http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jung, Jin Ah,Kim, Suk Ran,Kim, Tae-Eun,Kim, Jung-Ryul,Lee, Soo-Youn,Huh, Wooseong,Ko, Jae-Wook Dustri-Verlag Dr. Karl Feistle 2012 International Journal of Clinical Pharmacology and Vol.50 No.9
<P>LB80380, a dipivoxil ester prodrug of LB80331, is a novel antiviral agent for the treatment of chronic hepatitis B. The aim of this study was to compare the pharmacokinetic differences after single oral administrations of the free base and maleate formulations of LB80380 in healthy male subjects.</P>
Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects.
Choi, Hye Duck,Lee, Hye Jung,Lee, Sang Hun,Kim, Soo-Hwan,Choi, Chung Am,Chang, Min Jung,Shin, Wan Gyoon Dustri-Verlag Dr. Karl Feistle 2012 International journal of clinical pharmacology and Vol.50 No.5
<P>Cilostazol is frequently used to treat and prevent thrombosis in Korean patients.</P>
Kim, S.H.,Chang, W.S.,Kim, J.P.,Minn, Y.K.,Choi, J.,Chang, J.W.,Kim, T.S.,Park, Y.G.,Chang, J.H. Dustri-Verlag Dr. Karl Feistle 2011 Clinical neuropathology Vol.30 No.6
<P><U>Aims:</U> The stereotactic brain biopsy is an essential diagnostic procedure in modern neurologic patient management. A side-cutting biopsy needle is one of the most widely used needle types. Recently we found a characteristic tissue artifact named “peripheral compressing artifact” in the brain tissues biopsied using a side-cutting needle of Leksell’s system. We investigate prevalence, possible cause and its clinical implication of this type of artifact. <U>Materials and methods:</U> We examined the biopsies from 80 patients (44 cases of gliomas, 13 lymphomas, 7 germ cell tumors, 2 other tumors, 1 metastatic carcinoma, 4 non-tumorous conditions such as demyelinating disease and 8 non-diagnostic) in the stereotactic biopsy group with a suspected brain tumor, who underwent a stereotactic brain biopsy using side-cutting needle of Leksell’s system. We also evaluated 16 cases of open brain biopsies without Leksell’s system as a control group. <U>Results:</U> The artifact is a semi-circular or band-like tissue compression in the periphery of the biopsied tissue. This artifact was found in 30 (37.5%) out of 80 cases and 57 (11.9%) out of 477 biopsied pieces. It might be produced during rotating of the inner cannula of the biopsy needle. Histologically, it might be misinterpreted as “hypercellular”, “spindle”, “well circumscribed”, or rarely as “pseudopalisading” especially in glioma. <U>Conclusions:</U> Awareness of this artifact would help making the appropriate pathological diagnosis for glioma. </P>
A positron emission tomography microdosing study with sertraline in healthy volunteers.
Shin, Kwang-Hee,Kim, Kyu-Pyo,Lim, Kyoung Soo,Kim, Ji Who,Lee, Yun-Sang,Yang, Bo Yeun,Lee, Jae Sung,Jung, Jae-Min,Yoon, Seo-Hyun,Jang, In-Jin,Yu, Kyung-Sang Dustri-Verlag Dr. Karl Feistle 2012 International journal of clinical pharmacology and Vol.50 No.3
<P>This study explored microdosing methods for evaluating the distribution and pharmacokinetics (PK) of a central nervous system (CNS) drug candidate.</P>
Choi, Hyang-Ki,Oh, Minkyung,Kim, Eun Ji,Song, Geun Seog,Ghim, Jong-lyul,Shon, Ji-Hong,Kim, Ho-Sook,Shin, Jae-Gook Dustri-Verlag Dr. Karl Feistle 2015 International Journal of Clinical Pharmacology and Vol.53 No.2
<P> The aim of this study was to compare the pharmacokinetic characteristics of metformin between a fixed-dose combination (FDC) of voglibose/metformin and co-administered individual voglibose and metformin tablets in healthy Korean volunteers under fasting conditions. A randomized, open-label, single-dose, two-treatment, two-way crossover study with a 7-day wash-out period was conducted. Plasma samples were collected for up to 24 hours and were analyzed for metformin using a validated liquid chromatography tandem mass-spectrometry (LC/MS). A non-compartmental method was used to calculate the pharmacokinetic parameters. Vital signs and adverse events were monitored, and physical examinations and laboratory tests were conducted to evaluate safety. In total, 28 subjects completed the study. The geometric mean ratio (GMR) and the 90% confidence interval (CIs) of C<SUB>max</SUB> and AUC<SUB>0–t</SUB> of metformin were 102.4 (94.5 – 111.0) and 107.1 (100.1 – 114.7), respectively. In total, 7 adverse drug reactions occurred in 4 subjects during the study; of these, 3 cases were from 3 subjects in the test treatment group, and 4 cases were from 3 subjects in the reference treatment group. All adverse drug reactions had been reported previously, and all subjects recovered fully without any sequelae. In conclusion, the pharmacokinetic profiles of metformin in two different study treatments, a voglibose/metformin FDC vs. the coadministration of the individual formulations, met the regulatory criteria for bioequivalence in healthy Korean subjects under fasting conditions. There was no significant difference in safety profiles between the two treatments. </P>
Park, C W,Lim, J H,Youn, D -Y,Chung, S,Lim, M -H,Kim, Y K,Chang, Y S,Lee, J -H Dustri-Verlag, Dr. Karl Feistle 2011 Clinical nephrology Vol.75 No.1
<P>Bartter syndrome (BS) Type IV, associated with a G47R mutation in the BSND gene, is known to result in a mild renal phenotype. However, we report here on three brothers with varying degrees of renal dysfunction from mild to end-stage renal disease associated with renal barttin and ClC-K expression. The brothers had histories of polyhydramnios, prematurity, polyuria, deafness, and small body size. Laboratory findings showed hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and an increased urinary excretion of sodium, potassium and chloride, consistent with BS Type IV. Microscopic examination of renal tissue showed hyperplasia of cells at the juxtaglomerular apparatus with dilated atrophic tubules and tubulointerstitial fibrosis. A weak barttin signal related to CIC-K expression in the cytoplasm of tubule cells, but not the basement membrane, was noted. A sequence analysis of the BSND gene showed that the affected males were homozygous for a missense G47R mutation in exon 1 of BSND. These findings suggest that the G47R mutation results in a dramatic decrease in barttin expression, which appears to be related to the location of CIC-K being changed from the basement membrane to the cytoplasm in the tubule and might have varying effects on renal function associated with factors other than this gene.</P>
Kim, Sung Eun,Yi, SoJeong,Shin, Kwang-Hee,Kim, Tae-Eun,Kim, Min-Jeong,Kim, Youn Hoa,Yoon, Seo Hyun,Cho, Joo-Youn,Shin, Sang-Goo,Jang, In-Jin,Yu, Kyung-Sang Dustri-Verlag Dr. Karl Feistle 2012 International journal of clinical pharmacology and Vol.50 No.1
<P>LC15-0444, a newly developed selective dipeptidyl peptidase IV inhibitor, has the potential to be administered with other antihyperglycemic agents. The aim of this study was to investigate the interaction between LC15-0444 and pioglitazone by comparing the pharmacokinetics of both compounds and their metabolites.</P>