01mg/l NAA에서 배양한 모상근에서 0.505%로 대조구 원식물체보다 4-10배의 생산량을 보였다. The study aimed to measure growth rate of Atropa belladonna hairy root cultured under medium, various auxin(NAA, IBA, IAA, 2.4-D) and auxin concentration(0.01-100mg/l) and investigated tropane alkaloid content using HPLC. The growth rate of hairy root cultured for 30 days in MS and NN liquid medium were higher in NN medium as 3.51g than MS medium, growth rate of belladonna hairy root cultured in NN medium added various auxin and auxin concentration was the most effective in low concentration than high concentration, especially, was best in the medium supplemented with 0.01mg/l 2,4-D. Atropine content of hairy root cultured in 0.01mg/l and 0.1mg/l IAA produced 9-30 times than control and normal plant. scopolamine measured each 0.109%, 0.050% in control and normal plant, hairy root cultured in 0.01mg/l NAA produced 4-10 times than control and normal plant.

1982學年度 新入生 實態調査 結果分析

玄惠慶,許鐵洙 濟州大學校 學生生活硏究所 1982 學生生活硏究 Vol.5 No.-

1. 실태조사 결과 요약 1) 대학생의 적령을 만 17~19세라고 볼 때 이에 해당하는 학생이 87.7%, 만 20세 이상이 12.3%나 되며 특히 야간 강좌부에는 만 20세 이상의 학생들이 63.6%를 차지하고 있다. 2) 가족들의 주거지별 현황은 제주도가 96.6%, 타지역이 3.4%이며 가족수별 현황은 가구당 5명 이상의 가족을 지니고 있는 가구가 약 90% 정도가 된다. 3) 부모 모두 생존하고 있는 학생이 81.0%, 편부·모와 함께 생활하고 있는 학생이 18.5%가 되며 특히 야간 강좌부에는 약 90% 이상을 차지하고 있다. 4) 부모 또는 호주의 직업별 상태는 ① 농업(55.9%), ② 공무원(14.8%), ③ 상업(12.2%)의 순으로 비중을 보이고 있다. 5) 가정생활정도는 상에 속하는 학생이 약 10%, 하정도에 속하는 학생이 31.6%이다. 6) 출신 고교별 소재지 현황은 96.3%가 본도 출신이며 타도 출신 고교생은 3.7%이다. 또한 출신 고교별 계열 비율은 인문계가 76.7%, 실업계가 23.3%이다. 7) 대부분의 학생들이 재수 경험이 없으며(83.8%), 6.2%의 학생들이 재수경험이 있다. 8) 신체상태에 있어서 시력이 0.9이하의 시력을 가진 학생이 32%, 0.4이하가 전체 학생의 10%정도가 된다. 남학생보다 여학생들이 시력상태가 매우 좋지 않으며 따라서 안경을 착용하고 있는 학생이 25.5%나 되며 남학생보다 여학생이 안경을 많이 착용하고 있다. (35.2%) 신장은 160~169cm까지 45.0%이며 170cm 이상이나 되는 학생은 30%나 된다. 체중은 50~59kg이 평균 체중치(52.2%)이며, 흉위는 93cm 이상이 15.3%, 81cm 이하가 30.8%를 차지하고 있다. 9) 학생들의 건강상태는 대체로 건강한 편이나(94.2%), 허약한 학생이 5.8% 정도 있다. 10) 대부분의 학생들이 고교 재학시 심리검사를 실시하지 않았으며(60.6%), 실시했다하더라도 적성검사가 대부분이었다. 