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Guohua Yang,Xavier N. Siwe,Alain S. Leutou,Zhile Feng,장대해,Hong Dae Choi,강정숙,손병화,Viviane N. Nenkep 한국생약학회 2009 Natural Product Sciences Vol.15 No.3
The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. Bioassayguided fractionation of an organic extract led to the isolation of an acetophenone derivative, clavatol (2',4'- dihydroxy-3',5'-dimethylacetophenone) (1), and a benzodiazepine alkaloid, circumdatin A (2). Compound 1 showed moderate antibacterial activity against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus with minimum inhibitory concentration (MIC) values of 62.5, 62.5, 31.0 µg/mL, respectively, but compound 2 was inactive. Compounds 1 and 2 exhibited UV-A protection activity with ED50 values of 227.0 and 82.0 µM, respectively, indicating that they were more potent than the positive control, oxybenzone (ED50 350 µM), a common sunscreen agent.