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RISS 인기검색어
- 검색키워드
- 저자 : ( Bastsetseg Ulambayar ) (검색결과 6 건)
- 무료
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Association Between Epithelial Cytokines and Clinical Phenotypes of Elderly Asthma
Ulambayar, Bastsetseg,Lee, So-Hee,Yang, Eun-Mi,Ye, Young-Min,Park, Hae-Sim The Korean Academy of Asthma, Allergy and Clinical 2019 Allergy, Asthma & Immunology Research Vol.11 No.1
<P><B>Purpose</B></P><P>Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses in asthmatic airways. We investigated clinical features and epithelial derived cytokine levels in elderly asthmatics compared to non-elderly asthmatics in a cross-sectional cohort of adult asthmatics in order to further understand its pathogenic mechanisms.</P><P><B>Methods</B></P><P>A total of 1,452 adult asthmatics were enrolled from a single tertiary hospital and were classified into 2 groups: 234 elderly (≥ 60 years at initial diagnosis) and 1,218 non-elderly (< 60 years at initial diagnosis) asthmatics. Asthma-related clinical parameters were compared between the 2 groups. Serum levels of epithelial cell-derived cytokines including interleukin (IL)-31, IL-33, IL-8, eotaxin-2, transforming growth factor beta 1 (TGF-β1) and periostin were measured by enzyme-linked immunosorbent assay.</P><P><B>Results</B></P><P>Significantly higher prevalence rates of late-onset asthma (onset age ≥ 40 years) and severe asthma, as well as the lower rate of atopy, blood/sputum eosinophil counts, total immunoglobulin E and eosinophil cationic protein levels were noted in elderly asthmatics compared to non-elderly asthmatics (<I>P</I> < 0.05, respectively). The forced expiratory volume in 1 second (FEV1, % predicted) level tended to be lower in elderly asthmatics (<I>P</I> = 0.07). In addition, serum IL-33 and IL-31 levels were significantly lower in elderly asthmatics, while no differences were found in the serum level of IL-8, eotaxin-2, TGF-β1 or periostin. Among elderly asthmatics, subjects with severe asthma had lower FEV1 (% predicted) value, but showed significantly higher serum levels of eotaxin-2 and TGF-β1, than those with non-severe asthma (<I>P</I> < 0.05 for each).</P><P><B>Conclusions</B></P><P>These findings suggest that age-related changes of epithelial cell-derived cytokines may affect clinical phenotypes and severity of elderly asthma: decreased levels of IL-33 and IL-31 may contribute to less Th2 phenotype, while increased levels of eotaxin-2 and TGF-β1 may contribute to severity.</P>
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Bastsetseg Ulambayar,이희원,양은미,박해심,이경림,예영민 대한면역학회 2019 Immune Network Vol.19 No.3
Translationally controlled tumor protein (TCTP) is also known as histamine releasing factor as it has the ability to activate mast cells. To investigate the role of TCTP in the pathogenesis of chronic spontaneous urticaria (CSU), we evaluated serum level of TCTP and effect of TCTP on basophil and mast cell degranulation. TCTP levels in the sera from 116 CSU patients and 70 normal healthy controls (NCs) were measured by ELISA. CD203c expression on basophils from CSU patients and β-hexosaminidase release from Laboratory of Allergic Disease 2 mast cells were measured upon stimulation monomeric and dimeric TCTP. Non-reducing Western blot analysis was used for detecting dimeric TCTP. No difference was observed in serum TCTP levels between CSU patients and NCs (p=0.676). However, dimeric TCTP intensity on Western blot was stronger in CSU patients than in NCs. TCTP levels were higher in patients with severe CSU (p=0.049) and with IgG positivity to FcɛRIα (p=0.038). A significant positive correlation was observed between TCTP and eosinophil cationic protein levels (Spearman's rho=0.341; p=0.001). Both basophil and mast cell degranulation were significantly increased after stimulation with dimeric TCTP, but not with monomic TCTP. The ability of TCTP to activate basophil and mast cells is dependent on dimerization, suggesting that the inhibition of TCTP dimerization can be a therapeutic option for CSU. Association between TCTP levels and the presence of IgG to high affinity Fc epsilon receptor I alpha subunit in CSU patients indicates that autoimmune mechanisms may be involved in the dimerization of TCTP.
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S-668 IgG autoantibody to FcεRIα in chronic urticaria patients with doubtful clinical implication
( Bastsetseg Ulambayar ),( Ga-young Ban ),( Ji-ho Lee ),( Chang-gyu Jeong ),( Duy Le Pham ),( Hae-sim Park ),( Young-min Ye ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Chronic Spontaneous Urticaria (CSU) is common skin disorder characterized by persistent or recurrent itchy wheals and pruritus of at least 6 weeks duration where the autoimmune mechanism is involved. In this study, we aimed to evaluate the level of IgG autoantibody against FcεRIα (IgG to FcεRIα) in CSU patients by dot-blot immunoassay and investigate the association with other clinical parameters including autologous serum skin test (ASST), urticaria activity score (UAS) and other antibodies. Method: We enrolled 125 CSU patients and 63 healthy controls (NC). We detected serum IgG autoantibody to FcεRIα by using rapid Dot-Blot immunoassay. The cut-off value was determined as mean intensity plus 2 standard deviations of values from NC Result: We detected IgG autoantibody to FcεRIα in 27.2% of CSU patients, significantly higher than NC group (1.6%, p<0.001). There was no difference in frequency of IgG anti-FcεRIα between CSU patients with positive and negative ASST response (61.8% vs 47.3% p=0.149). A significant female preponderance among CSU patients with positive IgG to FcεRIα was observed (94.1% vs 65.9%, p<0.001). However, there was no significant association of IgG anti- FcεRIα with other clinical parameters including UAS, the presence of anti-thyroid antibody and ANA, atopic status, serum total IgE levels and clinical response to antihistamines. In contrast, the C3 level was significantly different according to the presence of anti- FcεRIα antibody (109.8±19.9 vs 123.5±31.3, p= 0.027). Conclusions: The prevalence of FcεRIα autoantibody was significantly higher in CSU patients, particularly in female compared to NC. However, IgG anti-FcεRIα positivity was low (27.2%) and clinical implication has not been established in CSU. It seems that the anti-FcεRIα autoantibody might be involved in complement activation rather than in a direct degranulation of mast cell or basophil. Keywords: Chronic Spontaneous Urticaria ; high-affinity immunoglobulin receptor; dot-blot immunoassay
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