2. 意見調査 結果 要約 1) 본 대학에 입학하게 된 가장 주된 요인은 생활비 부담을 덜기 위해서(22.8%)이며 입학이 용이(21.4%)한 점을 들고 있다. 2) 본교 지망에 가장 큰 영향을 준 사람으로는 자기 자신 스스로 학교 선택을 하였으며(44.2%), 가족들의 권유에 의해(37.0%)결정되었다. 3) 고교 재학시 희망했던 계열(학과)과 현재 입학한 계열(학과)과의 일치 정도에는 학교와 학과가 모두 불일치가, 28.4% 모두 일치가 27.2%를 나타내고 있다. 4) 전공계열(학과)을 선택한 이유로는 적성과 흥미에 따른 선택이 가장 많고(48.5%), 다음이 직업적 전망에 의한 선택을 들고 있다.(16.6%) 5) 입학한 전공계열에 대한 만족정도는 70.0% 만족을, 9.5%가 불만족을 표시하고 있다. 특히 야간강좌에서 83.3%의 학생이 가장 불만족의 반응을 보이고 있다. 또한 불만의 이유로는 적성·흥미가 맞지가 않으며(24.0%), 1차 지망학과가 아니고(19.7%), 장래 전망이 흐리다(14.0%)는 이유를 들고 있다. 6) 전과나 편입학을 희망하는 학생이 18.9%나 되며, 앞으로 유동성을 보인 학생이 32.8% 보이고 있다. 7) 전공계열(학과)에 대한 이해 정도는 보통으로서 대강 알고 지망한 학생이 71.8%이며 이해 정도가 낮은 수준에서의 지망이 17.0%로서 이해도가 낮은 편이다. 8) 학생들이 당면하고 있는 또는 예상되는 중요 문제를 반응빈도의 우선 순우로 정리하면 ① 학업문제(40.3%), ② 경제문제(36.9%), ③ 진로문제(36.4%), ④ 사회적 적응(26.7%) ⑤ 건강문제(16.0%)의 순으로 문제의 경향을 보이고 있다. 9) 개인 문제 해결을 위한 의논 대상은 ① 친구(27.9%) ② 지도교수(22.6%), ③ 가족(17.0%), ④ 선배(14.8%)의 순위를 나타내고 있다. 10) 써클활동의 참가여부는 대부분의 학생들이 기존의 서클들의 활동실태를 파악한 후에 참가 여부를 결정하겠다는 신중한 반응을 보이고 있다.(70.2%) 또한 희망하는 써클들의 반응 빈도를 세 가지만 순서대로 정리해보면 ① 교양(21.4%), ② 학문(15.2%), ③ 봉사(14.5%) 써클이다. 11) 대학생활 동안의 부직을 희망하는 학생이 전체 학생 중 약 80% 학생들이 부직을 희망하고 있으며 그 이유로서는 사회생활의 견문을 넓히기 위해서(35.7%)와 잡비 마련을 위해서(20.8%), 그리고 학비마련과 자립정신을 기르기 위함에 있는 것이다. 12) 대학생활을 위한 계획 수립이 38.6%의 학생은 수립되어 있으나 나머지 학생은 수립되어 있지 못하다. 또한 대학졸업 후의 계획을 우선 순위로 정리하면 ① 취직·사업(37.0%) ② 대학원 진학(36.0%), ③ 미정(13.3%)의 반응을 보이고 있다. 13) 학생들이 구상하고 있는 이상적인 대학생활은 인격을 도야하는 일이며(54.6%) 또한 학문을 연구하는 (32.6%) 장으로서의 역할 수행을 인식하고 있다. 14) 학생 자신이 대학생활동안 성취해야 할 목표를 인격완성에 두고 있으며(29.0%) 원만한 대인관계를 유지하고(21.4%), 폭넓은 교양을 습득하는 일(20.7%)에 두고 있다. 15) 학생들은 교수님들께 교수 - 학생간 원만한 인간관계를 유지하는 것을 가장 원하고 있으며(51.2%), 전공분야에 대한 연구활동(18.4%)과 인격적 소양(14.5%)을 갖추는 기대를 나타내고 있다. 16) 본교 신입생들이 바라는 바람직한 대학상은 대학의 역할과 기능을 제대로 수행하며 그 속에서 학문연구와 인격을 완성하고 원만한 대인관계를 형성하는 분위가기 갖추어진 대학을 염원하고 있다.

