http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 주제어 : High heparin sensitivity at neutral pH (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Boronic acid-functionalized oligoamine colorimetric heparin receptor
Joseph, Vincent S.,Hong, Jong-Dal Elsevier 2018 Colloids and surfaces. A, Physicochemical and engi Vol.543 No.-
<P><B>Abstract</B></P> <P>Here we developed a synthetic colorimetric heparin receptor (denoted as OHR) bearing phenylboronic acid (PBA) and intermediary cationic ammonium groups on a geometrically flat biocompatible oligoamine framework. OHR showed remarkable affinity for heparin (at physiological conditions) with a binding constant comparable to the best such values reported previously. The high affinity of OHR for heparin was ascribed primarily to the flat molecular geometry of the receptor, which apparently allowed for effective interactions of the cationic ammonium and PBA groups of OHR with the functional groups along the bulky polymer chain of heparin. Moreover, this high affinity of OHR for heparin under physiological conditions as well as the high biocompatibility of OHR are features that make OHR a promising candidate for use in potential biomedical applications including the bedside detection of heparin levels in human blood during surgery, and the use of heparin reversal agents.</P> <P><B>Graphical abstract</B></P> <P>We developed a synthetic colorimetric heparin receptor OHR bearing phenylboronic acid and intermediary cationic ammonium groups on a geometrically flat biocompatible oligoamine framework. OHR showed remarkable affinity for heparin (at physiological conditions), which was ascribed primarily to the flat molecular geometry of the receptor, which apparently allowed for effective interactions of OHR with the functional groups along the bulky polymer chain of heparin.</P> <P>[DISPLAY OMISSION]</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
