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프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성
최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.
EIA-709.1 Control Network Protocol을 이용한 필드버스 시스템 구현
최병욱,김정섭,이창희,김종배,임계영 제어·자동화·시스템공학회 2000 제어·자동화·시스템공학논문지 Vol.6 No.-
EIA-709.1 Control Network Protocol is the basic protocol of LonWorks systems that is emerging as a fieldbus device. In this paper, the protocol is implemented by using VHDL with FPGA and C program on an Intel 8051 processor. The protocol from the physical layer to the network layer of EIA-709.1 is implemented in a hardware leval. So it decreases the load of the CPU for implementing the protocol. We verify the commercial feasibility of the hardware through the communication test with Neuron Chip, based on EIA-709.1 protocol, which is used in industrial fields. The developed protocol based on FPGA becomes one of IP and we are able to implement SOC for the terminal device in the distributed control systems. Also, the result can be applicable to various industrial field because it is implemented by VHDL.
최병순,한효순,강성주,이상권,강순희,박종윤,남정희 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.4
학생들의 인지발달을 촉진시켜 학습효과를 높이려고 개발된 CASE 프로그램의 효과를 조사했다. 중학교 1학년(841명) 학생들이 연구에 참가하였으며, 같은 분량의 시간동안 실험반에서는 교육과정에 따른 과학 교과 수업과 '생각하는 과학' 활동을 병행하였고, 통제반에서는 과학교과 수업만을 수행하였다. 연구 초기에 논리적 사고력 검사(SRT II)를 이용하여 집단의 동질성을 비교하고, 2년 동안 실험반에 CASE프로그램을 처치한 후 이질동형겸사도구인 SRT VII을 이용하여 처치별, 성별, 인지수준별 인지가속에 대한 효과를 조사했다. CASE 프로그램에 의한 중학생들의 인지발달 가속효과는 중간검사에서는 보이지 않았으나, 사후검사에서 상당히 큰 것으로 확인되었다. 성별에 따라 CASE 프로그램의 효과를 비교한 결과 남??여 중학생들 모두에게 유의미한 인지가속이 이루어진 것으로 나타났다. 남학생들 보다 여학생들의 인지수준이 더 발달된 것으로 밝혀졌으며, 처치와 성별간 상호작용 효과는 나타나지 않았다. 학생들의 사전 인지수준에 따라 CASE 프로그램의 효과를 분석한 결과, 모든 인지수준에서 처치효과가 뚜렷하게 있었으나 특별한 경향성은 나타나지 않았다. 특히 초기 구체적 조작기(ES=1.1.)와 전조작기(ES=1.07), 그리고 구체적조작 후기(ES=1.01) 학생들에게 상당히 큰 효과가 있었다. 이상과 같은 CASE 프로그램의 성공적인 결과는 현행 우리나라 과학교육과정 개정과 교수방법 개선에 시사하는 바가 많다. In an attempt to accelerate the development of formal reasoning ability of students, 'Thinking Science' activities developed by the Cognitive Acceleration through Science Education(CASE) project were implemented to 841 students in 7th grade aged 12+ in six middle schools over a period of two years. Homogeneity between the CASE group and control group was tested with SRT Ⅱ, while the improvement of formal reasoning ability of the students was tested with SRT Ⅶ. The results were analyzed by treatment, gender, and cognitive levels of the students. Statistically significant gains were shown in the CASE group compared with those in the control group. Cognitive level of girls in the CASE group significantly increased as compared with the control group, while there was moderate effect in boys. These results implied that the thinking science activities were effective in cognitive acceleration of girls aged 12+. It was shown that much more CASE students in pre or concrete operational level shifted. to formal operational level as compared with the control group while there were significant effects in all levels (ES=0.31∼1.10) without showing any tendency.
대안기계를 갖는 Job Shop scheduling을 위한 발견적기법의 개발
최동순,정병희 한국경영과학회 1996 한국경영과학회 학술대회논문집 Vol.- No.2
This paper proposes a heuristic method for job shop scheduling with alternative machines. Our heuristic suggests four machine-selecting rules and two priority dispatching rules for modifying existent ones considering alternative machines, and then it extends existing nondelay/active job shop schedule generation. This heuristic provides good criteria(rules) in the selection of a proper machine among those performing a specific operation and for the dispatch of an operation to a selected machine and thus these rules permit the efficient job shop scheduling with alternative machines. The performances of our four machine-selecting rules in addition to the two priority dispatching rules, applied together with the existing 17 rules, are experimented and evaluated, respectively.
최병순,김효남,강순희,신인철 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1
The purpose of this study was to investigate and analyze the conception of elementary school students on evaporation and condensation, and then to verify the types of the conception. Forty-eight children from six elementary schools were sampled by stratified random sampling in Seoul and other provinces. They responded to the questionaire and the interview. This study was carried out according to the process of the basic study, the preliminary study, and the main study. The materials collected were classified and analyzed according to the types of children's ideas. The findings of this study were as follows: 1. The vocabulary used to describe the evaporation phenomena varied according to the situations, and the scientific term "evaporation" was more frequently used by the older groups. 2. Most children answered that the last location of water were air/sky/cloud. Air/cloud which represents the scientific conception of the location of water were mentioned by children of all ages. The higher the grade of the children were, the more scientific conception the children mentioned, however. 3. Most children referred to the heat as the factor of evaporation. Wind, on the other hand was mentioned by less than 10% of lower graders, and by about 30% of higher graders. 4. The result of asking children whether they thought it was possible to get the evaporated water back showed that about 70% of lower graders denied the possibility of the water being reversible. About 60% of higher graders, however, recognized that the water will be returned as rain or condensation. This increase may be associated with formal teaching of water cycle. 5. In the ideas of evaporation and condensation, some of the children have supernatural ideas and animism, which are most younger chilren's characteristics.