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아출(莪朮)의 Sesquiterpene 성분의 약물활성
신국현,윤기영,조태순,Shin, Kuk-Hyun,Yoon, Ki-Young,Cho, Tae-Soon 한국생약학회 1994 생약학회지 Vol.25 No.3
Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.
Chemical Constituents and Bioactivity of Curcuma aeruginosa Roxb.
Mohd. Aspollah Hj. Sukari,Suhaila Md. Saad,Nordin H Lajis,Mawardi Rahmani,Radzali Muse,Umi Kalsom Yusuf,Sugeng Riyanto 한국생약학회 2007 Natural Product Sciences Vol.13 No.3
study on the rhizomes of Curcuma aeruginosa has yielded three sesquiterpenes, whichwere identified as zedoarol (1), curcumenol (2) and isocurcumenol (3). The structures of the compounds weredetermined by Infrared Spectroscopy (IR), Nuclear Magnetic Resonance (1D and 2D NMR) and Mass Spectroscopy(MS). The crude extracts and pure compounds obtained were tested against pathogenic microbes and cancer cell linesKeywordsCurcuma aeruginosa, zedoarol, curcumenol, isocurcumenol, bioassay test