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임경수,이강현,이진웅,이부수,황성오,유수영,강성준 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1
The need for rapid diagnosis and treatment of life-threatening thoracic and intra-abdominal injury result in controversy over the appropriate triage of unconscious blunt trauma patients. To aid in early decisions for these patients, a prospective analysis of 98 patients with glasgow coma scale(GCS) scores≤8 was undertaken. Although intra-thoracic and intra-abdominal injuries were frequently identified based on systolic blood ressure, the use of clinical signs alone resulted in more missed injuries than did using the emergency ultrasonography. In normotensive patients(n=34), intra-thoracic injuries was identified in one patient(2.9%), and intra-abdominal injuries were in 7 patients(20.6%). In shock(systolic blood pressure<90mmHg) Pa-tients(n=64), thoracic injuries and intra-abdominal injuries were diagnosed in 8(12.5%) and 27 patients(42.3%), thoracic and abdominal combined injuries were identified in 11 patients(17.2%). The sensitivity, specificity, and accuracy of emergency ultrasonography were 96.3%, 91.7%, 94.9%. This study suggests that all unconscious trauma patients undergo immediate emergency ultrasonography to prevent missing life-threatening injuries.
임경수,황성오,임종천,이부수,이강현,이진웅 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2
In the guidelines of Advanced Trauma Life Support(ATLS), essential plane roentgenograms (chest AP vIew, cervical spine lateral view and pelvis AP view) are recommanded when primary survey and resuscitation phase are finished in care of multiple injured patients. A prospective study was carried on 376 multiple trauma patients who admitted to Wonju Christian Hospital from July, 1995 to October. We analyzed clinical significance of essential X-ray in multiple trauma patients, and classified the patients by their status of mentality. The one is alert group when their Glasgow Coma Scale(GCS) is over 13 point, the other is disoriented mentality group when their GCS are below 12 point. The alert group was redivided by presence of clnical symptoms and/or signs, and clinical significances of essential X-ray were analyzed. Among the 376 patients, 330 patients are alert group that their GCS score is over 13 point and 46 patients are disoriented group who's GCS were below 12 point. The detection rate of abnormality in essential X-ray is higher in disoriented group than alert group(cervical-spine lateral view : 13.5% vs 3.0% cheat AP view : 0.4%, pelvis AP view : 0%). This study suggests that their are no needs of taking essential X-ray in patients who is alert in mental state and have no clinical symptoms and/or signs.
이부수,김영식,이강현,황성오,임경수,박금수,윤정한,안무업,최경훈 대한응급의학회 1994 대한응급의학회지 Vol.5 No.2
Background : Mechanism of blood flow during cardiopulmonary resuscitation(CPR) in humans remains controversial and poorly understood, although cardiac or thoracic pump theory was proposed. We investigated cardiac movement, ventricular function and atrioventricular valve motion with aid of transesophageal echocardiography during precordial compression during CPR in humans. Methods and results : During CPR transesophageal echocardiography was performed in 14 patients with non-traumatic cardiac arrest. Manual precordial compression during CPR was performed according to American Heart Association guidelines. Mitral valve closed in 9 and did not close in 5 patients during "compression systole". Tricuspid valve closed during compression systole. Compression vector directed to right ventricle, basal portion of interventricular septum and left atrium. The heart rotated clockwise and the apex was more displaced than the base("swing motion"). Fractional shortening(FS) and ejection fraction(EF) of right ventricle exceeded those of left ventricle(FS : 55±9% vs 18±8%, p<0.05), EF : 79±9% vs 37±16%, p<0.05). FS and EF of left ventricle was higher in patients with systolic mitral valve closure than patients with persistent systolic opening of mitral valve(FS : 21±7 vs 13±7%, EF : 45±12 vs 22±12%, p<0.05), but FS and EF of right ventricle was not different. Conclusion : During precordial compression, the heart rotated clockwise and displaced. Systolic function of right ventricle exceeded left ventricle. Marked compression of right ventricle and systolic closure of tricuspid valve suggested that right ventricle functioned as a pump generating blood flow during precordial compression. Closure of mitral valve was dependant on systolic function of the left ventricle.