장애인을 위한 새로운 감성 인터페이스 연구

허환(Hwan Heo),이지우(Ji Woo Lee),이원오(Won Oh Lee),이의철(Eui Chul Lee),박강령(Kang Ryoung Park) 대한인간공학회 2011 大韓人間工學會誌 Vol.30 No.1

Objective: Making a new ergonomic interface system based on camera vision system, which helps the handicapped in home environment. Background: Enabling the handicapped to manipulate the consumer electronics by the proposed interface system. Method: A wearable device for capturing the eye image using a near-infrared(NIR) camera and illuminators is proposed for tracking eye gaze position(Heo et al., 2011). A frontal viewing camera is attached to the wearable device, which can recognize the consumer electronics to be controlled(Heo et al., 2011). And the amount of user's eye fatigue can be measured based on eye blink rate, and in case that the user's fatigue exceeds in the predetermined level, the proposed system can automatically change the mode of gaze based interface into that of manual selection. Results: The experimental results showed that the gaze estimation error of the proposed method was 1.98 degrees with the successful recognition of the object by the frontal viewing camera(Heo et al., 2011). Conclusion: We made a new ergonomic interface system based on gaze tracking and object recognition Application: The proposed system can be used for helping the handicapped in home environment

동충하초의 균사 및 배양액에 의한 면역 활성 비교

허진철 ( Jin Chul Heo ),남성희 ( Sung Hee Nam ),여주홍 ( Joo Hong Yeo ),윤철식 ( Chul Shick Yoon ),이광길 ( Kwang Gil Lee ),박철홍 ( Chul Hong Park ),남소현 ( So Hyun Nam ),손민식 ( Min Sik Son ),정신교 ( Shin Kyo Chung ),이상한 ( 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2009 한국식품저장유통학회지 Vol.16 No.2

Apoptotic Effect of Co-Treatment with a Natural Product, Chios Gum Mastic, and a Proteasome Inhibitor, Lactacystin, on Human Osteosarcoma Cells

Chul-Jung Baek,Ji-Ye Heo,Gyoo-Cheon Kim,Hyun-Ho Kwak,In-Ryoung Kim,Seung-Eun Lee,Chul-Hoon Kim,Na-Young Jeong,Bong-Soo Park 대한해부학회 2008 Anatomy & Cell Biology Vol.41 No.2

Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. Recently, it was reported that CGM induced apoptosis in a few cancer cells in vitro. Since recent studies indicated the synergistic interactions between the apoptotic stimulus and a proteasome inhibitor, the ubiquintin-proteasome pathway has become an attractive target in cancer therapy. And to date, there has been no report of the synergistic apoptotic effect between CGM and a proteasome inhibitor to become an attractive target in cancer therapy. Therefore, this study was undertaken to investigate the synergistic apoptotic effect of co-treatment with a natural product, CGM, and a proteasome inhibitor, lactacystin, on human osteosarcoma (HOS) cells. To investigate whether the co-treatment of CGM and lactacystin compared with each single treatment efficiently induced apoptosis on HOS cells, MTT assay, DNA electrophoresis, Hoechst staining, DNA hypoploidy assay, Westen blot analysis, immunofluorescent staining, proteasome activity and mitochondrial membrane potential (MMP) change were performed. In this study, HOS cells co-treated with CGM and lactacystin showed several lines of apoptotic manifestation such as nuclear condensation, DNA fragmentation, the reduction of MMP and proteasome activity, the decrease of DNA content, the release of cytochrome c into cytosol, the translocation of AIF and DFF40 (CAD) onto nuclei, and activation of caspase-7, caspase-3, PARP and DFF45 (ICAD) whereas each single treated HOS cells hardly showed. We presented data indicating that the co-treatment of CGM and lactacystin induced potentially apoptosis whereas each single treatment did slightly. Moreover, the co-treatment of CGM and lactacystin potentiated the inhibition of proteasome activity. Therefore, our data provide the possibility that combination therapy of CGM and lactacystin could be considered as a novel therapeutic strategy for human osteosarcoma.

A fraction of methylene chloride from Geum japonicum Thunberg inhibits tumor metastatic and angiogenic potential.

