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Wie, Myung-Bok,Song, Dong-Keun,Kim, Yung-Hi The Korean Society of Pharmacognosy 1993 생약학회지 Vol.24 No.3
We investigated the effects of single administration of Korean earthworm(Lamnodrilus gotai Hatai) juice (KEJ) on blood pressure and spontaneous motor activity in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats. We report that KEJ lowered blood pressure and spontaneous motor activity in SHR.
Antimicrobial Activities of Volatile Essential Oils from Korean Aromatic Plants
Shin, Kuk-Hyun,Chi, Hyung-Joon,Lim, Soon-Sung,Cho, Seon-Haeng,Moon, Hyung-In,Yu, Jae-Hyeun The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
Volatile essential oils obtained by steam distillation from 55 plant parts of 42 species of representative aromatic plants newly collected in Korean peninsula have been evaluated for antimicrobial activity against 5 microorganisms. The essential oils derived from 15 plant parts and 9 plant parts were found to exhibit very strong antimicrobial activities by more than 95% inhibition at 100 ${\mu}g/ml$ against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. Essential oil components such as l-limonene, ${\beta}-myrcene$, linalool, ${\gamma}-terpinene$, ${\alpha},{\beta}-phellandrene$, 1,8-cineole, l-borneol and bornylacetate, as a whole, have primarily contributed to the manifestation of the antimicrobial activity.
Monoamine Oxidase Inhibitors from Cinnamomi Cortex
Huong, Dang Thi Lan,Jo, Young-Su,Lee, Myung-Koo,Bae, Ki-Hwan,Kim, Young-Ho The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Four compounds were isolated from the dichloromethane fraction of Cinnamomi Cortex through bioassay-guided isolation. Their structures were identified as coumarin (1), 3,3-dimethoxy-1-propenyl benzene (2), cinnamic acid (3) and o-methoxy cinnamaldehyde (4) on the basis of spectroscopic data. All four compounds showed inhibitory activities in vitro against monoamine oxidase (MAO) prepared by mouse brain. The $IC_{50}$ values were $41.4\;{\mu}M\;(1),\;110.6\;{\mu}M\;(2),\;252.5\;{\mu}M\;(3)\;and\;83.1\;{\mu}M$ (4), respectively.
Anti-allergy Activity of Cinnamomi Cortex
Kim, Ra-Min,Kim, Young-Hee,Lee, Eun-Bang The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
The anti-allergy activity of Cinnamomum cassia cortex extract and its fractions were investigated in mice. The extract exhibited potent anaphylactic shock and Arthus reaction. Among the fractions obtained in the successive fractionation with n-hexane, butanol and acetone, the butanol insoluble portion was shown to have the activities.
Immunomodulatory Effect of Acidic Polysaccharide Fraction from Korean Red Ginseng (Panax ginseng)
Park, Kyeong-Mee,Jeong, Tae-Cheon,Kim, Young-Sook,Shin, Han-Jae,Nam, Ki-Yeul,Park, Jong-Dae The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Effects of red ginseng acidic polysaccharides (RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide $(100\;{\mu}g/ml)$ or concanavalin A $(1\;{\mu}g/ml)$ with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.
Flavonoids and Stilbenes as Repellents against the Blue Mussel, Mytilus edulis galloprovincialis
Singh, Inder Pal,Etoh, Hideo,Asai, Eiko,Kikuchi, Kojiro,Ina, Kazuo,Koyasu, Katsuya,Terada, Yukimasa The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.1
We studied the attachment-repelling activity of flavonoids, stilbenes, and their glycosides against the blue mussel Mytilus edulis galloprouincialis. Molecular mechanics calculations have shown that the most stable conformations of potent repellents 29 and 32 were the same. On the basis of these results, structure-activity relationships of these compounds are discussed.
Kim, Hye-Kyung,Moon, Kyung-Ho,Lee, Chung-Kyu The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Acorenone, a diterpene isolated from Acorus gramineus, showed strong resistance inhibitory activity against multi-drug resistant microorganisms such as Staphylococcus aureus SA2, which has resistance to 10 usual antibiotics including chloramphenicol (Cm). At the level of $5\;{\mu}g/ml$ when combined with $50\;{\mu}g/ml$ of Cm. Bacterial resistance to Cm is due to the presence in resistant bacteria of an enzyme, chloramphenicol acetyltransferase (CAT), which catalyses the acetyl-CoA dependent acetylation of the antibiotic at C-3 hydroxyl group. To elucidate the mechanism of resistant inhibitory effect, the acorenone which had the strongest resistant inhibitory activity, was investigated on the CAT assay. As the result, the combination of Cm and acorenone showed the strongest inhibitory activity on CAT as noncompetitive and dose dependent manner.
High Performance Liquid Chromatographic Analyses of Higenamine Enantiomers in Aconite Roots
Chung, Kyo-Soon,YunChoi, Hye-Sook,Hahn, Young-Hee The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
The enantiomers of higenamine were directly separated by high performance liquid chromatography using a chiral stationary phase and detected by UV. The R- and S-isomers of higenamine were eluted at the retention time of 22 min and 27 min, respectively. Higenamine was determined to be present as R-(+)-enantiomer not only in the embryo of Nelumbo nucifera, from which the separation of R-(+)-higenamine was reported, but also in various Aconite roots, from which higenamine was separated as optically inert racemic mixtures.
Effects of Tiliacorine on Voluntary Muscle and Blood Pressure
Khasnobis, Arnab,Seal, Tapan,Vedasiromoni, J. Rajan,Gupta, Malaya,Mukherjee, Biswapati The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1
Tiliacora racemosa Colebr. belongs to the family Menispermaceae, the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods $(UV,\;IR,\;^1H-NMR,\;Mass)$. Tiliacorine possesses neuromuscular blocking activity. It produces a dose dependent hypotensive effect in rats and cats, and this effect is blocked by atropine.
Min, Bok-Gi,Lee, Gyeong-Im,Ha, Joo-Young,Min, Kyung-Rak,Kim, Ju-Sun,Kang, Sam-Sik,Kim, Young-Soo The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.1
The CINC-1 is a member of rat interleukin-8 with chemotactic and activating properties to neutrophils. The CINC-1 induction in LPS-stimulated rat peritoneal macrophages was analyzed using a sensitive enzyme-linked immunosorbent assay. The peritoneal macrophages contained about 3 ng/ml as a basal level, and induced to maximal 18 ng/ml of CINC-1 by stimulation with 5 ${\mu}g/ml$ of LPS. Antiinflammatory steroids of dexamethasone and triamcinolon significantly suppressed the CINC-1 induction, where as aspirin and idomethacin did not show suppression. Inhibitory effects on the CINC-1 induction by natural triterpenoids having steroidal structures were analyzed. Among the 39 kinds of triterpenoids isolated from herbal medicines, acacigenin B and nigaichigoside F1 exhibited the highest suppression on the CINC-1 induction.