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혈액투석중인 말기신부전 환자에서 Fludrocortisone acetate (FCA) 투여 후 혈청 칼륨 저하 효과
류봉관,강대웅,정지용,윤나라,신병철,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1
Background: Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (fludrocortisono acetate) on serum potassium level in the serum of hyperkalemic end-stage renal disease patients. Methods: Fourteen patients on hemodialysis receiving fludrocortisone acetate (FCA) 0.1 mg/day were observed for 2 months periods. Consecutive monthly biochemical profiles were compared for the druration of the pre-and post-treatment of FCA. Result: Fourteen patients with mean age (±SE) of 51.5 years (4 males and 10 females) and mean hemodialysis period of 51.9 months were studied. Mean serum potassium levels significantly fell (p<0.05) during the post-FCA period (5.2±0.66 mEq/L) compared with potassium levels during the pre-FCA (5.8±0.43 mEq/L) period. Pre-and post-FCA values were not different for sodium, chloride, protein, albumin, AST/ALT, glucose, blood nitrogen, creatinine, phosphate and calcium. Conclusions: FCA appears to decrease serum potassium value in patients with end-stage renal disease. These results suggested that FCA could be effective to treat hyperkalemia without any adverse effect in patients undergoing hemodialysis.
藥鍼이 Freund's Complete Adjuvant와 Peptidoglycan Polysaccharide에 의해서 誘發된 白鼠의 關節炎에 미치는 영향
李秉澈,한명관,羅昌洙 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1
最近에 藥鍼療法이 많은 관심을 끌고 있다. 독특한 潤氣·六元의 原理에 依據하여 生體의 機能을 調整하고 病理狀態를 改變시켜, 疾病을 治療하는 新鍼療法중 하나이다. 이런 藥鍼療法은 매우 多樣한 疾患에 應用되고 있는데, 關節炎 治療에도 適用되고 있다. 牛黃·熊膽 藥鍼과 牛黃·猪膽 藥鍼의 效果를 比較 檢討하기 위하여 Freund's complete adjuvant와 peptidoglycan polysaccharide를 使用하여 關節炎을 誘發시킨 흰쥐에게 藥鍼을 施行하여 그 效果를 觀察하였다. Radioimmunoassy에 의한 PGE_2 含量을 測定하여 鎭痛 및 抗炎反應을 살펴보았고, 血液學的 檢査도 施行하였다. 또한 組織學的 所見을 觀察하여 組織의 損傷에 대한 回復程度를 比較檢討하였다. In order to investigate experimentally that Bovis Calculus, Ursi Fei Aqua-acupuncture(BUA) and Bovis Calculus, Susi Fei Aqua-acupuncture(BSA) have an effect on Arthritis in rats, the author inserted Aqua-acupuncture, electro-acupuncture, aspirin at corresponding with Chok-samni(ST36) and Hyunjong(GB39), and observed an concentration of the serum PGE_2 by method of the radioimmunoassay. The author also observed the histological feature of knee joint tissue. The results were as follows: 1. The BUA & BSA & aspirin group were decreased with statistical significance in the concentration of the serum PGE_2 as compared with the control group. 2. The BSA group were decreased with statistical significance in blood WBC as compared with the control group. 3. The control & experimental group were increased in blood RBC, Hb, Hct and decreased MCV, MCH as compared with the control group. 4. According to the histological studies, the BUA & BSA group were showed less than the control group in the damage of synovial cells and the least damage of synovial cells were showed in aspirin injection group.
Jeong, Byung-Kwan,Sung, You Na,Kim, Sung Joo,An, Soyeon,Park, Hosub,Hwang, Hee Sang,Kang, Hyo Jeong,Lee, Jae Hoon,Song, Ki Byung,Kim, Kyu-pyo,Hwang, Dae Wook,Lee, Sang Soo,Kim, Song Cheol,Hong, Seung- Elsevier 2019 Human pathology Vol.84 No.-
<P><B>Summary</B></P> <P>Identifying the accurate origin of periampullary cancers is important because different origins may trigger different clinicopathological behaviors. The presence of intraepithelial precursor lesions, including high-grade pancreatic intraepithelial neoplasias (PanINs) and/or high-grade biliary intraepithelial neoplasias (BilINs), may be suggestive of the origin of the periampullary carcinoma in challenging cases. To prove the usefulness of high-grade intraepithelial precursor lesions in identifying the origin of ambiguous periampullary cancers, the status and grades of PanINs and BilINs were evaluated in 256 periampullary carcinomas with a well-defined cancer origin as a test set, including 114 pancreatic cancers, 82 distal bile duct cancers, 54 ampullary cancers, and 6 duodenal cancers. One hundred twelve periampullary carcinomas with clinically equivocal epicenter either by radiologic imaging or by endoscopic finding used as a validation set. High-grade PanINs were found more commonly in pancreatic cancers than in distal bile duct, ampullary, and duodenal cancers both in test (<I>P</I> = .002) and validation sets (<I>P</I> < .001). Similarly, high-grade BilINs were identified more frequently in distal bile duct cancers than in ampullary, pancreatic, and duodenal cancers both in test (<I>P</I> < .001) and validation sets (<I>P</I> = .039). High-grade PanINs were found most commonly in pancreatic cancers, whereas high-grade BilINs were seen most frequently in distal bile duct cancers. In addition, both high-grade PanINs and high-grade BilINs are uncommonly noted in ampullary or duodenal cancers. The recognition of high-grade intraepithelial lesions can help identify the primary origin of periampullary cancers, especially when the epicenter of the periampullary cancer is ambiguous.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High-grade PanINs are found most commonly in pancreatic cancers. </LI> <LI> High-grade BilINs are seen most frequently in distal bile duct cancers. </LI> <LI> Recognition of high-grade PanINs or BilINs helps identify origins of periampullary cancers. </LI> </UL> </P>