Heo, Jin-Chul,Son, Minsik,Woo, Sang-Uk,Kweon, Mi-Ae,Yoon, Eun Kyung,Lee, Hee Kyung,Choi, Won-Sik,Cho, Kang-Jin,Lee, Sang-Han National Hellenic Research Foundation 2008 Oncology reports Vol.19 No.6

<P>The plant Geum japonicum Thunberg (GjT) has been used as a diuretic in traditional medicine. Herein, we report that the GjT extract blocks both the spread of human umbilical vein endothelial cells (HUVECs) on matrigel and the migration of B16 cells. We used various assays to test for cell attachment, spreading, wound healing and angiogenesis. A reverse transcription-polymerase chain reaction (RT-PCR) and a mitogen-activated protein kinase (MAPK) assay were also carried out for the mechanistic study of GjT. Our results showed that a fraction of methylene chloride fraction from GjT inhibited B16 cells during cell attachment and migration and suppressed tube formation in a dose-dependent manner. An RT-PCR analysis showed that the methylene chloride extract decreased the mRNA expression of CD44 and TIMP-2. A Western blot analysis of the phosphorylation of MAPK kinases (ERK, JNK and p38) showed that the GjT fraction increased the expression of phospho-JNK, suggesting that GjT has the potential to alleviate metastatic and angiogenic activity, via a phospho-JNK signaling pathway.</P>

Dykellic Acid Inhibits Cell Migration and Tube Formation by RhoA-GTP Expression

Heo, Jin-Chul,Park, Ja-Young,Woo, Sang-Uk,Rho, Jae-Rang,Lee, Ho-Jae,Kim, Sung-Uk,Kho, Yung-Hee,Lee, Sang-Han Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.11

<P>Dykellic acid, a novel factor initially identified from the culture broth of <I>Westerdykella multispora</I> F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and anti-angiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.</P>

The Role and Prospects of the Resident Inspectors in KINAC

Chul Heo 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1

KINAC began dispatching the resident inspector in 2012 to strengthen on-site Wolsong nuclear power plants (NPPs) regulations. The dispatched resident inspector is a member of the regional office of the Nuclear Safety and Security Commission (NSSC) and is in charge of technical support, on-site regulation of safeguards, and physical protection for the Wolsong regional office of NSSC. As the number of nuclear facilities in the ROK increased, the resident inspectors began to be dispatched to other regional offices. The resident inspectors were assigned to Hanul in November 2015, Kori in March 2017, Hanbit in March 2015, Saeul in March 2022, and Wolsong in March 2023. Accordingly, this paper intends to reflect on the increasing role of resident inspectors and predict on-site regulatory work in the field of nuclear control. The role of the resident inspectors is described in detail in the internal regulations of KINAC. Among the tasks in the common field is technical support at regional offices for the most critical areas of nuclear control implementation, and on-site verification of the matters requested by the director of each implementation division shall be carried out. Tasks in the field of safeguards include an on-site check of facility regulation review, implementation of national inspections, technical support for IAEA inspections, and information management. Among them, technical support work for Unannounced inspections should be the top priority. These days, in particular, the importance of reviewing the results of checking advanced information and containment and surveillance equipment by facility operators is emerging. Among the tasks performed by the resident inspectors, more than 80% of the functions related to physical protection account for. The resident inspectors check the status of the physical protection system by weekly/monthly/quarter, implement physical protection regulation review and inspection, conduct exercise evaluation, and perform technical support for special assessments. Recently, regulatory activities related to radioactive terrorism and the emergence of illegal drones have been strengthened. In the field of cybersecurity, where its role has recently been increasing, the resident inspectors are performing basic field regulation tasks. Similar to the area of physical protection, the resident inspectors check the cybersecurity system for weekly, monthly, and quarterly readiness, and on-site inspections of cybersecurity review and inspection technical support, exercise evaluation, and other requests are mainly performed. The role of the resident inspectors is expected to expand further in the future due to the increase in terrorist risks at home and abroad and changes in the regulatory environment. However, there is a limit to performing an increasing number of tasks, with the human resources of the resident inspectors limited to one to two for each site. If the resident inspectors are dispatched for each field of safety measures, physical protection, and cybersecurity, they can perform their duties more efficiently, but problems may arise in the operation of our personnel. Therefore, the proper and precise allocation of work while maintaining the current system is an essential part. The roles and prospects of the resident inspectors analyzed in this paper can be used to deploy the headquarters and field regulation personnel and set the direction of work in the future.