P104 : Effects of long pulse Nd:YAG laser treatment for onychomycosis
( Boo Kyoung Kang ),( Tae In Kim ),( Myong Il Bae ),( Sung Hyuk Moon ),( Min Kyung Shin ),( Mu Hyoung Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Recent research shows that lasers can inhibit fungal growth and that Nd:YAG 1064-nm lasers can penetrate as deep as the lower nail plate. In this study, we observed the effect of a long-pulse Nd:YAG 1064-nm laser on 55 nails of 19 patients with clinically and mycologically proven onychomycosis. Objectives: The aim of the present work was to examine the effects of Nd:YAG 1064-nm lasers on nail fungal infection. Methods: The 19 patients (55 nails) were in variable sessions with a two-week interval until the determination of efficacy of the laser treatment. Evaluations were done at baseline and at treatment termination. Outcome assessments included mycological examination and objective assessment by comparing photographs. Results: The treatment effective rates was 36.4% during the mean treatment period of at 7.4 months. The rate of clinical type was significantly different between responders and non-responders. We investigated that total dystrophic type was resistant to the laser treatment. Conclusion: Long pulse Nd:YAG 1064-nm laser was effective for onychomycosis. It is a simple and effective method without significant complications or side effects and is expected to become an alternative or replacement therapy for onychomycosis.
P137 : A study of the effects of physical dermabrasion combined with chemical peeling
( Boo Kyoung Kang ),( Tae In Kim ),( Myong Il Bae ),( Sung Hyuk Moon ),( Ki Heon Jeong ),( Jong Min Park ),( Dong Hye Suh ),( Sang Jun Lee ),( Min Kyung Shin ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Many comparative studies of chemical peeling and dermabrasion have been reported. However, no basic scientific data about the immediate effects after combined treatment of chemical peels and dermabrasion have been confirmed. Objectives: To evaluate the effect of the application of physical abrasion in combination with chemical peels. Methods: Three porcine were treated with physical abrasion using a water jet device in combination with an α-hydroxy acid solution, and the controlled skin samples received chemical peeling solution alone. The levels of growth factors and neuropeptides were measured with a multiplex immunoassay. Results: Skin treated with physical dermabrasion combined with chemical peeling showed prominent detachment and swelling of the stratum corneum, and fluid collection in the hair follicles. The mean cell count of CD34 positive fibroblasts and mast cells, levels of epidermal growth factor, fibroblast growth factor-2, vascular endothelial growth factor and neurotensin were significantly increased in the tissue treated with physical assault combined with a chemical peeling agent compared to the controlled skin. Conclusion: We concluded that physical dermabrasion combined with chemical peeling can be more effective than chemical peeling for the approach through the hair follicle.
Effect of Dieckol, a Component of <i>Ecklonia cava</i> , on the Promotion of Hair Growth
Kang, Jung-Il,Kim, Sang-Cheol,Kim, Min-Kyoung,Boo, Hye-Jin,Jeon, You-Jin,Koh, Young-Sang,Yoo, Eun-Sook,Kang, Sung-Myung,Kang, Hee-Kyoung Molecular Diversity Preservation International (MD 2012 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.13 No.5
<P>This study was conducted to evaluate the effect of <I>Ecklonia cava</I>, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of <I>E. cava</I> enzymatic extract (which contains more than 35% of dieckol) for 21 days, <I>E. cava</I> enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% <I>E. cava</I> enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with <I>E. cava</I> enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC). Especially, dieckol, among the isolated compounds from the <I>E. cava</I> enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the <I>E. cava</I> enzymatic extract and the isolated compounds from the <I>E. cava</I> enzymatic extract, the <I>E. cava</I> enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the <I>E. cava</I> enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from <I>E. cava</I> can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.</P>
( Boo Kyoung Kang ),( Tae In Kim ),( Myong Il Bae ),( Sung Hyuk Moon ),( Ki Heon Jeong ),( Su Kang Kim ),( Joo Ho Chung ),( Min Kyung Shin ),( Mu Hyoung Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Vitiligo is a pigmentary skin disorder characterized by the chronic and progressive loss of melanocytes. Human leukocyte antigen (HLA)-G is a nonclassic, major histocompatibility complex class I molecule that plays an important role in suppression of the immune response. Several recent studies have provided evidence that a 14-bp insertion/deletion polymorphism in the HLA-G gene might be associated with autoimmune disease. Objectives: Our aim in this study was to determine whether the 14-bp insertion/deletion polymorphism in the HLA-G gene contributes to the risk of developing non-segmental vitiligo (NSV) in the Korean population. Methods: We conducted a case-control association study of 192 NSV patients and 491 matched, unaffected controls. The HLA-G 14-bp insertion/deletion polymorphism was analyzed by gene scan after amplification using the polymerase chain reaction (PCR). Results: Genotypes for the 14-bp indel were different between the vitiligo group and Korean control group. The proportion of subjects with a homozygote 224 bp/224 bp genotype was significantly higher in the vitiligo group than the control group (7.1% vs. 3.5%, OR=2.25, 95% CI=1.06-4.76, P=0.039 in the recessive model). Conclusion: Our results suggest that the HLA-G 14-bp insertion/deletion polymorphism is associated with the development of NSV in the Korean population.